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Lung cancer: an update on the multidisciplinary approach from screening to palliative care. 肺癌：从筛查到姑息治疗的多学科方法的最新进展。
IF 2.3
Breathe Pub Date : 2024-08-27 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0117-2024
Georgia Hardavella, Joanna Chorostowska-Wynimko, Torsten Gerriet Blum
{"title":"Lung cancer: an update on the multidisciplinary approach from screening to palliative care.","authors":"Georgia Hardavella, Joanna Chorostowska-Wynimko, Torsten Gerriet Blum","doi":"10.1183/20734735.0117-2024","DOIUrl":"10.1183/20734735.0117-2024","url":null,"abstract":"<p><p><b>This issue of <i>Breathe</i> aims to provide a succinct overview of the current state of play in various aspects in thoracic oncology</b> https://bit.ly/3XQexmp.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"240117"},"PeriodicalIF":2.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A scoping review of lung cancer surgery with curative intent: workup, fitness assessment, clinical outcomes. 以治愈为目的的肺癌手术范围综述：准备工作、体能评估、临床结果。
IF 2.3
Breathe Pub Date : 2024-08-27 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0046-2024
Georgia Hardavella, Federica Carlea, Ioannis Karampinis, Alexandro Patirelis, Kalliopi Athanasiadi, Dimitrios Lioumpas, Joana Rei, Lucas Hoyos, Georgios Benakis, Edward Caruana, Eugenio Pompeo, Stefano Elia
{"title":"A scoping review of lung cancer surgery with curative intent: workup, fitness assessment, clinical outcomes.","authors":"Georgia Hardavella, Federica Carlea, Ioannis Karampinis, Alexandro Patirelis, Kalliopi Athanasiadi, Dimitrios Lioumpas, Joana Rei, Lucas Hoyos, Georgios Benakis, Edward Caruana, Eugenio Pompeo, Stefano Elia","doi":"10.1183/20734735.0046-2024","DOIUrl":"10.1183/20734735.0046-2024","url":null,"abstract":"<p><p>Lung cancer surgery with curative intent has significantly developed over recent years, mainly focusing on minimally invasive approaches that do not compromise medical efficiency and ensure a decreased burden on the patient. It is directly linked with an efficient multidisciplinary team that will perform appropriate pre-operative assessment. Caution is required in complex patients with several comorbidities to ensure a meaningful and informed thoracic surgery referral leading to optimal patient outcomes.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"240046"},"PeriodicalIF":2.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two women with unexplained dyspnoea: removing the blame game from the lungs. 两名不明原因呼吸困难的妇女：从肺部消除指责游戏。
IF 2.3
Breathe Pub Date : 2024-08-27 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0029-2024
Eirini Vasarmidi, Irini Lambiri, Eirini Foteinaki, Vaia Stamatopoulou, Ioanna Mitrouska, Georgios Pitsidianakis, Alexandros Patrianakos, Anthoula Plevritaki, Stylianos Michelakis, Vasilis Amargianitakis, Georgios Prinianakis, Sophia Schiza, Nikolaos Tzanakis
{"title":"Two women with unexplained dyspnoea: removing the blame game from the lungs.","authors":"Eirini Vasarmidi, Irini Lambiri, Eirini Foteinaki, Vaia Stamatopoulou, Ioanna Mitrouska, Georgios Pitsidianakis, Alexandros Patrianakos, Anthoula Plevritaki, Stylianos Michelakis, Vasilis Amargianitakis, Georgios Prinianakis, Sophia Schiza, Nikolaos Tzanakis","doi":"10.1183/20734735.0029-2024","DOIUrl":"https://doi.org/10.1183/20734735.0029-2024","url":null,"abstract":"<p><p><b>Hypoxaemia due to right-to-left atrial shunt with normal pressures in the right heart cavities represents an underdiagnosed condition. A systematic approach to hypoxaemic respiratory failure based on pathophysiology can lead to an accurate diagnosis.</b> https://bit.ly/4bTP8fJ.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"240029"},"PeriodicalIF":2.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11356787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of radiological imaging in the management of severe and difficult-to-treat asthma. 放射成像在严重和难治性哮喘治疗中的作用。
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0033-2024
Joshua Aigbirior, Amer Almaghrabi, Monder Lafi, Adel H Mansur
