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Lung Facts: a practical tool to strengthen respiratory advocacy in Europe. 肺的事实：一个实用的工具，加强呼吸倡导在欧洲。
IF 4.5
Breathe Pub Date : 2026-05-18 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0026-2026
Guy Joos, Amy Auer, Pippa Powell, Lauren Anderson, Joan B Soriano, Jana De Brandt, Chantal Raherison Semjen, Bruno Balbi, Aleksander Kania
{"title":"Lung Facts: a practical tool to strengthen respiratory advocacy in Europe.","authors":"Guy Joos, Amy Auer, Pippa Powell, Lauren Anderson, Joan B Soriano, Jana De Brandt, Chantal Raherison Semjen, Bruno Balbi, Aleksander Kania","doi":"10.1183/20734735.0026-2026","DOIUrl":"10.1183/20734735.0026-2026","url":null,"abstract":"<p><p>Respiratory diseases remain a leading health burden across Europe, yet national strategies are often fragmented or absent. The International Respiratory Coalition's Lung Facts platform offers a comprehensive, up-to-date resource for epidemiological and economic data for major respiratory conditions across 53 European countries. This viewpoint outlines the platform's development and the types of data available, including disease burden, societal costs and risk factor attribution. It also demonstrates how national coalitions are using it to advocate for respiratory health policies. By providing accessible, country-specific information in visual formats, Lung Facts supports benchmarking, evidence-based advocacy and planning of national respiratory strategies. The platform is a dynamic tool intended to strengthen respiratory health policy and empower stakeholders to act on the growing burden of lung disease.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"260026"},"PeriodicalIF":4.5,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro diagnostics for respiratory infections: current state and opportunities. 呼吸道感染的体外诊断：现状和机遇。
IF 4.5
Breathe Pub Date : 2026-05-18 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0310-2025
Ana Catalina Hernandez Padilla, Kateryna Viligorska, Juan Pablo Rodríguez Ruiz, Letizia Traversi, Maurizio Sanguinetti, Herman Goossens, Eva Polverino
{"title":"<i>In vitro</i> diagnostics for respiratory infections: current state and opportunities.","authors":"Ana Catalina Hernandez Padilla, Kateryna Viligorska, Juan Pablo Rodríguez Ruiz, Letizia Traversi, Maurizio Sanguinetti, Herman Goossens, Eva Polverino","doi":"10.1183/20734735.0310-2025","DOIUrl":"10.1183/20734735.0310-2025","url":null,"abstract":"<p><p>Acute respiratory tract infections represent a significant burden in primary care, with antibiotics often prescribed unnecessarily. This contributes to the escalating threat of antimicrobial resistance (AMR) by increasing the burden of infectious diseases and mortality risk. This is a report from a joint European Society of Clinical Microbiology and Infectious Diseases/European Respiratory Society research seminar held in November 2023 to discuss the role of <i>in vitro</i> diagnostic tests to combat AMR in community-acquired respiratory tract infections. We review the diagnostic tools available and in development, and the challenges related to their assessment, implementation in clinical settings and their overall impact on AMR.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250310"},"PeriodicalIF":4.5,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal immune dynamics in lung cancer progression and treatment. 肺癌进展和治疗的时空免疫动力学。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0335-2025
Chee Kuan Wong, Megat Hafizzuddin Bin Abd Hamid
{"title":"Spatiotemporal immune dynamics in lung cancer progression and treatment.","authors":"Chee Kuan Wong, Megat Hafizzuddin Bin Abd Hamid","doi":"10.1183/20734735.0335-2025","DOIUrl":"10.1183/20734735.0335-2025","url":null,"abstract":"<p><p>The lung tumour microenvironment is a complex and evolving ecosystem in which immune, stromal and malignant cells interact across both space and time. Spatial organisation determines whether immune cells can access and induce immune responses across tumour tissues, while temporal changes driven by disease progression and therapy reshape these interactions. Although advances in high-plex technologies have revealed discrete immune niches in lung cancer, particularly in nonsmall cell lung carcinoma (NSCLC), less is known about how these tissue landscape niches remodel over time. This review integrates spatial and temporal perspectives to provide a unified view of lung cancer immunobiology. We discuss how fibroblast activation, endothelial remodelling and extracellular matrix deposition restrict immune infiltration and how conventional therapies and targeted inhibitors can remodel these barriers. We highlight recent studies that reveal how immune functional states shift with treatment and cancer stages. Finally, we outline how emerging technologies (spatial transcriptomics, multiplex imaging and functional assays) offer new opportunities to link temporal transitions with spatial immune context. Understanding spatiotemporal dynamics will be key to stage-specific biomarker discovery, treatment optimisation and personalised strategies in NSCLC.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250335"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 71-year-old man presenting with cough and bilateral pulmonary opacities. 71岁男性，表现为咳嗽和双侧肺混浊。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0357-2025
