IF 2.3

Breathe Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.1183/20734735.0119-2024

Nicola Mortimer Ocean, Brijesh V Patel, Benjamin Garfield

引用次数: 0

From basic scientific research to the development of new drugs for pulmonary arterial hypertension: insights from activin-targeting agents. 从基础科学研究到肺动脉高压新药开发：活化素靶向药物的启示。

IF 2.3

Breathe Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.1183/20734735.0116-2024

Christophe Guignabert

{"title":"From basic scientific research to the development of new drugs for pulmonary arterial hypertension: insights from activin-targeting agents.","authors":"Christophe Guignabert","doi":"10.1183/20734735.0116-2024","DOIUrl":"10.1183/20734735.0116-2024","url":null,"abstract":"Pulmonary arterial hypertension (PAH) is a severe disorder of the pulmonary vasculature leading to right ventricular failure. This pulmonary vascular remodelling leads to increased pulmonary vascular resistance and high pulmonary arterial pressures. Despite the development of new therapies, many patients continue to experience significant morbidity and mortality. This review offers a comprehensive overview of the current understanding of PAH pathophysiology, with a focus on key mechanisms that contribute to pulmonary endothelial cell dysfunction and the pathological accumulation of pulmonary artery smooth muscle cells, mesenchymal cells and inflammatory cells in the walls of remodelled small pulmonary vessels, three processes central to the progression of PAH. In particular, it highlights recent developments in targeting the activin signalling pathway, a novel therapeutic approach that shows promise in modulating these pathological processes. The review also addresses the ongoing challenges in translating preclinical findings into effective clinical treatments, emphasising the importance of integrating human data with preclinical models and adopting innovative strategies to bridge the gap between research and clinical practice.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 1","pages":"240116"},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developments in the field of respiratory nursing in Türkiye. 我国呼吸护理领域的发展。

IF 2.3

Breathe Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.1183/20734735.0129-2024

Gamze Oğuz Erdem, Rahşan Çevik Akyil, Feride Taşkin Yilmaz

{"title":"Developments in the field of respiratory nursing in Türkiye.","authors":"Gamze Oğuz Erdem, Rahşan Çevik Akyil, Feride Taşkin Yilmaz","doi":"10.1183/20734735.0129-2024","DOIUrl":"10.1183/20734735.0129-2024","url":null,"abstract":"Nursing plays a critical role in delivering healthcare services. It is a health discipline encompassing both science and art, designed to support people from birth to the end of life, in health and illness. Nurses are required to identify the physical and psychological needs of individuals, families and society with a comprehensive, human-oriented approach and to meet these needs. Nursing provides essential services at every stage of healthcare, from health protection and improvement to disease treatment and rehabilitation. In Türkiye, nursing education is offered at high school, associate and undergraduate levels. Specialisation in a specific branch is possible through Master's and doctoral studies. However, there is no specialised branch or recognised certificate programme in respiratory nursing. Nurses specialising in respiratory diseases typically work in respiratory or intensive care units. Respiratory nurses play a crucial role in care and treatment management within the multidisciplinary team. This viewpoint provides information about the historical development of nursing, nursing education, and the status and development of respiratory nursing in Türkiye, as well as the efforts by the International Coalition for Respiratory Nursing to recognise respiratory nursing as a specialty worldwide.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 1","pages":"240129"},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living with pulmonary arterial hypertension: a patient's perspective on dyspnoea crises. 肺动脉高压患者对呼吸困难危机的看法。

IF 2.3

Breathe Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.1183/20734735.0231-2024

Natalia Maeva, Lucy Robinson

引用次数: 0

A 69-year-old man with generalised lymphadenopathy, glandular swelling and pleural effusion. 69岁男性，全身性淋巴结病，腺体肿胀和胸腔积液。

IF 2.3

Breathe Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.1183/20734735.0125-2024

Shan Kai Ing, Yih Hoong Lee, Nga Hung Ngu, Kelly Kee Yung Wong, Adam Malik Bin Ismail, Chan Sin Chai, Siew Teck Tie, Sze Shyang Kho

引用次数: 0

Artificial intelligence in respiratory care: perspectives on critical opportunities and challenges. 呼吸护理中的人工智能：关键机遇和挑战的观点。

