Brain Structure & Function最新文献_第7页

The scientific value of tractography: accuracy vs usefulness. 神经束造影的科学价值：准确性vs实用性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02921-9

Francois Rheault, Helen Mayberg, Michel Thiebaut de Schotten, Alard Roebroeck, Stephanie J Forkel

引用次数: 0

Rudolf Nieuwenhuys and the meaning of it all. Rudolf Nieuwenhuys和这一切的意义。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02926-4

R Jarrett Rushmore

引用次数: 0

Due to difference in anatomical definitions, population variability and tractography methods, it will not be possible to standardize brain tractography for users, or will it? 由于解剖学定义的不同、人群的差异性和脑束造影方法的不同，脑束造影是否可能对用户标准化？

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02924-6

Christian Beaulieu, Alessandro Daducci, Helen Mayberg, Alexander Leemans

引用次数: 0

Small brains but big challenges: white matter tractography in early life samples. 大脑小但挑战大：早期生命样本的白质束状图。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-28 DOI: 10.1007/s00429-025-02922-8

Jessica Dubois, Mareike Grotheer, Joseph Yuan-Mou Yang, Jacques-Donald Tournier, Christian Beaulieu, Catherine Lebel

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Fascinated by brain evolution. 对大脑进化着迷。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-26 DOI: 10.1007/s00429-025-02920-w

Loreta Medina

引用次数: 0

Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging. 老年性耳聋发病时听觉皮层的阳极直流电刺激可延缓皮层老化。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-25 DOI: 10.1007/s00429-025-02912-w

I S Fernández Del Campo, A J de la Fuente, I Díaz, I Plaza, M A Merchán

{"title":"Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging.","authors":"I S Fernández Del Campo, A J de la Fuente, I Díaz, I Plaza, M A Merchán","doi":"10.1007/s00429-025-02912-w","DOIUrl":"10.1007/s00429-025-02912-w","url":null,"abstract":"Presbycusis or age-related hearing loss (ARHL) affects millions of people worldwide, increasing their risk of cognitive decline and poor quality of life. However, ARHL remains an irreversible condition due to our inability to induce inner-ear hair cell regeneration. Nevertheless, multisession epidural stimulation of the auditory cortex (AC) at the onset of ARHL prevents hearing threshold elevation in naturally aging Wistar rats. Accordingly, we hypothesized that anodal direct current (DC) stimulation of the AC may also compensate for age-related maladaptive, activity-dependent changes. Here, we examined immunocytochemical markers in the AC, including early genes (c-fos and Arc), AMPA receptors (GluR2/3), parvalbumin (PV), and GAD67, along with auditory-evoked potentials (CAEPs) recorded in both auditory and visual (VC) cortices. When comparing 6 and 18.13-month-old rats without AC simulation, we observed loss of c-fos and Arc-positive neurons and decreased GluR2/3 expression, confirming altered AC neuronal network plasticity and activation. In addition, we noted changes in PV and decreased GAD67 immunoreactivity suggesting disrupted inhibition and significantly increased wave amplitudes in CAEPs, altered AC latencies, and decreased VC responses. By contrast, electrically stimulated rats showed no significant variations in early gene markers, GluR2/3, PV, or GAD67 with age, and the amplitudes and latencies of CAEPs recorded in their AC and VC resembled those of young rat. These findings indicate that anodal DC stimulation at the onset of ARHL delays AC aging by minimizing the loss of inhibition and preventing increases in cortical excitability in Wistar rats.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"56"},"PeriodicalIF":2.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Farewell Rudolf Nieuwenhuys, you neuroanatomical legend. 再见了，鲁道夫·纽文豪斯，你这个神经解剖学的传奇人物。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-23 DOI: 10.1007/s00429-025-02917-5

Michel Thiebaut de Schotten

引用次数: 0

Effects of early neuroanatomical variants on reading skills and brain function in typical adult Italian readers. 早期神经解剖变异对典型成年意大利语读者阅读技能和脑功能的影响。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-23 DOI: 10.1007/s00429-025-02919-3

Nicola Del Maschio, Camilla Bellini, Matteo Giannachi, Gianpaolo Del Mauro, Jubin Abutalebi

{"title":"Effects of early neuroanatomical variants on reading skills and brain function in typical adult Italian readers.","authors":"Nicola Del Maschio, Camilla Bellini, Matteo Giannachi, Gianpaolo Del Mauro, Jubin Abutalebi","doi":"10.1007/s00429-025-02919-3","DOIUrl":"10.1007/s00429-025-02919-3","url":null,"abstract":"Reading is a core feature of human communication that develops throughout intensive academic training. Recently, a group of studies examined whether neuroanatomical variants that predate literacy acquisition may influence reading abilities at later stages of life, yielding mixed results. To complement and expand previous knowledge, we used multimodal magnetic resonance imaging (MRI) to investigate whether distinct anatomical patterns of the left occipito-temporal sulcus (OTS), which hosts the so-called \"visual word form area\" (VWFA), are predictive of reading skills and brain activity in typical adult readers. Overall, our findings indicate that: (1) the pattern of the left OTS is not predictive of participants' scores on reading fluency tests; (2) the pattern of the left OTS is not predictive of local brain activity during sentence-reading; (3) individual differences in the left OTS pattern are associated with the functional architecture of the left OTS as assessed by resting-state fMRI. In conclusion, while it is well-established that the acquisition of reading skills modifies brain structure and function, the predictive role of early neuroanatomical variants on reading skills and brain function in typical readers remains equivocal. Environmental and experience-related factors may have a greater and predominant role in accounting for ultimate reading abilities in healthy populations.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"55"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus. 衰老人类海马体中认知和生活方式相关的微观结构变异。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-23 DOI: 10.1007/s00429-025-02908-6

