Neoadjuvant Chemotherapy for Urothelial Muscle-Invasive Bladder Cancer: Influence of Body Mass Index on Efficacy and Toxicity

Abstract

1.1. Background: Neoadjuvant Chemotherapy (NAC) and radi cal cystectomy with pelvic lymph node dissection are the cornerstone of therapy for patients with Muscle Invasive Bladder Cancer (MIBC). We assessed the potential influence of body mass index (BMI) on toxicity and efficacy of NAC in patients with MIBC. 1.2. Patients and Methods: Treatment duration, toxicity and efficacy of NAC were compared between obese patients receiving chemotherapy based on capping at a body-surface area of 2.2 m 2 and healthy weight patients. Obese patients were individually paired with normal BMI