Biology Open最新文献_第10页

Effects of ultraviolet radiation on the activity, survival, and growth of the critically endangered northern corroboree frog. 紫外线辐射对极度濒危的北方长尾蛙的活动、生存和生长的影响。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-05-15 Epub Date: 2025-05-13 DOI: 10.1242/bio.061827

Michael S McFadden, Aimee J Silla, Shannon R Kelleher, Phillip G Byrne

{"title":"Effects of ultraviolet radiation on the activity, survival, and growth of the critically endangered northern corroboree frog.","authors":"Michael S McFadden, Aimee J Silla, Shannon R Kelleher, Phillip G Byrne","doi":"10.1242/bio.061827","DOIUrl":"10.1242/bio.061827","url":null,"abstract":"Ultraviolet radiation (UVR) is known to have lethal and sublethal impacts on amphibians, yet effects on anuran growth, development and behaviour remain understudied. As the global amphibian extinction crisis worsens, and more species enter conservation breeding programs (CBPs), there is a growing need to understand interrelationships between UVR exposure, growth, and UVR avoidance behaviour. Here, we investigate the effect of ecologically appropriate UVR levels on post-metamorphic growth and activity in the critically endangered northern corroboree frog (Pseudophryne pengilleyi). UVR was provided at one of two levels (lower UVI, ∼0.2 and higher UVI, ∼0.75), for a period of 16 weeks, spanning the first growth phase before hibernation. Daily activity was significantly lower in frogs reared under the higher UVR treatment (mean±s.e.m=26.339%±0.757) compared to those receiving the lower UVR treatment (mean±s.e.m=35.660%±0.837). Despite these differences, there was no significant difference between treatment groups in survival or growth. These findings indicate that northern corroboree frogs may have the capacity to adjust their behaviour in response to UVR and suggest that behavioural plasticity might mitigate potential negative impacts of UVR exposure. We discuss the value of this knowledge for amphibian CBPs.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reorganization of the heterochromatin-associated gene-dense subcompartment in early neuronal development. 异染色质相关基因密集亚室在早期神经元发育中的重组。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-05-15 Epub Date: 2025-05-12 DOI: 10.1242/bio.062005

Nicolas J Scrutton Alvarado, Ziyu Zhao, Tomoko Yamada, Yue Yang

{"title":"Reorganization of the heterochromatin-associated gene-dense subcompartment in early neuronal development.","authors":"Nicolas J Scrutton Alvarado, Ziyu Zhao, Tomoko Yamada, Yue Yang","doi":"10.1242/bio.062005","DOIUrl":"10.1242/bio.062005","url":null,"abstract":"The 3D organization of the genome has emerged as an important regulator of cellular development. Post-mitotic neurons undergo conserved changes in genome organization, such as the inward radial repositioning of heterochromatin-rich chromosomes as they differentiate. Additionally, transcriptionally active but heterochromatin-associated gene-dense (hGD) regions significantly strengthen their long-distance interactions during cerebellar development. However, the specific developmental stages during which these nuclear changes take place have remained poorly defined. Here, we report that hGD regions relocalize toward the nuclear interior and strengthen their chromosomal interactions as immature granule neurons transition from active cell migration to subsequent stages of neuronal differentiation. During this period, hGD genomic regions are coordinately repositioned in the nucleus alongside their physically tethered heterochromatic chromocenters. Despite these major changes in nuclear organization, the hGD subcompartment remains distinct from other transcriptionally active or repressive nuclear bodies, including heterochromatic chromocenters, throughout development. Notably, these nuclear changes appear to be independent of transcriptional changes that occur during granule neuron differentiation. Together, our results provide insights into the developmental timing of structural changes in the chromosomes of post-mitotic neurons.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic exposure to nicotine in diet enhances the lethal effect of an entomopathogenic fungus in the ant Cardiocondyla obscurior. 长期暴露于饮食中的尼古丁增强了昆虫病原真菌对蚂蚁心髁突的致死作用。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-05-15 Epub Date: 2025-05-06 DOI: 10.1242/bio.061928

