British Poultry Science最新文献_第10页

Temperature manipulation during incubation: effect on embryo development and incidence of white striping and expression of related genes in broiler chickens from two commercial breeds. 孵化过程中的温度控制：对两种商品肉鸡胚胎发育和白条发生率以及相关基因表达的影响。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-08-30 DOI: 10.1080/00071668.2024.2383940

M Vafaeinia, S Yalcin

{"title":"Temperature manipulation during incubation: effect on embryo development and incidence of white striping and expression of related genes in broiler chickens from two commercial breeds.","authors":"M Vafaeinia, S Yalcin","doi":"10.1080/00071668.2024.2383940","DOIUrl":"10.1080/00071668.2024.2383940","url":null,"abstract":"1. This study evaluated the effects of cyclic eggshell temperature between 10 and 14 d of embryogenesis on traits viz. the expression of MYOZ2, PPARγ and GPx7 in breast muscle, meat quality and incidence of white striping at slaughter age.2. Eggs were obtained from Cobb and Ross broiler breeders to investigate the response of breeds to eggshell temperature, which regulated air temperature. A total of 784 eggs were incubated at either the control eggshell temperature (37.8°C) from 0 to 18 d or exposed to cyclic high eggshell temperature (CHT) at 38.8°C for 6 h/d between 10 and 14 d of incubation. The temperature was 36.8°C between 18 and 21 d. Hatched chicks were reared under optimum rearing conditions. The birds were sampled at 19 d of incubation, at hatch and at 42 d post-hatch.3. There was no effect of eggshell temperature on yolk-free body weight and residual yolk sac weight. The CHT chicks had wider breasts on the day of hatching.4. At hatch and 42d post-hatch, PPARγ expression in Cobb-CHT was upregulated 4.78-fold and downregulated 3.28-fold, respectively, compared to the Cobb-control. At slaughter age, chickens from Ross-CHT had 1.98- and 2.33-fold upregulated PPARγ and GPX7 expressions, respectively, compared to Ross-control. The CHT increased GPx7 expression in the Cobb-CHT day-old chicks compared to the Cobb-control. On ED19, MYOZ2 expression was upregulated in Cobb and downregulated in Ross by CHT.5. The effects of breed and eggshell temperature on pH15, L*, a*, expressible juice and cooking loss were not significant. The CHT increased the incidence of severe white striping lesions in Ross chickens.6. It was concluded eggshell temperature modulated embryo development, incidence of white striping and expression of related genes differently in the two commercial breeds.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"71-80"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated GWAS and transcriptome analysis reveals key genes associated with muscle fibre and fat traits in Gushi chicken. 综合 GWAS 和转录组分析揭示了与固始鸡肌肉纤维和脂肪特征相关的关键基因。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-10-04 DOI: 10.1080/00071668.2024.2400685

H Li, S Li, H Zhang, J Gu, Y Dai, R Wu, Y Wang, R Han, G Sun, Y Zhang, H Li, Y Zhao, G Li

{"title":"Integrated GWAS and transcriptome analysis reveals key genes associated with muscle fibre and fat traits in Gushi chicken.","authors":"H Li, S Li, H Zhang, J Gu, Y Dai, R Wu, Y Wang, R Han, G Sun, Y Zhang, H Li, Y Zhao, G Li","doi":"10.1080/00071668.2024.2400685","DOIUrl":"10.1080/00071668.2024.2400685","url":null,"abstract":"1. In the following experiment meat quality traits of a Gushi-Anka F2 resource population were measured, and their heritability estimated. Intramuscular fat (IMF) had medium heritability (0.35) but leg muscle fibre density (LMD), leg muscle fibre diameter (LMF), breast muscle fibre density (BMD), fresh fat content (FFA), and absolute dry fat content (AFC) had low heritability (0-0.2). The IMF presented the most important genetic additive effect among the poultry meat quality-related traits studied.2. The phenotypic data of meat quality traits in the Gushi-Anka F2 resource population were combined with genotyping by sequencing (GBS) data to obtain genotype data. Six meat quality traits in 734 birds were analysed by GWAS. Based on these variants, 83 significant (-log10(p) > 4.42) single nucleotide polymorphisms and four quantitative trait loci (QTL) regions corresponding to 175 genes were identified. Further linkage disequilibrium (LD) analysis was conducted on chromosome 13 (Chr13) and chromosome 27 (Chr27) QTL regions.3. Based on the transcriptome data and GWAS results, 12 shared genes - ITGB3, DNAJC27, ETV4, C7orf50, FKBP1B, G3BP1, IGF2BP1, KCNH6, LOC416263, SCARA5, SMIM5 and TBL1XR1 were identified as candidate genes influencing muscle fibre and fat traits.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"31-41"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of intraperitoneal injection of Glycyrrhizin on central regulation of food intake in broilers injected with LPS. 腹腔注射甘草酸苷对注射 LPS 的肉鸡摄食中枢调节的影响

