A García, V Araujo, I Bautista, C Rodriguez, V López, S Gaytan, R Cruz, T Garcia, L Leyva, A Kandeil, R Webby
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引用次数: 0
Abstract
1. Highly pathogenic avian influenza (HPAI) A(H7N3) viruses have continued to circulate in Mexican poultry since their initial identification in the summer of 2012. Although several control strategies have been implemented, the virus has spread to several states, causing enormous economic losses in the commercial poultry sector. Important factors to ensure vaccine potency include a close match between the antigen and circulating strains and using sufficient antigen to protect the birds and prevent shedding during subsequent infections.2. The following study investigated the haemagglutin (HA) concentration of an adjuvanted vaccine produced from a reverse genetics-modified low-pathogenic avian influenza A(H7N3) virus that could protect chickens against homologous challenge. Inactivated vaccine formulations with different HA concentrations (0.8, 1.1, 1.3 and 3.1 μg/0.5 ml haemagglutinin) were prepared and tested in chickens.3. The results showed that the formulations containing 1.1 μg or more of HA per 0.5 ml dose protected the birds against disease symptoms and reduced viral replication when compared with the vaccine containing 0.8 μg/0.5 ml.
期刊介绍:
From its first volume in 1960, British Poultry Science has been a leading international journal for poultry scientists and advisers to the poultry industry throughout the world. Over 60% of the independently refereed papers published originate outside the UK. Most typically they report the results of biological studies with an experimental approach which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: anatomy, embryology, biochemistry, biophysics, physiology, reproduction and genetics, behaviour, microbiology, endocrinology, nutrition, environmental science, food science, feeding stuffs and feeding, management and housing welfare, breeding, hatching, poultry meat and egg yields and quality.Papers that adopt a modelling approach or describe the scientific background to new equipment or apparatus directly relevant to the industry are also published. The journal also features rapid publication of Short Communications. Summaries of papers presented at the Spring Meeting of the UK Branch of the WPSA are published in British Poultry Abstracts .