BMJ Open Ophthalmology最新文献

{"title":"Exploring emotion identification and categorisation in simulated central vision loss: an event-related potential study.","authors":"Gopinath Madheswaran, Ramesh S Ve, Shonraj Ballae Ganeshrao, Rajiv Raman, Hari Prakash Palaniswamy","doi":"10.1136/bmjophth-2025-002689","DOIUrl":"https://doi.org/10.1136/bmjophth-2025-002689","url":null,"abstract":"","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-inferiority study of the efficacy of ranibizumab BS compared with aflibercept in patients with macular oedema due to untreated branch retinal vein occlusion: REMEDY-BRVO study - study protocol.","authors":"Ai Toride, Kenta Ashikaga, Shutaro Yamamoto, Takanori Nakagawa, Ayumi Ouchi-Usui, Atsuhide Takesue, Gaku Ishida, Yoshinari Sadamatsu, Kazutaka Adachi, Toshihiko Ohta, Koichi Ono, Daisuke Takami, Tetsuya Tajika, Toshiaki Hirakata, Yoshimune Hiratsuka, Shintaro Nakao","doi":"10.1136/bmjophth-2026-002799","DOIUrl":"https://doi.org/10.1136/bmjophth-2026-002799","url":null,"abstract":"","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexity of recognising, diagnosing and managing corneal neuropathic pain.","authors":"Ali Adel Ne'ma Abdullah, Scott Hau, Sajjad Ahmad","doi":"10.1136/bmjophth-2026-003108","DOIUrl":"10.1136/bmjophth-2026-003108","url":null,"abstract":"","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral subretinal administration of HORA-PDE6β in patients with retinitis pigmentosa harbouring mutations in the <i>PDE6β</i> gene: study protocol of HORA-PDE6β-001 phase I/II clinical trial.","authors":"Jean-Baptiste Ducloyer, Guylène Le Meur, Alexandra Poinas, Fanny Billaud, Alexandre Vallon, Rudy Chatry-Konig, Lyse Giraud, Solène Poivet, Catherine Ivan, Soraya Saiagh, Maelle Leray, Alexandra Jobert, Aurélie Le Thuaut, Emilie Le Blanc, Catherine Mathis, Sandrine Meunier, Catherine Delva, Michel Weber, Pierre Lebranchu","doi":"10.1136/bmjophth-2025-002592","DOIUrl":"10.1136/bmjophth-2025-002592","url":null,"abstract":"","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-continuous centile curves reveal upper-tail divergence of anisometropia in 389 056 schoolchildren: implications for risk stratification in myopia control.","authors":"Naiyila Xiaokaiti, Xiaolong Li, Yan Wang, Yi-Yun Huang, Ning Li, Nurahou Aiyinu, Yunxian Gao, Yong Zhao","doi":"10.1136/bmjophth-2026-002958","DOIUrl":"10.1136/bmjophth-2026-002958","url":null,"abstract":"<p><strong>Objective: </strong>To characterise the age-continuous distribution of anisometropia in a large school-based cohort, derive age-specific centile curves and determine whether age-related increases in anisometropia reflect a generalised distributional shift or selective divergence in the upper tail.</p><p><strong>Methods and analysis: </strong>This school-based cross-sectional study included 389 056 children aged 6-18 years from five prefectures of Xinjiang, China, examined from March to June 2025 after prespecified exclusions. Spherical-equivalent anisometropia (Aniso_SE) was the absolute interocular difference in spherical equivalent; clinically significant anisometropia was defined as Aniso_SE≥1.00 dioptre (D). Age-specific prevalence was modelled using restricted cubic splines; centile curves were generated by quantile regression; and school-level clustering was accounted for using mixed-effects models.</p><p><strong>Results: </strong>Mean age was 11.79 years and 50.2% were male. Mean Aniso_SE was 0.44 D and 42 917 participants (11.03%) had clinically significant anisometropia. Prevalence increased non-linearly with age, peaking at approximately 17%-19% around age 16 years. The median remained stable at about 0.25 D, whereas the 90th percentile exceeded 1.00 D by age 12 years and reached 1.4 D by age 16 years. Age and myopia severity were independently associated with clinically significant anisometropia.</p><p><strong>Conclusions: </strong>Age-related worsening of anisometropia was driven by selective upper-tail divergence rather than a generalised distributional shift. Age-continuous centile curves may help identify children requiring closer monitoring in school-based myopia control programmes.</p>","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compliance with post-school vision screening referral: a systematic review.","authors":"Jinli Cui, Shuxi Zhuo, Yimin Qin, Jiayi Wang, Ruoyang Chen, Wenyong Huang, Lingyi Liang, Xiaotong Han","doi":"10.1136/bmjophth-2026-002876","DOIUrl":"10.1136/bmjophth-2026-002876","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate referral compliance rates and evaluate intervention effectiveness after post-school vision screening in children and adolescents.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, CINAHL, Web of Science and the Cochrane Library for studies published from January 2015 to December 2025. Eligible studies reported referral compliance data for school-aged populations. Study quality was assessed using the Effective Public Health Practice Project tool. Due to significant heterogeneity, a narrative synthesis was conducted. The review protocol was registered with PROSPERO (CRD420251268955).