Breathe最新文献_第10页

Scars from the pandemic: understanding post-COVID-19 interstitial lung disease. 大流行的伤疤：了解covid -19后间质性肺病。

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0037-2025

Tharun Shyam, Christiana Atuaka, Medha Venigalla, Odai Sinokrot

{"title":"Scars from the pandemic: understanding post-COVID-19 interstitial lung disease.","authors":"Tharun Shyam, Christiana Atuaka, Medha Venigalla, Odai Sinokrot","doi":"10.1183/20734735.0037-2025","DOIUrl":"10.1183/20734735.0037-2025","url":null,"abstract":"Five years after the COVID-19 pandemic, the world continues to record acute cases of COVID-19 infection and witness its residual effects. Lung injury persisting beyond the resolution of acute viral pneumonia has been a known entity since the severe acute respiratory syndrome outbreak in 2005. However, residual interstitial lung disease (ILD) secondary to COVID-19 infection has become a new entity of interest due to the widespread and global impact of COVID-19. Post-COVID-19 ILD (PC-ILD) has emerged as a unique entity with age, male sex, smoking and the severity of acute illness as risk factors. Using current evidence, we discuss possible mechanisms for disease occurrence and the genetic similarities between PC-ILD and idiopathic pulmonary fibrosis. Characteristic radiographic findings, pulmonary function abnormalities and potential therapies are also discussed. As the world moves away from the acute phase of the pandemic, obtaining information on the long-term consequences of this disease becomes even more crucial. Continued research in this field is vital to guide decisions and obtain better outcomes in treatment and follow-up.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250037"},"PeriodicalIF":3.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond genes: a clinician's guide to epigenetics. 超越基因：临床医生的表观遗传学指南。

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0227-2024

Petar Popov, Renata Z Jurkowska

引用次数: 0

Mycoplasma pneumoniae respiratory tract infections in children: when and how to diagnose and treat. 儿童肺炎支原体呼吸道感染：何时以及如何诊断和治疗。

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0046-2025

Lara Sharplin, Vikas Goyal

{"title":"Mycoplasma pneumoniae respiratory tract infections in children: when and how to diagnose and treat.","authors":"Lara Sharplin, Vikas Goyal","doi":"10.1183/20734735.0046-2025","DOIUrl":"10.1183/20734735.0046-2025","url":null,"abstract":"Mycoplasma pneumoniae is a frequent cause of respiratory tract infections in both children and adults, responsible for up to 30% of community-acquired pneumonia cases in children. While many infected individuals remain asymptomatic, common symptoms include fever - which is typically short-lived - and a persistent cough, sometimes lasting weeks. Early identification of M. pneumoniae is crucial for effective management. However, distinguishing it from other viral or bacterial lower respiratory tract infections based on symptoms alone is unreliable due to the nonspecific clinical presentation. Currently, the most accurate method for diagnosing M. pneumoniae is PCR testing, as traditional culture methods are slow and technically challenging. Paired serology testing is also used for diagnosis. It is important to evaluate locally available diagnostic resources. First-line treatment typically involves macrolide antibiotics, despite lack of robust data for their use. However, widespread use has contributed to increasing macrolide resistance, especially in Asia, prompting consideration of alternatives like fluoroquinolones and tetracyclines. In severe or treatment-resistant cases, additional therapies such as prednisolone, intravenous immunoglobulin or bronchoscopy may be used, although evidence supporting their routine application is limited. Overall, clinical decisions should be individualised, guided by local transmission patterns, available diagnostics and emerging antibiotic resistance patterns.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250046"},"PeriodicalIF":3.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of simple pulmonary function testing in unravelling the presence of respiratory muscular dysfunction in two patients with interstitial lung diseases. 简单肺功能试验在揭示两例间质性肺疾病患者存在呼吸肌肉功能障碍中的作用

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0223-2024

Pierantonio Laveneziana, Matthieu Le Mélédo, Thomas Gille

引用次数: 0

Rethinking early childhood spirometry: integrated solutions for technical, psychological and interpretative barriers. 重新思考儿童早期肺活量测定：技术、心理和解释障碍的综合解决方案。

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0194-2025

Radu Marian Gheorghiu, Iustina Violeta Stan

引用次数: 0

Surgical interventions for pleural infection. 胸膜感染的外科干预。

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0105-2025

Maria Giovanna Mastromarino, Alessandra Lenzini, Giacomo Rabazzi, Andrea Castaldi, Vittorio Aprile, Stylianos Korasidis, Marcello Carlo Ambrogi, Marcello Migliore, Marco Lucchi

