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Early career members' committee updates and reflections of an ECMC Chair and co-Chair mandates. 早期职业成员委员会更新和反思ECMC主席和联合主席的任务。
IF 3.4
Breathe Pub Date : 2025-12-16 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0006-2025
Thomas Gille, Sara Cuevas Ocaña
{"title":"Early career members' committee updates and reflections of an ECMC Chair and co-Chair mandates.","authors":"Thomas Gille, Sara Cuevas Ocaña","doi":"10.1183/20734735.0006-2025","DOIUrl":"10.1183/20734735.0006-2025","url":null,"abstract":"<p><p><b>An overview of the ERS early career members' committee (ECMC), the role of the Chair and co-Chair of the ECMC, what the outgoing Chair and co-Chair achieved during their mandate and what they think the next steps should be</b> https://bit.ly/48IghDF.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250006"},"PeriodicalIF":3.4,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12706591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing COPD management through novel pharmacological agents: ensifentrine and dupilumab. 通过新型药物推进COPD治疗：恩西芬汀和杜匹单抗。
IF 3.4
Breathe Pub Date : 2025-12-16 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0206-2025
Lauren L Walkon, James R Burmeister, Michael Nazmifar, Forrest Bohler, Anna Kochanowska-Karamyan, Samuel A Allen
{"title":"Advancing COPD management through novel pharmacological agents: ensifentrine and dupilumab.","authors":"Lauren L Walkon, James R Burmeister, Michael Nazmifar, Forrest Bohler, Anna Kochanowska-Karamyan, Samuel A Allen","doi":"10.1183/20734735.0206-2025","DOIUrl":"10.1183/20734735.0206-2025","url":null,"abstract":"<p><p>COPD is a progressive respiratory condition characterised by persistent airflow limitation and chronic inflammation. Despite advances in bronchodilator and corticosteroid therapy, many patients, particularly those with eosinophilic inflammation, remain inadequately managed. This review highlights two recently approved therapies, ensifentrine and dupilumab, which represent a shift toward precision medicine in COPD management. Ensifentrine, a dual phosphodiesterase 3 and 4 inhibitor, offers both bronchodilatory and anti-inflammatory effects, improving lung function and reducing exacerbations. Dupilumab targets interleukin-4 and interleukin-13 signalling, addressing type 2 inflammatory pathways prominent in eosinophilic COPD. Key clinical trials (ENHANCE, BOREAS, NOTUS) demonstrate the efficacy of these agents in improving forced expiratory volume in 1 s, reducing exacerbation rates, and enhancing quality of life in select patient subgroups. By focusing on disease endotypes, these novel therapies underscore the growing role of personalised treatment approaches in COPD. Continued investigation into biomarkers and long-term outcomes will be essential for integrating these therapies into routine clinical practice.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250206"},"PeriodicalIF":3.4,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12706593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of interventional pulmonology in management of pulmonary nodules during lung cancer screening. 介入肺脏学在肺癌筛查期间肺结节管理中的作用。
IF 3.4
Breathe Pub Date : 2025-12-16 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0256-2024
Carla Carvalho, Saskia van Heumen, Faustina Funke, Marjolein A Heuvelmans, Mariana Serino, Armin Frille, Guido Marchi, Evangelia Koukaki, Georgia Hardavella, Maria Joana Catarata
{"title":"The role of interventional pulmonology in management of pulmonary nodules during lung cancer screening.","authors":"Carla Carvalho, Saskia van Heumen, Faustina Funke, Marjolein A Heuvelmans, Mariana Serino, Armin Frille, Guido Marchi, Evangelia Koukaki, Georgia Hardavella, Maria Joana Catarata","doi":"10.1183/20734735.0256-2024","DOIUrl":"10.1183/20734735.0256-2024","url":null,"abstract":"<p><p>The implementation of lung cancer screening with low-dose computed tomography has significantly increased the detection of pulmonary nodules, most of which are peripherally located and difficult to access. Effectively addressing these findings remains a clinical challenge, particularly in balancing diagnostic accuracy with procedural risk. Advances in interventional pulmonology have enabled minimally invasive approaches that may support both diagnosis and treatment, especially in selected patients with peripherally located nodules or limited surgical options. However, evidence on their effectiveness, accessibility and integration into screening workflows remains variable. In this review, we discuss the current role of interventional pulmonology in the context of lung cancer screening, outlining its potential benefits, limitations, and areas requiring further research to define its place within multidisciplinary care.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"240256"},"PeriodicalIF":3.4,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12706594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovation in technologies for monitoring lung function in patients with respiratory disease. 呼吸系统疾病患者肺功能监测技术的创新。
IF 3.4
Breathe Pub Date : 2025-11-18 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0001-2025