</p><p><strong>Results: </strong>A total of 30 articles were included. Real-world referral compliance rates were suboptimal, with a median of 43.1% (range: 12.0-79.7%). Analysis of 14 intervention studies revealed three main strategies for improving compliance: the on-site care model which provided prescriptions for eyeglasses at school, the referral pathway model which provided clear instructions regarding the pathway to follow-up care, and the education model which provided health education and referral encouragement primarily. On-site care achieved relatively higher compliance rates (51.8-96.0%), whereas providing a clear referral pathway also benefited referral compliance (25.0-65.7%). However, the education model alone is insufficient to significantly improve compliance (21.3-24.5%).</p><p><strong>Conclusions: </strong>Referral compliance is suboptimal and variable. It is crucial for settings to provide on-site care whenever feasible. Alternatively, establishing clear referral pathways is essential to ensure that children receive the appropriate eye care they need.</p>","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of postoperative cystoid macular oedema after primary posterior surgical capsulotomy during combined phacovitrectomy for epiretinal membrane and macular hole.","authors":"Karolin Deichl, Leonard Coulibaly, Navid Johannigmann-Malek, Mathias Maier, Peter Charbel Issa, Sofia Groselli, Carmen Baumann","doi":"10.1136/bmjophth-2025-002717","DOIUrl":"10.1136/bmjophth-2025-002717","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the risk of postoperative cystoid macular oedema (PCME) and assess the safety of primary posterior surgical capsulotomy (PPSC) during combined phacovitrectomy for epiretinal membrane (ERM) or full-thickness macular hole (MH).</p><p><strong>Methods and analysis: </strong>This is a retrospective cohort study of patients who had undergone combined phacovitrectomy for idiopathic ERM or MH with or without PPSC. Primary outcome measure was the incidence of PCME at 2-month follow-up; secondary outcome measures were the incidence of PCME at 6-month and 12-month follow-up and the rate of intraocular lens (IOL)-associated complications.</p><p><strong>Results: </strong>249 eyes of 249 patients who underwent combined 23-gauge phacovitrectomy for idiopathic ERM (n=176; 70.7%) or MH (n=73; 29.3%) were included in this study. 123 eyes were treated without a PPSC (group 1) and 126 eyes with a PPSC (group 2). Across the 12-month follow-up period, new onset of PCME occurred in 7/123 eyes (5.7%) in group 1 and 4/126 eyes (3.2%) in group 2 (p=0.37). There was no significant difference in the rate of PCME between eyes that were treated for an ERM and eyes that were treated for an MH (7/176 (4.0%) and 4/73 (5.5%), respectively, p=0.74). There was no case of IOL dislocation or decentration.</p><p><strong>Conclusion: </strong>PPSC during phacovitrectomy for idiopathic ERM and MH does not seem to increase the risk of PCME or IOL-related complications and prevents the need for future Nd:YAG capsulotomy, thereby reducing hospital visits, patients' burden and costs. Our study was powered to detect a 10% higher PCME rate in the PPSC group. To detect a difference of only 5% between the two groups, a sample size of 400 per group would be required.</p>","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring visual and quality of life outcomes in nystagmus: a scoping review.","authors":"Noah Clancy, James Self, Jane Vennik, Helena Lee","doi":"10.1136/bmjophth-2026-002887","DOIUrl":"10.1136/bmjophth-2026-002887","url":null,"abstract":"<p><strong>Introduction: </strong>Pathological nystagmus of all aetiologies can cause visual disability and reduced quality of life. Recent research has characterised the dynamic nature of the condition and questioned the validity of widely used outcome measures, such as visual acuity (VA), as an accurate measure of visual function in nystagmus. VA only describes the spatial resolving capacity of the visual system for high contrast stimuli, whereas good visual function requires numerous components including contrast sensitivity, colour vision, depth perception and oculomotor functions. For these reasons, the literature on nystagmus, particularly interventional studies, has been inconsistent with regard to the outcome measures used.</p><p><strong>Methods: </strong>We performed a scoping literature review to characterise all published measures and instruments for determining functional vision and quality of life in patients with nystagmus.</p><p><strong>Results: </strong>A total of 235 articles were included in the study, accounting for 5880 patients with nystagmus. Articles spanned six continents and eight decades of research. We identified 10 grouped outcome measures including VA (27 outcomes, 84 instruments), nystagmus features (33 outcomes, 4 instruments), visual function (11 outcomes, 30 instruments), ocular morphology (3 outcomes, 5 instruments), orthoptic and ocular alignment features (20 outcomes, 63 instruments), reading assessment (8 outcomes, 6 instruments), visual search assessment (4 outcomes, 4 instruments), foveation/function models (8 outcomes), patient-reported outcomes (30 outcomes) and non-ocular features (6 outcomes).