Jason Rissanen, Dalial Freitak

{"title":"Chronic exposure to nicotine in diet enhances the lethal effect of an entomopathogenic fungus in the ant Cardiocondyla obscurior.","authors":"Jason Rissanen, Dalial Freitak","doi":"10.1242/bio.061928","DOIUrl":"10.1242/bio.061928","url":null,"abstract":"Nicotine is a naturally occurring alkaloid that has acute toxic effects for insects and affects their behaviour even in sublethal amounts. In addition, nicotine is shown to accumulate and pollute environments through the use of commercially produced pesticides and tobacco products. We investigated how nicotine-polluted diets in two different concentrations impacted colony fitness in the ant Cardiocondyla obscurior, compared to a nicotine-free diet. We measured brood production and development, changes in relative abundances of bacterial endosymbionts, and worker survival in combination with a fungal pathogen. Chronic exposure to nicotine caused a concentration-dependent effect in enhancing the lethality of the fungal infection, with higher concentrations causing higher mortality in infected colonies. In the absence of pathogens, nicotine had no effect on worker survival. Furthermore, nicotine did not affect brood production or development, nor clearly affect the abundances of the bacterial endosymbionts. Our results show that nicotine pollution in the environment can negatively affect ant fitness through synergistic effects in combination with a fungal pathogen. Pathogens play a significant part in the decline of insects, and the influence that nicotine pollution may have in exacerbating them should receive more attention.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Open and closed economies as possible alternative strategies to resource heterogeneity in ants. 开放和封闭经济作为蚂蚁资源异质性的可能替代策略。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-05-15 Epub Date: 2025-05-27 DOI: 10.1242/bio.061976

Kazuki Tsuji, Aye T Win

{"title":"Open and closed economies as possible alternative strategies to resource heterogeneity in ants.","authors":"Kazuki Tsuji, Aye T Win","doi":"10.1242/bio.061976","DOIUrl":"10.1242/bio.061976","url":null,"abstract":"Ant colonies have either a single nest (monodomy) or multiple nests (polydomy). A challenge is to explain their adaptive significance, specifying costs and benefits of each colony type. An explanation for ant polydomy is adaptation to spatially heterogeneous environments. With polydomy a colony can exchange complementary nutrition among nests within the entire colony occupying a wide territory. We tested this resource redistribution hypothesis using two closely related species, i.e. the polydomous ant Pheidole megacephala and the monodomous ant Pheidole noda. We put each colony in an artificially polydomous setting with two nests connected by tubes. We provided liquid food lacking protein to one nest and that lacking carbohydrates to the other nest. P. megacephala almost totally failed to produce brood when the connecting tubes were clipped, whereas it improved reproductive performance when the tubes were open. In marked contrast, P. noda managed to maintain high performance for a long period even when only nutritionally biased food was provided, most likely by relying on stored provisions that compensated for the missing nutrients. Based on these data, we propose the hypothesis that ant polydomy is an open economic strategy to counter heterogeneity in resource distribution 'spatially' by trading between nests and extending the resource searching area, whereas monodomy may be a closed economic strategy to cope with resource heterogeneity 'temporally' by withstanding food-depressed periods with stored nutrition and by efficient utilization of frugal diets. More empirical data in other ant taxa are necessary to test generality of this idea.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 5","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental short-term heatwaves negatively impact body weight gain and survival during larval development in Bombus terrestris L. (Hymenoptera: Apidae). 实验性短期热浪对地蜂幼虫发育过程中体重增加和存活率有负面影响。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-04-15 Epub Date: 2025-04-25 DOI: 10.1242/bio.061781

Laura Wögler, Christoph Kurze

{"title":"Experimental short-term heatwaves negatively impact body weight gain and survival during larval development in Bombus terrestris L. (Hymenoptera: Apidae).","authors":"Laura Wögler, Christoph Kurze","doi":"10.1242/bio.061781","DOIUrl":"10.1242/bio.061781","url":null,"abstract":"Climate change-induced heatwaves threaten global biodiversity, including crucial pollinators like bumblebees. In particular, the increasing frequency, duration and intensity of heatwaves is alarming. Despite these projections, little is known about the effects of short-term heatwaves on insect larval development. Hence, we investigated the impact of simulated heatwaves on the development of 4th instar larvae (L4) of Bombus terrestris L. (Hymenoptera: Apidae) using an in vitro rearing method. Individual larvae were incubated at 37°C and 38°C for a period of 4 days, with a constant rearing temperature of 34°C as the control. We examined body weight gain, developmental duration, survival to adult stage, and adult body size (i.e. dry mass, intertegular distance, and head width). A simulated heatwave of 37°C did not significantly affect larval development, but 38°C impaired larval body mass gain. While developmental duration and adult body size were unaffected, an acute heat stress of 38°C during the L4 stage reduced the probability of pupae reaching adulthood. These findings highlight the potential for heatwaves to negatively affect bee populations by impairing larval growth and reducing survival to the adult stage, which may have severe implications for colony fitness.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphlight theory inspired by raptors: musculoskeletal modeling and muscle control in Falco peregrinus wing flapping. 受猛禽启发的变形光理论：飞鹰翅膀拍动中的肌肉骨骼建模和肌肉控制。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-04-15 Epub Date: 2025-04-10 DOI: 10.1242/bio.061859

