{"title":"Serum uric acid-to-creatinine ratio as a predictor for the severity of coronary artery lesions.","authors":"Tingfen Wang, Tingyu Wang, Runfeng Zhang","doi":"10.1186/s13104-026-07906-3","DOIUrl":"10.1186/s13104-026-07906-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the correlation between the serum uric acid-to-creatinine ratio (SUA/Scr) and the severity of coronary artery lesions in coronary heart disease (CHD) patients, and evaluate its predictive value for lesion severity.</p><p><strong>Results: </strong>Among 528 CHD patients, SUA/Scr showed a stepwise increase with worsening coronary lesion severity, with significant differences in all pairwise comparisons (all P < 0.05). Multivariate logistic regression revealed SUA/Scr as an independent risk factor for severe lesions (OR = 101.844, 95% CI 29.076 ~ 356.726, P < < 0.001). ROC analysis demonstrated superior predictive efficacy of SUA/Scr (AUC = 0.840, cutoff 5.35, sensitivity 80.60%, specificity 75.20%) compared to SUA or Scr alone. SUA/Scr is closely associated with coronary lesion severity and serves as an independent predictor with valuable clinical utility.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stage-wise variation in serum C-reactive protein and cardiovascular risk in chronic kidney disease of uncertain etiology among Sri Lankans; a preliminary study.","authors":"Hansani Niroshika, Harshi Weerakoon, Nalaka Herath, Sujani Premathilake, Prasad Jayasooriya, Kosala Weerakoon","doi":"10.1186/s13104-026-07914-3","DOIUrl":"10.1186/s13104-026-07914-3","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease of uncertain etiology (CKDu) is a progressive nephropathy histologically characterized by tubulointerstitial fibrosis with varying degrees of inflammatory infiltrations. C-reactive protein (CRP) is an acute phase protein that serves as a marker of systemic inflammation and cardiovascular disease (CVD) risk. Therefore, this study aimed to evaluate serum CRP levels in patients with CKDu and to assess their association with renal function and CVD risk.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 40 clinically diagnosed CKDu patients at different severity stages (stage 2 (n = 5, 12.5%), stage 3A (n = 8, 20.0%), stage 3B (n = 10, 25.0%), stage 4 (n = 10, 25.0%), and stage 5 (n = 7, 17.5%). As the control group, age and sex matched 16 apparently healthy individuals (mean age 52.19 ± 10.26 years, 56.2% male) were recruited. CRP concentrations were measured using immunoturbidimetry (range 0-150 mg/L), and CVD risk was categorized based on CDC/AHA guideline. Patients with CRP > 10 mg/L were excluded to minimize confounding from potential underlying infections.</p><p><strong>Results: </strong>CRP levels across CKDu stages demonstrated a nonlinear trend with significant peak at stage 3A (1.6 mg/L; IQR: 1.08-2.95), compared to their matched control subjects (0.50 mg/L; IQR 0.30-1.73; p = 0.0045), followed by a decline in later stages. No significant association was observed between CRP and eGFR (r = 0.11, 95% CI -0.21 to 0.41, p = 0.49). After classifying the CKDu patients for CVD risk, Stage 3A patients had higher odds of increased CVD risk than controls (odds ratio = 21.0, p = 0.0236) followed by stage 3B (odds ratio = 13.5, p = 0.0352). Further, CVD risk stratification was not confounded by age, sex, and renal function indicators (eGFR and serum creatinine).</p><p><strong>Conclusion: </strong>Elevated CRP levels and associated CVD risk in CKDu patients appear most pronounced in intermediate disease stages (3A-3B), providing a rationale for a large longitudinal study.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148270298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Estefanía Vásquez-Muñoz, Blanca Priscila Maldonado-Pacheco, Samuel Olegario Iñiguez-Jimenez
{"title":"Psychomotor development in children aged 12-23 months from communities in southern Ecuador: a descriptive research note.","authors":"Diana Estefanía Vásquez-Muñoz, Blanca Priscila Maldonado-Pacheco, Samuel Olegario Iñiguez-Jimenez","doi":"10.1186/s13104-026-07896-2","DOIUrl":"10.1186/s13104-026-07896-2","url":null,"abstract":"<p><strong>Objective: </strong>To describe psychomotor development in children aged 12 to 23 months from rural and urban communities in southern Ecuador using the Abbreviated Development Scale (EAD-1).</p><p><strong>Results: </strong>A total of 138 children were evaluated in the cantons of Calvas and Gonzanamá (56.5% male; mean age 17.75 months [95% CI: 17.14-18.36]). Most participants were classified in the medium developmental category (51.4%), while 24.6% were categorized in the alert level. The personal-social domain showed the highest proportion of alert classifications (42.8%), followed by the hearing-language and gross motor domains (28.3% each). Fine motor-adaptive performance showed more favorable distributions, with most children classified in the medium and medium-high categories. These findings reflect developmental performance within a non-probabilistic sample and should be interpreted as descriptive.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristiane B Patroclo, Bia L Ramalho, Juliana S Maia, Fernanda F Torres, Kelly R Braghetto, Claudia D Vargas
