Breathe最新文献

{"title":"Patient experience: impact of environmental conditions on severe asthma.","authors":"Irantzu Muerza, Rory Harris","doi":"10.1183/20734735.0178-2023","DOIUrl":"https://doi.org/10.1183/20734735.0178-2023","url":null,"abstract":"<p><p><b>Climate change is a direct threat to the respiratory health of people with difficult-to-control severe asthma and directly affects the daily life of patients.</b> https://bit.ly/49etd24.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230178"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pleural based mass in a post-partum woman.","authors":"Padraic C Ridge, Daphne Chen-Maxwell, Caroline Brodie, Anne Marie Quinn, John Bruzzi, David Breen","doi":"10.1183/20734735.0156-2023","DOIUrl":"10.1183/20734735.0156-2023","url":null,"abstract":"<p><p><b>Can you diagnose this case of a 27-year-old female who presented 1-week post-partum with an incidental finding of intrathoracic masses and probable hilar lymphadenopathy?</b> https://bit.ly/3S3ejVK.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230156"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"microRNAs in exhaled breath condensate for diagnosis of lung cancer in a resource-limited setting: a concise review.","authors":"Divyanjali Rai, Bijay Pattnaik, Sunil Bangaru, Jaya Tak, Jyoti Kumari, Umashankar Verma, Rohit Vadala, Geetika Yadav, Rupinder Singh Dhaliwal, Sunil Kumar, Rakesh Kumar, Deepali Jain, Kalpana Luthra, Kunzang Chosdol, Jayanth Kumar Palanichamy, Maroof Ahmad Khan, Addagalla Surendranath, Saurabh Mittal, Pawan Tiwari, Vijay Hadda, Karan Madan, Anurag Agrawal, Randeep Guleria, Anant Mohan","doi":"10.1183/20734735.0125-2023","DOIUrl":"10.1183/20734735.0125-2023","url":null,"abstract":"<p><p>Lung cancer is one of the common cancers globally with high mortality and poor prognosis. Most cases of lung cancer are diagnosed at an advanced stage due to limited diagnostic resources. Screening modalities, such as sputum cytology and annual chest radiographs, have not proved sensitive enough to impact mortality. In recent years, annual low-dose computed tomography has emerged as a potential screening tool for early lung cancer detection, but it may not be a feasible option for developing countries. In this context, exhaled breath condensate (EBC) analysis has been evaluated recently as a noninvasive tool for lung cancer diagnosis. The breath biomarkers also have the advantage of differentiating various types and stages of lung cancer. Recent studies have focused more on microRNAs (miRNAs) as they play a key role in tumourigenesis by regulating the cell cycle, metastasis and angiogenesis. In this review, we have consolidated the current published literature suggesting the utility of miRNAs in EBC for the detection of lung cancer.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230125"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical treatment of pleural infection: antibiotic duration and corticosteroid usefulness.","authors":"Vasileios Skouras, Foteini Chatzivasiloglou, Marianthi Iliopoulou, Theofani Rimpa","doi":"10.1183/20734735.0134-2023","DOIUrl":"https://doi.org/10.1183/20734735.0134-2023","url":null,"abstract":"<p><p>The data about the optimal duration of antibiotics and the usefulness of corticosteroids in the management of parapneumonic effusion and pleural infection are scarce. Two randomised controlled trials evaluating short antibiotic courses (ODAPE and SLIM) and another trial assessing the benefit from corticosteroid use (STOPPE) in this setting were recently published. The aim of this journal club is to present these trials and discuss their significance and limitations. ODAPE compared the efficacy and safety of a short (2 weeks) <i>versus</i> an extended (3 weeks) course of amoxicillin-clavulanate in community-acquired complicated parapneumonic effusions, while SLIM compared the efficacy and safety of short (14-21 days) <i>versus</i> longer (28-42 days) antibiotic courses in patients with community- or hospital-acquired pleural infection. STOPPE assessed the benefit from dexamethasone use in patients with community-acquired pneumonia and concomitant pleural effusion. Both ODAPE and SLIM found that shorter antibiotic courses produce less adverse events while being equally efficacious to the longer courses in a subgroup of patients, such as those with pleural infection that is stabilised with only medical treatment and does not require surgery. In contrast, STOPPE found no benefit from the use of dexamethasone in unselected patients with pneumonia and pleural effusion. Due to the significant limitations of these trials, further studies are required to confirm these findings.</p><p><strong>Commentary on: </strong>Hassan M, <i>et al</i>. The Short <i>versus</i> Long Antibiotic Course for Pleural Infection Management (SLIM) randomised controlled open-label trial. <i>ERJ Open Res</i> 2023; 9: 00635-2022.Porcel JM, <i>et al</i>. Two <i>vs</i>. three weeks of treatment with amoxicillin-clavulanate for stabilized community-acquired complicated parapneumonic effusions. A preliminary non-inferiority, double-blind, randomized, controlled trial. <i>Pleura Peritoneum</i> 2020; 5: 20190027.Fitzgerald DB, <i>et al</i>. Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): a pilot randomized clinical trial. <i>Am J Respir Crit Care Med</i> 2022; 205: 1093-1101.