Brain Research Bulletin最新文献

{"title":"Health awareness correlates with whole-brain gray matter volume in healthy adults","authors":"Keisuke Kokubun ,&nbsp;Kiyotaka Nemoto ,&nbsp;Yoshinori Yamakawa","doi":"10.1016/j.brainresbull.2025.111547","DOIUrl":"10.1016/j.brainresbull.2025.111547","url":null,"abstract":"<div><div>As populations continue to age, interest in brain health is increasing. However, little is known about the relationship between health awareness and brain health in healthy adults. In this study, psychological questionnaire data from 184 participants were analyzed using multiple regression, with brain structural measures obtained by MRI as the dependent variables. Health awareness was positively associated with gray matter volume (GMV) in the whole brain, temporal lobe, and occipital lobe, after controlling for sex, age, education, and BMI. These associations remained significant after correction for multiple comparisons. Consistent with self-regulated learning (SRL) strategy theory, being health conscious may help individuals adopt and maintain behaviors that support brain health. To our knowledge, this is the first study to demonstrate a correlation between health awareness and brain structure in healthy adult men and women.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111547"},"PeriodicalIF":3.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystathionine-β-synthase-derived hydrogen sulfide contributes to glucocorticoid-induced depressive-like behaviors in rats by modulating neuroinflammation","authors":"Ying Zhao ,&nbsp;Shi-Yi Ye ,&nbsp;Long Li ,&nbsp;Yi-Heng Li ,&nbsp;Jin-Qiong Zhan ,&nbsp;Li-Li Zheng ,&nbsp;Yuan-Jian Yang ,&nbsp;Bo Wei ,&nbsp;Shu-Zhen Jiang ,&nbsp;Xiao-Yan Cheng","doi":"10.1016/j.brainresbull.2025.111549","DOIUrl":"10.1016/j.brainresbull.2025.111549","url":null,"abstract":"<div><h3>Background</h3><div>Long-term treatment of glucocorticoids (GCs) may lead to depressive adverse effect. Hydrogen sulfide (H₂S) is implicated in the pathophysiology of depression and has an ability to modulate neuroinflammatory, which underlies the pathogenesis of depression. The aim of this study was to investigate whether H₂S signaling contributed to dexamethasone (DEX)-induced depression in a rat model.</div></div><div><h3>Methods</h3><div>Rats were subcutaneously injected with DEX (5 mg/kg) once daily for 28 days. The behavioral performances were examined by social interaction test (SIT), sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST). The expressions of cystathionine-β-synthase (CBS) and inducible nitric oxide synthase (iNOS) were measured by western blotting and immunofluorescence assay. Cytokine levels were examined by enzyme-linked immunosorbent assay (ELISA) kits. The morphological changes of neurons in rat hippocampal CA1 region were observed using H.E. staining.</div></div><div><h3>Results</h3><div>We found that chronic DEX treatment caused obvious depressive-like behaviors in rats, and the levels of H₂S and CBS, the predominant H₂S-producing enzyme in the brain, were significantly reduced in the hippocampus of DEX-treated rats. Overexpression of CBS increased the levels of H₂S and CBS protein in the hippocampus and attenuated the depressive-like behaviors in DEX-treated rats, whereas inhibition of CBS activity abolished the beneficial effects of CBS elevation. Mechanismly, chronic DEX treatment reduced the levels of anti-inflammatory cytokines IL-10 and TGF-β, increased the levels of pro-inflammatory cytokines IL-1β and TNF-α, and caused neuronal damage in the hippocampus of rats, while CBS overexpression reversed these changes caused by DEX treatment. Furthermore, the increased protein level of iNOS, a marker of microglia polarizing to M1 phenotype to produce pro-inflammatory effects, in the hippocampus of DEX-treated rats was also restored by CBS overexpression.</div></div><div><h3>Conclusion</h3><div>These results indicate that CBS-derived H₂S contributes to glucocorticoid-induced depressive-like behaviors in rats, and the effects of H₂S signaling might involve the regulation of neuroinflammation.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111549"},"PeriodicalIF":3.