{"title":"The role of radiological imaging in the management of severe and difficult-to-treat asthma.","authors":"Joshua Aigbirior, Amer Almaghrabi, Monder Lafi, Adel H Mansur","doi":"10.1183/20734735.0033-2024","DOIUrl":"10.1183/20734735.0033-2024","url":null,"abstract":"<p><p>Radiological imaging has proven to be a useful tool in the assessment of asthma, its comorbidities and potential complications. Characteristic chest radiograph and computed tomography scan findings can be seen in asthma and in other conditions that can coexist with or be misdiagnosed as asthma, including chronic rhinosinusitis, inducible laryngeal obstruction, excessive dynamic airway collapse, tracheobronchomalacia, concomitant COPD, bronchiectasis, allergic bronchopulmonary aspergillosis, eosinophilic granulomatosis with polyangiitis, and eosinophilic pneumonia. The identification of the characteristic radiological findings of these conditions is often essential in making the correct diagnosis and provision of appropriate management and treatment. Furthermore, radiological imaging modalities can be used to monitor response to therapy.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"240033"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: "Rolling out new anti-tuberculosis drugs without diagnostic capacity". T. Ness, L.H. Van, I. Petermane, R. Duarte, C. Lange, D. Menzies and D.M. Cirillo on behalf of the UNITE4TB Consortium. Breathe 2023; 19: 230084. 勘误："在没有诊断能力的情况下推广抗结核新药"。T. Ness、L.H. Van、I. Petermane、R. Duarte、C. Lange、D. Menzies 和 D.M. Cirillo 代表 UNITE4TB 联盟。呼吸 2023; 19: 230084.
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.5084-2023
{"title":"Erratum: \"Rolling out new anti-tuberculosis drugs without diagnostic capacity\". T. Ness, L.H. Van, I. Petermane, R. Duarte, C. Lange, D. Menzies and D.M. Cirillo on behalf of the UNITE4TB Consortium. <i>Breathe</i> 2023; 19: 230084.","authors":"","doi":"10.1183/20734735.5084-2023","DOIUrl":"https://doi.org/10.1183/20734735.5084-2023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/20734735.0084-2023.].</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: "Treatment-shortening regimens for tuberculosis: updates and future priorities". F. Saluzzo, V.A. Adepoju, R. Duarte, C. Lange and P.P.J. Phillips on behalf of the UNITE4TB Consortium12. Breathe 2023; 19: 230028. 勘误："结核病缩短疗程疗法：最新情况和未来优先事项"。F. Saluzzo、V.A. Adepoju、R. Duarte、C. Lange 和 P.P.J. Phillips 代表 UNITE4TB 联合会12。呼吸 2023；19：230028。
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.5028-2023
{"title":"Erratum: \"Treatment-shortening regimens for tuberculosis: updates and future priorities\". F. Saluzzo, V.A. Adepoju, R. Duarte, C. Lange and P.P.J. Phillips on behalf of the UNITE4TB Consortium12. <i>Breathe</i> 2023; 19: 230028.","authors":"","doi":"10.1183/20734735.5028-2023","DOIUrl":"https://doi.org/10.1183/20734735.5028-2023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/20734735.0028-2023.].</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling the diagnostic pathology and molecular biomarkers in lung cancer. 揭示肺癌的病理诊断和分子生物标记物。
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0192-2023
Andriani Charpidou, Georgia Hardavella, Efimia Boutsikou, Emmanouil Panagiotou, Gökçen Ömeroğlu Simsek, Koen Verbeke, Daniela Xhemalaj, Joanna Domagała-Kulawik
{"title":"Unravelling the diagnostic pathology and molecular biomarkers in lung cancer.","authors":"Andriani Charpidou, Georgia Hardavella, Efimia Boutsikou, Emmanouil Panagiotou, Gökçen Ömeroğlu Simsek, Koen Verbeke, Daniela Xhemalaj, Joanna Domagała-Kulawik","doi":"10.1183/20734735.0192-2023","DOIUrl":"10.1183/20734735.0192-2023","url":null,"abstract":"<p><p>The progress in lung cancer treatment is closely interlinked with the progress in diagnostic methods. There are four steps before commencing lung cancer treatment: estimation of the patient's performance status, assessment of disease stage (tumour, node, metastasis), recognition of histological subtype, and detection of biomarkers. The resection rate in lung cancer is <30% and >70% of patients need systemic therapy, which is individually adjusted. Accurate histological diagnosis is very important and it is the basis of further molecular diagnosis. In many cases only small biopsy samples are available and the rules for their assessment are defined in this review. The use of immunochemistry with at least thyroid transcription factor 1 (TTF1) and p40 is decisive in distinction between lung adenocarcinoma and squamous cell carcinoma. Molecular diagnosis and detection of known driver mutations is necessary for introducing targeted therapy and use of multiplex gene panel assays using next-generation sequencing is recommended. Immunotherapy with checkpoint inhibitors is the second promising method of systemic therapy with best results in tumours with high programmed death-ligand 1 (PD-L1) expression on cancer cells. Finally, the determination of a full tumour pattern will be possible using artificial intelligence in the near future.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"230192"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 46-year-old woman presenting with anterior mediastinal mass and superior vena cava obstruction syndrome. 一名 46 岁女性，出现前纵隔肿块和上腔静脉阻塞综合征。
