Brain Research Bulletin最新文献

{"title":"The mirror preference test: A reverse translational approach to study anomalous subjective experience in rats","authors":"Daria Chestnykh ,&nbsp;Liubov S. Kalinichenko ,&nbsp;Stephan von Hörsten ,&nbsp;Johannes Kornhuber ,&nbsp;Christian P. Müller","doi":"10.1016/j.brainresbull.2025.111247","DOIUrl":"10.1016/j.brainresbull.2025.111247","url":null,"abstract":"<div><div>Significant advancements have been made in the treatment of psychotic disorders, yet current pharmacotherapy remains inadequate. Symptoms related to the misinterpretation of reality are crucial for diagnosis but pose challenges for preclinical research. In humans, a Mirror-Gazing test is used to examine abnormal self-experience and to predict the risk of schizophrenia. To address this, we developed a task to evaluate anomalous subjective experiences in rats using a Mirror-Preference test. Here we demonstrate that naive rats show a preference for a mirror chamber, which was followed by significant habituation over a series of trials. In subsequent tests, we utilized dimmed lighting and net-covered mirrors to induce incomplete mirror images. Acute stimulation with amphetamine (AMPH, 3 mg/kg, i.p.) further increased the preference for the mirror. In a model of psychosis induced by chronic AMPH administration, rats showed fewer and shorter interactions with the mirror but maintained their preference for the chamber where psychotic-like animals were given additional AMPH stimulation (1.5 mg/kg, i.p.) before testing. Here, a surprising reversal in chamber preference was observed, along with decreased frequency and duration of mirror contact, suggesting mirror avoidance. The AMPH-presensitized rats also exhibited hyperlocomotion and elevated anxiety, indicative of psychotic-like behaviour. Although self-recognition in rodents is debatable, recent studies suggest they can discriminate mirror images. We propose that limited visual perception that meets brain monoamine sensitization may trigger visual illusions as part of a psychotic-like state in rats. This novel approach can be utilized to test intervention strategies for psychosis in rats.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111247"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143196043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats\" [Brain Res. Bull. 185 (2022) 28-38].","authors":"Xiangrong Chen, Guan Wei, Ding Li, Youwu Fan, Yile Zeng, Zhengting Qian, Zhen Jia, Yong Tang, Yan Shi, Heming Wu, Xiang Li","doi":"10.1016/j.brainresbull.2025.111244","DOIUrl":"https://doi.org/10.1016/j.brainresbull.2025.111244","url":null,"abstract":"","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":" ","pages":"111244"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized prediction of multi-domain intelligence quotient in bipolar disorder patients using resting-state functional connectivity.","authors":"Xiaoyu Li, Wei Wei, Linze Qian, Xiaojing Li, Mingli Li, Ioannis Kakkos, Qiang Wang, Hua Yu, Wanjun Guo, Xiaohong Ma, George K Matsopoulos, Liansheng Zhao, Wei Deng, Yu Sun, Tao Li","doi":"10.1016/j.brainresbull.2025.111238","DOIUrl":"https://doi.org/10.1016/j.brainresbull.2025.111238","url":null,"abstract":"<p><strong>Background: </strong>Although accumulating studies have explored the neural underpinnings of intelligence quotient (IQ) in patients with bipolar disorder (BD), these studies utilized a classification/comparison scheme that emphasized differences between BD and healthy controls at a group level. The present study aimed to infer BD patients' IQ scores at the individual level using a prediction model.</p><p><strong>Methods: </strong>We applied a cross-validated Connectome-based Predictive Modeling (CPM) framework using resting-state fMRI functional connectivity (FCs) to predict BD patients' IQ scores, including Verbal IQ (VIQ), Performance IQ (PIQ), and Full-Scale IQ (FSIQ). For each IQ domain, we selected the FCs that contributed to the predictions and described their distribution across eight widely-recognized functional networks. Moreover, we further explored the overlapping patterns of the contributed FCs for different IQ domains.</p><p><strong>Results: </strong>The CPM achieved statistically significant prediction performance for three IQ domains in BD patients. Regarding the contributed FCs, we observed a widespread distribution of internetwork FCs across somatomotor visual, dorsal attention, and ventral attention networks, demonstrating their correspondence with aberrant FCs correlated to cognition deficits in BD patients. A convergent pattern in terms of contributed FCs for different IQ domains was observed, as evidenced by the shared-FCs with a leftward hemispheric dominance.</p><p><strong>Conclusions: </strong>The present study preliminarily explored the feasibility of inferring individual IQ scores in BD patients using the FCs-based CPM framework. It is a step toward the development of applicable techniques for quantitative and objective cognitive assessment in BD patients and contributes novel insights into understanding the complex neural mechanisms underlying different IQ domains.</p>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":" ","pages":"111238"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cortical macrostructural and microstructural changes with cognitive performance and gene expression in subcortical ischemic vascular disease patients with cognitive impairment","authors":"Jing Huang ,&nbsp;Runtian Cheng ,&nbsp;Xiaoshuang Liu ,&nbsp;Li Chen ,&nbsp;Tianyou Luo","doi":"10.1016/j.brainresbull.2025.111239","DOIUrl":"10.1016/j.brainresbull.2025.111239","url":null,"abstract":"<div><h3>Objective</h3><div>Previous researches have demonstrated that patients with subcortical ischemic vascular disease (SIVD) exhibited brain structure abnormalities. However, the cortical macrostructural and microstructural characteristics and their relationship with cognitive scores and gene expression in SIVD patients remain largely unknown.