The activity of glutamatergic neurons in the dorsal-ventral poles of the dentate gyrus regulates distinct phenotypes of depression in mice

IF 3.7 3区 医学 Q2 NEUROSCIENCES
Jinping Wang , Hongjie Li , Yusi Hua , Lanyu Zhang , Xiaoqin Jiang , Xinchuan Wei
{"title":"The activity of glutamatergic neurons in the dorsal-ventral poles of the dentate gyrus regulates distinct phenotypes of depression in mice","authors":"Jinping Wang ,&nbsp;Hongjie Li ,&nbsp;Yusi Hua ,&nbsp;Lanyu Zhang ,&nbsp;Xiaoqin Jiang ,&nbsp;Xinchuan Wei","doi":"10.1016/j.brainresbull.2025.111413","DOIUrl":null,"url":null,"abstract":"<div><div>Depression is a heterogeneous mental disorder. The dorsal and/or ventral dentate gyrus (DG) has been implicated in the pathophysiology of depression. However, it remains unclear whether the activities of glutamatergic neurons in the dorsal and ventral DG contribute to the heterogeneity of depression. In the present study, we conduct a series of depression-related behavior tests by activating or inhibiting the activity of glutamatergic neurons in the dorsal and ventral DG using chemical genetic methods. It is found that inhibiting the dorsal DG glutamatergic neurons induces social deficits, as well as learning and memory dysfunction, while activating them improves social behaviors and alleviated social deficits induced by chronic stress. Conversely, inhibiting the ventral DG glutamatergic neurons increases anxiety and despair-like symptoms, and activating them reduces anxiety and despair-like symptoms and alleviates these symptoms caused by chronic stress. Our study highlights the necessity of incorporating dorsoventral axis-specific analyses of DG in subsequent investigations to better understand the pathophysiological heterogeneity of depression.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"228 ","pages":"Article 111413"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research Bulletin","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0361923025002254","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Depression is a heterogeneous mental disorder. The dorsal and/or ventral dentate gyrus (DG) has been implicated in the pathophysiology of depression. However, it remains unclear whether the activities of glutamatergic neurons in the dorsal and ventral DG contribute to the heterogeneity of depression. In the present study, we conduct a series of depression-related behavior tests by activating or inhibiting the activity of glutamatergic neurons in the dorsal and ventral DG using chemical genetic methods. It is found that inhibiting the dorsal DG glutamatergic neurons induces social deficits, as well as learning and memory dysfunction, while activating them improves social behaviors and alleviated social deficits induced by chronic stress. Conversely, inhibiting the ventral DG glutamatergic neurons increases anxiety and despair-like symptoms, and activating them reduces anxiety and despair-like symptoms and alleviates these symptoms caused by chronic stress. Our study highlights the necessity of incorporating dorsoventral axis-specific analyses of DG in subsequent investigations to better understand the pathophysiological heterogeneity of depression.
小鼠齿状回背-腹极谷氨酸能神经元的活动调节不同的抑郁表型
抑郁症是一种异质性精神障碍。背侧和/或腹侧齿状回(DG)与抑郁症的病理生理有关。然而,尚不清楚背侧和腹侧DG的谷氨酸能神经元的活动是否导致了抑郁症的异质性。在本研究中,我们通过化学遗传方法激活或抑制DG背侧和腹侧谷氨酸能神经元的活性,进行了一系列抑郁相关行为测试。研究发现,抑制背侧DG谷氨酸能神经元可导致社交缺陷和学习记忆功能障碍,而激活DG谷氨酸能神经元可改善社交行为,缓解慢性应激导致的社交缺陷。相反,抑制腹侧DG谷氨酸能神经元会增加焦虑和绝望样症状,激活它们会减少焦虑和绝望样症状,缓解慢性应激引起的这些症状。我们的研究强调了在后续研究中纳入DG的背腹侧轴特异性分析的必要性,以更好地了解抑郁症的病理生理异质性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Brain Research Bulletin
Brain Research Bulletin 医学-神经科学
CiteScore
6.90
自引率
2.60%
发文量
253
审稿时长
67 days
期刊介绍: The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信