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The CheckMate 816 trial: a milestone in neoadjuvant chemoimmunotherapy of nonsmall cell lung cancer. CheckMate 816 试验：非小细胞肺癌新辅助化疗免疫疗法的里程碑。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0044-2024
Marie Mayenga, Ana Rita Pedroso, Marion Ferreira, Thomas Gille, Maria Joana Pereira Catarata, Boris Duchemann
{"title":"The CheckMate 816 trial: a milestone in neoadjuvant chemoimmunotherapy of nonsmall cell lung cancer.","authors":"Marie Mayenga, Ana Rita Pedroso, Marion Ferreira, Thomas Gille, Maria Joana Pereira Catarata, Boris Duchemann","doi":"10.1183/20734735.0044-2024","DOIUrl":"https://doi.org/10.1183/20734735.0044-2024","url":null,"abstract":"<p><p>Advancements in immunotherapy in the perioperative setting have revolutionised the treatment of resectable nonsmall cell lung cancer (NSCLC). Here we present the methodology and results of the clinical trial CheckMate 816 demonstrating the benefit of neoadjuvant therapy with nivolumab plus chemotherapy compared with chemotherapy alone. Furthermore, this article discusses the implications for future practice in resectable NSCLC and the need for future research.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240044"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An elderly woman with acute respiratory failure and diffuse pulmonary changes. 一名老年妇女出现急性呼吸衰竭和弥漫性肺部病变。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0055-2024
Chun Ian Soo, Wai Ling Leong, Nadia Fareeda Muhammad Gowdh, Leng Cheng Sia, Vijayan Munusamy, Chee Kuan Wong, Nazarina Abdul Rahman
{"title":"An elderly woman with acute respiratory failure and diffuse pulmonary changes.","authors":"Chun Ian Soo, Wai Ling Leong, Nadia Fareeda Muhammad Gowdh, Leng Cheng Sia, Vijayan Munusamy, Chee Kuan Wong, Nazarina Abdul Rahman","doi":"10.1183/20734735.0055-2024","DOIUrl":"https://doi.org/10.1183/20734735.0055-2024","url":null,"abstract":"<p><p><b>Mucoepidermoid carcinoma is a rare primary tumour of the lung. Diagnosis can be made after careful exclusion of other lung neoplasms, especially those with overlapping histological and radiological features.</b> https://bit.ly/4fcISSm.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240055"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights from the Respiratory Failure and Mechanical Ventilation Conference 2024. 2024 年呼吸衰竭和机械通气会议要点。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0105-2024
Clara Bianquis, Giancarlo De Leo, Giorgio Morana, Marta Duarte-Silva, Santi Nolasco, Rūdolfs Vilde, Athiwat Tripipitsiriwat, Pedro Viegas, Martins Purenkovs, Marieke Duiverman, Christian Karagiannids, Christoph Fisser
{"title":"Highlights from the Respiratory Failure and Mechanical Ventilation Conference 2024.","authors":"Clara Bianquis, Giancarlo De Leo, Giorgio Morana, Marta Duarte-Silva, Santi Nolasco, Rūdolfs Vilde, Athiwat Tripipitsiriwat, Pedro Viegas, Martins Purenkovs, Marieke Duiverman, Christian Karagiannids, Christoph Fisser","doi":"10.1183/20734735.0105-2024","DOIUrl":"https://doi.org/10.1183/20734735.0105-2024","url":null,"abstract":"<p><p>The Respiratory Intensive Care Assembly of the European Respiratory Society gathered in Berlin to organise the third Respiratory Failure and Mechanical Ventilation Conference in February 2024. The conference covered key points of acute and chronic respiratory failure in adults. During the 3-day conference ventilatory strategies, patient selection, diagnostic approaches, treatment and health-related quality of life topics were addressed by a panel of international experts. In this article, lectures delivered during the event have been summarised by early career members of the Assembly and take-home messages highlighted.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240105"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Con: indwelling pleural catheters cause harm to patients. 反方：留置胸膜导管会对患者造成伤害。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0111-2024
Katie Adams, Rahul Bhatnagar
