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Artificial intelligence in tuberculosis: a new ally in disease control. 结核病中的人工智能：疾病控制的新盟友。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0056-2024
Mairi McClean, Traian Constantin Panciu, Christoph Lange, Raquel Duarte, Fabian Theis
{"title":"Artificial intelligence in tuberculosis: a new ally in disease control.","authors":"Mairi McClean, Traian Constantin Panciu, Christoph Lange, Raquel Duarte, Fabian Theis","doi":"10.1183/20734735.0056-2024","DOIUrl":"10.1183/20734735.0056-2024","url":null,"abstract":"<p><p>The challenges to effective tuberculosis (TB) disease control are considerable, and the current global targets for reductions in disease burden seem unattainable. The combination of complex pathophysiology and technical limitations results in difficulties in achieving consistent, reliable diagnoses, and long treatment regimens imply serious physiological and socioeconomic consequences for patients. Artificial intelligence (AI) applications in healthcare have significantly improved patient care regarding diagnostics, treatment and basic research. However, their success relies on infrastructures prioritising comprehensive data generation and collaborative research environments to foster stakeholder engagement. This viewpoint article briefly outlines the current and potential applications of advanced AI models in global TB control and the considerations and implications of adopting these tools within the public health community.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240056"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-flow nasal cannula is an expensive and clunky placebo: myth or maxim? 高流量鼻插管是一种昂贵而笨重的安慰剂：神话还是格言？
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0185-2023
Gareth A L Jones, Padmanabhan Ramnarayan
{"title":"High-flow nasal cannula is an expensive and clunky placebo: myth or maxim?","authors":"Gareth A L Jones, Padmanabhan Ramnarayan","doi":"10.1183/20734735.0185-2023","DOIUrl":"10.1183/20734735.0185-2023","url":null,"abstract":"<p><p>High-flow nasal cannula (HFNC) is now a commonly used noninvasive method of providing respiratory support to children and young people. Its rapid spread into varied clinical applications has often left assessment of the evidence of its mechanism of action and clinical benefit lagging behind its uptake. This review will discuss the proposed mechanisms of action of HFNC, review the evidence base for its use, cover its applications in paediatrics and outline its limitations.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230185"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of central sleep apnoea: a review of non-hypercapnic causes. 中枢性睡眠呼吸暂停的管理：非高窒息原因综述。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0235-2023
Yizhong Zheng, Jian Eu Tai, Brendon J Yee
{"title":"Management of central sleep apnoea: a review of non-hypercapnic causes.","authors":"Yizhong Zheng, Jian Eu Tai, Brendon J Yee","doi":"10.1183/20734735.0235-2023","DOIUrl":"https://doi.org/10.1183/20734735.0235-2023","url":null,"abstract":"<p><p>Central sleep apnoea (CSA) is characterised by recurrent episodes of airway cessation or reduction in the absence of respiratory effort. Although CSA is less common than obstructive sleep apnoea, it shares similar symptoms. CSA can be secondary to various medical conditions, high altitude and medication exposure. CSA can also emerge during obstructive sleep apnoea therapy. There are a range of treatment options and selecting the right therapy requires an understanding of the pathophysiology of CSA. This review explores the aetiology, pathophysiology and clinical management of non-hypercapnic CSA.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230235"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pro: indwelling pleural catheters cause harm to patients. 赞成：留置胸膜导管会对患者造成伤害。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0034-2024
Beenish Iqbal, Eihab Bedawi, Najib M Rahman
{"title":"Pro: indwelling pleural catheters cause harm to patients.","authors":"Beenish Iqbal, Eihab Bedawi, Najib M Rahman","doi":"10.1183/20734735.0034-2024","DOIUrl":"https://doi.org/10.1183/20734735.0034-2024","url":null,"abstract":"<p><p>Malignant pleural effusions (MPE) tend to recur and require definitive treatment with either chest drain and talc pleurodesis or indwelling pleural catheters (IPCs), which offer similar symptomatic benefits. In recent years, IPCs have become popular due to the presumed convenience of an outpatient procedure followed by home drainage leading to a misconception of IPCs being an ideal treatment for MPE. However, IPCs predispose the patient to multiple complications and have significant physical and psychological implications that are under-recognised. Patients require additional clinical reviews, hospital admissions and treatment for these complications related to IPCs. Additionally, there is a huge psychological impact of living with a home catheter that is a constant reminder of their cancer and this has been shown to affect quality of life negatively. Hence, IPCs should not be considered the \"ideal\" treatment for MPE management and clinicians should reflect the equipoise of the evidence for the benefits and accurately reflect the adverse effects of IPCs in their discussions with patients to facilitate informed decision making.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240034"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: "Steroids in severe community-acquired pneumonia". S. Ananth, A.G. Mathioudakis, J. Hansel. Breathe 2024; 20: 240081. 勘误："社区获得性重症肺炎中的类固醇"。S. Ananth, A.G. Mathioudakis, J. Hansel.呼吸 2024; 20: 240081.