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0038-2024
Soumi Chakraborty, Suranjan Mukherjee, Arighna Mukherjee, Mithun Chaudhuri
{"title":"A 46-year-old woman presenting with anterior mediastinal mass and superior vena cava obstruction syndrome.","authors":"Soumi Chakraborty, Suranjan Mukherjee, Arighna Mukherjee, Mithun Chaudhuri","doi":"10.1183/20734735.0038-2024","DOIUrl":"10.1183/20734735.0038-2024","url":null,"abstract":"<p><p><b>Mucormycosis can rarely lead to an anterior mediastinal mass and a high index of suspicion is necessary so that intervention can be carried out at an early stage.</b> https://bit.ly/4aUuqvc.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"240038"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary management of mesothelioma. 间皮瘤的当代管理。
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0175-2023
Mark D J Neilly, Jennifer Pearson, Akari Win Thu, Carolyn MacRae, Kevin G Blyth
{"title":"Contemporary management of mesothelioma.","authors":"Mark D J Neilly, Jennifer Pearson, Akari Win Thu, Carolyn MacRae, Kevin G Blyth","doi":"10.1183/20734735.0175-2023","DOIUrl":"10.1183/20734735.0175-2023","url":null,"abstract":"<p><p>Pleural mesothelioma (PM) is an aggressive asbestos-associated thoracic malignancy with a median survival of 12-18 months. Due to continued asbestos use in many nations, global incidence is rising. Causes due to non-occupational, environmental exposure are also rising in many countries despite utilisation bans. For many years, platinum--pemetrexed chemotherapy was the solitary licensed therapy, but first-line combination immune checkpoint blockade has recently demonstrated improved outcomes, with both regimes tested in predominantly late-stage cohorts. In the second-line setting, single-agent nivolumab has been shown to extend survival and is now available for routine use in some regions, while second-line chemotherapy has no proven role and opportunities for clinical trials should be maximised in relapsed disease. Surgery for \"technically resectable\" disease has been offered for decades in many expert centres, but the recent results from the phase III MARS2 trial have challenged this approach. There remains no robustly proven standard of care for early-stage PM. The clinical trial landscape for PM is complex and increasingly diverse, making further development of specialist PM multidisciplinary teams an important priority in all countries. The observation of improving outcomes in centres that have adopted this service model emphasises the importance of high-quality diagnostics and equitable access to therapies and trials. Novel therapies targeting a range of aberrations are being evaluated; however, a better understanding of the molecular drivers and their associated vulnerabilities is required to identify and prioritise treatment targets.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"230175"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleural effusion in a patient with previous alcohol excess. 一名酗酒患者的胸腔积液。
IF 2.3
Breathe Pub Date : 2024-07-16 eCollection Date: 2024-06-01 DOI: 10.1183/20734735.0036-2024
Richard Eddery, Lucy Searle, Mubashar Iqbal, Victoria Athey
{"title":"Pleural effusion in a patient with previous alcohol excess.","authors":"Richard Eddery, Lucy Searle, Mubashar Iqbal, Victoria Athey","doi":"10.1183/20734735.0036-2024","DOIUrl":"10.1183/20734735.0036-2024","url":null,"abstract":"<p><p><b>Pleural amylase and/or lipase should be analysed in cases of pleural effusion in patients with pancreatic disease or a history of excess alcohol consumption.</b> https://bit.ly/3Rk5UfO.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 2","pages":"240036"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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