Abnormal intrinsic brain activity patterns in patients with carbon monoxide poisoning associated with neurotransmitter profiles.

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-10-06 DOI:10.1016/j.brainresbull.2025.111566

Hongkun Liu, Hongyi Zheng, Gengbiao Zhang, Lan Luo, Jiayan Zhuang, Xuewen Wang, Hui Tan, Bixia Wu, Weijia Li, Yingwen Li, Wenbin Zheng

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引用次数: 0

Abstract

Currently, no study has comprehensively evaluated local neuronal activity in the brain following carbon monoxide poisoning (COP). Moreover, the corresponding pathological changes in brain disease are not randomly distributed, and the molecular mechanism underlying the abnormal neuronal activity pattern associated with COP remains unknown. In this study, low-frequency fluctuation amplitude (ALFF) was combined with neurotransmitter maps to initially explore potential brain activity patterns related to COP and their potential neurochemical basis. In COP patients, brain activity in regions of the higher order association network was decreased, while brain activity in regions of the lower order sensorimotor network was increased, and brain activity in these regions was correlated with the severity of clinical symptoms. In addition, abnormal intrinsic brain activity patterns in COP patients were spatially correlated with the density of neurotransmitter receptors and transporters for monoaminergic neurotransmission (i.e., norepinephrine, serotonin, and dopamine), and N-methyl-D-aspartate receptors. These results suggest that ALFF can characterize COP-related intrinsic brain activity abnormalities, which may be driven by specific neurotransmitter signals in the brain, and that low-frequency fluctuation in specific brain regions can be used to explain clinical symptoms and neurocognitive manifestations.

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一氧化碳中毒患者异常的内在脑活动模式与神经递质谱相关。

目前，还没有研究全面评估一氧化碳中毒（COP）后大脑局部神经元的活动。此外，脑部疾病相应的病理改变并非随机分布，与COP相关的异常神经元活动模式的分子机制尚不清楚。在本研究中，低频波动幅度（ALFF）与神经递质图谱相结合，初步探索与COP相关的潜在大脑活动模式及其潜在的神经化学基础。在COP患者中，高阶关联网络区域的脑活动减少，而低阶感觉运动网络区域的脑活动增加，并且这些区域的脑活动与临床症状的严重程度相关。此外，COP患者异常的脑内活动模式与神经递质受体、单胺类神经递质（即去甲肾上腺素、血清素和多巴胺）和n -甲基- d -天冬氨酸受体的密度存在空间相关性。这些结果表明，ALFF可以表征cop相关的内在脑活动异常，这可能是由大脑中特定的神经递质信号驱动的，并且特定大脑区域的低频波动可以用来解释临床症状和神经认知表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.