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A 69-year-old man with generalised lymphadenopathy, glandular swelling and pleural effusion. 69岁男性，全身性淋巴结病，腺体肿胀和胸腔积液。
IF 2.3
Breathe Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.1183/20734735.0125-2024
Shan Kai Ing, Yih Hoong Lee, Nga Hung Ngu, Kelly Kee Yung Wong, Adam Malik Bin Ismail, Chan Sin Chai, Siew Teck Tie, Sze Shyang Kho
{"title":"A 69-year-old man with generalised lymphadenopathy, glandular swelling and pleural effusion.","authors":"Shan Kai Ing, Yih Hoong Lee, Nga Hung Ngu, Kelly Kee Yung Wong, Adam Malik Bin Ismail, Chan Sin Chai, Siew Teck Tie, Sze Shyang Kho","doi":"10.1183/20734735.0125-2024","DOIUrl":"10.1183/20734735.0125-2024","url":null,"abstract":"<p><p><b>Patients with multisystemic presentation including respiratory symptoms and generalised lymphadenopathy should alert the clinician to this potential diagnosis</b> https://bit.ly/4eJ0PHT.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 1","pages":"240125"},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in respiratory care: perspectives on critical opportunities and challenges. 呼吸护理中的人工智能：关键机遇和挑战的观点。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0189-2023
David Drummond, Ireti Adejumo, Kjeld Hansen, Vitalii Poberezhets, Gregory Slabaugh, Chi Yan Hui
{"title":"Artificial intelligence in respiratory care: perspectives on critical opportunities and challenges.","authors":"David Drummond, Ireti Adejumo, Kjeld Hansen, Vitalii Poberezhets, Gregory Slabaugh, Chi Yan Hui","doi":"10.1183/20734735.0189-2023","DOIUrl":"10.1183/20734735.0189-2023","url":null,"abstract":"<p><p>Artificial intelligence (AI) is transforming respiratory healthcare through a wide range of deep learning and generative tools, and is increasingly integrated into both patients' lives and routine respiratory care. The implications of AI in respiratory care are vast and multifaceted, presenting both promises and uncertainties from the perspectives of clinicians, patients and society. Clinicians contemplate whether AI will streamline or complicate their daily tasks, while patients weigh the potential benefits of personalised self-management support against risks such as data privacy concerns and misinformation. The impact of AI on the clinician-patient relationship remains a pivotal consideration, with the potential to either enhance collaborative care or create depersonalised interactions. Societally, there is an imperative to leverage AI in respiratory care to bridge healthcare disparities, while safeguarding against the widening of inequalities. Strategic efforts to promote transparency and prioritise inclusivity and ease of understanding in algorithm co-design will be crucial in shaping future AI to maximise benefits and minimise risks for all stakeholders.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230189"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ERS/ATS Global Lung Function Initiative normal values and classifying severity based on z-scores instead of per cent predicted. ERS/ATS全球肺功能倡议正常值，并根据z分数而不是预测的百分比对严重程度进行分类。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0227-2023
Rachel Ong-Salvador, Pierantonio Laveneziana, Franciscus de Jongh
{"title":"ERS/ATS Global Lung Function Initiative normal values and classifying severity based on z-scores instead of per cent predicted.","authors":"Rachel Ong-Salvador, Pierantonio Laveneziana, Franciscus de Jongh","doi":"10.1183/20734735.0227-2023","DOIUrl":"10.1183/20734735.0227-2023","url":null,"abstract":"<p><p>Among the most discussed issues in the field of pulmonary function testing are reference equations and standardised methods of interpreting pulmonary function test (PFT) results. The Global Lung Function Initiative (GLI) task force gathered information from multiple countries with diverse ethnicities to create a multi-ethnic reference formula suitable for a broad age range. Their first output was the GLI-2012 spirometry reference equations. Together with the GLI-2012 reference equations, the GLI document recommended the use of z-scores to standardise the interpretation of PFT results. Z-scores were introduced as an alternative to per cent predicted and fixed thresholds in interpreting PFTs. After more than a decade, there is still debate on which method of interpretation is better.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230227"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The more stars, the brighter! Interview with the ECM award winner 2023. 星星越多越亮！采访2023年ECM奖得主。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0175-2024