Sreosi Samajdar, Mayur Goel, Suranjan Mukherjee, Kanika Gupta
{"title":"A 71-year-old man presenting with cough and bilateral pulmonary opacities.","authors":"Sreosi Samajdar, Mayur Goel, Suranjan Mukherjee, Kanika Gupta","doi":"10.1183/20734735.0357-2025","DOIUrl":"10.1183/20734735.0357-2025","url":null,"abstract":"<p><p><b>Lung adenocarcinoma, a major cause of morbidity and mortality, can present with various CT signs, often mimicking other conditions. Appropriate investigations, including bronchoscopy with BAL and biopsy, should be carried out for diagnosis.</b> https://bit.ly/3YNWHzY.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250357"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The European Respiratory Society guideline for management of adult bronchiectasis: clinical summary. 欧洲呼吸学会成人支气管扩张管理指南：临床总结。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0001-2026
James D Chalmers, Oriol Sibila, Beatriz Herrero Cortina, Merete B Long, Sanjay H Chotirmall, Stefano Aliberti
{"title":"The European Respiratory Society guideline for management of adult bronchiectasis: clinical summary.","authors":"James D Chalmers, Oriol Sibila, Beatriz Herrero Cortina, Merete B Long, Sanjay H Chotirmall, Stefano Aliberti","doi":"10.1183/20734735.0001-2026","DOIUrl":"10.1183/20734735.0001-2026","url":null,"abstract":"<p><p>This review provides an overview of the 2025 European Respiratory Society guidelines for adult bronchiectasis. We cover the initial assessment of patients with bronchiectasis to identify the underlying cause, pharmacotherapy including long-term oral and inhaled antibiotic treatment, anti-inflammatory treatments and mucoactive drugs, and non-pharmacological treatments including airway clearance and pulmonary rehabilitation. We provide examples of how to implement the guideline algorithms in practice including how to manage patients during an acute exacerbation and the deteriorating patient. An important component of the new guideline is assessing patients' future risk of exacerbation, which takes into account not just prior history of exacerbations, but also severity of baseline symptoms and additional risk factors such as the underlying cause of bronchiectasis and infection with pathogens like <i>Pseudomonas aeruginosa</i>. The guideline provides an evidence-based framework for identifying the appropriate treatments for individual patients taking into account the heterogeneity and complexity of bronchiectasis.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"260001"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Find your career: the ERS "My Career Path" series. 找到你的职业：ERS“我的职业道路”系列。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0263-2025
Sachin Ananth, Joachim Aerts, Sanjay H Chotirmall, Georgia Hardavella, MeiLan K Han, Eva Millqvist, Maria Molina-Molina, Philip L Molyneaux, Catharina C Moor, Alyn Morice, Florence Schleich, Sejal Saglani, Amelia Shoemark, Lena Uller, Sheila Ramjug, Augusta Beech
{"title":"Find your career: the ERS \"My Career Path\" series.","authors":"Sachin Ananth, Joachim Aerts, Sanjay H Chotirmall, Georgia Hardavella, MeiLan K Han, Eva Millqvist, Maria Molina-Molina, Philip L Molyneaux, Catharina C Moor, Alyn Morice, Florence Schleich, Sejal Saglani, Amelia Shoemark, Lena Uller, Sheila Ramjug, Augusta Beech","doi":"10.1183/20734735.0263-2025","DOIUrl":"10.1183/20734735.0263-2025","url":null,"abstract":"<p><p><b>The ERS \"My Career Path\" series provides an excellent insight into different subspecialties in respiratory medicine. All episodes can be found on the ERS Respiratory Channel.</b> https://bit.ly/4sADqiS.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250263"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood eosinophil count as a biomarker for therapy guidance in COPD and asthma exacerbations. 血液嗜酸性粒细胞计数作为COPD和哮喘加重治疗指导的生物标志物。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0329-2025
Anuradha Nalika Godallage, Dil Afrose, Melika Valizadeh, Augusta Beech, Jens-Ulrik S Jensen, Pradeesh Sivapalan
