Potential Of Stem Cell Based Therapy To Treat Celiac Disease And Its Complications

Abstract

Celiac Disease affects 1% of the population in the Western world, however, the number of affected people is rising due to high gluten diets. Celiac disease is caused by a number of things involving interactions between genetic, environmental, and immunological factors. Lack of a comprehensive model to conduct trials on makes treating celiac disease a difficult feat. In terms of clinical trials, low incidence and variability in patients are significant obstacles in the establishment of treatments. Stem cells play a pivotal role in chronic inflammatory pathologies due to their ability to regenerate and differentiate into numerous cell types as well as their essential role in homeostasis. Mesenchymal stem cells are highly proliferating, multipotent stromal cells that can cross the HLAQ barrier and lack immunogenicity. Based on these properties, mesenchymal stem cells are able to maintain the epithelial barrier, prevent villous atrophy, and subdue inflammation in CD patients and have proven to be successful in multiple clinical trials. For this reason, stem cells, primarily mesenchymal, possess the potential to be an effective therapy and should be further researched