Senani N H Rathnayake, Joana Cruz, Sara Cuevas Ocaña, Mareike Lehmann, Heleen Demeyer
{"title":"The more stars, the brighter! Interview with the ECM award winner 2023.","authors":"Senani N H Rathnayake, Joana Cruz, Sara Cuevas Ocaña, Mareike Lehmann, Heleen Demeyer","doi":"10.1183/20734735.0175-2024","DOIUrl":"https://doi.org/10.1183/20734735.0175-2024","url":null,"abstract":"<p><p><b>In this early career forum, the 2023 ECM awardee shares her insights into research, her career path, her personal life and collaborations (@Mkg_Lehmann)</b> https://bit.ly/4f0AiVY.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240175"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success. 结核病生物标志物的进展：揭示危险因素、活动性疾病和治疗成功。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0003-2024
Jodie A Schildkraut, Niklas Köhler, Christoph Lange, Raquel Duarte, Stephen H Gillespie
{"title":"Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success.","authors":"Jodie A Schildkraut, Niklas Köhler, Christoph Lange, Raquel Duarte, Stephen H Gillespie","doi":"10.1183/20734735.0003-2024","DOIUrl":"10.1183/20734735.0003-2024","url":null,"abstract":"<p><p>Tuberculosis (TB) is a major global health threat and demands improved diagnostic and treatment monitoring methods. Conventional diagnostics, such as sputum smear microscopy and culture, are limited by slow results and low sensitivity, particularly in certain patient groups. Recent advances in biomarker research offer promising solutions in three key areas: risk of disease, diagnosis of active disease and monitoring of treatment response. For risk assessment, novel genetic signatures and metabolites show potential in predicting the progression from TB infection to active TB. A 16-gene signature, for example, predicts this progression with significant accuracy. In diagnosing active TB, RNA-based transcriptomic signatures provide higher diagnostic accuracy than traditional methods. These signatures, such as a three-gene RNA sequence, effectively differentiate active TB from other diseases and infections, addressing issues of specificity and sensitivity. Monitoring treatment response is crucial, given the varying response rates in treating TB. Emerging biomarkers focus on bacterial burden and host response. They offer more precise and timely assessments of treatment efficacy, enhance personalised treatment approaches and potentially improve patient outcomes. These advancements in biomarkers for TB risk, diagnosis and treatment response represent significant steps towards more effective TB management and control, aligning with global efforts to decrease the burden of TB. Here we aim to highlight several promising biomarkers used to predict risk of disease progression, active TB disease and treatment success.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240003"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung volume reduction: surgery versus endobronchial valves. 肺减容：手术还是支气管内瓣膜。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0107-2024
Laurens J Ceulemans, Dorina Esendagli, Giuseppe Cardillo, Marcello Migliore
{"title":"Lung volume reduction: surgery <i>versus</i> endobronchial valves.","authors":"Laurens J Ceulemans, Dorina Esendagli, Giuseppe Cardillo, Marcello Migliore","doi":"10.1183/20734735.0107-2024","DOIUrl":"10.1183/20734735.0107-2024","url":null,"abstract":"<p><p>Volume reduction is a disease-modifying treatment that aims to reshape the diseased lung towards a more normal total lung capacity by removing severely damaged and overinflated lung parenchyma. It is an effective therapeutic strategy in well-selected patients, resulting in improvements in exercise tolerance, lung function, quality of life and survival. The most widespread strategies for volume reduction are either video-assisted thoracoscopic surgery or bronchoscopic lung volume reduction. It is crucial to decide which approach would be more suitable for specific patients, as this is related to the outcome of the procedure. Factors like emphysema distribution on computed tomography, the presence or absence of collateral ventilation, the patient's pulmonary function tests, a history of other comorbidities and previous interventions might all influence the choice of procedure. It is crucial that this decision is taken by a multidisciplinary expert team to have the best outcome and fewer complications.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240107"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonged weaning from mechanical ventilation: who, what, when and how? 延长机械通气脱机时间：谁，什么，何时以及如何脱机？
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0122-2024
