" Urine-Derived Stem Cells With The Capacity For Regeneration And Differentiation: The Importance Of Telomerase Activity "

Abstract

Former stem cell research and clinical application has relied on stem cells derived from bone marrow, blood, or organ-specific biopsy that requires invasive and painful procedures to obtain the stem cells. However, there are stem cells in human urine that can be used for research and potential application. This only requires a urine sample, which provides a large quantity of stem cells and good quality stem cells. These urine-derived stem cells have been used in research since the initial discovery in 2008. They can be used for cell therapy, disease modeling, and pharmacological testing. This article focuses on the most recent study from the Wake Forest Institute for Regenerative Medicine regarding urine-derived stem cells and telomerase activity. It examined whether or not telomerase activity affects the regenerative potential in urine-derived stem cells. The study found that positive telomerase activity stem cells had a higher population doubling and a shorter doubling time. Positive telomerase activity cells had strong positive markers for cell differentiation in osteogenic, smooth muscle, and urothelial cell lineages. There were not as many differences between positive and negative telomerase activity in their surface markers except positive telomerase activity cells had more cells with a strong positive expression of CD105. to donate the that are not used to research. Yet, it is still in limited supply for research purposes along with the primary ethical concerns [2]. There is an alternative origin for stem cells which is in human One can obtain adult somatic stem cells from the components of urine. This is a great source of stem cells since it obtained from a urine sample which is and there is an tangible Urine is 95% and the other is a variety of other molecules. It contains organic molecules uric acid. It contains ions like chloride, it The study showed that urine stem cells did better overall if they were from younger donors and if they had positive telomerase activity. Lastly, the chromosome stability and tumor formation assays had the same results regardless of telomerase activity.