</div></div><div><h3>Methods</h3><div>This study collected 3D-T1 and diffusion tensor imaging data from 30 SIVD patients with cognitive impairment (SIVD-CI) and 32 normal controls. The between-group comparative analyses of cortical thickness, area, volume, local gyrification index (LGI), and mean diffusivity (MD) were conducted with a general linear model. Moreover, the associations between the significant neuroimaging values and the cognitive scores and gene expression values from Allen Human Brain Atlas database were evaluated using partial least squares regression and partial correlation analysis.</div></div><div><h3>Results</h3><div>SIVD-CI patients showed significant decreases in cortical thicknesses across 18 regions, cortical volumes across three regions, and cortical LGI across five regions, as well as significant increases in cortical MD across five regions (<em>P</em> &lt; 0.05). The significantly reduced cortical thicknesses of the right insula, left superior temporal gyrus, left central anterior gyrus, and left caudal anterior cingulate cortex, as well as the significantly reduced cortical LGI in left caudal anterior cingulate cortex, were significantly positively correlated with different cognitive scores (<em>P</em> &lt; 0.05). Furthermore, the abnormal cortical structural indicators were found to be significantly related to nine risk genes (VCAN, APOE, EFEMP1, SALL1, BCAN, KCNK2, EPN2, DENND1B and XKR6) (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The specific cortical structural damage may be related to specific cognitive decline and specific risk genes in SIVD-CI patients.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111239"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143196634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose metabolism impairment in major depressive disorder","authors":"Fanhao Meng ,&nbsp;Jing Wang ,&nbsp;Long Wang ,&nbsp;Wei Zou","doi":"10.1016/j.brainresbull.2025.111191","DOIUrl":"10.1016/j.brainresbull.2025.111191","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a common mental disorder with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains unclear. Patients with MDD experience systemic and localized impairments in glucose metabolism throughout the disease course, disrupting various processes such as glucose uptake, glycoprotein transport, glycolysis, the tricarboxylic acid cycle (TCA), and oxidative phosphorylation (OXPHOS). These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. These mechanical changes contribute to the pathogenesis of MDD and severely interfere with the prognosis. Herein, we summarized the impairment of glucose metabolism and its pathophysiological mechanisms in patients with MDD. In addition, we briefly discussed potential pharmacological interventions for glucose metabolism to alleviate MDD, including glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, and pioglitazone, to encourage the development of new therapeutics.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"221 ","pages":"Article 111191"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural decoding reveals dynamic patterns of visual chunk memory processes","authors":"Chantat Leong ,&nbsp;Fei Gao ,&nbsp;Zhen Yuan","doi":"10.1016/j.brainresbull.2025.111208","DOIUrl":"10.1016/j.brainresbull.2025.111208","url":null,"abstract":"<div><div>Chunk memory constitutes the basic unit that manages long-term memory and converts it into immediate decision-making processes, it remains unclear how to interpret and organize incoming information to form effective chunk memory. This paper investigates electroencephalography (EEG) patterns from the perspective of time-domain feature extraction using chunk memory in visual statistical learning and combines time-resolved multivariate pattern analysis (MVPA). The GFP and MVPA results revealed that chunk memory processes occurred during specific time windows in the learning phase. These processes included attention modulation (P1), recognition and feature extraction (P2), and segmentation for long-term memory conversion (P6). In the decision-making stage, chunk memory processes were encoded by four ERP components. Scene processing correlated with P1, followed by feature extraction facilitated by P2, encoding process (P4), and segmentation process (P6). This paper identifies the early process of chunk memory through implicit learning and applies univariate and multivariate approaches to establish the neural activity patterns of the early chunk memory process, which provides ideas for subsequent related studies.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"221 ","pages":"Article 111208"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury","authors":"Na Xu ,&nbsp;Zihuan Sun ,&nbsp;Weikang Guan ,&nbsp;Yiming Liu ,&nbsp;Yun Gao ,&nbsp;Chaoxian Yang","doi":"10.1016/j.brainresbull.2025.111216","DOIUrl":"10.1016/j.brainresbull.2025.111216","url":null,"abstract":"<div><div>Poly (lactic-co-glycolic acid) (PLGA) is an important biomaterial for tissue defect repair, but its application in replacing missing brain tissue needs improvement. Mesenchymal stem cells (MSCs) have been used to treat various neurological diseases, but they face challenges when filling large tissue defects. The purpose of this study was to investigate the effects of PLGA combined with MSCs transplantation on brain structure and neural function in rats with traumatic brain injury (TBI), and explore its possible mechanism. The results showed that both PLGA transplantation and PLGA+MSCs transplantation could improve the brain structure and promote nerve function recovery in rats with TBI, with PLGA+MSCs transplantation being superior to PLGA transplantation. Furthermore, compared to PLGA transplantation alone, PLGA+MSCs transplantation further reduced brain injury and cell apoptosis, promoted neuron survival, and improved synaptic plasticity. Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"221 ","pages":"Article 111216"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease","authors":"Su Yan ,&nbsp;Jun Lu ,&nbsp;Bingfang Duan ,&nbsp;Hongquan Zhu ,&nbsp;Tian Tian ,&nbsp;Yuanyuan Qin ,&nbsp;Yuanhao Li ,&nbsp;Wenzhen Zhu","doi":"10.1016/j.brainresbull.2025.111222","DOIUrl":"10.1016/j.brainresbull.2025.111222","url":null,"abstract":"<div><h3>Background</h3><div>Increasing evidence has documented cortical involvement at all stages of PD. The local vulnerabilities within certain brain regions in PD have been previously demonstrated, whereas its underlying genetic and neurochemical factors remain unclear. This study aims to investigate the spatial spectrum of cortical atrophy in Parkinson’s disease (PD) and link these variances in gray matter properties and curvature respectively to putative molecular pathways and neurotransmitter factors.</div></div><div><h3>Methods</h3><div>We recruited 141 clinically diagnosed PD patients and 70 healthy controls. Cortical morphological abnormalities of PD were obtained by intergroup comparisons in gray matter properties metrics and curvature measurements. Then we performed gene-category enrichment and spatial correlation analyses to evaluate the specific correspondence between cortical alteration in PD and genetic expression from the Allen Human Brain Atlas and normative neurotransmitter atlases from Neuromaps.</div></div><div><h3>Results</h3><div>We found decreased gray matter properties in temporal, somatomotor, cingulate and occipital cortices, decreased curvature measures in occipital, temporal and orbitofrontal cortices, and increased curvature measures in somatomotor, prefrontal and posterior parietal cortices for PD patients. The related genes were enriched for the glucose metabolism, mitochondrial function, and post-translational histone modifications processes. In addition, the serotonin and norepinephrine transporter devoted more to gray matter properties alterations while the dopamine, gamma-aminobutyric acid receptors, and norepinephrine transporter were strong contributors of curvature abnormalities in PD.</div></div><div><h3>Conclusions</h3><div>Collectively, the present study offered interpretation of cortical morphological alterations and the cortical pathogenic theory in PD from genetic and neurochemical perspectives, which inspire further research on new pharmacotherapeutic approaches.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"221 ","pages":"Article 111222"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients","authors":"Si-Jie Chen ,&nbsp;Qing-Yang Li ,&nbsp;Jiang Zhou ,&nbsp;Qian Wu ,&nbsp;Yu Zhang ,&nbsp;Qian-Qian Zhang ,&nbsp;Hao Hu ,&nbsp;Xiao-Quan Xu ,&nbsp;Fei-Yun Wu ,&nbsp;Qi Niu","doi":"10.1016/j.brainresbull.2025.111229","DOIUrl":"10.1016/j.brainresbull.2025.111229","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the differences in brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis (ALS-L and ALS-B, respectively) patients using resting-state functional MRI (rs-fMRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).</div></div><div><h3>Materials and methods</h3><div>The rs-fMRI data were collected from 41 ALS patients (11 ALS-B and 30 ALS-L) and 25 healthy controls (HC). ALFF and ReHo values were calculated, and group differences were assessed using one-way ANCOVA and two-sample t-tests. Correlation analyses with clinical measures were conducted. Support vector machine (SVM) analysis was performed to distinguish ALS subtypes.</div></div><div><h3>Results</h3><div>Compared with ALS-L, ALS-B showed increased ALFF values in the right gyrus rectus/ orbital part of right middle frontal gyrus, orbital part of left middle frontal gyrus and left dorsolateral superior frontal gyrus/ left medial superior frontal gyrus and decreased ALFF values in the left superior occipital gyrus (FDR-corrected, P &lt; 0.05). Both ALS subtypes demonstrated distinct ALFF alterations compared to HC. Differences in ReHo values were only found between ALS-B and HC. Correlation analyses revealed associations between ALFF in specific brain regions and ALS clinical scores. SVM analysis achieved an accuracy of 90.2 %, with an AUC of 0.909 in differentiating ALS-B and ALS-L.</div></div><div><h3>Conclusion</h3><div>ALS-B and ALS-L patients had distinct alterations in brain spontaneous neural activity, which could serve as potential biomarkers for accurately distinguishing these two subtypes. Our findings offer a new insight into the neural mechanism of ALS, underscoring the importance of personalized diagnostic approaches for this complex neurological disorder.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"221 ","pages":"Article 111229"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons” [Brain Res. Bull. 154 (2020) 32–42]","authors":"Xiu-Qi Bao,&nbsp;Lu Wang,&nbsp;Han-Yu Yang,&nbsp;Li-Yan Hou,&nbsp;Qing-Shan Wang,&nbsp;Dan Zhang","doi":"10.1016/j.brainresbull.2024.111188","DOIUrl":"10.1016/j.brainresbull.2024.111188","url":null,"abstract":"","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"221 ","pages":"Article 111188"},"PeriodicalIF":3.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}