Journal of stem cell research最新文献

{"title":"The Effects Of Stem Cells On Acute Ischemic Strokes","authors":"Abigail Stock, V. Gallicchio","doi":"10.52793/jscr.2023.4(1)-46","DOIUrl":"https://doi.org/10.52793/jscr.2023.4(1)-46","url":null,"abstract":"A stroke is a neurological disease that causes damage to the brain due to an obstruction of blood supply. Stroke prevalence has shown a drastic increase as the world’s population ages. The effects of a stroke can lead to long-lasting brain damage, long-term disability, or death. Current treatment options are limited","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41813001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cell Therapy For Glioblastoma","authors":"Abby Lin, V. Gallicchio","doi":"10.52793/jscr.2023.4(1)-45","DOIUrl":"https://doi.org/10.52793/jscr.2023.4(1)-45","url":null,"abstract":"Glioblastoma is a devastating grade IV cancer that affects the central nervous system and the spinal cord primarily in older adults but can also affect youth. The progression of the disease causes symptoms such as headaches and epilepsy. With such a severe and devasting prognosis and little ability to extend or cure the disease, researchers have been trying to find the best treatments to help patients suffering from Glioblastoma. Although the goal of Glioblastoma is not only to treat the disease but to cure it, current animal in vivo studies have shown promising therapeutic effects in mesenchymal stem cells, induced neural stem cells","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44378186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implication Of Covid-19 Infection On PRP Extraction In A Patient Suffering From Knee Osteoarthritis","authors":"Pooja Pithadia, S. Tulpule","doi":"10.52793/jscr.2023.4(1)-44","DOIUrl":"https://doi.org/10.52793/jscr.2023.4(1)-44","url":null,"abstract":"Background Knee osteoarthritis (KOA) is one of the most prevalent degenerative diseases that cause pain and disability. None of the currently available treatments reverses or heals the degenerative nature of this condition. There were many research studies on the efficacy of PRP therapy in early KOA patients. However, there was no clinical study on its extraction or administration in a COVID-19 patient with KOA.Hence, the main objective of this observational study was to analyse the implication of COVID-19 infection on PRP extraction along with Red Blood Cell Distribution Width (RDW) and platelet count levels.","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47392583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Of Stem Cell Based Therapy To Treat Celiac Disease And Its Complications","authors":"Hetvi K Solanki, V. Gallicchio","doi":"10.52793/jscr.2023.4(1)-43","DOIUrl":"https://doi.org/10.52793/jscr.2023.4(1)-43","url":null,"abstract":"Celiac Disease affects 1% of the population in the Western world, however, the number of affected people is rising due to high gluten diets. Celiac disease is caused by a number of things involving interactions between genetic, environmental, and immunological factors. Lack of a comprehensive model to conduct trials on makes treating celiac disease a difficult feat. In terms of clinical trials, low incidence and variability in patients are significant obstacles in the establishment of treatments. Stem cells play a pivotal role in chronic inflammatory pathologies due to their ability to regenerate and differentiate into numerous cell types as well as their essential role in homeostasis. Mesenchymal stem cells are highly proliferating, multipotent stromal cells that can cross the HLAQ barrier and lack immunogenicity. Based on these properties, mesenchymal stem cells are able to maintain the epithelial barrier, prevent villous atrophy, and subdue inflammation in CD patients and have proven to be successful in multiple clinical trials. For this reason, stem cells, primarily mesenchymal, possess the potential to be an effective therapy and should be further researched","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45045006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cells As Potential Regenerative Treatment For Retinal Degenerative Diseases And Diabetic Retinopathy","authors":"Tania Yacu, V. Gallicchio","doi":"10.52793/jscr.2023.4(1)-42","DOIUrl":"https://doi.org/10.52793/jscr.2023.4(1)-42","url":null,"abstract":"Retinal degeneration is a major cause of blindness and visual impairment in over 30 million people worldwide and can permanently destroy retinal ganglion cells. Retinal degenerative diseases result in irreversible loss of vision and can often lead to lowering one’s quality of life. Due to retinal ganglion cells being incapable of regenerating, there is a current need for finding therapeutic treatments. Mesenchymal stem cells have been identified in its therapeutic potential to reverse damage already done by these diseases and restore vision. Mesenchymal stem cells are also the most used cell type for regeneration in many pathologies. Currently, researchers have shown promising results when tested on animals, specifically rats. This review outlines the recent progress in restoring vision loss using mesenchymal stem cells. The aim of this study was to review the current use of bone marrow and adipose tissue derived mesenchymal stem cells and how researchers have applied it to retinal degenerative disease and diabetic retinopathy.","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42807857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\" The Use Of Stem Cells In The Surgical Treatment Of Cleft Palate \"","authors":"Caroline C. McCall, V. Gallicchio","doi":"10.52793/jscr.2021.3(3)-41","DOIUrl":"https://doi.org/10.52793/jscr.2021.3(3)-41","url":null,"abstract":"Mesenchymal stem cells, pluripotent and differentiable cells found naturally within bone marrow, adipose tissue, the blood of the umbilical cord, and dental pulp have the capability to transform the field of oral surgery. With the capability to differentiate into different types of tissue, stem cells are currently being studied as an alternative to autologous bone grafting for treatment of cleft palate in young children. The long-standing treatment of autologous