Clinics of oncology最新文献

{"title":"The Use of the Infrared Laser Therapy of 890-910 NM for the Treatment Breast Cancer (Experimental and Clinical Study)","authors":"V. Mikhaylov","doi":"10.47829/coo.2022.6103","DOIUrl":"https://doi.org/10.47829/coo.2022.6103","url":null,"abstract":"The experimental studies were conducted with Walker's carcinosarcoma n256 (from the U.S.A. bank), cancer of the mammary gland (RMK-1). Spontaneous –mice with mammary glands cancer (type B). The tasks were as follows: to study the effect of different doses LLLT on the growth of experimental tumors. Evaluation of the effectiveness by applying LLLT in combination with various chemotherapeutic agents (vincristin, 5-Fu, ciclophosphan). Research of LLLR effect on different types of tumors show that this treatment can be used for tumors-statistic effect and for increasing life-span in animals. Applying LLLR in combination with chemotherapeutic agents causes tumors-static action. The most effective combination was LLLT + vincristin which caused the inhibition of tumor growth in Walker's carcinosarcoma-by 92,87%, in RMK-1 - by 90,29% in comparing to controls. The combination of LLLT with HpD showed - the effect of laser therapy takes place in 30 min before the irradiation and is accompanied by a sharp reduction of the preparation's accumulation in the tumor cells.","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75915603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cancer Patients","authors":"L. L., Y. M, Che Y, L. K, W. X, Y. G, T. Y, L. H., Wu C, Fang Z, Jiang W, W. W","doi":"10.47829/coo.2022.6901","DOIUrl":"https://doi.org/10.47829/coo.2022.6901","url":null,"abstract":"Objective: The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration. Methods: We retrospectively studied inpatients diagnosed with primary NSCLC and treated between May 2015 and July 2017. The basic clinical information and blood test data before and after treatment were collected. According to the clinical reference range of normal ion concentration, the patients were divided into three groups: low, normal and high level. Kaplan-Meier curve was used to analyze the difference of overall survival (OS) prognosis among each group. The correlation between ion concentration and other clinical parameters was further analyzed. Finally, a prognostic nomogram model was established by LASSO-COX method. Results: In the 1237 patients cohort, the median follow-up period was 861 days (range 3-2128 days). Firstly, 6 serum ions were included in the study, and only sodium (Na) and chloride (cl) ions were significantly associated with OS. Low level patients were found nearly just in III-IV stage patients, in contrast, high level patients distribute evenly in all stages. Then, correlation analysis showed that increased Na and cl concentrations were associated with decreased neutrophil number and elevated lymphocyte proportion. Finally, prognostic model analysis showed that cl is a crucial parameter. Conclusion: Serum Na and cl ion concentrations are closely related to the OS of lung cancer patients, and should be considered as clinical prognostic factors.","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81762685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Patients’ Disease-Labels on Disease Experience For Patients Living Longer with Incurable Cancer: A Qualitative Study","authors":"Buiting Hm, Ho Vky, Busink V, Campmans X, Reyners Ak, Smit E, V. D, Sonke Gs","doi":"10.47829/coo.2022.61501","DOIUrl":"https://doi.org/10.47829/coo.2022.61501","url":null,"abstract":"Importance: Advances in oncology have resulted in prolonged disease trajectories, also for patients with incurable cancer. This has induced discussions about the ‘right’ medical terminology. The impact of choosing a specific disease-label on well-being can be high. Objective: To examine the impact of disease labels on disease experience in patients living longer with incurable cancer. Design: Qualitative study based on short conversations in the outpatient clinic in a Dutch comprehensive cancer hospital (2015-2018) supplemented with in-depth interviews from hospitals (2021). Setting: Hospital and home setting (via Zoom) Participants: We included 29 short conversations and 4 indepth interviews with patients with incurable breast and lung cancer, all in stable (but incurable) condition. Main outcome measures: We specifically focused on disease labelling and patient’s mood (positive/negative mindset) during the disease course. Results: A substantial group of patients (n=21) used (or explicitly not used) disease-labels in their short conversations about their disease. They varied in their preference regarding disease-labels (e.g. ‘chronic’, ‘palliative’, ‘human’ etc.). Patients with a more positive stance seemed more comfortable with the label ‘chronic’, whereas patients with a less positive stance seemed to perceive disease-labels such as ‘chronic’ as a lifelong burden. Some patients preferred not to label their disease at all. Healthcare professionals’ use of disease-labels could sometimes distress patients, especially when patients heard different disease-labels from different healthcare professionals. Patients not using any disease-label in their communication (n=12), seemed to be less engaged with their disease. Conclusions: Patients labeling their disease is part of their coping strategy. More research is warranted to explore which disease-labels suit different patients confronted with incurable cancer, best.","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80402588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit of Serum Thymidine Kinase 1 Concentration for Risk Assessment from Gastric Neoplasms Progression to Carcinomas: A Systematic Review and Meta-analysis","authors":"Ailian Hei, Hongbo Ma, Maogang Li, Jin Li, Ji Zhou, E. He, S. Skog","doi":"10.47829/coo.2022.6601","DOIUrl":"https://doi.org/10.47829/coo.2022.6601","url":null,"abstract":"Background: Human Thymidine kinase 1 (hTK1), a key enzyme involved in the DNA synthesis during S-phase of the cell cycle and upregulation of cell proliferation, thus it is reliable tumor proliferating biomarker for assessment of tumor proliferation rate in serum and in tissue in oncology. This meta-analysis is investigation whether the serum TK1 concentration（STK1p）based on hTK1-IgY-polyclonal-antibody can provide a benefit for risk assessment from gastric neoplasm progression to gastric carcinoma (GC) as well as for evaluation of treatment effect in GC. 1.2. Methods: Relevant studies were identified from the following electronic databases: PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, the Chongqing VIP Chinese Science and Technology Periodical Database and Chinese Biomedical Literature Database from May 1, 2008, until November 30, 2021. Study quality was evaluated by the modified Newcastle-Ottawa Scale. Pooled estimates of weighted mean difference (MD), sensitivity analyses and publication bias were evaluated using Review manager and STATA software. RESULTS: Twenty-seven studies included to 1,909 GCs and 1,229 neoplasms (superficial gastritis, chronic gastritis, atrophic and gastric ulcers) and 2,260 tumor-frees. The results showed that STK1p levels increased significantly in the following manner (P<.0.006): tumor-free < superficial gastritis < chronic gastritis < atrophic gastritis < gastric ulcer < GC. The STK1p value of the GCs one-month-post-surgery decline significantly by 66% compared to pre-surgery. 1.3. Conclusion: STK1p value has the potential to be an early risk warning indicator for early gastric neoplasms progression to GCs and to be a helpful index for monitoring the response to surgery. 1.4. Core Tip: In spite of improvements in diagnosis and treatment the long-term survival rate for a large number of GCs is still dismal. Hence, it is important to explore serum biomarkers for early prediction of risk gastric neoplasms into GCs. In this meta-analysis, the STK1p as a prognostic biomarker was investigated showed significantly higher in GCs compere to different neoplasm and tumor-free people and was significantly reduced one-month post-surgery. It demonstrates that STK1p as tumor proliferating serum-biomarker, can be not only used for early risk gastric neoplasm progression and evaluation of treatment effect in GC patients, but also for a variety of other tumor types in clinical setting.","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79245037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hpv Infection in the Lekoumou and Niari Departments (Congo Brazzaville)","authors":"Ngatali Cfs, B. Af, N. Jb, Doukaga Moussavou R, M. D","doi":"10.47829/coo.2022.6101","DOIUrl":"https://doi.org/10.47829/coo.2022.6101","url":null,"abstract":"1.1. Objective: to determine the prevalence of HPV infection in women in Lekoumou and Niari departments. 1.2. Patients and Methods: We carried out a descriptive and cross-sectional study over a period of 7 months from January to July 2019 in the department of Lekoumou. 