Investigating the effect of Ranolazine drug on the pathophysiology of asthma in a rat model.

IF 1.7 Q2 MULTIDISCIPLINARY SCIENCES

BMC Research Notes Pub Date : 2025-08-29 DOI:10.1186/s13104-025-07455-1

Maryam Sadeghi, Sarina Shahrooz, Mehdi Aghamohammadi, Hadi Khodabandeloo, Nasrin Amiri-Dashatan, Mehdi Koushki, Seyyed Shamsadin Athari

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Abstract

Objective: Asthma is a common multifactorial inflammatory disease affecting both children and adults. Various cells and cytokines contribute to this inflammatory process. Smooth muscle contraction, vascular congestion, and airway edema lead to airway narrowing, which is an important factor in asthma. This study explores the potential impact of Ranolazine, a sodium blocker used for chronic angina, on asthmatic rats. By investigating the drug's effects on vascular and lung tissue changes, this research seeks to offer perspectives on innovative treatment approaches for asthma.

Results: Ranolazine treatment showed minimal impact on serum IgE levels in asthmatic rats, with a slight reduction that was statistically insignificant. However, Ranolazine treatment resulted in a significant decrease in perivascular and peribronchial inflammation levels compared to the asthmatic group, suggesting a potential therapeutic effect on lung histology changes associated with asthma pathophysiology.

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探讨雷诺嗪对哮喘大鼠模型病理生理的影响。

目的：哮喘是儿童和成人常见的多因素炎症性疾病。多种细胞和细胞因子参与了这一炎症过程。平滑肌收缩、血管充血、气道水肿导致气道狭窄，是哮喘发生的重要因素。本研究探讨了雷诺嗪（一种用于慢性心绞痛的钠阻滞剂）对哮喘大鼠的潜在影响。通过研究药物对血管和肺组织变化的影响，本研究旨在为哮喘的创新治疗方法提供观点。结果：雷诺嗪治疗对哮喘大鼠血清IgE水平的影响很小，有轻微的降低，统计学上不显著。然而，与哮喘组相比，雷诺嗪治疗导致血管周围和支气管周围炎症水平显著降低，提示对与哮喘病理生理相关的肺组织学改变有潜在的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.