Dimitrios Toumpanakis, Omar S Usmani
{"title":"Innovation in technologies for monitoring lung function in patients with respiratory disease.","authors":"Dimitrios Toumpanakis, Omar S Usmani","doi":"10.1183/20734735.0001-2025","DOIUrl":"10.1183/20734735.0001-2025","url":null,"abstract":"<p><p>Pulmonary function testing is a pillar of respiratory medicine, contributing to the diagnosis and monitoring of respiratory diseases and supporting therapeutic decisions. The aim of this review is to summarise advances in the field of lung function monitoring, presenting both innovation in current everyday lung function testing, as well as newer physiological and functional imaging techniques. We highlight the potential clinical utility of novel digital tools, such as smart inhalers, wearables and sensors, that enable continuous real-time monitoring of lung physiological parameters and assessment of therapeutic interventions. Finally, current evidence for the application of artificial intelligence tools, such as machine- and deep-learning algorithms, in lung function interpretation is discussed.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250001"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiology of dyspnoea in pleural effusion. 胸腔积液中呼吸困难的病理生理学。
IF 3.4
Breathe Pub Date : 2025-11-18 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0238-2025
Lucía Ferreiro, María Elena Toubes, Vanessa Riveiro Blanco, Luis Valdés
{"title":"Pathophysiology of dyspnoea in pleural effusion.","authors":"Lucía Ferreiro, María Elena Toubes, Vanessa Riveiro Blanco, Luis Valdés","doi":"10.1183/20734735.0238-2025","DOIUrl":"10.1183/20734735.0238-2025","url":null,"abstract":"<p><p>Pleural effusion induces an increase in pleural pressure, resulting in a cascade of changes in the physiological parameters of the thoracic cavity. These changes include increased volume of the rib cage, abnormal gas exchange, impaired respiratory mechanics, and abnormal diaphragmatic movements. Such alterations have a significant clinical impact, including the development of specific symptoms such as dyspnoea. Dyspnoea secondary to pleural effusion has a complex physiopathology. Notably, the severity of dyspnoea often shows a poor correlation with effusion size and may not improve after fluid drainage. The symptomatic relief experienced by patients after fluid drainage is largely attributed to improvements in the length-tension relationship of the respiratory muscles. Importantly, dyspnoea in these cases results from the abnormal shape and restricted motion of the ipsilateral hemidiaphragm, coupled with an increased compensatory respiratory drive aimed at preserving adequate ventilation. Fluid drainage reduces diaphragmatic distension, restoring diaphragmatic mobility, reducing inspiratory neural drive, and enhancing the neuromechanical coupling of the diaphragm, all of which contribute to dyspnoea relief. This review explores current evidence regarding the pathophysiological mechanisms underlying dyspnoea in pleural effusion and the therapeutic effects of thoracentesis.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250238"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights of the Sleep and Breathing Conference 2025. 2025年睡眠与呼吸会议的亮点。
IF 3.4
Breathe Pub Date : 2025-11-18 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0174-2025
Matteo Siciliano, Federico Giordani, Lara Benning, Elisa Perger, Zoe Bousraou, Caterina Antonaglia, Sophia Schiza, Esther Irene Schwarz
{"title":"Highlights of the Sleep and Breathing Conference 2025.","authors":"Matteo Siciliano, Federico Giordani, Lara Benning, Elisa Perger, Zoe Bousraou, Caterina Antonaglia, Sophia Schiza, Esther Irene Schwarz","doi":"10.1183/20734735.0174-2025","DOIUrl":"10.1183/20734735.0174-2025","url":null,"abstract":"<p><p>The 2025 Sleep and Breathing Conference, co-hosted by the European Respiratory Society (ERS) and the European Sleep Research Society (ESRS), presented the latest advances in sleep disordered breathing and related fields. This comprehensive overview, written by Early Career Members of ERS Assembly 4, highlights the key scientific and clinical takeaways from the event. Symposia were dedicated to the pathophysiology of obstructive sleep apnoea (OSA), the role of intermittent hypoxia and autonomic dysregulation, diagnostic work-up, and treatment approaches for OSA, including the perspective of patients. Updates on central sleep apnoea, comorbid insomnia and sleep apnoea, obesity hypoventilation syndrome and sleep disordered breathing in neuromuscular disease were also presented. The event emphasised the importance of phenotyping, individualised treatment approaches and the integration of physiology into clinical decision-making in sleep disordered breathing.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250174"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First episode of psychosis in a patient undergoing tuberculosis treatment. 正在接受肺结核治疗的病人首次精神病发作。
IF 3.4
Breathe Pub Date : 2025-11-18 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0186-2025
John Murray, Lorraine Dolan, Ciara MacKenna, John Cooney, Joseph Keane, Anne Marie McLaughlin