Di Tang, Kai Chen, Yanbin Dai, Yang Liu, Yibo Zhao, Kunpeng Wang, Siyu Wang, Zhongyong Fan

{"title":"Morphlight theory inspired by raptors: musculoskeletal modeling and muscle control in Falco peregrinus wing flapping.","authors":"Di Tang, Kai Chen, Yanbin Dai, Yang Liu, Yibo Zhao, Kunpeng Wang, Siyu Wang, Zhongyong Fan","doi":"10.1242/bio.061859","DOIUrl":"10.1242/bio.061859","url":null,"abstract":"Falco peregrinus can achieve highly maneuverable flight through their morphing wing structure, which has significant research value. However, there has been limited research on the F. peregrinus wing musculoskeletal system. In this study, musculoskeletal modeling, flapping movement, and muscle function of F. peregrinus wing were studied through computer modeling and simulation to better understand the biomechanics of F. peregrinus wing flapping. Using anatomical data and the musculoskeletal modeling method based on OPENSIM, a three-dimensional model of the F. peregrinus wing was developed. Based on the experimental data, the flapping movements were reconstructed, muscle movements during different stages of flapping were simulated, and the function of muscles in the flapping process was analyzed. While this study provides valuable insights into the muscle function of F. peregrinus wing during flapping, it also highlights certain limitations, such as the simplification of musculoskeletal structures and joints in the modeling approach and deviations from actual F. peregrinus wing movements. This study provides both experimental and analytical methods for raptor wing flapping research, potentially reducing the need for live experiments and offering valuable insights into the mechanisms of raptor flapping.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into Octopus maya cathepsins from metatranscriptome and genome: structure evolutionary relationships and functional role prediction in digestive processes. 从亚转录组和基因组对章鱼玛雅组织蛋白酶的见解：结构进化关系和消化过程中的功能角色预测。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-04-15 DOI: 10.1242/bio.061778

Daisy Pineda-Suazo, Francisco Guillén-Chable, Wendy Itzel Escobedo-Hinojosa, Clara E Galindo-Sánchez, Carlos Rosas

{"title":"Insights into Octopus maya cathepsins from metatranscriptome and genome: structure evolutionary relationships and functional role prediction in digestive processes.","authors":"Daisy Pineda-Suazo, Francisco Guillén-Chable, Wendy Itzel Escobedo-Hinojosa, Clara E Galindo-Sánchez, Carlos Rosas","doi":"10.1242/bio.061778","DOIUrl":"10.1242/bio.061778","url":null,"abstract":"Physiological response to feeding is crucial for various production factors such as feed catabolism and growth. Despite growing significance in red Octopus maya aquaculture, large-scale commercial production is limited by not sufficiently knowing their nutritional needs, especially their digestive physiology. Since this species is carnivorous, one of the main feeding aspects is directed to protein digestion, but its enzymatic digestive repertoire has not been studied yet at genomic and transcriptomic levels. This study searched for protease enzymes encoded in O. maya genome and expressed in the transcriptome, allowing an initial annotation of genes involved in protein catabolism; 117 amino acid sequences related to 'octopus digestive enzymes' were retrieved from 66 available-species' genomes in the NCBI database, coding for cathepsins, papilins, and metalloproteases. Homology analysis identified 36 homologous sequences from O. maya transcriptome and three from its genome. Phylogenetic analysis grouped 37 of 39 sequences into 11 of 14 main clades, offering new insights into the evolutionary relationships and functional roles of these proteases. Phylogenetic and motif analyses resulted in selecting 19 amino acid O. maya sequences using multiple sequence alignment that were used to generate three-dimensional protein models. The obtained models revealed a diverse structural architecture among 16 modelled cathepsins; however, their catalytic potential to fully clarify their role in protein hydrolysis and cellular processes remains to be determined. Foundational data provides insights into biochemistry and physiology behind O. maya protein digestion. Further complementation of these results with enzymatic characterization of the identified proteases should allow for improved diet formulation in order to foster this species aquaculture.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unpredictable aggressive defence of the venomous snake, Crotalus ravus, towards predators and humans. 毒蛇（Crotalus ravus）对掠食者和人类的不可预测的攻击性防御。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-04-15 Epub Date: 2025-04-02 DOI: 10.1242/bio.061791

