Brain Research Bulletin最新文献

{"title":"Anxiety- and nociception-like behaviours in mature adult mice induced by audiovisual overstimulation during infancy","authors":"Jessica L.S. Lima ,&nbsp;Amanda R. Amaral ,&nbsp;Ana Mayra de O. Cavalcante ,&nbsp;Ana Kaline O. Chagas ,&nbsp;Denise Nunes Oliveira ,&nbsp;Juliana C. Melo ,&nbsp;Gerlânia de O. Leite ,&nbsp;Barry J. Sessle ,&nbsp;Adriana R. Campos","doi":"10.1016/j.brainresbull.2025.111314","DOIUrl":"10.1016/j.brainresbull.2025.111314","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the behavioural effects in adult mice previously subjected to audiovisual overstimulation during infancy and adolescence.</div></div><div><h3>Methods</h3><div>Mice aged 21, 26 and 36 days (p21, p26 and p36) underwent auditory (70 db) and visual (flashing lights) stimulation for 2 or 6 h per day until p64; naive animals were used as controls. At p200, tests assessed respectively motor activity (open field test), depression (forced swimming and splash tests), anxiety (hole board, plus maze and marble burying tests, aggression (resident-intruder test), and nociception (von Frey and hot plate tests).</div></div><div><h3>Results</h3><div>There were no significant (ANOVA, p &gt; 0.05) behavioural changes in forced swimming, splash, hole board, or marble burying tests between overstimulated and naive groups. However, the p21 group showed significantly (ANOVA, p &lt; 0.05) increased anxiety-like behaviour (2 h) in the elevated plus maze test and altered nociceptive behaviour in the von Frey test (2 and 6 h). The p26 group (2 h) displayed significantly reduced rearing behaviours, fewer entries in the plus maze test, and faster reaction times to noxious thermal stimulation (2 h).</div></div><div><h3>Conclusion</h3><div>Audiovisual overstimulation during early development can promote anxiety-like behaviour and affect nociceptive behaviour in adult mice.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111314"},"PeriodicalIF":3.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics and concordance alterations of intrinsic brain activity indices in stroke-induced Broca’s aphasia varies based on first language: A resting-state fMRI analysis","authors":"Linazi Gu ,&nbsp;Sijing Li ,&nbsp;Mei Qu ,&nbsp;Yanling Xi","doi":"10.1016/j.brainresbull.2025.111312","DOIUrl":"10.1016/j.brainresbull.2025.111312","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the changes in intrinsic brain activity (IBA) among individuals with Broca aphasia (BA) after a stroke.</div></div><div><h3>Methods</h3><div>We collected information from 60 participants. The participants were categorized into four groups according to language (Uyghur and Chinese) and BA status (BA and healthy): Uyghur aphasia patients (UA), Uyghur healthy control subjects (UH), Chinese aphasia patients (CA), and Chinese healthy control subjects (CH). Each group comprised 15 individuals. The shifting dynamics and concordance of regional IBA indices were examined via sliding time-window analysis. A two-way analysis of variance (ANOVA) was conducted with the IBA indices to test for regions with interactions between language and BA status. Partial correlation analysis was employed to evaluate the relationships between various indices and language behaviors.</div></div><div><h3>Results</h3><div>Participants with head motion exceeding 3 mm translation or 3° rotation were excluded, leaving 9, 12, 13, and 15 participants in the UA, CA, UH, and CH groups, respectively. Seven IBA indices were activated in 16 brain regions in the four groups. In detail, two-way ANOVA revealed a significant interaction between language and BA status in four IBA dynamic indices (amplitude of low-frequency fluctuations (ALFF), Regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC)) in 11 brain regions (P &lt; 0.000). For the other three dynamic indices (fractional amplitude of low-frequency fluctuation (fALFF), Voxel-mirrored homotopic connectivity (VMHC), and Global signal connectivity (GSCorr)), no interaction was observed among the four groups. However, the main effect analysis of the BA state demonstrated significant differences across a total of six brain regions (P &lt; 0.000). The concordance alterations in fALFF, ReHo, VMHC, DC, and GSCorr in the right calcarine fissure and the surrounding cortex were significantly lower in CA than in CH (P = 0.000), significantly higher in UA than in CA (P = 0.025), and significantly lower in UH than CH (P = 0.000).