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-09-09 DOI: 10.1080/00071668.2024.2396451

A Rahdari, F Hamidi

{"title":"The effect of intraperitoneal injection of Glycyrrhizin on central regulation of food intake in broilers injected with LPS.","authors":"A Rahdari, F Hamidi","doi":"10.1080/00071668.2024.2396451","DOIUrl":"10.1080/00071668.2024.2396451","url":null,"abstract":"1. Poultry farming faces challenges regarding correct hygiene and nutrition. One of the challenges is gram-negative bacteria that stimulate pro-inflammatory reactions through lipopolysaccharide (LPS) and cause disease and anorexia. Liquorice, a medicinal plant containing glycyrrhizin (Glz; a saponin and emulsifier compound) as its main active ingredient, was injected into broilers to investigate any beneficial effects on feed intake in LPS-injected broilers.2. The study involved three experiments using 72 male broiler chickens in each, to examine the impact of Glz on feed intake, especially when challenged with lipopolysaccharide (LPS) by intra-peritoneal (IP) injection to cause inflammation (n = 24). Experiment 1 was conducted to examine the effects of intraperitoneal injection of Glz (12.5, 25 and 50 mg) on feed intake in chickens. In experiment 2, the effects of intracerebroventricular injections of LPS (6.25, 12.5 and 25 ng) were examined. The third experiment investigated the impact of IP injection of Glz on inflammation induced by LPS.3. Injection of Glz significantly increased feed intake in a dose-dependent manner. Whereas LPS significantly reduced the feed intake in feed-deprived chickens (p < 0.05).4. In conclusion, Glz can neutralise the feed intake reduction caused by inflammation in broilers, highlighting its potential role in modulating feed intake in broilers.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"124-130"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of different housing systems on the oxidative defence system, heterophil functions, cellular immune response and cytokines in laying hens. 不同饲养方式对蛋鸡氧化防御系统、异性嗜血杆菌功能、细胞免疫反应和细胞因子的影响

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-09-04 DOI: 10.1080/00071668.2024.2395500

M Erek, E Matur

{"title":"Effects of different housing systems on the oxidative defence system, heterophil functions, cellular immune response and cytokines in laying hens.","authors":"M Erek, E Matur","doi":"10.1080/00071668.2024.2395500","DOIUrl":"10.1080/00071668.2024.2395500","url":null,"abstract":"1. This study investigated the effects of different housing systems on oxidative defence mechanisms, heterophil functions, cellular immune response and cytokine production in laying hens. One hundred and twenty laying hens were allocated into one of four groups: conventional cages, furnished cages, deep litter, and free range.2. Housing system did not affect malondialdehyde concentrations and enzymatic antioxidant status. Ascorbic acid values were higher in deep-litter hens than in those in conventional cages and free range.3. Phagocytic and chemotactic activities tended to rise in the deep-litter system, and oxidative burst was higher than in furnished cages. Cytotoxic T cells were decreased in furnished cages, both cytotoxic and helper T cells decreased in deep litter compared to free range.4. The IL-2 and IL-13 expression was higher in deep litter than in conventional cages, and IL-6 expression was higher in furnished cages than in free range.5. Housing system had no significant effects on the oxidative defence system; however, they affected heterophil functions, cellular defence mechanisms and cytokine production. The results suggested that breeders need to consider the housing system's potential effects on immune defence responses while applying a breeding strategy appropriate for animal welfare and consumer demand.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalase, superoxide dismutase and butylated hydroxytoluene benefit mid-term storage of red-legged partridge sperm (Alectoris rufa). 过氧化氢酶、超氧化物歧化酶和丁基羟基甲苯有利于红腿鹧鸪精子（Alectoris rufa）的中期储存。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-10-11 DOI: 10.1080/00071668.2024.2394185