O Azucena Núñez-Valdez, Melissa Plasman, Víctor Hugo Reynoso

{"title":"Unpredictable aggressive defence of the venomous snake, Crotalus ravus, towards predators and humans.","authors":"O Azucena Núñez-Valdez, Melissa Plasman, Víctor Hugo Reynoso","doi":"10.1242/bio.061791","DOIUrl":"10.1242/bio.061791","url":null,"abstract":"Antipredation behaviour is of high importance for the survival of prey animals, but it is also vital for the predator to understand the antipredator behaviour of potentially dangerous prey. Venomous snakes are particularly dangerous for their predators and humans, as a defensive bite may result in death. Here, we studied the behavioural response of the Mexican pigmy rattlesnake Crotalus ravus to the approach of simulated predators (birds and fox) and human, contrasting this to their predatory behaviour. Results showed that C. ravus defensive behaviour depended on the predator and was more aggressive towards humans. Mostly, for each type of behaviour the approach distance at first occurrence was similar among trials with different predators and reduced from freezing>rattling>escape>bite. However, we did not find clear behavioural patterns. In bird and fox trials, snakes always rattled or escaped before biting, however warning signals were not always displayed before biting and bite frequency was high in human trials, suggesting that this snake is dangerous for humans. Our results demonstrate that these snakes are flexible in their response to potential threats, but that the approach distance that elicits specific behaviours is mostly fixed.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive evolution of cytochrome b in songbirds. 鸣禽细胞色素 b 的适应性进化。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-04-15 Epub Date: 2025-04-14 DOI: 10.1242/bio.061908

Hagai Rottenberg

{"title":"Adaptive evolution of cytochrome b in songbirds.","authors":"Hagai Rottenberg","doi":"10.1242/bio.061908","DOIUrl":"10.1242/bio.061908","url":null,"abstract":"The mitochondrial bc1 complex catalyzes the oxidation of ubiquinol by reducing cytochrome c. Cytochrome b, the catalytic core of bc1, generates superoxide during the oxidation of ubiquinol. Excessive superoxide production is known to accelerate aging and neurodegeneration. Songbirds (oscine, Passeri) exhibit lower production of mitochondrial reactive oxygen species (ROS) and greatly accelerated evolution of cytochrome b, relative to all other modern birds, suggesting adaptive selection for lower generation of ROS. Here, we identified songbird-specific substitutions in modern bird's cytochrome b amino-acid sequences and examined the high-resolution structures of the chicken bc1 complex in an effort to predict the effect of these substitutions on the function of bc1. Many of the songbird-specific substitutions cluster around sites that are critical for the function of bc1. One cluster of substitutions interacts with heme BH. A second cluster of substitutions interacts with residues in the ubiquinone reduction site, Qi. Both groups of substitution may affect the rate of reduction of ubiquinone at the Qi site. Another cluster of cytochrome b substitutions interacts with the hinge region of the Rieske protein that transfers electron from cytochrome b to cytochrome c1. These songbird-specific substitutions appear to be selected to modulate the rate of both ubiquinol oxidation at the Qo site and ubiquinone reduction at the Qi site thereby modulating the rate of superoxide production. These findings are compatible with the hypothesis that cytochrome b evolution in songbirds was driven by selection of substitutions that reduce the rate of superoxide production thereby increasing songbird lifespan and cognitive abilities.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon. 非洲绿松石鳉端脑的早期生长和细胞异质性。

IF 1.8 4区生物学

Biology Open Pub Date : 2025-04-15 Epub Date: 2025-04-22 DOI: 10.1242/bio.061984

Caroline Zandecki, Valerie Mariën, Rajagopal Ayana, Jolien Van Houcke, Lutgarde Arckens, Eve Seuntjens

{"title":"Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon.","authors":"Caroline Zandecki, Valerie Mariën, Rajagopal Ayana, Jolien Van Houcke, Lutgarde Arckens, Eve Seuntjens","doi":"10.1242/bio.061984","DOIUrl":"https://doi.org/10.1242/bio.061984","url":null,"abstract":"The African turquoise killifish (Nothobranchius furzeri) is becoming a favorable model for neurobiological research. The combination of a short lifespan and a declining neuroregenerative capacity upon aging makes it ideally suited for research on brain aging and regeneration. A remarkable cellular diversity makes up the young-adult killifish telencephalon, characterized by highly proliferative non-glial progenitors and spatially distinct radial glia subtypes. In contrast to a relatively slow embryonic development, hatching is followed by a period of accelerated growth, in which the brain experiences a period of rapid expansion and maturation. In this study, we quantified the growth progression and maturation of the killifish telencephalon during early post-embryonic development. We discovered that, similar to in zebrafish, neuro-epithelial cells abut the neurogenic niches from early life onwards. Spatial data revealed qualitative and quantitative differences along the anterior-posterior axis and between pallial and subpallial regions in terms of growth pace. We confirmed generation of GABAergic neurons from the subpallial neurogenic niche and glutamatergic neurons from two pallial niches. Our data further showed a more widespread appearance of inhibitory neurons at hatching compared to in zebrafish.","PeriodicalId":9216,"journal":{"name":"Biology Open","volume":"14 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0