</div></div><div><h3>Conclusion</h3><div>In conclusion, alterations in IBA dynamics and concordance were observed in individuals from UA, UH, CA, and CH. These findings suggest that the IBA dynamic index varies across brain regions of BA patients with different local languages, providing a novel perspective for investigating brain alterations by analyzing temporal dynamics using rs-fMRI data.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111312"},"PeriodicalIF":3.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulated brain dynamics in the visualmotor network in type 2 diabetes patients and their relationship with cognitive impairment","authors":"Ying Yu ,&nbsp;Bo Hu ,&nbsp;Xin-Wen Yu ,&nbsp;Yan-Yan Cui ,&nbsp;Xin-Yu Cao ,&nbsp;Min-Hua Ni ,&nbsp;Si-Ning Li ,&nbsp;Pan Dai ,&nbsp;Qian Sun ,&nbsp;Xiao-Yan Bai ,&nbsp;Yao Tong ,&nbsp;Xiao-Rui Jing ,&nbsp;Ai-Li Yang ,&nbsp;Sheng-Ru Liang ,&nbsp;Li-Juan Du ,&nbsp;Shuo Guo ,&nbsp;Lin-Feng Yan ,&nbsp;Bin Gao ,&nbsp;Guang-Bin Cui ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.brainresbull.2025.111313","DOIUrl":"10.1016/j.brainresbull.2025.111313","url":null,"abstract":"<div><h3>Objective</h3><div>Type 2 diabetes mellitus (T2DM) is a significant risk factor for mild cognitive impairment (MCI). Here, we identified a T2DM-specific effective connectivity (EC) network, the dynamic features of which could be used to distinguish T2DM patients with MCI from healthy controls (HC) and correlation with cognitive performance.</div></div><div><h3>Methods</h3><div>Local and multicentered T2DM patients and matched HC who underwent functional magnetic resonance imaging were recruited. Their static and dynamic effective connectivity were compared. The relationships between connectome characteristics and cognitive performance were also evaluated.</div></div><div><h3>Results</h3><div>The nodes of the T2DM-related static causality network included the anterior central gyrus, tail of the parahippocampal gyrus, posterior superior temporal sulcus, posterior central parietal lobe, posterior central gyrus and V5 region of the occipital lobe. The V5 region of the visual cortex was the core node. In the multicentered dataset, compared with the HC group, the T2DM with MCI group had significantly greater fractional window and mean dwell time. Fractional windows of the state, which was dominated by the interaction of the nodes from SomMot_Network, Limbic_Network, Default_Network, in the T2DM-specific network increased with poorer cognitive performance in T2DM with MCI patients.</div></div><div><h3>Conclusion</h3><div>Our findings provide insights into the neurobiological mechanisms of the cognitive impairment of T2DM patients from a dynamic network perspective, which may ultimately inform more targeted and effective strategies to prevent MCI.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111313"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards automatic assessment of atypical early motor development?","authors":"Ori Ossmy ,&nbsp;Georgina Donati ,&nbsp;Aman Kaur ,&nbsp;Mohammad Saber Sotoodeh ,&nbsp;Gillian Forrester","doi":"10.1016/j.brainresbull.2025.111311","DOIUrl":"10.1016/j.brainresbull.2025.111311","url":null,"abstract":"<div><div>Atypical motor development is an early indicator for several neurodevelopmental conditions, including cerebral palsy and Rett Syndrome, prompting early diagnosis and intervention. While not currently part of the diagnostic criteria for other conditions like Autism Spectrum Disorder, the frequent retrospective diagnosis of motor impairments alongside these conditions highlights the necessity of a deeper understanding of the relations between motor and cognitive development. Traditional clinical assessments, while considered the gold standard, rely on movement characteristics discernible to the trained eye of professionals. The emergence of automated technologies, including computer vision and wearable sensors, promises more objective and scalable detections. However, these methods are not without challenges, including concerns over data quality, generalizability, interpretability, and ethics. By reviewing recent advances, we highlight the potential and the challenges of integrating automated detections into research and clinical practice. While we agree that these technologies can revolutionize pediatric care, we believe their use must be tempered with caution and supported by clinical expertise to ensure effective outcomes.