B Bernal, I Gallarosa-García, A Toledano-Díaz, C Castaño, R Velázquez, O Torres, M G Gil, J Santiago-Moreno

{"title":"Catalase, superoxide dismutase and butylated hydroxytoluene benefit mid-term storage of red-legged partridge sperm (Alectoris rufa).","authors":"B Bernal, I Gallarosa-García, A Toledano-Díaz, C Castaño, R Velázquez, O Torres, M G Gil, J Santiago-Moreno","doi":"10.1080/00071668.2024.2394185","DOIUrl":"10.1080/00071668.2024.2394185","url":null,"abstract":"1. The present study assessed the effect of different antioxidants on the quality of chilled/frozen-thawed sperm of red-legged partridge.2. Sperm samples from 40 red-legged partridges were collected and extended 1:1 (v:v) with Lake and Ravie 84, supplemented with ascorbic acid or butylated hydroxytoluene (BHT) at 0, 0.2, 0.4, 0.8 mM and catalase (CAT) or superoxide dismutase (SOD) at 0, 100, 200 and 300 IU/ml. Ten sperm samples were used per concentration. Motility and viability were evaluated in fresh and after 6 h of chilling at 5°C or after freezing-thawing.3. For chilled sperm, the presence of ascorbic acid decreased viability and several motility variables; BHT 0.8 mM increased non-progressive motility (NPM, 26.7 ± 1.99 vs. 20.7 ± 2.12); CAT 200 IU/ml improved the rectilinear velocity (40.4 ± 4.63 μ/s vs. 29.9 ± 4.62 μ/s) and linear progression ratio (52.8 ± 3.11% vs. 45.4 ± 2.98%); SOD 100 IU/ml increased NPM (24.5 ± 1.21% vs. 19.3 ± 1.75%) and tended to improve total progressive motility (42.7 ± 3.33% vs. 33.2 ± 3.26%, p = 0.07). Using an extender supplemented with CAT 200 or SOD 100 did not improve the post-thawed sperm quality.4. The present work provides an advance in the optimisation of chilling and freezing protocols for red-legged partridge sperm.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"131-138"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplementing pigeon grit with acidifier improves metabolism and the reproductive performance of breeding pigeons as well as the development of growth performance of squabs. 在鸽砂中添加酸化剂可改善种鸽的新陈代谢和繁殖性能，以及乳鸽的生长发育性能。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-09-30 DOI: 10.1080/00071668.2024.2400692

S Zheng, Y Tang, W Huang, W Zhang, Y Zhang, M Yang, H Lu, Z Li, Y He, X Qiu, Y Liu, Z Gou, Z Qiu, Y Bin, Z Zhang, H Gao, W Wang, J Peng, Y Huang, Y Liang

{"title":"Supplementing pigeon grit with acidifier improves metabolism and the reproductive performance of breeding pigeons as well as the development of growth performance of squabs.","authors":"S Zheng, Y Tang, W Huang, W Zhang, Y Zhang, M Yang, H Lu, Z Li, Y He, X Qiu, Y Liu, Z Gou, Z Qiu, Y Bin, Z Zhang, H Gao, W Wang, J Peng, Y Huang, Y Liang","doi":"10.1080/00071668.2024.2400692","DOIUrl":"10.1080/00071668.2024.2400692","url":null,"abstract":"1. This study evaluated the effectiveness of different types of acidifiers on reproductive performance, body weight loss and plasma biochemical indices of breeding pigeons as well as on growth performance, carcass characteristics, meat quality and plasma biochemical indices of squabs.2. In a 45 d trial, 144 pairs of European white Mimas pigeons were selected and randomly divided into three experimental groups. Three groups of pigeons were fed plain pigeon grit (NC), pigeon grit supplemented with 5% single acidifier (SAG) and pigeon grit supplemented with 5% combined acidifiers (CAG).3. Supplementing with SAG and CAG significantly increased the weight gain in male pigeons from 1-12 d of incubation. However, SAG and CAG had no significant effect on the feed intake of breeding pigeons during incubation, but significantly increased total feed intake of breeding pigeons during the lactation period. Breeder pigeons fed SAG and CAG had significantly higher egg-laying rate at 40 d. In addition, feeding SAG and CAG significantly increased growth rate and slaughter weight of squabs, but SAG reduced the diameter of pectoral muscle fibres. Biochemical indices showed that feeding SAG and CAG improved metabolism and increased the liver function of breeder pigeons and squabs.4. In conclusion, supplementing pigeon grit with acidifiers increased feed intake of breeding pigeons during lactation, protected liver function, enhanced reproductive performance and promoted the growth and development of squabs.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"81-91"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole genome analysis of Salmonella Gallinarum strains isolated from a fowl typhoid outbreak in southern Brazil. 从巴西南部禽伤寒疫情中分离出的加里纳氏沙门氏菌菌株的全基因组分析。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-09-11 DOI: 10.1080/00071668.2024.2394973