100 women ranging in age from 16 to 73 years old. The variables studied were as follows: age, marital status, level of education, risk factors for the onset of HPV infection, age at first sexual intercourse, number of sexual partners, parity, gesture. The multivariate analysis was done between age, number of level of instruction, parity, age of first sexual intercourse and number of sexual Partners. The statistical analysis and the data processing were carried out by the Excel 2016 software and the graph pad prism version 5 software. The statistical test used was the chi-square test. 1.3. Results: During this study we collected 100 women. The mean age of the patients was 34.6 ± 11.9 with ranges ranging from 16 to 73 years. The most represented age groups were that of 20-29 years (31%) and that of 30-39 years (29%). The most represented level of education was the college level in 53% of cases follow-up of the level of primary education in 25% of cases . Almost ¾ of our study population were married women (74%), single people represented only 22% of the study population. The mean age at first intercourse was 16.4 ± 2.3 with extremes ranging from 12 to 25 years. Almost all of the women (97%) had had their first sexual intercourse before the age of 20. The average number of sexual partners was 5.3 ± 3.2 with extremes ranging from 1 to 15 partners, 53% of women had at least 5 sexual partners. The mean number of pregnancies was 4.9 ± 2.8 with extremes ranging from 0 to 13 pregnancies. Almost half of the women (49%) have carried between 4-7 pregnancies. The mean number of deliveries (parity) was 3.6 ± 2.4 with extremes ranging from 0 to 12 deliveries. 36% of our study population had between 4 and 7 deliveries. Bivariate analysis failed to find a statistically significant difference between age and number of sexual partners, between age of first intercourse and level of education and parity. 1.4. Conclusion: Cervical cancer is a public health problem. Prevalence of infection of HPV is relatively high in our context of low incomes countries. It is important to know this prevalence in order to assure prevention of cervical cancer.","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82896278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporate Experiences as a Medical Oncologist to Enlighten Severe Loss of a Loved One: An Optimistic Perspective","authors":"Buiting Hm, Sonke Gs","doi":"10.47829/coo.2022.61701","DOIUrl":"https://doi.org/10.47829/coo.2022.61701","url":null,"abstract":"","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75773859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life and Love Stories During Corona Times: A General Public and Cancer Patient’s Experience","authors":"H. Buiting, Luis L Gonzalez, Miguel A Lara, K. Beernaert, Vincent KY Ho, G. Sonke","doi":"10.47829/coo.2022.61001","DOIUrl":"https://doi.org/10.47829/coo.2022.61001","url":null,"abstract":"Introduction: The past COVID pandemic clearly showed us how difficult relationships (either as oncology patients, or as a healthy human being/a couple) can be. Being socially isolated or precisely the opposite, e.g., living tightly together can become difficult during extreme situations. This paper focuses on the quality of relationships during the COVID pandemic and beyond; differences between the Spanish and Dutch population are compared. Methods: With short, on-line questionnaires focusing on present as well as past COVID-experiences among the Dutch (n=70) and Spanish (n=98) general public, we tried to get a grip on the emotional impact of a serious crisis, such as the COVID pandemic. Results: Our Spanish sample almost all reported that well-being changed during the pandemic (95%). Only a few (9%) of our Spanish respondents reported to experience problems of loneliness during the COVID-pandemic; this percentage was much higher among the Dutch sample (39% of all respondents). Emotional support was generally reported as rather high among Spanish respondents ranging from 95% or higher to the importance they attached of having a special person being around as well as family support. The added value Dutch respondents attached towards family support was a little lower (70% and 65% respectively). The frequency of respondents not being anxious was higher among the Dutch sample (43% versus 15% in the Spanish sample). Spanish respondents however at the same time experienced (despite their reported anxiety) a more meaningful life (87% of people in the spanish versus 13% of people in the Dutch sample). Discussion: Although high frequencies of emotional support were reported among Dutch and Spanish respondents, relationships in itself either seemed to have become more difficult or stronger. It further seemed that respondents’ mood did not have a tremendous impact on the perceived quality of their relationships. Regardless in how difficult a situation can be, your own mindset as well as cultural differences to a great extent seems to determine perceived