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111311"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remifentanil stabilizes hemodynamics with modulating subthalamic beta oscillation during deep brain stimulation","authors":"Pin-Han Huang ,&nbsp;Shin-Yuan Chen ,&nbsp;Jen-Hung Wang ,&nbsp;Yu-Shen Pan ,&nbsp;Sheng-Huang Lin","doi":"10.1016/j.brainresbull.2025.111310","DOIUrl":"10.1016/j.brainresbull.2025.111310","url":null,"abstract":"<div><div>General anesthesia is a promising method for advanced Parkinson's disease patients unable to tolerate awake deep brain stimulation (DBS) surgery. However, anesthetic agents must be kept at relatively low levels to preserve the quality of intraoperative microelectrode recordings, which can lead to unstable hemodynamic conditions. Remifentanil, with its sedative and analgesic properties, could offer a solution. This study retrospectively analyzed microelectrode recordings of the subthamic nucleus (STN) and hemodynamic responses in patients with Parkinson's disease who received deep brain stimulation surgery under controlled volatile anesthesia with/without remifentanil infusion. From October 2017 to June 2019, 24 patients with Parkinson's disease who received bilateral subthalamic deep brain stimulation surgery in Hualien Tzu Chi Hospital with (n = 12) or without remifentanil infusion (n = 12) were enrolled in this study. We conducted a comprehensive spike analysis, examining frequency, inter-spike interval properties, modified burst index, modified pause index, and modified pause ratio. Additionally, we performed spike frequency spectrum analysis to investigate oscillatory activity in high-frequency, multi-unit, and single-unit neuronal activity. Our findings revealed no differences in STN firing characteristics, while a significant decrease in high beta power was observed in multi-unit activity in the remifentanil group. Notably, nine patients in the non-remifentanil group required additional nicardipine, whereas none in the remifentanil group did. Conclusively, for patients with advanced Parkinson's disease sensitive to external stimulation at low minimum alveolar concentration, remifentanil co-administration is an option to avoid unstable hemodynamic conditions during subthalamic deep brain stimulation surgery.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111310"},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis","authors":"Qianqian Li ,&nbsp;Zengqin Wang ,&nbsp;Fengli Li ,&nbsp;Songlin Liu ,&nbsp;Yuhong Ding ,&nbsp;Junmei Yan ,&nbsp;Xing Feng ,&nbsp;Mei Li","doi":"10.1016/j.brainresbull.2025.111305","DOIUrl":"10.1016/j.brainresbull.2025.111305","url":null,"abstract":"<div><h3>Background</h3><div>Pyroptosis has been reported to play a pathogenic role in neonatal hypoxic-ischemic brain damage (HIBD). Absence in melanoma 2 (AIM2) is an inflammasome involved in pyroptosis.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the role of AIM2 in hypoxic-ischemia (HI)-induced pyroptosis and brain damage in a neonatal rat HIBD model.</div></div><div><h3>Methods</h3><div><em>In vivo,</em> we injected a lentivirus that overexpressed or knocked down AIM2 into the lateral ventricle of rats within 24 h after birth and prepared a 7-day Sprague Dawley (SD) rat HIBD model. <em>In vitro,</em> we transfected lentiviruses overexpressing or knocking down AIM2 into cultured primary neurons and established an oxygen/glucose deprivation/reoxygenation (OGD/R) model. 2,3,5-triphenyltetrazolium chloride (TTC) staining was used to determine infarct size. Hematoxylin and eosin and Nissl staining were used to evaluate morphological changes in the damaged brain. Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) assays were used to determine cell viability and toxicity. Pyroptosis was observed using transmission electron microscopy.</div></div><div><h3>Results</h3><div>AIM2 expression significantly increased in the HI-induced cortex of neonatal rats. Lentivirus-mediated overexpression of AIM2 significantly aggravates HI-induced brain injury and OGD/R-induced neuronal injury <em>in vivo</em> and <em>in vitro.</em> The lentivirus-mediated AIM2 knockdown significantly reversed these adverse effects. In addition, AIM2 overexpression increased HI-induced pyroptosis in neonatal rats <em>in vivo</em> and <em>in vitro,</em> whereas AIM2 knockdown suppressed HI-induced pyroptosis via the AIM2/Caspase-1/GSDMD pathway.</div></div><div><h3>Conclusion</h3><div>These findings show that the upregulation of AIM2 activates pyroptosis and plays a pathogenic role in neonatal HIBD.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111305"},"PeriodicalIF":3.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AdipoRon attenuates depression-like behavior in T2DM mice via inhibiting inflammation and regulating autophagy","authors":"Wenyan Zhao ,&nbsp;Yahong Li ,&nbsp;Yuliang Zhou ,&nbsp;Jinying Zhao ,&nbsp;Yanyu Lu ,&nbsp;Zhipeng Xu","doi":"10.1016/j.brainresbull.2025.111308","DOIUrl":"10.1016/j.brainresbull.2025.111308","url":null,"abstract":"<div><div>Adiponectin, an adipocyte-derived adipokine, exerts anti-inflammatory effects in the brain, but its specific function in type 2 diabetes mellitus(T2DM) has not been elucidated. Based on the common physiological and pathological mechanisms of T2DM and depression, this study revealed the protective effect of AdipoRon on T2DM-related depressive behavior and its molecular biological mechanism in vivo. Our results showed that AdipoRon treatment enhanced the sucrose consumption of T2DM mice in sucrose preference experiment, reduced the immobility time in the forced swimming experiment, and increased the total movement distance and cross times in the open field experiment. AdipoRon treatment inhibited the apoptosis of hippocampal cells, increased the number of synapses in the prefrontal cortex and hippocampus, and enhanced the density of dendritic spines in CA1 region of T2DM mice. AdipoRon could reduce NLRP3, ASC and IL-1β levels in the hippocampus and prefrontal cortex, increase the ratio of p-AMPK/AMPK and decrease p-mTOR/mTOR expression in T2DM mice. Furthermore, AdipoRon treatment increased the ratio of LC3II/LC3I and the expression of AdipoR1 in the prefrontal cortex and hippocampus of T2DM mice. All of these findings support the idea that AdipoRon reduces neuroinflammation and stimulates autophagy in T2DM mice via activating the AdipoR1/AMPK/mTOR pathway. AdipoRon may be a novel therapeutic agent for T2DM complicated depression.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111308"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free water imaging reveals asynchronous dopaminergic degeneration in substantia nigra and ventral tegmental area in prodromal and early Parkinson's disease","authors":"Kaiyue Ding ,&nbsp;Yu Shen ,&nbsp;Yan Bai ,&nbsp;Wei Wei ,&nbsp;Neil Roberts ,&nbsp;Ningli Wang ,&nbsp;Xinhui Wang ,&nbsp;Guofeng Shen ,&nbsp;Xianchang Zhang ,&nbsp;Chaowei Sun ,&nbsp;Xiaosheng Song ,&nbsp;Meiyun Wang","doi":"10.1016/j.brainresbull.2025.111309","DOIUrl":"10.1016/j.brainresbull.2025.111309","url":null,"abstract":"<div><h3>Purpose</h3><div>The ventral tegmental area (VTA), which is rich in dopaminergic neurons, may play a role in influencing clinical symptoms in Parkinson's Disease (PD). However, the degeneration dynamics of the VTA during the early and prodromal stages of PD remain unclear. This study aims to explore microstructural changes in the VTA among prodromal PD patients with idiopathic REM sleep behavior disorder (iRBD) and early-stage PD patients using free water imaging (FWI) to assess free water (FW) and its correlation with clinical symptoms.</div></div><div><h3>Method</h3><div>Diffusion tensor imaging data from 238 participants, including 69 healthy controls (HC), 54 iRBD patients, and 115 PD patients. FW values were computed using a bi-tensor model, and comparisons were done between the HC, iRBD, and PD groups. Additionally, the relationship between FW values in the VTA and substantia nigra pars compacta (SNc) and clinical symptoms was explored through baseline assessments and longitudinal tracking of iRBD patients.