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.5081-2024
{"title":"Erratum: \"Steroids in severe community-acquired pneumonia\". S. Ananth, A.G. Mathioudakis, J. Hansel. <i>Breathe</i> 2024; 20: 240081.","authors":"","doi":"10.1183/20734735.5081-2024","DOIUrl":"https://doi.org/10.1183/20734735.5081-2024","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/20734735.0081-2024.].</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"245081"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 inflammation in COPD: is it just asthma? 慢性阻塞性肺病的 2 型炎症：仅仅是哮喘吗？
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0229-2023
Augusta Beech, Andrew Higham, Sophie Booth, Vickram Tejwani, Frederik Trinkmann, Dave Singh
{"title":"Type 2 inflammation in COPD: is it just asthma?","authors":"Augusta Beech, Andrew Higham, Sophie Booth, Vickram Tejwani, Frederik Trinkmann, Dave Singh","doi":"10.1183/20734735.0229-2023","DOIUrl":"10.1183/20734735.0229-2023","url":null,"abstract":"<p><p>COPD is a heterogeneous condition, with tobacco smoking being the main environmental risk factor. The presence of type 2 (T2) inflammation is a well-recognised feature of asthma; however, it is now apparent that a subset of COPD patients also displays evidence of T2 inflammation with respect to elevated eosinophil counts and altered gene and protein expression of several T2 inflammatory mediators. T2 inflammatory mediators represent an attractive therapeutic target in both COPD and asthma; however, the efficacy of pharmaceutical interventions varies between diseases. Furthermore, the nature of some shared clinical features also differs. We provide a narrative review of differences in the nature of T2 inflammation between COPD and asthma, which may partly explain phenotypic differences between diseases. We focus on evidence from studies of pulmonary histopathology, sputum and epithelial gene and protein expression, and response to pharmacological interventions targeted at T2 inflammation.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230229"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The CheckMate 816 trial: a milestone in neoadjuvant chemoimmunotherapy of nonsmall cell lung cancer. CheckMate 816 试验：非小细胞肺癌新辅助化疗免疫疗法的里程碑。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0044-2024
Marie Mayenga, Ana Rita Pedroso, Marion Ferreira, Thomas Gille, Maria Joana Pereira Catarata, Boris Duchemann
{"title":"The CheckMate 816 trial: a milestone in neoadjuvant chemoimmunotherapy of nonsmall cell lung cancer.","authors":"Marie Mayenga, Ana Rita Pedroso, Marion Ferreira, Thomas Gille, Maria Joana Pereira Catarata, Boris Duchemann","doi":"10.1183/20734735.0044-2024","DOIUrl":"https://doi.org/10.1183/20734735.0044-2024","url":null,"abstract":"<p><p>Advancements in immunotherapy in the perioperative setting have revolutionised the treatment of resectable nonsmall cell lung cancer (NSCLC). Here we present the methodology and results of the clinical trial CheckMate 816 demonstrating the benefit of neoadjuvant therapy with nivolumab plus chemotherapy compared with chemotherapy alone. Furthermore, this article discusses the implications for future practice in resectable NSCLC and the need for future research.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240044"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An elderly woman with acute respiratory failure and diffuse pulmonary changes. 一名老年妇女出现急性呼吸衰竭和弥漫性肺部病变。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0055-2024
Chun Ian Soo, Wai Ling Leong, Nadia Fareeda Muhammad Gowdh, Leng Cheng Sia, Vijayan Munusamy, Chee Kuan Wong, Nazarina Abdul Rahman