well-being.","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73887106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Black Fungus is One of the Bad Consequences of COVID 19","authors":"Elbossaty Wf","doi":"10.47829/coo.2021.5202","DOIUrl":"https://doi.org/10.47829/coo.2021.5202","url":null,"abstract":"","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83136788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Therapy Reduces Nauseas and Pain of Patients Undergoing Autologous Hematopoietic Stem Cells Transplantation","authors":"Dóro Ca, Neto Jz","doi":"10.47829/coo.2021.5502","DOIUrl":"https://doi.org/10.47829/coo.2021.5502","url":null,"abstract":"1. Abstract 1.1. Objective: The autologous hematopoietic stem cell transplantation (HSCT Aut) is a therapeutic medical treatment for various neoplastic hematologic, congenital, genetic or acquired disorders. In this procedure which combines high-dose chemotherapy and/ or radiotherapy and has a high degree of cytotoxicity, the patient experiences solitary confinement, which causes psychological distress, anxiety, mood, fatigue, nauseas, pain and can lead him/ her to depression. Music therapy was applied with the purpose of decreasing this social confinement, measuring the variables nausea and pain, and verifying whether this intervention can decrease these symptoms. This is a randomized clinical trial. 1.2. Method: n = 45 patients were selected randomly. n = 24 were selected for the Experimental Music Therapy Group (EMG) and n = 21 for the Control Group (CG) which received the standard treatment. Interventions of live music were applied using music therapy methods and techniques, by a qualified music therapist. Assessment and quantification made using visual analog scale (VAS). 1.3. Results: The student t test and covariance analysis applied, (p < 0.05) were considered statistically significant when comparing the groups, reducing nauseas and pain significantly Conclusion: Music therapy reduced nausea and pain of the patients undergoing autologous hematopoietic stem cells transplantation, providing bio-psychosocial welfare. 2. Introduction The motivation to carry out this investigation took place through music therapy sessions applied in a previous study during the trajectory in the master's degree, developed at the bone marrow transplant service of the clinical hospital complex of the Federal University of Paraná, located in the city of Curitiba, capital of Paraná, Brazil. Variables that were not, investigated but that provoked reflections, due to the patients' reports. Many reported having slept better on the days when music therapy was applied, others forgot about the pain during the music therapy experience; there were also reports of decreased nausea and expressions of relaxation. Hematopoietic Stem Cell Transplantation (HSCT) is a therapeutic clinical treatment that consists of replacing hematopoietic stem cells of the diseased bone marrow, or deficit, with healthy cells [1]. This procedure combines high doses of chemotherapy, radiotherapy and has a high degree of toxicity, causing damage to the quality of life of patients for 100 days after transplantation [2], the organic toxicity causes heart problems, osteoporosis, infections, cataracts, infertility. In addition, pulmonary and other organ complications occur [3], highlighting the patient's fragility in the face of a malignant disease that threatens life causing physical, social and emotional changes from diagnosis to more advanced stages of the disease [4]. Currently around the world, it is possible to perceive through pub-","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89847209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant Chemotherapy for Urothelial Muscle-Invasive Bladder Cancer: Influence of Body Mass Index on Efficacy and Toxicity","authors":"N. Belaube, C. Dumont, C. Bonnet, H. Gauthier, S. Culine","doi":"10.47829/COO.2021.4303","DOIUrl":"https://doi.org/10.47829/COO.2021.4303","url":null,"abstract":"1.1. Background: Neoadjuvant Chemotherapy (NAC) and radi cal cystectomy with pelvic lymph node dissection are the cornerstone of therapy for patients with Muscle Invasive Bladder Cancer (MIBC). We assessed the potential influence of body mass index (BMI) on toxicity and efficacy of NAC in patients with MIBC. 1.2. Patients and Methods: Treatment duration, toxicity and efficacy of NAC were compared between obese patients receiving chemotherapy based on capping at a body-surface area of 2.2 m 2 and healthy weight patients. Obese patients were individually paired with normal BMI","PeriodicalId":92766,"journal":{"name":"Clinics of oncology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86421261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}