{"title":"First episode of psychosis in a patient undergoing tuberculosis treatment.","authors":"John Murray, Lorraine Dolan, Ciara MacKenna, John Cooney, Joseph Keane, Anne Marie McLaughlin","doi":"10.1183/20734735.0186-2025","DOIUrl":"10.1183/20734735.0186-2025","url":null,"abstract":"<p><p><b>Psychosis is a potential side-effect of isoniazid therapy that clinicians involved in the care of patients with tuberculosis should be aware of.</b> https://bit.ly/4n2gXrX.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250186"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From a patient's experience: why healthcare professionals must consider aspergillosis. 从病人的经验：为什么卫生保健专业人员必须考虑曲霉病。
IF 3.4
Breathe Pub Date : 2025-11-18 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0258-2025
Lisa McNeil, Lucy Robinson
{"title":"From a patient's experience: why healthcare professionals must consider aspergillosis.","authors":"Lisa McNeil, Lucy Robinson","doi":"10.1183/20734735.0258-2025","DOIUrl":"https://doi.org/10.1183/20734735.0258-2025","url":null,"abstract":"<p><p><b>Aspergillosis is often overlooked, but recognising it early in patients with chronic or recurrent lung infections can be life-changing. Lisa's experience shows why clinicians must consider aspergillosis.</b> https://bit.ly/3WPqas3.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250258"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The utility of a rigid bronchoscope. 刚性支气管镜的作用。
IF 3.4
Breathe Pub Date : 2025-11-18 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0252-2024
Kalliopi Athanassiadi, Kwon Joong Na, Katarzyna Zanowska, Rita Costa, Sarra Zairi, Giuseppe Cardillo, Natalia Motas, Veronica Manolache, Marcello Migliore
{"title":"The utility of a rigid bronchoscope.","authors":"Kalliopi Athanassiadi, Kwon Joong Na, Katarzyna Zanowska, Rita Costa, Sarra Zairi, Giuseppe Cardillo, Natalia Motas, Veronica Manolache, Marcello Migliore","doi":"10.1183/20734735.0252-2024","DOIUrl":"10.1183/20734735.0252-2024","url":null,"abstract":"<p><p>Rigid bronchoscopy is a specialised endoscopic modality utilising a rigid scope instrument to afford direct visualisation and intervention within the central airways. In contradistinction to flexible bronchoscopy, the augmented working channel of the rigid instrument permits the introduction of larger-calibre instrumentation, thereby facilitating complex therapeutic procedures. These procedures encompass, <i>inter alia</i>, foreign body retrieval, endoluminal tumour debulking, airway stent deployment, and the management of life-threatening haemoptysis. While the procedure mandates general anaesthesia and a high level of operator expertise, rigid bronchoscopy provides superior airway control and the capacity to address complex airway pathologies that may be refractory to flexible bronchoscopy.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"240252"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12624403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of macrolides in the treatment of community-acquired pneumonia: risks and benefits. 大环内酯类药物治疗社区获得性肺炎：风险与益处
IF 3.4
Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0190-2025
Fatimah Al-Zergani, Simone Bastrup Israelsen, Thomas Benfield, Markus Fally
{"title":"The use of macrolides in the treatment of community-acquired pneumonia: risks and benefits.","authors":"Fatimah Al-Zergani, Simone Bastrup Israelsen, Thomas Benfield, Markus Fally","doi":"10.1183/20734735.0190-2025","DOIUrl":"10.1183/20734735.0190-2025","url":null,"abstract":"<p><p>This Journal club aims to evaluate the recent evidence about the potential benefits of macrolides as add-on therapy in the treatment of community-acquired pneumonia (CAP), an area where the data remain conflicting. Four studies with diverse methodology (the ACCESS trial, a Greek cohort study, a UK-based cohort study and a recent meta-analysis) have aimed to assess either potential immunomodulatory effects, clinical response or hard end-points like mortality when macrolides are added to the treatment regimen for hospitalised patients with CAP. The ACCESS trial, a randomised controlled trial (RCT), demonstrated improved early clinical response and immunomodulatory effects with clarithromycin, while the Greek cohort study showed reduced 28-day mortality and delayed organ dysfunction with clarithromycin. The cohort study from the UK found no added benefit of macrolides on 30-day mortality or decline in Sequential Organ Failure Assessment score. The recent meta-analysis supported a survival advantage of macrolides, favouring clarithromycin over azithromycin. However, study limitations like heterogeneity, confounding risks and the lack of head-to-head comparisons of individual macrolides remain of concern. Macrolide treatment decisions may benefit from individualised risk assessment; however, future research should focus on identifying subgroups who might benefit from macrolides and comparative analyses of macrolide agents through large-scale RCTs.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250190"},"PeriodicalIF":3.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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