N N Rizzo, A S P Núncio, R Levandowski, C A D Nascimento, K A Borges, T Q Furian, L Ruschel Dos Santos, F Pilotto, L B Rodrigues, V P Nascimento

引用次数: 0

Mannan oligosaccharide as an alternative to infeed antibiotics to improve growth performance of broilers: a meta-analysis. 用甘露寡糖替代饲料抗生素提高肉鸡生长性能：一项荟萃分析。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-08-30 DOI: 10.1080/00071668.2024.2391764

B R Polidoro, M J K de Oliveira, F D S C Braga, G D V Polycarpo

{"title":"Mannan oligosaccharide as an alternative to infeed antibiotics to improve growth performance of broilers: a meta-analysis.","authors":"B R Polidoro, M J K de Oliveira, F D S C Braga, G D V Polycarpo","doi":"10.1080/00071668.2024.2391764","DOIUrl":"10.1080/00071668.2024.2391764","url":null,"abstract":"1. The purpose of this meta-analysis was to evaluate the effect of mannan oligosaccharide (MOS) as an alternative to antibiotic growth promoters (AGP) on feed intake (FI), body weight gain (BWG), and feed conversion ratio (FCR) of broilers.2. Data from 75,594 broilers were extracted from 17 articles (19 trials) published between January 2010 and March 2023. The main criteria for the publication selection were as follows, at least three treatments applied (negative control group without MOS or AGP versus MOS or AGP supplementation), presence of performance results, and intra-experimental variation associated with the mean of response (such as standard error). Treatments were classified as control, MOS, or AGP, and adjusted means of treatment were compared. Additionally, the average daily gain (ADG) and average daily feed intake (ADFI) of each type of supplementation were calculated relative (Δ) to the control group (ΔADFI and ΔADG) and expressed as a percentage of the difference.3. Broilers receiving a diet supplemented with MOS had a 3.7% better BWG and 3% better FCR compared to the control diet (P < 0.001), but these variables were similar to the group receiving AGP supplementation. No significant difference was detected in FI among treatments (P > 0.050). The relationship between ΔADG and ΔADFI was linear for the MOS and AGP-supplemented group (P < 0.050). The ΔADG of broilers fed diets supplemented with MOS or AGP was 6.4% and 4.54% when ΔADFI was zero, respectively. The ΔADG of MOS increased by 0.58% for every 1% of increasing observed in ΔADFI. The corresponding value for the increased ΔADG for the AGP group was 0.69%.4. The results of this meta-analysis indicated that MOS supplementation is effective in increasing BWG and reducing FCR, similar to broilers fed a diet supplemented with AGP. Therefore, MOS is a safe and sustainable alternative for AGP-free poultry production.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"98-106"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of dietary calcium and microbial phytase on the bioavailability of two sources of zinc in broilers. 日粮钙和微生物植酸酶对肉鸡两种锌源生物利用率的影响。

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-09-25 DOI: 10.1080/00071668.2024.2383920

