Biology Open最新文献_第5页

Underwater audiogram of the grey seal (Halichoerus grypus). 灰海豹（灰海豹）的水下听力图。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-08-15 Epub Date: 2025-08-19 DOI: 10.1242/bio.062059

Andreas Ruser, Kirstin Anderson Hansen, Magnus Wahlberg, Tobias Schaffeld, Ursula Siebert

引用次数: 0

Heatwaves reduce mating frequency in an aquatic insect. 热浪降低了水生昆虫的交配频率。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-08-15 Epub Date: 2025-07-31 DOI: 10.1242/bio.062091

Md Tangigul Haque, Shatabdi Paul, Md Kawsar Khan

{"title":"Heatwaves reduce mating frequency in an aquatic insect.","authors":"Md Tangigul Haque, Shatabdi Paul, Md Kawsar Khan","doi":"10.1242/bio.062091","DOIUrl":"10.1242/bio.062091","url":null,"abstract":"Heatwaves are becoming more frequent and intense across the globe due to global warming. Heatwaves - unusual daytime and nighttime high temperatures over three consecutive days - can disrupt physiological functions of organisms, reducing fitness. Insects are stressed because of the increasing frequency and intensity of temperature extremes. While many studies have focused on insect behaviour during heatwaves in laboratory settings, the impact of natural heatwaves in the wild remains understudied. Here, we investigated the impact of natural heatwaves on mating behaviour, flight activity, and local abundance in the damselfly, Xanthagrion erythroneurum. We found that damselfly mating frequency decreased, while flight number and net population abundance remained unchanged during natural heatwaves. The decreased mating frequency may suggest a sex-specific decoupling of mate-searching efforts under thermal stress. Heatwave driven disruptions in mating behaviours and the occurrence of more frequent and acute heatwaves in the future may have long-term consequences for damselfly populations. Our results provide crucial data of the behaviour of thermally sensitive insects to heatwaves, which could assist in developing effective conservation strategies for maintaining biodiversity in a warming world.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification. 连接蛋白41.8控制及时的造血干细胞和祖细胞规范。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-08-15 Epub Date: 2025-08-12 DOI: 10.1242/bio.062118

Tim Petzold, Sarah Brivio, Tanja Linnerz, Masakatsu Watanabe, Holger Gerhardt, Julien Y Bertrand

引用次数: 0

Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish (Danio rerio) model of melanoma. 磷酸化缺陷诱导的cAMP早期抑制因子（ICER）在转基因斑马鱼黑色素瘤模型中调节肿瘤的发生和存活。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-08-15 Epub Date: 2025-08-14 DOI: 10.1242/bio.061904

Justin Wheelan, Melissa Spigelman, Angelo Cirinelli, James Reilly, Carlos A Molina

{"title":"Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish (Danio rerio) model of melanoma.","authors":"Justin Wheelan, Melissa Spigelman, Angelo Cirinelli, James Reilly, Carlos A Molina","doi":"10.1242/bio.061904","DOIUrl":"10.1242/bio.061904","url":null,"abstract":"Melanoma, the most lethal form of skin cancer, is commonly associated with mutations in the BRAF gene, particularly BRAFV600E, which drives tumor proliferation via the ERK1/2 signaling cascade. While BRAF inhibitors initially demonstrate efficacy, therapeutic resistance remains a significant challenge. Emerging evidence implicates the cAMP signaling pathway, particularly the cAMP response element-binding protein (CREB) and its repressor, inducible cAMP early repressor (ICER), in melanoma progression and drug resistance. ICER, a transcriptional repressor regulated via Ras/MAPK-mediated phosphorylation and ubiquitination, is degraded in melanoma, undermining its tumor-suppressive role. In a brafV600E; p53 (loss of function) transgenic zebrafish (Danio rerio) model, we investigated the role of a ubiquitin-resistant ICER mutant (S35-41A-ICER) in tumor progression. Transgenic fish expressing S35-41A-ICER exhibited extended survival and reduced tumor invasiveness compared to wild-type ICER. RNA sequencing revealed dysregulation of CREB/CREM targets and compensatory pathways, including Rap1 and PI3K/AKT signaling, as well as candidate gene targets of ICER regulation, including the protein kinase A catalytic subunit prkacaa. Our findings suggest that a ubiquitin resistant ICER mitigates melanoma progression and represses oncogenic pathways in a brafV600E melanoma context.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SlicerMorph photogrammetry: an open-source photogrammetry workflow for reconstructing 3D models. SlicerMorph摄影测量：用于重建3D模型的开源摄影测量工作流程。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-08-15 Epub Date: 2025-08-29 DOI: 10.1242/bio.062126