{"title":"A public database on traumatic brachial plexus injury: data collection and sharing.","authors":"Cristiane B Patroclo, Bia L Ramalho, Juliana S Maia, Fernanda F Torres, Kelly R Braghetto, Claudia D Vargas","doi":"10.1186/s13104-026-07780-z","DOIUrl":"10.1186/s13104-026-07780-z","url":null,"abstract":"<p><strong>Objectives: </strong>To create a public digital database centered on adult traumatic brachial plexus injury (TBPI). TBPI mainly affects young males, usually involved in motorcycle accidents, often leading to severe motor and sensory impairment in the affected upper limb. This initiative aimed at encouraging data sharing and reuse. Managing data from TBPI may enable the identification of functional markers associated with clinical improvement in individuals with TBPI and foster the development of new investigative tools to elucidate its mechanisms.</p><p><strong>Data description: </strong>Detailed electronic questionnaires were designed to collect epidemiological, physical, and clinical data. The free software Neuroscience Experiments System (NES) was employed to support data storage and management. Hence, data from 170 Brazilian adult individuals with TBPI with varying degrees of functional impairment were collected. The Unified Admission Assessment (Q44071_unified-admission-assessment) was devised to register the first evaluation by the TBPI research group. The Unified Follow-up Assessment (Q92510_unified-follow-up-assessment) was created to register subsequent follow-up visits. The Unified Surgical Evaluation (Q61802_unified-surgical-evaluation) was designed to record the surgical procedures used for brachial plexus reconstruction. Data collection occurred between 2014 and 2020.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13321503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ida Kabirian, Fatemeh Zahra Karimi, Seyed Reza Mazloum, Malihe Amirian
{"title":"The impact of supportive counseling on resilience in infertile women following unsuccessful in vitro fertilization: a randomized controlled trial study.","authors":"Ida Kabirian, Fatemeh Zahra Karimi, Seyed Reza Mazloum, Malihe Amirian","doi":"10.1186/s13104-026-07910-7","DOIUrl":"10.1186/s13104-026-07910-7","url":null,"abstract":"<p><p>Given the high prevalence of IVF failure and its psychological impact, this study aimed to determine the effect of supportive counseling on resilience in infertile women following unsuccessful in vitro fertilization. Sixty-five infertile women after the failure of the first IVF started the study, but only 60 completed the trial. In the intervention group, individual supportive counseling was conducted during four sessions lasting 60 min each once a week. For the control group, routine care of the infertility center has been done. Before the intervention, there was no statistically significant difference in the total score of resilience and its subscales between the two groups. However, four weeks post-intervention, the total score of resilience and its subscales increased significantly in the intervention group compared to the control group, with an increase of 15.06 ± 15.14 in the intervention group and a decrease of 12.93 ± 13.03 in the control group (p < 0.001). Eight weeks post-intervention, the total score of resilience and its subscales increased significantly in the intervention group compared to the control group, with an increase of 20.60 ± 16.86 in the intervention group and a decrease of 17.80 ± 17.34 in the control group (p < 0.001). Based on the findings of this study, supportive counseling effectively enhanced resilience in infertile women following IVF failure.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saleh A Mohamed, Azza M Abdel-Aty, Rashad M Saleh, Omar A M Al-Bar, Yaaser Q Almulaiky
{"title":"Phenolic profile, antioxidant and antibacterial activities of Balanites aegyptiaca fruit peel.","authors":"Saleh A Mohamed, Azza M Abdel-Aty, Rashad M Saleh, Omar A M Al-Bar, Yaaser Q Almulaiky","doi":"10.1186/s13104-026-07649-1","DOIUrl":"10.1186/s13104-026-07649-1","url":null,"abstract":"<p><strong>Background: </strong>The Balanites aegyptiaca fruit possesses bioactive properties, which may be attributed to its phenolic compounds. However, identifying these phenolic compounds has become increasingly relevant to understanding such activities. Generally, fruit peel contains high content of phenolic compounds compared with flesh. Therefore, this study aimed to identify the profile of phenolic compounds in B. aegyptiaca fruit peel extract (BAFPE) and evaluate their antioxidant and antibacterial activities.