bone-grafting, while very effective, has many risks associated with it such as graft rejection, post-operative morbidity, and long recovery time. The harvesting and transplantation of stem cells using bio-compatible scaffolding that will differentiate and form new bone tissue is the future of valvuloplasty protocol in the field of oral surgery. This paper will investigate the way in which this treatment will be performed, the advantages and risks of stem cell therapy, the future applications, as well as the issue of global accessibility to innovative treatment such as this.","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46025394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\" Pluripotent Stem Cells: Potential, Limitation, And Challenges \"","authors":"S. Trebinjac","doi":"10.52793/jscr.2021.3(3)-39","DOIUrl":"https://doi.org/10.52793/jscr.2021.3(3)-39","url":null,"abstract":"The research of stem cells and their application in clinical practice represents one of the most exciting areas in modern science. Due to their specific properties, stem cells offer the possibility of restoring damaged tissues and the function of impaired organs. Pluripotent cells of embryonic origin as well as reprogrammed adult cells have the greatest regenerative potential, but also carry the greatest risk of tumor development and autoimmune reactions. In addition, the use of embryonic cells is ethically unacceptable because it implies the destruction of the embryo. This manuscript analyzes the potential of pluripotent stem cells, but also the limitations and challenges that scientists are currently facing.","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48705633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"genesispub.org/efficacy-and-safety-of-regenerative-treatment-in-knee-osteoarthritis-patients-after-covid-19-vaccination","authors":"Pooja Pithadia, S. Tulpule, M. K. Rehman, Elmuntasir Mahmoud, Mrinalini Singh","doi":"10.52793/jscr.2021.3(3)-38","DOIUrl":"https://doi.org/10.52793/jscr.2021.3(3)-38","url":null,"abstract":"","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48107513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\" Stem Cell Therapy In Regenerative Medicine And Tissue Engineering \"","authors":"Rajeshwar Reddy Kasarla, L. Pathak","doi":"10.52793/jscr.2021.3(3)-37","DOIUrl":"https://doi.org/10.52793/jscr.2021.3(3)-37","url":null,"abstract":"Stem cell therapy is introduction of new adult stem cells into damaged tissue in order to treat disease or injury. Any disease in which there is tissue degeneration can be a potential candidate for stem cell therapy: Alzheimer’s disease, Parkinson’s disease, Spinal cord injury, Heart disease, Severe burns, Diabetes. Stem cells could be used to repair or replace damaged neurons (Regenerate spinal cord), repair of damaged organs such as the liver and pancreas. Stem cell transplantation (SCT) is the term now used in preference to bone marrow transplantation (BMT). Potential uses of stem cells include restoring blood cell production, therapeutic cloning for tissue repair , and cancer treatment. Stem cells are used inbasic research for clarification of complex events that occur during human development, and understanding molecular basis of cancer, molecular mechanisms for gene control. Stem cells can provide specific cell types (pluripotent stem cells) to test new drugs, and to reduce animal testing. This article summarizes the evolution of stem cell therapy to highlight its importance and further research.","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46046316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\" Urine-Derived Stem Cells With The Capacity For Regeneration And Differentiation: The Importance Of Telomerase Activity \"","authors":"Taylor Blake, V. Gallicchio","doi":"10.52793/jscr.2021.3(3)-40","DOIUrl":"https://doi.org/10.52793/jscr.2021.3(3)-40","url":null,"abstract":"Former stem cell research and clinical application has relied on stem cells derived from bone marrow, blood, or organ-specific biopsy that requires invasive and painful procedures to obtain the stem cells. However, there are stem cells in human urine that can be used for research and potential application. This only requires a urine sample, which provides a large quantity of stem cells and good quality stem cells. These urine-derived stem cells have been used in research since the initial discovery in 2008. They can be used for cell therapy, disease modeling, and pharmacological testing. This article focuses on the most recent study from the Wake Forest Institute for Regenerative Medicine regarding urine-derived stem cells and telomerase activity. It examined whether or not telomerase activity affects the regenerative potential in urine-derived stem cells. The study found that positive telomerase activity stem cells had a higher population doubling and a shorter doubling time. Positive telomerase activity cells had strong positive markers for cell differentiation in osteogenic, smooth muscle, and urothelial cell lineages. There were not as many differences between positive and negative telomerase activity in their surface markers except positive telomerase activity cells had more cells with a strong positive expression of CD105. to donate the that are not used to research. Yet, it is still in limited supply for research purposes along with the primary ethical concerns [2]. There is an alternative origin for stem cells which is in human One can obtain adult somatic stem cells from the components of urine. This is a great source of stem cells since it obtained from a urine sample which is and there is an tangible Urine is 95% and the other is a variety of other molecules. It contains organic molecules uric acid. It contains ions like chloride, it The study showed that urine stem cells did better overall if they were from younger donors and if they had positive telomerase activity. Lastly, the chromosome stability and tumor formation assays had the same results regardless of telomerase activity.","PeriodicalId":92258,"journal":{"name":"Journal of stem cell research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49633857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}