V Khaksar, F Hervo, N Même, A R Monteiro, A Narcy

{"title":"Effects of dietary calcium and microbial phytase on the bioavailability of two sources of zinc in broilers.","authors":"V Khaksar, F Hervo, N Même, A R Monteiro, A Narcy","doi":"10.1080/00071668.2024.2383920","DOIUrl":"10.1080/00071668.2024.2383920","url":null,"abstract":"1. The objective of this study was to test the effect of microbial phytase and calcium (Ca) levels on the Zn bioavailability depending on the Zn source.2. A total of 144, one-day-old broilers received a diet containing 40 mg Zn/kg for 1 week. They were then assigned to one of the eight experimental treatments during 2 weeks. Diets contained 27 mg native Zn and were formulated according to a 2 × 2 × 2 factorial design with two added Zn sources (23 mg Zn/kg), sulphate (ZnSO4) or oxide (ZnO); two dietary Ca levels of either 6 (low) or 10 g/kg (moderate); and two microbial phytase levels, of either 0 or 750 phytase unit/kg.3. Moderate Ca plus phytase improved body weight gain (BWG) and low Ca level without microbial phytase decreased tibia weight (Ca × Phy; p = 0.049). Zinc oxide resulted in a higher tibia development (i.e. tibia weight and length; p < 0.05) and BWG (p = 0.009) and lower FCR (p < 0.001) compared to ZnSO4.4. Phytase improved tibia Zn concentration especially in birds given ZnSO4 compared to ZnO (Zn × Phy; p = 0.049). Moderate Ca diets improved tibial characteristics and Zn deposition compared to low Ca diets (p < 0.05).5. Soluble Zn in the gizzard increased in the presence of phytase (p = 0.011), while higher dietary Ca reduced this in birds receiving ZnO (p = 0.004). In the jejunum, Zn solubility was higher with phytase (p = 0.008).6. Under the conditions of this study, dietary levels of Ca and microbial phytase affect Zn availability in broilers more than the Zn source.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"107-115"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of goose-derived adiponectin peptide gADP3 on LPS-induced inflammatory injury in goose liver. 鹅源性脂肪连接蛋白肽 gADP3 对 LPS 诱导的鹅肝炎症损伤的影响

IF 1.6 3区农林科学

British Poultry Science Pub Date : 2025-02-01 Epub Date: 2024-09-09 DOI: 10.1080/00071668.2024.2393960

B Ma, Y Zheng, S Liu, Y Qiu, X Xing, M Gao, Z Cao, X Luan

{"title":"Effect of goose-derived adiponectin peptide gADP3 on LPS-induced inflammatory injury in goose liver.","authors":"B Ma, Y Zheng, S Liu, Y Qiu, X Xing, M Gao, Z Cao, X Luan","doi":"10.1080/00071668.2024.2393960","DOIUrl":"10.1080/00071668.2024.2393960","url":null,"abstract":"1. This study evaluated the effects and mechanisms of action of the peptide gADP3 on hepatic inflammatory injury induced by lipopolysaccharide (LPS).2. Hepatic inflammatory injury was induced in geese by intraperitoneal injection of LPS and gADP3, and the adiponectin receptor agonist AdipoRon (positive control) was used for potential amelioration. Serum inflammatory factor levels, liver function-related biochemical indicators and oxidative stress-related biochemical parameters in the liver tissues were determined. The expression levels of adiponectin and its receptors, inflammation and oxidative stress-related genes and key signalling molecules involved in adiponectin, inflammation and oxidative stress signalling pathways in liver tissues were detected.3. The peptide gADP3 alleviated inflammatory cell infiltration and hepatic inflammatory changes, reversed the decrease in serum albumin (ALB), total protein (TP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) content or activity induced by LPS and increased the activity of the antioxidant enzymes CAT (catalase), SOD (superoxide dismutase) and GSH-Px (glutathione peroxidase).4. The peptide gADP3 upregulated the expression of antioxidant enzyme-related genes GCLC, HO-1 and NQO1 in liver tissues, decreased the levels of inflammatory factors like TNF-α, IL-1β, IL-6, IFN-γ and TGF-β and reduced mRNA expression levels of inflammatory-related genes TNF-α, IL-1β, iNOS and TGF-β. Additionally, it increased the mRNA and protein expression levels of adiponectin and its receptors, as well as key molecules in the adiponectin signalling pathway like AMPK and PPARα. In addition, gADP3 reversed the changes in mRNA or protein expression of inflammatory and oxidative stress signalling pathway-related genes P38MAPK, NF-κBP65, TLR4 and Nrf2 in liver tissues caused by LPS treatment.5. In conclusion, goose-derived adiponectin peptide gADP3, similar to the adiponectin receptor agonist AdipoRon, attenuated LPS-induced hepatic inflammatory injury in geese.","PeriodicalId":9322,"journal":{"name":"British Poultry Science","volume":" ","pages":"49-62"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0