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230134"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the clinical pharmacist in the respiratory or sleep multidisciplinary team.","authors":"Jessica Clements, Elaine Bowman, Rowan Tolhurst, Maeve Savage, Alicia Piwko, Christabelle Chen, Elaine Lyons, Nixon Leung, Sarah Mulholland, Gráinne d'Ancona","doi":"10.1183/20734735.0123-2023","DOIUrl":"https://doi.org/10.1183/20734735.0123-2023","url":null,"abstract":"<p><p>The role of the pharmacist has evolved significantly, not least over the last 20 years. It delivers a skilled profession with a vital role in medicines optimisation and the management of patients with a respiratory or sleep disorder. While pharmacists are capable of acting as independent practitioners delivering direct patient care, this article explores their contribution to multidisciplinary teams within asthma, COPD, cystic fibrosis, tuberculosis, interstitial lung disease and sleep medicine. Having identified patient cohorts needing specialist medicines support, notably those with poor medicines adherence or specific medicines-related needs (for example during adolescence, or women who are pregnant or breastfeeding), these pharmacists work within primary, secondary and specialist tertiary care. The aim of this review is to share and inspire innovative models of working to include more pharmacists in respiratory and sleep medicine.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230123"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why and how should children be protected from the deluge of vaping related media and marketing overexposure?","authors":"David White, Andrew Bush, Alan R Smyth, Jayesh Mahendra Bhatt","doi":"10.1183/20734735.0141-2023","DOIUrl":"https://doi.org/10.1183/20734735.0141-2023","url":null,"abstract":"<p><p>E-cigarettes are products delivering nicotine <i>via</i> inhalation and are devised to mimic tobacco smoking. While they were initially introduced as a device putatively to aid with smoking cessation, their use is now far broader than that. Use by children is significantly increasing. There is growing evidence of the potential harms of vaping. E-liquids used for e-cigarettes contain a wide range of harmful substances, and the clinical consequences of this are now being increasingly demonstrated, such as the rise in cases of e-cigarette- or vaping-associated lung injury. In addition, early use may result in long-term nicotine addiction. Vaping companies utilise marketing methods that distinctly target young people, and weak legislation in the UK allows them free rein to expose children to vaping. In this review we demonstrate why children must be protected from vaping. We must have stringent legislation to prevent easy access to e-cigarettes, including banning the convenience and affordability disposable vapes provide, and prevent marketing that does not warn about the potential health effects. The Australia approach of prescription or pharmacy only access for smoking cessation should be considered to limit exposure of children and minimise use by nonsmokers.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230141"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the power of neutral and inclusive language in tuberculosis prevention and care.","authors":"Pedro Barbosa, Mariana Vieira, João Pedro Ramos, Raquel Duarte","doi":"10.1183/20734735.0157-2023","DOIUrl":"10.1183/20734735.0157-2023","url":null,"abstract":"<p><p>Language plays a crucial role in shaping discourses and responses related to disease, particularly tuberculosis (TB). Stigmatising language and attitudes surrounding TB can lead to discrimination and marginalisation of affected individuals, creating barriers to seeking proper diagnosis and treatment. The terminology used to describe TB-affected individuals can be disempowering and criminalising, reinforcing an \"othering\" of those affected. To combat this, engaging with TB-affected communities is essential to co-construct a neutral and inclusive vocabulary that respects the dignity of individuals and fosters empathy and support. Thus, an inclusive language approach empowers affected individuals as active participants in their health management, encouraging open communication and the development of support networks. By adopting a neutral and inclusive language system, healthcare providers and communities can work together to remove unnoticed hurdles and align with the World Health Organization's TB care and prevention goals.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230157"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic ultrasound for pneumothorax and infectious effusion: from equine beginnings to clinical cornerstone.","authors":"Casper Falster, Elise Noël-Savina, Thomas Gille, Pia Pietersen","doi":"10.1183/20734735.0153-2023","DOIUrl":"https://doi.org/10.1183/20734735.0153-2023","url":null,"abstract":"<p><p><b>Routine clinical application of thoracic ultrasound has greatly enhanced the process of diagnosing and treating patients with pneumothorax and infectious effusion by minimising radiation exposure and facilitating prompt diagnosis</b> https://bit.ly/3FO6jBg.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230153"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A young boy with diabetic ketoacidosis and non-resolving pneumonia.","authors":"Rakesh Kodati, Narendra Kumar Narahari, Anuradha Tadepalli, Nishika Madireddy, Bhaskar Kakarla, Paramjyothi Gongati","doi":"10.1183/20734735.0161-2023","DOIUrl":"https://doi.org/10.1183/20734735.0161-2023","url":null,"abstract":"<p><p><b>Classic radiological signs of invasive fungal disease, especially pulmonary mucormycosis in a predisposed individual should alert the physician to initiate empiric anti-fungal therapy.</b> https://bit.ly/40gt4Hm.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230161"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing and managing pleural disease.","authors":"Brian D Kent","doi":"10.1183/20734735.0230-2023","DOIUrl":"10.1183/20734735.0230-2023","url":null,"abstract":"<p><p><b>This issue of <i>Breathe</i> focuses on the management of pleural disease</b> https://bit.ly/4a7dh1S.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"19 4","pages":"230230"},"PeriodicalIF":2.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}