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verbascoside inhibits OGD/R-induced SK-N-SH cell injury by regulating METTL14/CHAC1/NRF2/SLC7A11/GPX4 pathway","authors":"Liwei Wen ,&nbsp;Cheng Zhang ,&nbsp;Xia Zhou ,&nbsp;Jiaxing Feng ,&nbsp;Qiang Li ,&nbsp;Fubing Yang","doi":"10.1016/j.brainresbull.2025.111543","DOIUrl":"10.1016/j.brainresbull.2025.111543","url":null,"abstract":"<div><h3>Background</h3><div>The potential therapeutic value of verbascoside (VB) has been reported in a variety of diseases, including cerebral hemorrhage. In this study, we aimed to explore the underlying mechanism of VB in cerebral ischemic stroke.</div></div><div><h3>Methods</h3><div>The <em>in vitro</em> ischemic stroke model was established by Oxygen-glucose deprivation/reoxygenation (OGD/R) model. CCK-8 assay and EdU assay were performed for cell proliferation. Flow cytometry analysis was adopted to analyze cell apoptosis. ELISA kits were used to estimate the concentrations of inflammatory factors. Ferroptosis-related markers were examined with indicated commercial kits. The relations of METTL14, CHAC1 and IGF2BP2 were analyzed by MeRIP assay, RIP assay and Actinomycin D assay. Gene expression was determined by qRT-PCR and western blot.</div></div><div><h3>Results</h3><div>VB promoted the proliferation and inhibited apoptosis, inflammation and ferroptosis in OGD/R-treated SK-N-SH cells. VB decreased METTL14 expression in OGD/R-treated SK-N-SH cells and METTL14 knockdown alleviated OGD/R-induced injury of SK-N-SH cells. METTL14 and IGF2BP2 mediates m6A modification of CHAC1. CHAC1 overexpression abrogated the effects of METTL14 knockdown on OGD/R-induced SK-N-SH cell injury. Moreover, the effects of VB on OGD/R-treated SK-N-SH cell proliferation, apoptosis, inflammation and ferroptosis were abated by elevating METTL14 or CHAC1. Besides, VB reduced the levels of NRF2, SLC7A11 and GPX4 in OGD/R-treated SK-N-SH cells, while METTL14 or CHAC1 overexpression reversed the effects.</div></div><div><h3>Conclusion</h3><div>VB promoted the proliferation and inhibited apoptosis, inflammation and ferroptosis in OGD/R-treated SK-N-SH cells by regulating METTL14/CHAC1/NRF2/SLC7A11/GPX4 pathway.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111543"},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enriched environment ameliorates neurobehavioral abnormalities, hippocampal inflammation, and synaptic dysfunction in adult male mice exposed to intermittent hypoxia during pregnancy","authors":"Shi-Kun Fang ,&nbsp;Fei Hu ,&nbsp;Yu Zhang ,&nbsp;Wei-Zhong Lun ,&nbsp;Yue-Ming Zhang ,&nbsp;Xue-Yan Li ,&nbsp;Kai-Xuan Zhang ,&nbsp;Zhen-Yu Hu ,&nbsp;Ru-Meng Wei ,&nbsp;Chong-Yang Ren ,&nbsp;Gui-Hai Chen","doi":"10.1016/j.brainresbull.2025.111544","DOIUrl":"10.1016/j.brainresbull.2025.111544","url":null,"abstract":"<div><h3>Background</h3><div>Sleep apnea during gestation is marked by intermittent hypoxia (IH) and frequent arousals in humans. Prenatal exposure to IH (PIH) is believed to negatively impact the neurodevelopment of offspring born to women who experience sleep apnea during pregnancy. Research using rodent models has demonstrated that enriched environments (EE) can alleviate behavioral indicators of neuropsychiatric and cognitive impairments, potentially through modulation of inflammatory responses and synaptic mechanisms. However, the specific effects of EE on PIH-induced neurobehavioral alterations in adult animals, and the underlying biological mechanisms and potential correlations, remain largely unclear and warrant further investigation.</div></div><div><h3>Methods</h3><div>Pregnant C57BL/6J mice were exposed to IH or normoxic conditions during gestational days 15–21, after which their male offspring were housed in either enriched or standard environments from weaning through adulthood. anxiety-like behavior (ALB) was assessed using the Open Field Test (OFT) and Elevated Plus Maze (EPM), while depressive-like behavior (DLB) was measured through the Tail Suspension Test (TST) and Forced Swim Test (FST); memory and learning abilities were measured using the Morris Water Maze (MWM). Moreover, levels of hippocampal TNF-α, IL-6, and IL-1β were quantified using ELISA. Western blotting (WB) and RT-qPCR were employed to assess the protein and mRNA expression of NF-κB/NLRP3 pathway-related molecules, as well as GFAP, Iba1, SYN, PSD-95, GAP-43, and Arc. Additionally, immunofluorescence (IF) staining was carried out to detect the expression of GFAP, Iba1, GAP-43, PSD-95, SYN, and Arc.