{"title":"Con: indwelling pleural catheters cause harm to patients.","authors":"Katie Adams, Rahul Bhatnagar","doi":"10.1183/20734735.0111-2024","DOIUrl":"https://doi.org/10.1183/20734735.0111-2024","url":null,"abstract":"<p><p>Indwelling pleural catheters (IPCs) have rapidly grown in popularity since their introduction for the management of recurrent pleural effusions. In malignant pleural effusions especially, there has been a shift away from measuring pleurodesis success and towards more patient-centred outcomes. Multiple randomised controlled trials have shown that despite lower rates of pleurodesis, symptom control and quality of life outcomes are comparable when compared to alternatives such as talc pleurodesis. IPCs have the added benefit of minimising inpatient hospital stays and reducing the need for recurrent pleural interventions, key priorities for patients with palliative disease. As a result, IPC treatment is associated with excellent patient satisfaction coupled with acceptably low complication rates. Furthermore, in patients with a short life expectancy they confer a cost benefit for the healthcare system. Far from causing harm, IPCs are now recommended as first-line treatment by current clinical guidelines. In malignant pleural disease, guidance advocates IPCs should be offered as a first-line option with the focus on patient priorities and preferences. Ultimately IPCs provide a safe, effective, ambulatory option for managing recurrent pleural effusions.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240111"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palliative care in lung cancer: tumour- and treatment-related complications in lung cancer and their management. 肺癌姑息治疗：肺癌与肿瘤和治疗相关的并发症及其处理。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0203-2023
Dragana Jovanovic, Vesna Ceriman-Krstic, Pınar Akın Kabalak, Lucia Viola, Konstantinos Papatheodosiou
{"title":"Palliative care in lung cancer: tumour- and treatment-related complications in lung cancer and their management.","authors":"Dragana Jovanovic, Vesna Ceriman-Krstic, Pınar Akın Kabalak, Lucia Viola, Konstantinos Papatheodosiou","doi":"10.1183/20734735.0203-2023","DOIUrl":"https://doi.org/10.1183/20734735.0203-2023","url":null,"abstract":"<p><p>Palliative care pertains to the holistic multidimensional concept of \"patient-centred\" care. It is an interprofessional specialty, primarily aiming to improve quality of care for cancer patients and their families, from the time of diagnosis of malignant disease, over the continuum of cancer care, and extending after the patient's death to the period of bereavement to support the patient's family. There are various complex and frequently unmet needs of lung cancer patients and their families/caregivers, not only physical but also psychological, social, spiritual and cultural. Systematic monitoring of patients' symptoms using validated questionnaires and patient-reported outcomes (PROs), on a regular basis, is highly encouraged and recommended in recent guidelines on the role of PRO measures in the continuum of cancer clinical care. It improves patient-physician communication, physician awareness of symptoms, symptom control, patient satisfaction, health-related quality of life and cost-effectiveness. This implies that all treating physicians should improve their skills in communication with lung cancer patients/relatives and become more familiar with this multidimensional assessment, repeatedly screening patients for palliative care needs. Therefore, they should receive education and training to develop palliative care knowledge, skills and attitudes. This review is dedicated to lung cancer palliative care essentials that should be within the competences of treating physicians, <i>i.e.</i> pneumologists/thoracic oncologists.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230203"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small cell lung cancer and neuroendocrine tumours. 小细胞肺癌和神经内分泌肿瘤。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0004-2024
Ivelina Pandjarova, Darlene Mercieca, Rolof G P Gijtenbeek, João Oliveira Pereira, Alberto Fantin, Nadia Castaldo, Elli Keramida, Kanwar Pannu, Assia Konsoulova, Avinash Aujayeb
{"title":"Small cell lung cancer and neuroendocrine tumours.","authors":"Ivelina Pandjarova, Darlene Mercieca, Rolof G P Gijtenbeek, João Oliveira Pereira, Alberto Fantin, Nadia Castaldo, Elli Keramida, Kanwar Pannu, Assia Konsoulova, Avinash Aujayeb","doi":"10.1183/20734735.0004-2024","DOIUrl":"https://doi.org/10.1183/20734735.0004-2024","url":null,"abstract":"<p><p>Lung cancer is one of the leading causes of death worldwide. It can broadly be divided into small cell lung cancer (SCLC) and nonsmall cell lung cancer. There have been many advances over the recent years in both fields. The purpose of this review is to provide a concise summary of SCLC for the general respiratory readership.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240004"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of lung function data: turning snapshots into stories. 整合肺功能数据：把快照变成故事。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0082-2024
Samuel R Wallbanks, Calvin Apen