</div></div><div><h3>Results</h3><div>FW values in the SNc significantly increased in iRBD and PD patients compared to HC, with the PD group exhibiting even higher FW values. Initially, the FW values in the VTA in iRBD patients did not significantly differ from those of HC but increased in early PD, correlating with anxiety and motor deficits. Longitudinal tracking revealed FW increases in the SNc and VTA in iRBD patients over time.</div></div><div><h3>Conclusion</h3><div>The present findings revealed a desynchronized degeneration pattern between the VTA and SNc, with no degeneration observed in the prodromal phase but gradual changes over time, leading to pronounced VTA degeneration in early PD. This underscores the impact of early VTA changes on PD symptoms, contributing to understanding of PD pathophysiology.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111309"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating the role of Pou3f1 in striatal development: Evidence from transgenic mouse models","authors":"Xiaolei Song ,&nbsp;Fengzhu Zhang ,&nbsp;Danyu Han ,&nbsp;Jingzhe Yu ,&nbsp;Qian Ren ,&nbsp;Xiaoming Xin ,&nbsp;Rongliang Guo ,&nbsp;Weidong Le","doi":"10.1016/j.brainresbull.2025.111302","DOIUrl":"10.1016/j.brainresbull.2025.111302","url":null,"abstract":"<div><div>The striatum, a critical component of the basal ganglia, is essential for motor control, cognitive processing, and emotional regulation. Medium spiny neurons (MSNs) are the primary neuronal population in the striatum, classified into D1 and D2 subtypes. The transcription factor <em>Pou3f1</em> has been hypothesized to play a crucial role in the development of pyramidal neurons. Recently, a comprehensive analysis of the human embryonic scRNA-seq dataset predicted and emphasized the bridging function of <em>POU3F1</em> between striatal progenitor cells and immature neurons, though this finding lacked genetic validation. In this study, we found that <em>Pou3f1</em> expression was significantly reduced after <em>Six3</em> deletion. However, <em>Pou3f1</em> deletion does not significantly affect the number or subtype composition of MSNs, nor the proliferation and differentiation of progenitor cells, in our <em>Pou3f1</em> conditional knockout (cko) mice, challenging the <em>in silico</em> predictions based on human data. These results suggest that <em>Pou3f1</em> is not required for the specification, generation, or differentiation of MSNs, though its potential involvement in other aspects of striatal development cannot be entirely ruled out.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111302"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and challenges of using allogeneic vs. autologous sources for neuronal cell replacement in Parkinson’s disease: Insights from non-human primate studies","authors":"Marina E. Emborg ,&nbsp;Jeanette M. Metzger ,&nbsp;Kevin D’Amour ,&nbsp;Julia C. Colwell ,&nbsp;Lindsey C. Neumann ,&nbsp;Ai Zhang ,&nbsp;Howard J. Federoff","doi":"10.1016/j.brainresbull.2025.111297","DOIUrl":"10.1016/j.brainresbull.2025.111297","url":null,"abstract":"<div><div>Intracerebral grafting of dopamine-producing cells is proposed as a strategy to replace the typical neurons lost to Parkinson’s disease (PD) and improve PD motor symptoms. Non-human primate studies have provided clues on the relationship between the host’s immune response and grafting success. Herein, we discuss how the host’s immune system differentially affects the graft depending on the origin of the cells and reflect on the advantages and limitations of the immune paradigms utilized to assess graft-related outcomes. We also consider new strategies to minimize or circumvent the host’s immunological response and related preclinical research needed to identify the most promising new approaches to be translated into the clinic.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"224 ","pages":"Article 111297"},"PeriodicalIF":3.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}