</p><p><strong>Results: </strong>In this study, the great phenolic and flavonoid contents of 1040 mg GAE/100 g DW and 287 mg CE/100 g DW were detected in BAFPE, respectively. The main phenolic compounds identified by the HPLC analysis of BAFPE were gallic acid, apigenin-7-glucoside, rutin, quercetin, and catechin. The antioxidant activity of BAFPE was assessed by 2,2- diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-[3-ethyl-benzothiazoline]-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), phosphomolybdenum complex (PMC) and reducing power (RP) assays. The BAFPE showed an efficient antibacterial activity against five human pathogenic bacterial strains with low minimum inhibition concentration (MIC) values. After 8 to 10 h, every examined bacterial strain was entirely dead in the time-killing curves. The correlation of phenolic compounds and antibacterial activity has been discussed. These findings demonstrated that BAFPE can serve as the free radicals neutralizer and antibacterial agent.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13262220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum magnesium deficiency and its metabolic-vascular correlates in adults with type 2 diabetes mellitus at a Nigerian Tertiary Hospital.","authors":"Tajudin Adesegun Adetunji, David Olubukunmi Soyoye, Muzamil Olamide Hassan, Oluwasegun Ijarotimi, Gbenga Joshua Odunlami, Ummulkhair Funke Adetunji, Okechukwu Obumneme Ezekpo, Yetunde Akuma, Adetokunbo Ajala, Babatope Ayodeji Kolawole, Rosemary Temidayo Ikem","doi":"10.1186/s13104-026-07901-8","DOIUrl":"10.1186/s13104-026-07901-8","url":null,"abstract":"<p><strong>Objectives: </strong>To compare serum magnesium levels between patients with type 2 diabetes mellitus (T2DM) and age- and sex-matched non-diabetic controls, and evaluate the relationship between serum magnesium, β-cell function, glycaemic control, nephropathy, and peripheral arterial disease (PAD).</p><p><strong>Results: </strong>In this hospital-based cross-sectional study, 83 patients with T2DM and 83 matched controls were evaluated. Serum magnesium was measured using inductively coupled plasma-optical emission spectrometry, while β-cell function and insulin resistance were assessed using the HOMA2 model. Nephropathy was assessed by albumin-creatinine ratio, and PAD by ankle-brachial index. Median serum magnesium levels were significantly lower in patients with T2DM than in controls [0.40 (0.30-0.43) vs. 0.88 (0.76-1.02) mmol/L, p < 0.001]. Hypomagnesaemia was present in all diabetic participants. Serum magnesium correlated positively with HOMA2-%β (rho = 0.47, p = 0.002), fasting insulin (rho = 0.42, p = 0.003), and HOMA2-IR (rho = 0.43, p = 0.004), but not HbA1c (rho = - 0.13, p = 0.21). Patients with microalbuminuria had significantly lower β-cell function indices (p = 0.002), while serum magnesium showed no significant association with albuminuria or PAD. These findings suggest that hypomagnesaemia is prevalent among Nigerian patients with T2DM and may reflect impaired β-cell function rather than established vascular complications.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minh Van Hoang, Lan Thi Hoang Vu, Quyen Thi Tu Bui, Hoang Tu Le, Trang Thu Vu, Toan Quoc Luu, Don Nguyen, Uyen Thai Tran, Bao Quoc Tran, Lam Tuan Nguyen, Truong Duc Lai, Annie Chu, Angela Pratt, Leanne Riley, Tuan Thanh Nguyen
{"title":"Hypertension and its association with behavioral risk factors for non-communicable diseases: insights from the 2021 Vietnam WHO STEPS survey.","authors":"Minh Van Hoang, Lan Thi Hoang Vu, Quyen Thi Tu Bui, Hoang Tu Le, Trang Thu Vu, Toan Quoc Luu, Don Nguyen, Uyen Thai Tran, Bao Quoc Tran, Lam Tuan Nguyen, Truong Duc Lai, Annie Chu, Angela Pratt, Leanne Riley, Tuan Thanh Nguyen","doi":"10.1186/s13104-026-07909-0","DOIUrl":"10.1186/s13104-026-07909-0","url":null,"abstract":"<p><strong>Objectives and methods: </strong>To estimate the prevalence of hypertension and examine its associations with individual and clustered behavioral risk factors among Vietnamese adults using nationally representative data from the 2021 Vietnam WHO STEPS survey. We conducted a cross-sectional, survey-weighted analysis. The hypertension prevalence analysis included 3,809 adults aged 18-69 years with valid blood pressure measurements, and multivariable regression analyses were conducted among 3,748 participants with complete data on hypertension, behavioral risk factors, BMI, and socio-demographic covariates. Behavioral risk factors included current tobacco smoking, current alcohol drinking, insufficient physical activity, and inadequate fruit/vegetable intake, examined individually and as an unweighted cumulative index ranging from 0 to 4.</p><p><strong>Results: </strong>The survey-weighted crude prevalence of hypertension was 26.4%, with higher prevalence among men than women and a strong age gradient. In individual-risk-factor models, alcohol drinking and inadequate fruit/vegetable intake remained associated with higher odds of hypertension after adjustment. The cumulative behavioral risk factor index showed a graded association with hypertension, with the highest adjusted odds among participants with all four risk factors. These findings provide updated evidence on hypertension and behavioral risk factor clustering in Vietnam and support integrated NCD prevention and hypertension control strategies, while causal inference cannot be made.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nur Aliah, Muhamad Firdaus Syahmi Sam-On, Mohd Rohaizad Md Roduan, Ermy Azziaty Rozali, Nurul Nadhirah