{"title":"Integration of lung function data: turning snapshots into stories.","authors":"Samuel R Wallbanks, Calvin Apen","doi":"10.1183/20734735.0082-2024","DOIUrl":"https://doi.org/10.1183/20734735.0082-2024","url":null,"abstract":"<p><p>Missing or inaccessible lung function measurements, gathered over time, have the potential to stagnate or impair clinical care decisions being made. This jeopardises patient safety and often contributes to excessive resource utilisation. Data integration is fundamental to clinical decision-making and entails amalgamating lung function data from multiple sources in a user-friendly format. Despite this, current systems for recording lung function data are suboptimal, with copious gaps in the clinical picture arising from missing or inaccessible lung function measurements. This article discusses the importance of data integration for lung function, with a call to action for key stakeholders involved in the performance, management and interpretation of such tests.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240082"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roadside serendipity: an accident can lead to a rare diagnosis. 路边的偶然：一场事故可能导致罕见的诊断。
IF 2.3
Breathe Pub Date : 2024-11-12 eCollection Date: 2024-10-01 DOI: 10.1183/20734735.0104-2024
Simone Ielo, Andrea Campione, Nicola Leone, Cristiana Bellan, Raffaele Scala
{"title":"Roadside serendipity: an accident can lead to a rare diagnosis.","authors":"Simone Ielo, Andrea Campione, Nicola Leone, Cristiana Bellan, Raffaele Scala","doi":"10.1183/20734735.0104-2024","DOIUrl":"https://doi.org/10.1183/20734735.0104-2024","url":null,"abstract":"<p><p><b>Find out about some of the diagnostic considerations in the field of rare pleural disease</b> https://bit.ly/3xYefzA.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"240104"},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversies in the clinical management of chronic pulmonary aspergillosis. 慢性肺曲霉菌病临床治疗中的争议。
IF 2.3
Breathe Pub Date : 2024-10-01 DOI: 10.1183/20734735.0234-2023
Xinxin Hu, Kathryn Hulme, Liana Brien, Sonya Natasha Hutabarat, Zinta Harrington
{"title":"Controversies in the clinical management of chronic pulmonary aspergillosis.","authors":"Xinxin Hu, Kathryn Hulme, Liana Brien, Sonya Natasha Hutabarat, Zinta Harrington","doi":"10.1183/20734735.0234-2023","DOIUrl":"10.1183/20734735.0234-2023","url":null,"abstract":"<p><p>Chronic pulmonary aspergillosis has a range of manifestations from indolent nodules to semi-invasive infection. Patients may be asymptomatic or have chronic symptoms such as cough and weight loss or present with life-threatening haemoptysis. The physician can choose from a range of available therapies including medical therapy with antifungals, minimally invasive therapy with intracavitary antifungal therapy and surgery involving open thoracotomy or video-assisted thoracoscopic surgery. The patients with the most severe forms of pulmonary infection may not be surgical candidates due to their underlying pulmonary condition. The management of haemoptysis can include tranexamic acid, bronchial artery embolisation, antifungals or surgery. There are few controlled studies to inform clinicians managing complex cases, so a multidisciplinary approach may be helpful.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230234"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung imaging methods: indications, strengths and limitations. 肺部成像方法：适应症、优势和局限性。
IF 2.3
Breathe Pub Date : 2024-10-01 DOI: 10.1183/20734735.0127-2023
Dávid László Tárnoki, Kinga Karlinger, Carole A Ridge, Fanni Júlia Kiss, Tamás Györke, Elzbieta Magdalena Grabczak, Ádám Domonkos Tárnoki
{"title":"Lung imaging methods: indications, strengths and limitations.","authors":"Dávid László Tárnoki, Kinga Karlinger, Carole A Ridge, Fanni Júlia Kiss, Tamás Györke, Elzbieta Magdalena Grabczak, Ádám Domonkos Tárnoki","doi":"10.1183/20734735.0127-2023","DOIUrl":"10.1183/20734735.0127-2023","url":null,"abstract":"<p><p>Imaging methods are fundamental tools to detect and diagnose lung diseases, monitor their treatment and detect possible complications. Each modality, starting from classical chest radiographs and computed tomography, as well as the ever more popular and easily available thoracic ultrasound, magnetic resonance imaging and nuclear medicine methods, and new techniques such as photon counting computed tomography, radiomics and application of artificial intelligence, has its strong and weak points, which we should be familiar with to properly choose between the methods and interpret their results. In this review, we present the indications, strengths and main limitations of methods for chest imaging.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"20 3","pages":"230127"},"PeriodicalIF":2.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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