Vaccine dosage haemagglutinin concentration required to protect birds against highly pathogenic avian influenza A(H7N3) virus and reduce viral replication.

IF 1.7 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
A García, V Araujo, I Bautista, C Rodriguez, V López, S Gaytan, R Cruz, T Garcia, L Leyva, A Kandeil, R Webby
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引用次数: 0

Abstract

1. Highly pathogenic avian influenza (HPAI) A(H7N3) viruses have continued to circulate in Mexican poultry since their initial identification in the summer of 2012. Although several control strategies have been implemented, the virus has spread to several states, causing enormous economic losses in the commercial poultry sector. Important factors to ensure vaccine potency include a close match between the antigen and circulating strains and using sufficient antigen to protect the birds and prevent shedding during subsequent infections.2. The following study investigated the haemagglutin (HA) concentration of an adjuvanted vaccine produced from a reverse genetics-modified low-pathogenic avian influenza A(H7N3) virus that could protect chickens against homologous challenge. Inactivated vaccine formulations with different HA concentrations (0.8, 1.1, 1.3 and 3.1 μg/0.5 ml haemagglutinin) were prepared and tested in chickens.3. The results showed that the formulations containing 1.1 μg or more of HA per 0.5 ml dose protected the birds against disease symptoms and reduced viral replication when compared with the vaccine containing 0.8 μg/0.5 ml.

保护鸟类免受高致病性甲型禽流感(H7N3)病毒感染和减少病毒复制所需的疫苗剂量血凝素浓度。
1. 自2012年夏季首次发现高致病性禽流感(HPAI) A(H7N3)病毒以来,该病毒继续在墨西哥家禽中传播。尽管已经实施了若干控制战略,但该病毒已蔓延到若干州,给商业家禽部门造成巨大的经济损失。确保疫苗效力的重要因素包括抗原与流行毒株之间的密切匹配,并使用足够的抗原来保护鸟类并防止在随后的感染期间脱落。下面的研究调查了由反向遗传修饰的低致病性禽流感a (H7N3)病毒制成的佐剂疫苗的血凝素(HA)浓度,该疫苗可以保护鸡免受同源攻击。制备了血凝素浓度分别为0.8、1.1、1.3和3.1 μg/0.5 ml的灭活疫苗,并进行了鸡体试验。结果表明,与含有0.8 μg/0.5 ml的疫苗相比,每0.5 ml剂量含有1.1 μg或更多HA的配方可以保护鸟类免受疾病症状的侵害,并减少病毒复制。
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来源期刊
British Poultry Science
British Poultry Science 农林科学-奶制品与动物科学
CiteScore
3.90
自引率
5.00%
发文量
88
审稿时长
4.5 months
期刊介绍: From its first volume in 1960, British Poultry Science has been a leading international journal for poultry scientists and advisers to the poultry industry throughout the world. Over 60% of the independently refereed papers published originate outside the UK. Most typically they report the results of biological studies with an experimental approach which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: anatomy, embryology, biochemistry, biophysics, physiology, reproduction and genetics, behaviour, microbiology, endocrinology, nutrition, environmental science, food science, feeding stuffs and feeding, management and housing welfare, breeding, hatching, poultry meat and egg yields and quality.Papers that adopt a modelling approach or describe the scientific background to new equipment or apparatus directly relevant to the industry are also published. The journal also features rapid publication of Short Communications. Summaries of papers presented at the Spring Meeting of the UK Branch of the WPSA are published in British Poultry Abstracts .
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