Music Therapy Reduces Nauseas and Pain of Patients Undergoing Autologous Hematopoietic Stem Cells Transplantation

1. Abstract 1.1. Objective: The autologous hematopoietic stem cell transplantation (HSCT Aut) is a therapeutic medical treatment for various neoplastic hematologic, congenital, genetic or acquired disorders. In this procedure which combines high-dose chemotherapy and/ or radiotherapy and has a high degree of cytotoxicity, the patient experiences solitary confinement, which causes psychological distress, anxiety, mood, fatigue, nauseas, pain and can lead him/ her to depression. Music therapy was applied with the purpose of decreasing this social confinement, measuring the variables nausea and pain, and verifying whether this intervention can decrease these symptoms. This is a randomized clinical trial. 1.2. Method: n = 45 patients were selected randomly. n = 24 were selected for the Experimental Music Therapy Group (EMG) and n = 21 for the Control Group (CG) which received the standard treatment. Interventions of live music were applied using music therapy methods and techniques, by a qualified music therapist. Assessment and quantification made using visual analog scale (VAS). 1.3. Results: The student t test and covariance analysis applied, (p < 0.05) were considered statistically significant when comparing the groups, reducing nauseas and pain significantly Conclusion: Music therapy reduced nausea and pain of the patients undergoing autologous hematopoietic stem cells transplantation, providing bio-psychosocial welfare. 2. Introduction The motivation to carry out this investigation took place through music therapy sessions applied in a previous study during the trajectory in the master's degree, developed at the bone marrow transplant service of the clinical hospital complex of the Federal University of Paraná, located in the city of Curitiba, capital of Paraná, Brazil. Variables that were not, investigated but that provoked reflections, due to the patients' reports. Many reported having slept better on the days when music therapy was applied, others forgot about the pain during the music therapy experience; there were also reports of decreased nausea and expressions of relaxation. Hematopoietic Stem Cell Transplantation (HSCT) is a therapeutic clinical treatment that consists of replacing hematopoietic stem cells of the diseased bone marrow, or deficit, with healthy cells [1]. This procedure combines high doses of chemotherapy, radiotherapy and has a high degree of toxicity, causing damage to the quality of life of patients for 100 days after transplantation [2], the organic toxicity causes heart problems, osteoporosis, infections, cataracts, infertility. In addition, pulmonary and other organ complications occur [3], highlighting the patient's fragility in the face of a malignant disease that threatens life causing physical, social and emotional changes from diagnosis to more advanced stages of the disease [4]. Currently around the world, it is possible to perceive through pub-