</div></div><div><h3>Results</h3><div>In offspring mice, PIH induced ALBs and DLBs, cognitive deficits, elevated hippocampal levels of pro-inflammatory cytokines, upregulation of GFAP, Iba1, and NF-κB/NLRP3 pathway-associated molecules, and reduced expression of synaptic plasticity proteins, including GAP-43, PSD-95, and SYN; however, subsequent treatment with an EE effectively reversed these alterations</div></div><div><h3>Conclusions</h3><div>EE attenuates PIH-induced inflammatory responses in the hippocampus through suppression of the NF-κB/NLRP3 signaling cascade and alleviates synaptic dysfunction caused by PIH.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111544"},"PeriodicalIF":3.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutation of ube3a causes developmental abnormalities and autism-like molecular and behavioral alterations in zebrafish","authors":"Godfried Dougnon ,&nbsp;Lana Rummel ,&nbsp;Hideaki Matsui","doi":"10.1016/j.brainresbull.2025.111542","DOIUrl":"10.1016/j.brainresbull.2025.111542","url":null,"abstract":"<div><div>Mutations in the <em>UBE3A</em> gene are responsible for neurodevelopmental disorders (NDDs), including Angelman syndrome (AS), which is characterized by developmental delays, impaired motor coordination, and cognitive disabilities. In recent years, <em>UBE3A</em> mutations have also been linked to autism spectrum disorders (ASD), due to their significant role in synaptic plasticity and cognitive function. Although substantial research has utilized mammalian models, the zebrafish (<em>Danio rerio</em>) provides unique opportunities to investigate gene functions owing to their transparent embryos, rapid development, and suitability for large-scale genetic and behavioral studies. In this study, we characterized a zebrafish model harboring a point mutation (T &gt; A) in exon 3 of the zebrafish <em>ube3a</em> gene, which induces a stop codon resulting in a truncated protein. We performed comprehensive developmental, behavioral, and molecular analyses to investigate the impact of Ube3a dysfunction at both larval and adult stages. We observed alterations in embryonic development, significant locomotor deficits, including stereotypic movements, and reduced social preference and aggressiveness. Furthermore, RNA sequencing analysis of both larvae and adults revealed dysregulation in chromatin, nucleosome, protein-DNA, and primary cilia-related genes. Our findings provide a functional characterization of the <em>ube3a</em> mutation in zebrafish at both larval and adult stages. This zebrafish model offers new insights into the roles of <em>UBE3A</em> in neurodevelopment and behavior, expanding our understanding of its dysfunction in NDDs.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111542"},"PeriodicalIF":3.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biophysically constrained dynamical modelling of the brain using multimodal magnetic resonance imaging","authors":"Siddharth Bansal ,&nbsp;Bradley S. Peterson ,&nbsp;Chaitanya Gupte ,&nbsp;Siddhant Sawardekar ,&nbsp;Maria J. Gonzalez Anaya ,&nbsp;Maricar Ordonez ,&nbsp;Deepa Bhojwani ,&nbsp;Jonathan D. Santoro ,&nbsp;Ravi Bansal","doi":"10.1016/j.brainresbull.2025.111541","DOIUrl":"10.1016/j.brainresbull.2025.111541","url":null,"abstract":"<div><div>We propose a Biophysically Restrained Analog Integrated Neural Network (<strong>BRAINN</strong>), an analog electrical network that models the dynamics of brain function. The network interconnects analog electrical circuits that simulate two tightly coupled brain processes: (1) propagation of an action potential, and (2) regional cerebral blood flow in response to the metabolic demands of signal propagation. These two processes are modeled by two branches of an electrical circuit comprising a resistor, a capacitor, and an inductor. We estimated the electrical components from <em>in vivo</em> multimodal MRI together with the biophysical properties of the brain applied to state-space equations, reducing arbitrary parameters such that the dynamic behavior is determined by neuronal integrity. Electrical circuits were interconnected at Brodmann areas to form a network using neural pathways traced with diffusion tensor imaging data. We built BRAINN in Simulink, MATLAB, using longitudinal multimodal MRI data from 20 healthy controls and 19 children with leukemia. BRAINN stimulated by an impulse applied to the lateral temporal region generated sustained activity. Stimulated BRAINN functional connectivity was comparable (within ±1.3 standard deviations) to measured resting-state functional connectivity in 40 of the 55 pairs of brain regions. Control system analyses showed that BRAINN was stable for all participants. BRAINN controllability in patients relative to healthy participants was disrupted prior to treatment but improved during treatment. BRAINN is scalable as more detailed regions and fiber tracts are traced in the MRI data. A scalable BRAINN will facilitate study of brain behavior in health and illness, and help identify targets and design transcranial stimulation for optimally modulating brain activity.