{"title":"Surgical interventions for pleural infection.","authors":"Maria Giovanna Mastromarino, Alessandra Lenzini, Giacomo Rabazzi, Andrea Castaldi, Vittorio Aprile, Stylianos Korasidis, Marcello Carlo Ambrogi, Marcello Migliore, Marco Lucchi","doi":"10.1183/20734735.0105-2025","DOIUrl":"10.1183/20734735.0105-2025","url":null,"abstract":"Pleural infection (PI) remains a serious clinical condition associated with high morbidity, prolonged hospitalisation and significant mortality, despite advances in medical therapy. Characterised by infection and inflammation within the pleural cavity, PI is increasingly complicated by antimicrobial resistance. While antibiotics and drainage constitute first-line treatment, surgical intervention becomes essential in advanced or refractory cases. Video-assisted thoracoscopic surgery (VATS) has emerged as the preferred minimally invasive approach in early-stage disease, offering advantages such as reduced post-operative pain, shorter hospital stays and faster recovery. In more complex stages, open decortication or thoracotomy may still be required. This narrative review explores the full spectrum of surgical strategies - including VATS, open decortication, open window thoracostomy, vacuum-assisted closure therapy and the innovative FlexVATS technique - highlighting their indications, timing and evolving roles in contemporary practice. We also underscore the importance of post-operative care, emphasising respiratory rehabilitation, pain management, nutritional support and infection surveillance. Prognostic tools, particularly the RAPID score, are discussed for their potential to guide early risk stratification and optimise timing of surgical intervention. Given the complex nature of PI, a multidisciplinary approach involving thoracic surgeons, pulmonologists, infectious disease specialists, physiotherapists and nutritionists is essential. A patient-centred, multimodal treatment strategy tailored to disease stage and individual risk factors remains the cornerstone of successful recovery. Continued research into long-term outcomes and advanced diagnostics is critical to improving care in this challenging clinical domain.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 4","pages":"250105"},"PeriodicalIF":3.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peri-procedural cardiac arrest at medical thoracoscopy in a patient with pleural mesothelioma causing resultant heart failure and an intractable pleural effusion. 胸膜间皮瘤患者胸腔镜术中心脏骤停导致心力衰竭和难治性胸腔积液。

IF 3.4

Breathe Pub Date : 2025-10-14 eCollection Date: 2025-10-01 DOI: 10.1183/20734735.0175-2025

Gemma Hood, Samuel Lakey, Elizabeth Turnbull, Avinash Aujayeb

引用次数: 0

The role of weight management in sleep disordered breathing. 体重管理在睡眠呼吸障碍中的作用。

IF 3.4

Breathe Pub Date : 2025-09-16 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0182-2025

William Griffin, Carel W le Roux, Helen M Heneghan, Donal O'Shea, John F Garvey

{"title":"The role of weight management in sleep disordered breathing.","authors":"William Griffin, Carel W le Roux, Helen M Heneghan, Donal O'Shea, John F Garvey","doi":"10.1183/20734735.0182-2025","DOIUrl":"10.1183/20734735.0182-2025","url":null,"abstract":"Sleep disordered breathing (SDB) has a significant impact on public health, with obesity being a major contributing factor. Obstructive sleep apnoea (OSA) and obesity hypoventilation syndrome (OHS) are primary conditions in SDB, strongly linked to increased body mass index. Obesity exacerbates airway narrowing, reduces lung volumes and promotes inflammation, aggravating OSA and OHS. Weight loss, achieved through nutritional therapies, pharmacotherapy or surgical therapies, reduces apnoea-hypopnea index and associated obesity-related complications. Caloric restriction and exercise provide modest improvements, often independently of substantial weight reduction. Bariatric surgery achieves substantial improvements in many cases but displays variability in outcomes. Emerging pharmacological treatments, such as glucagon-like peptide-1 receptor agonists, show promise for patients with concurrent obesity and SDB. Personalised interventions, including physiological phenotyping and multidisciplinary management, would provide effective treatment strategies. Further research into long-term outcomes, novel therapies and mechanisms beyond weight reduction is essential. Obesity prevention also remains crucial for mitigating the burden of SDB globally. This review will evaluate the role of obesity management strategies in improving SDB outcomes, and will highlight the bidirectional relationship between obesity and SDB, emphasising an integrated patient-centred approach.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"250182"},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Massive" haemoptysis. “大规模”咯血。

IF 3.4

Breathe Pub Date : 2025-09-16 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0045-2025

Ali Hafiz, Anmol Baidwan

引用次数: 0

Bilateral pleural effusions, ascites and pulmonary emboli: Meigs syndrome. 双侧胸腔积液，腹水和肺栓塞：Meigs综合征。

IF 3.4

Breathe Pub Date : 2025-09-16 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0289-2024

Ahmed Etman, Avinash Aujayeb

引用次数: 0