{"title":"Blood eosinophil count as a biomarker for therapy guidance in COPD and asthma exacerbations.","authors":"Anuradha Nalika Godallage, Dil Afrose, Melika Valizadeh, Augusta Beech, Jens-Ulrik S Jensen, Pradeesh Sivapalan","doi":"10.1183/20734735.0329-2025","DOIUrl":"10.1183/20734735.0329-2025","url":null,"abstract":"<p><p>This Journal club evaluates recent evidence on the role of blood eosinophil count (BEC) as a biomarker to guide therapy in patients with acute exacerbations of COPD and asthma. The review focuses on three studies with different methodological approaches: a biomarker-directed corticosteroid trial (Bafadhel <i>et al</i>., 2012), an acute biologic therapy trial using benralizumab (ABRA, 2025) and a long-term biologic therapy trial using mepolizumab (COPD-HELP, 2025). The biomarker-directed corticosteroid study demonstrated non-inferior symptom improvement while reducing steroid exposure, highlighting the potential to personalise therapy based on BEC. The ABRA trial showed that a single injection of benralizumab reduced treatment failure, prolonged time to exacerbation and improved symptom scores in patients with high eosinophils. By contrast, the COPD-HELP trial found no significant effect of mepolizumab on readmission or mortality, despite substantial eosinophil reduction. Limitations include small sample sizes, heterogeneous populations and reliance on surrogate end-points in some studies. These findings support the use of BEC-guided therapy in acute settings but suggest that long-term biologic treatment post-exacerbation may not improve hard outcomes. Future research should focus on precision medicine strategies targeting eosinophilic exacerbations and identifying patient subgroups who benefit most from biomarker-guided interventions.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250329"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of breathlessness and unexpected antibodies: stating the obvious. 一个呼吸困难和意想不到的抗体的病例：这是显而易见的。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0358-2025
Ilias E Dimeas, Garifallia Perlepe, Paraskevi Kirgou, Cormac McCarthy, Zoe Daniil
{"title":"A case of breathlessness and unexpected antibodies: stating the obvious.","authors":"Ilias E Dimeas, Garifallia Perlepe, Paraskevi Kirgou, Cormac McCarthy, Zoe Daniil","doi":"10.1183/20734735.0358-2025","DOIUrl":"10.1183/20734735.0358-2025","url":null,"abstract":"<p><p><b>A patient developed breathlessness after starting pravastatin, with transient anti-HMGCR positivity and interstitial changes. Statin withdrawal led to full recovery, highlighting the importance of drug causality assessment in ILD.</b> https://bit.ly/4rdPDZl.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250358"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary toxicity of immune checkpoint inhibitors. 免疫检查点抑制剂的肺毒性。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0276-2025
Sean Garvey, Parthiban Nadarajan
{"title":"Pulmonary toxicity of immune checkpoint inhibitors.","authors":"Sean Garvey, Parthiban Nadarajan","doi":"10.1183/20734735.0276-2025","DOIUrl":"10.1183/20734735.0276-2025","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have brought about major advances in the treatment of cancer over the past 15 years. With a growing armoury of these immunotherapies available and an ever-expanding list of indications for their use, ICIs have become a standard of care in the treatment of cancers including nonsmall cell lung cancer, melanoma and renal cell carcinoma. ICIs are generally well tolerated by patients; however, they bring with them a novel class of toxicities, termed immune-related adverse events. ICI-associated pneumonitis (CIP) is among the most clinically important immune-related adverse events due to both its high incidence and associated morbidity. CIP is associated with a nonspecific clinical presentation, a heterogeneous imaging appearance and an unpredictable clinical course. In this review, we discuss the biology of immune checkpoint inhibition and the epidemiology, clinical manifestations and management of CIP. Additionally, we discuss less well described manifestations of ICI-related pulmonary toxicity: immune-mediated pleural effusion and sarcoid-like reactions.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250276"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare but critical complication of malignant pleural effusion management. 恶性胸腔积液治疗中一种罕见但关键的并发症。
IF 4.5
Breathe Pub Date : 2026-04-14 eCollection Date: 2026-04-01 DOI: 10.1183/20734735.0235-2025
Sheetal Chaurasia, Amir Asyraf Bin Mohd Rushdan, Chan Tha A Hing, Arvindran A L Alaga, Rakesh Panchal
{"title":"A rare but critical complication of malignant pleural effusion management.","authors":"Sheetal Chaurasia, Amir Asyraf Bin Mohd Rushdan, Chan Tha A Hing, Arvindran A L Alaga, Rakesh Panchal","doi":"10.1183/20734735.0235-2025","DOIUrl":"10.1183/20734735.0235-2025","url":null,"abstract":"<p><p><b>Cases of IPC malposition are rare. Clinicians managing patients with inadequate drainage of an IPC should be aware of this possibility. A prompt CT may be needed to confirm IPC tip position and ensure there is no visceral or vascular injury.</b> https://bit.ly/4bOOFi2.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"22 2","pages":"250235"},"PeriodicalIF":4.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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