{"title":"Physicochemical and nutritional characteristics of an underutilised edible fern (Stenochlaena palustris) incorporated into a dates-based food matrix.","authors":"Nur Aliah, Muhamad Firdaus Syahmi Sam-On, Mohd Rohaizad Md Roduan, Ermy Azziaty Rozali, Nurul Nadhirah","doi":"10.1186/s13104-026-07895-3","DOIUrl":"10.1186/s13104-026-07895-3","url":null,"abstract":"<p><strong>Objective: </strong>Underutilised edible plants represent important but insufficiently characterised nutritional resources within plant-based food systems. Stenochlaena palustris is a wild edible fern widely consumed in Southeast Asia; however, its incorporation into formulated food matrices remains poorly documented. The objective of this study was to generate initial physicochemical and nutritional data for dates-based food formulations incorporating S. palustris powder at different inclusion levels, providing validated baseline compositional information on an underutilised edible fern within a contemporary plant-based food system.</p><p><strong>Results: </strong>Dates-based energy bars were formulated with S. palustris powder at 2.5% and 5.0% (w/w), alongside a control formulation without fern inclusion. Proximate composition, sugar profile, mineral content, antioxidant activity, and selected physicochemical properties were determined using validated analytical methods by an accredited laboratory. Incorporation of S. palustris was associated with observed increases in dietary fibre, ash, and protein, with generally higher values of selected minerals, including calcium, magnesium, iron, and zinc, in the fortified formulations compared to the control, while total energy values remained comparable across formulations. Water activity values for all formulations were below 0.48, and total flavonoid content increased with higher fern inclusion, while DPPH antioxidant activity was highest in the control formulation. As each formulation was analysed as a single composite sample, the data are presented as baseline compositional observations.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148194603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Doaa M E Musa, Abdelrhman A Mohammed, Yasir B Ahmed, Duaa H Ibrahim, Leila M A Abdelgader, Ghanem M Mahjaf, Alhaj S M A Ali, Babbiker Mohammed Taher Gorish, Nadir Abuzeid
{"title":"Molecular detection and low prevalence of Human Herpesvirus 6 (HHV-6) among male blood donors in Kassala, Sudan: a preliminary single-center study.","authors":"Doaa M E Musa, Abdelrhman A Mohammed, Yasir B Ahmed, Duaa H Ibrahim, Leila M A Abdelgader, Ghanem M Mahjaf, Alhaj S M A Ali, Babbiker Mohammed Taher Gorish, Nadir Abuzeid","doi":"10.1186/s13104-026-07903-6","DOIUrl":"10.1186/s13104-026-07903-6","url":null,"abstract":"<p><strong>Objective: </strong>Human herpesvirus 6 (HHV-6) is a latent beta-herpesvirus with potential transfusion-transmissible relevance, particularly in immunocompromised recipients. Data on HHV-6 viremia among Sudanese blood donors are extremely limited. This study aimed to determine the molecular prevalence of HHV-6 DNA among blood donors in Kassala, Sudan. A descriptive cross-sectional study was conducted at Kassala Teaching Hospital. Only male donors were included due to extremely low female donation rates in this setting. Whole-blood samples (n = 180) were screened for HHV-6 DNA using real-time PCR, followed by multiplex PCR for genotyping attempts. Due to the small number of positive cases, comparisons were considered exploratory and descriptive.</p><p><strong>Results: </strong>HHV-6 DNA was detected in 2.78% (5/180) of donors. No significant associations were found between HHV-6 positivity and age group, region, or ABO/Rh blood groups. Hematological parameters showed no significant differences between HHV-6-positive and negative donors. Genotyping was unsuccessful for all positive samples, likely due to the high cycle threshold (Ct) values (38.7-39.9), indicating low viral DNA levels. HHV-6 viremia was infrequent among blood donors in Kassala. Given the very small number of positive cases (n = 5), failed genotyping, and lack of serological confirmation, these findings are exploratory and preliminary. Larger multicenter studies with more sensitive methods are needed.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13459371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}