Neeraj M Shah, Nicholas Hart, Georgios Kaltsakas
{"title":"Prolonged weaning from mechanical ventilation: who, what, when and how?","authors":"Neeraj M Shah, Nicholas Hart, Georgios Kaltsakas","doi":"10.1183/20734735.0122-2024","DOIUrl":"10.1183/20734735.0122-2024","url":null,"abstract":"<p><p>Weaning from invasive mechanical ventilation is an important part of the management of respiratory failure patients. Patients can be classified into those who wean on the first attempt (simple weaning), those who require up to three attempts (difficult weaning) and those who require more than three attempts (prolonged weaning). The process of weaning includes adequately treating the underlying cause of respiratory failure, assessing the readiness to wean, evaluating the response to a reduction in ventilatory support, and eventually liberation from mechanical ventilation and extubation or decannulation. Post-extubation respiratory failure is a contributor to poorer outcomes. Identifying and addressing modifiable risk factors for post-extubation respiratory failure is important; noninvasive ventilation and high-flow nasal cannulae may be useful bridging aids after extubation. Factors to consider in the pathophysiology of prolonged mechanical ventilation include increased respiratory muscle load, reduced respiratory muscle capacity and reduced respiratory drive. Management of these patients involves a multidisciplinary team, to first identify the cause of failed weaning attempts, and subsequently optimise the patient's physiology to improve the likelihood of being successfully weaned from invasive mechanical ventilation.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240122"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does inhaler adherence really matter in severe asthma? 吸入器的依从性对严重哮喘真的重要吗？
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0001-2024
Gráinne d'Ancona, Brian D Kent
{"title":"Does inhaler adherence really matter in severe asthma?","authors":"Gráinne d'Ancona, Brian D Kent","doi":"10.1183/20734735.0001-2024","DOIUrl":"10.1183/20734735.0001-2024","url":null,"abstract":"<p><p>Inhaled therapies, primarily the inhaled corticosteroid (ICS), have been the cornerstone of asthma treatment since the 1960s. They have been shown to reduce symptom burden, morbidity and mortality, and potentially avoid unnecessary and unscheduled healthcare. However, some people have severe asthma, defined by an inability to gain or maintain consistent disease control despite appropriate use of high dose ICS-containing inhalers. In this review, we discuss whether it is appropriate to demand adherence to a treatment this cohort are demonstrably resistant to.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240001"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unusual case of a dry cough. 罕见的干咳。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0141-2024
Alannah Murray, Laura Piggott, James O'Hanlon, Ignacio Martin-Loeches, Barry Kennedy
{"title":"An unusual case of a dry cough.","authors":"Alannah Murray, Laura Piggott, James O'Hanlon, Ignacio Martin-Loeches, Barry Kennedy","doi":"10.1183/20734735.0141-2024","DOIUrl":"10.1183/20734735.0141-2024","url":null,"abstract":"<p><p><b>This is the first case report detailing co-infection with both PJP and disseminated histoplasmosis in a patient without HIV infection, and it highlights the immune-suppressive potential of poorly controlled diabetes and liver cirrhosis</b> https://bit.ly/4dXUOX4.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240141"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral spontaneous pneumothorax in a patient with rheumatoid arthritis and accelerated nodulosis. 双侧自发性气胸合并类风湿关节炎及加速结节。
IF 2.3
Breathe Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0083-2024
Roshini Kurian, Sajeel Ahmed, Avinash Aujayeb, Ben Thompson
{"title":"Bilateral spontaneous pneumothorax in a patient with rheumatoid arthritis and accelerated nodulosis.","authors":"Roshini Kurian, Sajeel Ahmed, Avinash Aujayeb, Ben Thompson","doi":"10.1183/20734735.0083-2024","DOIUrl":"10.1183/20734735.0083-2024","url":null,"abstract":"<p><p><b>One of the respiratory complications of rheumatoid arthritis (RA) is formation of lung nodules, which can rupture to cause pneumothoraces. We present a case of recurrent pneumothoraces due to accelerated RA nodulosis, secondary to biologic therapy.</b> https://bit.ly/3WBhgOe.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240083"},"PeriodicalIF":2.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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