Oshane O Thomas, Chi Zhang, A Murat Maga

引用次数: 0

From Primary Cell to Organoid: the proliferative fate international conference and workshop. 从原代细胞到类器官：增殖命运国际会议暨研讨会。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-07-15 Epub Date: 2025-07-18 DOI: 10.1242/bio.061970

Mohamed Jemaà, Amine Bourzam, Marwen Ben Fdilen, Mariem Sellami

{"title":"From Primary Cell to Organoid: the proliferative fate international conference and workshop.","authors":"Mohamed Jemaà, Amine Bourzam, Marwen Ben Fdilen, Mariem Sellami","doi":"10.1242/bio.061970","DOIUrl":"10.1242/bio.061970","url":null,"abstract":"Cell culture is an essential tool for basic, biomedical and translational research. This can be as routine as growing cell lines for toxicity assays, as specific and personalised as patient-derived cell culture, or it can mimic physiological conditions such as organoid culture. In order to train and promote collaborative research among North African researchers in the field of cell culture, a consortium formed by the Faculty of Sciences of Tunis, Tunisia, the Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, the Merck Group and Learn and Win decided to organise a North African conference and workshop on complex cell culture, from primary cells to organoids. For 1 week, from 18 to 23 November 2024, more than 500 young researchers and students in the life sciences and more than 30 international speakers and trainers met at the Faculty of Sciences in Tunis, Tunisia, to discuss cell culture technology and protocols, from primary cell culture to organoids, with a strong focus on technologies and discoveries. This meeting review describes the scientific event and highlights the main results of both the conferences and the practical sessions.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflections on the EMBO Workshop: Neuroscience of Sleep 2025. EMBO研讨会的反思：睡眠神经科学2025。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-07-15 Epub Date: 2025-07-28 DOI: 10.1242/bio.062079

Rahul Kumar, Ritika Mukherji, Kamakshi Singh

{"title":"Reflections on the EMBO Workshop: Neuroscience of Sleep 2025.","authors":"Rahul Kumar, Ritika Mukherji, Kamakshi Singh","doi":"10.1242/bio.062079","DOIUrl":"10.1242/bio.062079","url":null,"abstract":"The inaugural EMBO workshop on the neuroscience of sleep took place from 11th-13th March 2025 at the India Habitat Centre in New Delhi, India, and marked a milestone for the global sleep research community. It overlapped with the 25th anniversary of the discovery of sleep in Drosophila, and the meeting celebrated the scientific advances in recognising sleep as a deeply conserved and biologically vital process. With around 85 participants from across the globe, the workshop brought together scientists to explore the biological, molecular, and computational dimensions of sleep across scales. The conference program included keynote lectures from the pioneers in sleep research, exciting new studies on sleep's role in regulating neural computation, metabolism, and plasticity, and reflected the increasing interest in the field for sleep studies in non-model organisms in natural settings. In addition to the science, the conference involved thoughtful talks and conversations around women in science, gender equity, and varied career paths, with many participants sharing their own experiences. The meeting being hosted in India allowed space for meaningful exchange, collaboration, and mentorship among researchers of the Global South. This Meeting Review captures an overview of the scientific discussions that made this event a success.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocyte secretome remodeling under iron deficiency: potential implications for brain iron homeostasis. 铁缺乏下星形胶质细胞分泌组重塑：对脑铁稳态的潜在影响。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-07-15 Epub Date: 2025-07-09 DOI: 10.1242/bio.062057