{"title":"An elderly woman with acute respiratory failure and diffuse pulmonary changes.","authors":"Chun Ian Soo, Wai Ling Leong, Nadia Fareeda Muhammad Gowdh, Leng Cheng Sia, Vijayan Munusamy, Chee Kuan Wong, Nazarina Abdul Rahman","doi":"10.1183/20734735.0055-2024","DOIUrl":"https://doi.org/10.1183/20734735.0055-2024","url":null,"abstract":"<p><p><b>Mucoepidermoid carcinoma is a rare primary tumour of the lung. Diagnosis can be made after careful exclusion of other lung neoplasms, especially those with overlapping histological and radiological features.</b> https://bit.ly/4fcISSm.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240055"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights from the Respiratory Failure and Mechanical Ventilation Conference 2024. 2024 年呼吸衰竭和机械通气会议要点。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0105-2024
Clara Bianquis, Giancarlo De Leo, Giorgio Morana, Marta Duarte-Silva, Santi Nolasco, Rūdolfs Vilde, Athiwat Tripipitsiriwat, Pedro Viegas, Martins Purenkovs, Marieke Duiverman, Christian Karagiannids, Christoph Fisser
{"title":"Highlights from the Respiratory Failure and Mechanical Ventilation Conference 2024.","authors":"Clara Bianquis, Giancarlo De Leo, Giorgio Morana, Marta Duarte-Silva, Santi Nolasco, Rūdolfs Vilde, Athiwat Tripipitsiriwat, Pedro Viegas, Martins Purenkovs, Marieke Duiverman, Christian Karagiannids, Christoph Fisser","doi":"10.1183/20734735.0105-2024","DOIUrl":"https://doi.org/10.1183/20734735.0105-2024","url":null,"abstract":"<p><p>The Respiratory Intensive Care Assembly of the European Respiratory Society gathered in Berlin to organise the third Respiratory Failure and Mechanical Ventilation Conference in February 2024. The conference covered key points of acute and chronic respiratory failure in adults. During the 3-day conference ventilatory strategies, patient selection, diagnostic approaches, treatment and health-related quality of life topics were addressed by a panel of international experts. In this article, lectures delivered during the event have been summarised by early career members of the Assembly and take-home messages highlighted.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240105"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Con: indwelling pleural catheters cause harm to patients. 反方：留置胸膜导管会对患者造成伤害。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0111-2024
Katie Adams, Rahul Bhatnagar
{"title":"Con: indwelling pleural catheters cause harm to patients.","authors":"Katie Adams, Rahul Bhatnagar","doi":"10.1183/20734735.0111-2024","DOIUrl":"https://doi.org/10.1183/20734735.0111-2024","url":null,"abstract":"<p><p>Indwelling pleural catheters (IPCs) have rapidly grown in popularity since their introduction for the management of recurrent pleural effusions. In malignant pleural effusions especially, there has been a shift away from measuring pleurodesis success and towards more patient-centred outcomes. Multiple randomised controlled trials have shown that despite lower rates of pleurodesis, symptom control and quality of life outcomes are comparable when compared to alternatives such as talc pleurodesis. IPCs have the added benefit of minimising inpatient hospital stays and reducing the need for recurrent pleural interventions, key priorities for patients with palliative disease. As a result, IPC treatment is associated with excellent patient satisfaction coupled with acceptably low complication rates. Furthermore, in patients with a short life expectancy they confer a cost benefit for the healthcare system. Far from causing harm, IPCs are now recommended as first-line treatment by current clinical guidelines. In malignant pleural disease, guidance advocates IPCs should be offered as a first-line option with the focus on patient priorities and preferences. Ultimately IPCs provide a safe, effective, ambulatory option for managing recurrent pleural effusions.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240111"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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