</p><p><strong>Conclusion: </strong>We have confirmed that there is significant heterogeneity in visual function and quality of life outcome measures in the nystagmus literature. It is evident that one or few measures are insufficient to measure all the relevant outcomes from interventional nystagmus studies. Therefore, we propose a Delphi project using our data to determine a standardised core outcome set for interventional nystagmus studies.</p>","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Classification of Functioning, Disability and Health (ICF) Core Sets for Vision Loss: results of a Delphi consensus study.","authors":"Lorenzo Billiet, Stijn De Baets, Hilde Van Der Aa, Ruth M A van Nispen, Dominique Van De Velde","doi":"10.1136/bmjophth-2025-002686","DOIUrl":"10.1136/bmjophth-2025-002686","url":null,"abstract":"<p><strong>Objective: </strong>To enable consistent assessment and communication across clinical practice, research and policy, condition-specific International Classification of Functioning, Disability and Health (ICF) Core Sets can be beneficial. Vision loss substantially affects individuals' functioning across physical, social and environmental domains. Therefore, this study aimed to develop both a comprehensive and brief ICF Core Sets for Vision Loss by integrating perspectives of researchers, healthcare professionals and individuals with visual impairment. Using evidence generated in previous multiphase preparatory studies, this study synthesises these outcomes and reaches international consensus through a Delphi process to determine the most relevant ICF categories.</p><p><strong>Methods: </strong>A structured decision-making and consensus process was implemented, integrating evidence from previous phases of the Core Set development. Using the Delphi technique, an international panel of experts identified ICF categories for inclusion in the ICF Core Sets.</p><p><strong>Results: </strong>Thirty-two experts from 15 countries participated in the consensus meeting. The comprehensive ICF Core Set comprises 97 second-level ICF categories: 19 (20%) related to body functions, six (6%) to body structures, 52 (54%) to activities and participation and 20 (21%) to environmental factors. The brief ICF Core Set includes 12 second-level categories: two (17%) body functions; eight (67%) activities and participation and two (17%) environmental factors.</p><p><strong>Conclusion: </strong>The ICF Core Sets for Vision Loss provide a standardised, clinically relevant framework that supports assessment, treatment planning and interdisciplinary communication. Their use may improve monitoring of functioning over time and enhance care for individuals with vision loss.</p>","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression with myopia control spectacles: identifying predictors of response to defocus incorporated multiple segment and highly aspherical lenslets spectacles in the French myopia cohort.","authors":"Rime Najji, Jost B Jonas, Mark Bullimore, Serge Resnikoff, Alain M Bron, Clément Giraud, Christine Fernandez-Maloigne, Rupert Bourne, Nicolas Leveziel","doi":"10.1136/bmjophth-2026-002940","DOIUrl":"10.1136/bmjophth-2026-002940","url":null,"abstract":"<p><strong>Objective: </strong>To identify predictive factors of myopia progression in children wearing highly aspherical lenslets (HAL) and defocus incorporated multiple segment (DIMS) spectacles.</p><p><strong>Methods and analysis: </strong>The 3-year longitudinal, retrospective real-world study included progressive children (≤ -0.5 dioptre (D)/year), aged 4-14 years collected from the French Myopia Cohort, between 2020 and 2025 who were prescribed myopia control spectacles (MCS). Myopia progression (spherical equivalent, D/year) was assessed at 12±3, 24±3 and 36±3 months after treatment initiation. A latent class growth model, adjusted for age, identified potential poor responders to MCS. Model performance was evaluated using Akaike information criterion, entropy and posterior class-membership probabilities. Logistic regression was then used to determine factors associated with persistent progression under MCS, including treatment group, renewal rate, baseline age, spherical equivalent, J0 and J45, sex and initial progression.</p><p><strong>Results: </strong>A total of 723 children (mean age 8.9 ± 2.4 years) were included, with no baseline differences between the DIMS and the HAL groups. Latent class growth modelling identified three distinct progression profiles: stable, moderate myopia progression and progressive myopia, with slopes of -0.05, -0.31 and -0.58 D/year, respectively. Fast initial progression strongly predicted progressive myopia class, while neither treatment type influenced class allocation. Progression risk under treatment was statistically independent of age, sex and baseline myopia.</p><p><strong>Conclusions: </strong>Our study is limited as it examines only two types of myopia control treatments and lacks data on environmental factors. Myopic children treated with DIMS or HAL showed three distinct progression trajectories, with a small group of progressors continuing to progress at a clinically meaningful rate.</p>","PeriodicalId":9286,"journal":{"name":"BMJ Open Ophthalmology","volume":"11 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}