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111541"},"PeriodicalIF":3.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical thinning and microstructural integrity disruption in white matter hyperintensities","authors":"Xin Wang ,&nbsp;Jie Hu ,&nbsp;Xiaosan Wu ,&nbsp;Wei Wang ,&nbsp;Xiaohui Xie ,&nbsp;Shanshan Cao ,&nbsp;Feng Geng ,&nbsp;Panpan Hu ,&nbsp;Yanghua Tian ,&nbsp;Kai Wang ,&nbsp;Jun Zhang","doi":"10.1016/j.brainresbull.2025.111525","DOIUrl":"10.1016/j.brainresbull.2025.111525","url":null,"abstract":"<div><h3>Background</h3><div>The relationships between white matter microstructure, cortical atrophy, and cognitive function in cerebral small vessel disease (CSVD)-related white matter hyperintensities (WMHs) patients are unclear.</div></div><div><h3>Methods</h3><div>71 right-handed WMHs patients (mild, n = 23; moderate, n = 27; severe, n = 21) and 35 healthy controls (HCs） were included. Tract-based spatial statistics (TBSS) assessed microstructure via fractional anisotropy (FA) and mean diffusivity (MD). Surface-based morphometry (SBM) measured morphology. Cognitive function was evaluated with a standardized scale. Multivariate regression, correlation, and mediation analyses were conducted.</div></div><div><h3>Results</h3><div>Patients with moderate to severe WMHs exhibited impaired cognitive function, reduced FA, increased MD in extensive white matter, and decreased cortical thickness compared to HCs (P &lt; 0.05). Cortical thinning was observed in the insula, superior frontal gyrus, supramarginal gyrus, transverse temporal gyrus, superior temporal gyrus, pars opercularis, postcentral gyrus, pars triangularis, precentral gyrus, and anterior cingulate. Moreover, FA and MD were respectively significantly correlated with cortical thickness. Mediation analysis revealed cortical thinning in specific regions (e.g., left insula, supramarginal gyrus, transverse temporal gyrus) mediated the association between FA (69 %) and MD (93 %) with Verbal Fluency Test (VFT) scores.</div></div><div><h3>Conclusion</h3><div>WMHs patients exhibited white matter microstructure degeneration and reduced cortical thickness, both linked to cognitive decline. Specific left-hemisphere cortical thinning mediated the relationship between white matter microstructure and VFT performance, revealing mechanisms of WMHs-related cognitive decline.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111525"},"PeriodicalIF":3.7,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglia-Astroglia-Neuron network following stroke: Novel insight into extracellular vesicles communication","authors":"Hao Wan ,&nbsp;Yicheng Cui ,&nbsp;Yanyang Zeng ,&nbsp;Jianbin Hu ,&nbsp;Meihua Li ,&nbsp;Zhipeng Xiao","doi":"10.1016/j.brainresbull.2025.111537","DOIUrl":"10.1016/j.brainresbull.2025.111537","url":null,"abstract":"<div><div>Stroke is one of the leading causes of death and disability worldwide, with ischemic stroke accounting for the majority of cases. Intercellular communication is critical to its prognostic impact, and extracellular vesicles (EVs) are an emerging important mechanism. EVs are increasingly recognized as key mediators of crosstalk between neurons and glial cells, affecting processes such as neuroinflammation, oxidative stress and tissue repair. More previous studies have focused on signaling and information exchange between the two types of cells. This paper reviews the EVs-mediated triad interaction between neurons, astrocytes and microglia after stroke based on the spatiotemporal entanglement of them. Not only the intercellular crosstalk of EVs of microglial, astrocytic, or neuronal origins is explored in detail, the cargoes carried by EVs and their mechanisms of action are resolved, but also the overlapping parts in the EVs-mediated cellular communication mechanisms are analyzed, such as the NF-κB signaling pathway and miR-124 which play an important and complex role in a variety of intercellular communications. On this basis, EVs were revealed to have potential as biomarkers and therapeutic carriers. The aim of this paper is to contribute to our deeper understanding of stroke pathophysiology and to inspire new possible therapeutic strategies.