IF 2.3

Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0189-2023

David Drummond, Ireti Adejumo, Kjeld Hansen, Vitalii Poberezhets, Gregory Slabaugh, Chi Yan Hui

{"title":"Artificial intelligence in respiratory care: perspectives on critical opportunities and challenges.","authors":"David Drummond, Ireti Adejumo, Kjeld Hansen, Vitalii Poberezhets, Gregory Slabaugh, Chi Yan Hui","doi":"10.1183/20734735.0189-2023","DOIUrl":"10.1183/20734735.0189-2023","url":null,"abstract":"Artificial intelligence (AI) is transforming respiratory healthcare through a wide range of deep learning and generative tools, and is increasingly integrated into both patients' lives and routine respiratory care. The implications of AI in respiratory care are vast and multifaceted, presenting both promises and uncertainties from the perspectives of clinicians, patients and society. Clinicians contemplate whether AI will streamline or complicate their daily tasks, while patients weigh the potential benefits of personalised self-management support against risks such as data privacy concerns and misinformation. The impact of AI on the clinician-patient relationship remains a pivotal consideration, with the potential to either enhance collaborative care or create depersonalised interactions. Societally, there is an imperative to leverage AI in respiratory care to bridge healthcare disparities, while safeguarding against the widening of inequalities. Strategic efforts to promote transparency and prioritise inclusivity and ease of understanding in algorithm co-design will be crucial in shaping future AI to maximise benefits and minimise risks for all stakeholders.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230189"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ERS/ATS Global Lung Function Initiative normal values and classifying severity based on z-scores instead of per cent predicted. ERS/ATS全球肺功能倡议正常值，并根据z分数而不是预测的百分比对严重程度进行分类。

IF 2.3

Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0227-2023

Rachel Ong-Salvador, Pierantonio Laveneziana, Franciscus de Jongh

引用次数: 0

The more stars, the brighter! Interview with the ECM award winner 2023. 星星越多越亮！采访2023年ECM奖得主。

IF 2.3

Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0175-2024

Senani N H Rathnayake, Joana Cruz, Sara Cuevas Ocaña, Mareike Lehmann, Heleen Demeyer

引用次数: 0

Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success. 结核病生物标志物的进展：揭示危险因素、活动性疾病和治疗成功。

IF 2.3

Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0003-2024

Jodie A Schildkraut, Niklas Köhler, Christoph Lange, Raquel Duarte, Stephen H Gillespie

{"title":"Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success.","authors":"Jodie A Schildkraut, Niklas Köhler, Christoph Lange, Raquel Duarte, Stephen H Gillespie","doi":"10.1183/20734735.0003-2024","DOIUrl":"10.1183/20734735.0003-2024","url":null,"abstract":"Tuberculosis (TB) is a major global health threat and demands improved diagnostic and treatment monitoring methods. Conventional diagnostics, such as sputum smear microscopy and culture, are limited by slow results and low sensitivity, particularly in certain patient groups. Recent advances in biomarker research offer promising solutions in three key areas: risk of disease, diagnosis of active disease and monitoring of treatment response. For risk assessment, novel genetic signatures and metabolites show potential in predicting the progression from TB infection to active TB. A 16-gene signature, for example, predicts this progression with significant accuracy. In diagnosing active TB, RNA-based transcriptomic signatures provide higher diagnostic accuracy than traditional methods. These signatures, such as a three-gene RNA sequence, effectively differentiate active TB from other diseases and infections, addressing issues of specificity and sensitivity. Monitoring treatment response is crucial, given the varying response rates in treating TB. Emerging biomarkers focus on bacterial burden and host response. They offer more precise and timely assessments of treatment efficacy, enhance personalised treatment approaches and potentially improve patient outcomes. These advancements in biomarkers for TB risk, diagnosis and treatment response represent significant steps towards more effective TB management and control, aligning with global efforts to decrease the burden of TB. Here we aim to highlight several promising biomarkers used to predict risk of disease progression, active TB disease and treatment success.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240003"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung volume reduction: surgery versus endobronchial valves. 肺减容：手术还是支气管内瓣膜。

IF 2.3

Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0107-2024

Laurens J Ceulemans, Dorina Esendagli, Giuseppe Cardillo, Marcello Migliore

引用次数: 0

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