Mariam Duhaini, Habiba S Shamroukh, Zhi Zhang, Kalyan C Kondapalli

{"title":"Astrocyte secretome remodeling under iron deficiency: potential implications for brain iron homeostasis.","authors":"Mariam Duhaini, Habiba S Shamroukh, Zhi Zhang, Kalyan C Kondapalli","doi":"10.1242/bio.062057","DOIUrl":"10.1242/bio.062057","url":null,"abstract":"The brain is the most metabolically active organ in the body and has a high demand for iron. Iron deficiency impairs brain function and is linked to various neurological disorders. To maintain iron homeostasis, astrocytes respond to iron levels and signal brain microvascular endothelial cells (BMVECs), which regulate iron import into the brain. However, the specific signaling molecules released by astrocytes remain largely unknown. In this study, we addressed this by performing a global proteomic analysis of the secretome of primary mouse astrocytes cultured under iron-deficient conditions. Quantitative mass spectrometry demonstrated significant remodeling of the astrocyte secretome in response to iron deficiency, affecting critical pathways related to metabolic reprogramming, stress responses, and cellular communication. We identified specific secreted factors with potential roles in paracrine signaling, with their secretion supported by prediction analysis. Our analysis also revealed novel condition-specific proteins. These findings provide new insights into astrocyte communication under iron stress and its potential influence on iron availability at the blood-brain barrier. This study establishes a foundation for future investigations into astrocyte-secreted factors and their roles in neurological diseases associated with iron dysregulation.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How octopuses use and recruit additional arms to find and manipulate visually hidden items. 章鱼如何使用和招募额外的手臂来寻找和操纵视觉上隐藏的物品。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-07-15 Epub Date: 2025-07-10 DOI: 10.1242/bio.062011

Ashley J Gendreau, Camille Boucaud, Kendra C Buresch, Allison S Rooney, Halia Morris, Roger T Hanlon

{"title":"How octopuses use and recruit additional arms to find and manipulate visually hidden items.","authors":"Ashley J Gendreau, Camille Boucaud, Kendra C Buresch, Allison S Rooney, Halia Morris, Roger T Hanlon","doi":"10.1242/bio.062011","DOIUrl":"10.1242/bio.062011","url":null,"abstract":"Shallow-water benthic octopuses are tactile creatures that explore their environment mainly using chemotactile receptors in their suckers. Details of how they coordinate multiple arms to sense and manipulate items remain unknown. We developed a behavioral assay that exploits their natural foraging behavior to quantify how octopuses use and recruit their arms when searching for and investigating items in a visually occluded environment. Fourteen Octopus bimaculoides were presented with an opaque rock dome to 'blindly' explore for one of five items placed inside. During 117 experimental trials, 2327 arm actions and 394 coordinated arm recruitments were video recorded. Octopuses most often recruited the nearest-neighboring arm when manipulating items (44%). Recruitment of more distant arms was collectively observed (56%). The most common recruitment patterns were (1) initial arm→nearest neighbor→nearest neighbor and (2) initial arm→nearest neighbor→second arm over. We discovered that octopuses used all eight arms with similar frequency and most often engaged three, four, or five arms simultaneously. These findings further demonstrate the flexibility and functionality of all eight arms and indicate that octopuses can use all eight arms equally, which may inform research into arm neuroanatomy as well as the design of coordinated soft robotic arms.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cuticular microstructure of the locust femur-tibia joint. 蝗虫股骨-胫骨关节角质层微观结构。

IF 1.7 4区生物学

Biology Open Pub Date : 2025-07-15 Epub Date: 2025-07-31 DOI: 10.1242/bio.061934

Christoph Bruns, Vassileios Bekas, Susanna Labisch, Jan-Henning Dirks

引用次数: 0