Tyler Agyekum, Cindy L García, Felix Fay, Olivier Parent, Aurélie Bussy, Gabriel A Devenyi, M Mallar Chakravarty

{"title":"Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus.","authors":"Tyler Agyekum, Cindy L García, Felix Fay, Olivier Parent, Aurélie Bussy, Gabriel A Devenyi, M Mallar Chakravarty","doi":"10.1007/s00429-025-02908-6","DOIUrl":"10.1007/s00429-025-02908-6","url":null,"abstract":"Age-related hippocampal alterations often accompany cognitive decline, a significant risk factor for dementias. Modifiable lifestyle factors may help preserve hippocampal neural tissue and slow neurodegeneration and potentially promote cognition in old age. Here, we sought to identify the relationship between lifestyle and cognition in the context of the hippocampal microstructure across the lifespan. We used data from 494 subjects (36-100 years old) without cognitive impairment from the Human Connectome Project-Ageing study. We estimated hippocampal microstructure using myelin-sensitive (T1w/T2w ratio), inflammation-sensitive (MD) and fibre-sensitive (FA) MRI markers. We identified microstructural-lifestyle/-cognition using non-negative matrix factorization to integrate MRI measures into a multivariate spatial signature of hippocampal microstructure covariance followed by partial least squares analysis. Our results reveal that the preservation of axon density and myelin in regions corresponding to subicular regions and CA1 to CA3 regions are negatively associated with age, and is associated with improved performance in executive function tasks, however, this is also associated with a decreased performance in memory tasks. We also show that microstructure is preserved across the hippocampus when there is normal hearing levels, physical fitness and insulin levels and this is negatively associated with age in the presence of cardiovascular risk factors like high body mass index, blood pressure, triglycerides and blood glucose that are in turn associated with hippocampal neurodegeneration. Taken together, our results suggest that lifestyle factors like normal hearing, physical fitness and normal insulin levels may help preserve hippocampal microstructure which may be useful in maintaining optimum performance on executive function tasks and potentially other modes of cognition.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"53"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced brain myelination and cognitive development in young children associated with milk fat globule membrane (MFGM) intake: a temporal cohort study. 与乳脂球膜（MFGM）摄入相关的幼儿脑髓鞘形成和认知发育增强：一项时间队列研究

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-19 DOI: 10.1007/s00429-025-02907-7

Sean C L Deoni, Jennifer Beauchemin, Viren D'Sa

{"title":"Enhanced brain myelination and cognitive development in young children associated with milk fat globule membrane (MFGM) intake: a temporal cohort study.","authors":"Sean C L Deoni, Jennifer Beauchemin, Viren D'Sa","doi":"10.1007/s00429-025-02907-7","DOIUrl":"10.1007/s00429-025-02907-7","url":null,"abstract":"Myelination is an important neurodevelopmental process that facilitates efficient brain messaging and connectivity, and contributes to the emergence and refinement of cognitive skills and abilities. Healthy maturation of the myelinated white matter requires coordinated delivery of key nutritional building blocks, including short and long-chain polyunsaturated fatty acids, phospholipids, and sphingolipids. While many of these nutrients are amply supplied by breastmilk, they may not be present in sufficient quantity in infant formula milk. Milk fat globule membrane (MFGM) is a rich source of phospholipids, including sphingomyelin and has been associated with improved cognitive development in infants and children when added to infant formula. To determine if added bovine MFGM is also associated with improved myelination, this study used myelin-sensitive MRI to compare myelination trends in healthy infants and toddlers, 0-2 years of age, who received the same branded infant formula with and without added bovine MFGM in two temporal cohorts: Without Added MFGM between 2010 and 2017; and With Added MFGM between 2018-2020. Concurrent with imaging, cognitive development was assessed using the Mullen Scales of Early Learning (MSEL). Matched for important demographic and socioeconomic characteristics, we found that children who received infant formula with added MFGM showed improved myelination in motor-related areas (motor cortices, internal capsule, and cerebellum) and improved MSEL gross and fine motor scores. No significant differences in verbal or overall cognitive ability scores were noted. These results support the importance of phospholipids, sphingolipids, and sphingomyelin in promoting brain myelination and cognitive development.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"52"},"PeriodicalIF":2.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0