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111537"},"PeriodicalIF":3.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synaptic vesicle protein 2A regulates mossy fiber sprouting in a drug-resistant epilepsy rat model via laminin α5/integrin β1","authors":"Yongfei Shi ,&nbsp;Yi Xu ,&nbsp;Yinlin Hu ,&nbsp;Langtao Liu ,&nbsp;Chen Li ,&nbsp;Siyin Ren ,&nbsp;Guofeng Wu ,&nbsp;Likun Wang","doi":"10.1016/j.brainresbull.2025.111536","DOIUrl":"10.1016/j.brainresbull.2025.111536","url":null,"abstract":"<div><div>Drug-resistant epilepsy (DRE) is frequently characterized by pathological mossy fiber sprouting (MFS), which is a defining indicator of aberrant synaptic remodeling within the hippocampus. Despite extensive investigations of the molecular underpinnings of MFS, they remain only partially elucidated. Synaptic vesicle protein 2 A (SV2A) is a key modulator of neurotransmitter exocytosis that has been associated with epileptogenesis. However, its involvement in structural neural plasticity throughout epileptogenic progression remains unclear. In this study, a pilocarpine-induced rat model of DRE was utilized to evaluate the influence of SV2A on MFS. Immunofluorescence, western blot analysis, and the lentivirus-mediated modulation of SV2A expression revealed that SV2A suppression intensified both MFS and seizure severity. Mechanistically, the results of co-immunoprecipitation combined with mass spectrometry suggested that a deficiency of SV2A could facilitate aberrant axonal sprouting via disruption of the laminin α5 (LAMA5)/integrin β1 (ITGB1) signaling cascade. Subsequent validation confirmed that decreased LAMA5 expression and attenuated ITGB1 activation in SV2A-deficient rats were contributory factors to pathological axonal sprouting. These findings implicate SV2A as a critical determinant of structural plasticity in epileptogenesis and highlight the LAMA5/ITGB1 axis as a promising therapeutic avenue for DRE.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111536"},"PeriodicalIF":3.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced imaging and localization techniques in brain tumor resection: A review for precision tumor removal","authors":"Xizi Song ,&nbsp;Peishan Huang ,&nbsp;Xiuyun Liu ,&nbsp;Huijie Yu ,&nbsp;Jin Wei ,&nbsp;Dong Ming","doi":"10.1016/j.brainresbull.2025.111533","DOIUrl":"10.1016/j.brainresbull.2025.111533","url":null,"abstract":"<div><div>Brain tumors are one of the most dangerous cancers with serious effects on human health. The primary treatment approach involves a combination of surgery, supplemented by postoperative radiotherapy. The growth pattern of malignant tumor is typically infiltrative, posing a challenge in visually distinguishing the tumor from the surrounding normal brain tissue during surgery. In order to mitigate the risk of potential neurological damage, an increasing number of imaging and localization techniques and devices are being employed. Commonly used preoperative functional neuroimaging techniques, such as magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS), have proven to be powerful tools in neurosurgery. MRI aids in visualizing important functional areas involved in the tumor as well as the conduction pathways, and TMS assists in assessing cortical function. This enhanced preoperative information contributes to refining surgical planning and reduced risks in the surgery. The application of intraoperative functional neuroimaging techniques (neuronavigation (NN), intraoperative ultrasound (IOUS), fluorescence guided technique (FGT) and intraoperative neurophysiological monitoring (IONM)), has improved the gross total removal (GTR) of glioma in functional brain regions. NN, IOUS and FGT enable real-time exploration of tumor structures, providing valuable guidance for resection. Concurrently, IONM is employed to highlight the relationship between tumor and the functional cortex, with the aim of preventing or minimizing neurological deficits. These approaches ensure precision in tumor resection and help safeguard neurological function during surgery. This paper discusses the potential advantages and limitations of these techniques used in glioma surgery, and provides directions for the development of techniques.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111533"},"PeriodicalIF":3.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}