Brain Structure & Function最新文献_第10页

Receptor architecture of the macaque lateral geniculate nucleus. 猕猴外侧膝状核的受体结构。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-19 DOI: 10.1007/s00429-026-03109-5

Marina Saito, Lucija Rapan, Meiqi Niu, Ling Zhao, Sei-Ichi Tsujimura, Hiromasa Takemura, Nicola Palomero-Gallagher

{"title":"Receptor architecture of the macaque lateral geniculate nucleus.","authors":"Marina Saito, Lucija Rapan, Meiqi Niu, Ling Zhao, Sei-Ichi Tsujimura, Hiromasa Takemura, Nicola Palomero-Gallagher","doi":"10.1007/s00429-026-03109-5","DOIUrl":"10.1007/s00429-026-03109-5","url":null,"abstract":"The lateral geniculate nucleus (LGN) is a key thalamic nucleus in the primate visual system that relays visual information from the retina to cortical visual areas. While functional and microanatomical characteristics of the LGN and its layers have been extensively studied, previous investigations on its receptor architecture have been restricted to a small subset of neurotransmitter receptors. To characterise the receptor architecture of the macaque LGN in greater detail, we analysed in vitro autoradiography data to quantify the density of 15 neurotransmitter receptors at the sublayer level, thus improving our understanding of the molecular architecture supporting primate visual function. For comparison, we also determined the densities of these receptors in the primary visual cortex (V1) at a laminar level. Though comparable in shape, the receptor fingeprints of magnocellular layers were larger than those of parvocellular layers. In contrast, receptor fingerprints of cytoarchitectonic layers in V1 differed in both shape and size. Ionotropic/metabotropic and excitatory/inhibitory receptor ratios were significantly larger in V1 than in the LGN, suggesting a greater prominence of inhibitory neurotransmission in the latter region. The nicotinic α4β2 receptor was the only receptor type with a higher density in the LGN compared to V1, highlighting the particular importance of acetylcholine in the modulation of visual stimuli. These findings provide insights into the receptor architecture underlying functions of the LGN, with implications for mechanisms such as visual signal encoding and surround suppression.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuroanatomy and connectivity of the ventral striatum and ventral capsule area in the Göttingen minipig. Göttingen迷你猪腹侧纹状体和腹侧囊区的神经解剖学和连通性。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-14 DOI: 10.1007/s00429-026-03115-7

Anna Sofie R B Poulsen, Hamed Zaer, Bjarke Søgaard, Andreas N Glud, Jens Christian H Sørensen, Dariusz Orlowski

{"title":"The neuroanatomy and connectivity of the ventral striatum and ventral capsule area in the Göttingen minipig.","authors":"Anna Sofie R B Poulsen, Hamed Zaer, Bjarke Søgaard, Andreas N Glud, Jens Christian H Sørensen, Dariusz Orlowski","doi":"10.1007/s00429-026-03115-7","DOIUrl":"10.1007/s00429-026-03115-7","url":null,"abstract":"A considerable proportion of patients with major depressive disorder (MDD) do not respond to current treatments. Deep brain stimulation has shown promise as an intervention but has yielded inconsistent outcomes, potentially due to the complex biopsychosocial nature of MDD and the lack of standardized large animal models. The ventral striatum/ventral capsule brain area (VS/VC), involved in emotional and behavioral regulation, is a proposed DBS target. The Göttingen minipig (GM) is an emerging non-primate large animal model; however, the anatomy and connectivity of the GM VS/VC remain poorly characterized. To characterize the neuroanatomy and connectivity of the GM VS/VC region, we have used four female minipigs, which underwent MRI-guided stereotaxic unilateral injection of retrograde (FluoroGold) and anterograde (Biotinylated Dextran Amine) tracers into the VS/VC. Postmortem brains were coronally cryosectioned into 40 µm-thick sections, Nissl-stained, and analyzed for tracer distribution. Additional non-injected GM brains were immunostained using antibodies against calbindin, substance P, myelin basic protein, DARPP-32, tyrosine hydroxylase, and choline acetyltransferase to describe cytoarchitecture. The GM VS/VC exhibited bidirectional connectivity with limbic, associative, and sensorimotor regions, paralleling human nigrostriatal and mesolimbic circuits. The cytoarchitecture, particularly of the nucleus accumbens, is similar to that of primates, including the human brain. The GM VS/VC demonstrates anatomical and connectivity features similar to those found in humans and rodents, supporting its translational potential for modeling neuropsychiatric conditions and testing interventions such as DBS.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in neural stress responses over psychosocial stress exposure. 神经应激反应在社会心理应激暴露中的性别差异。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-14 DOI: 10.1007/s00429-026-03121-9

Daifeng Dong, Chuting Li, Chang Cheng, Xiaoqiang Sun, Ge Xiong, Shuqiao Yao, Xiaocui Zhang, Xiang Wang

{"title":"Sex differences in neural stress responses over psychosocial stress exposure.","authors":"Daifeng Dong, Chuting Li, Chang Cheng, Xiaoqiang Sun, Ge Xiong, Shuqiao Yao, Xiaocui Zhang, Xiang Wang","doi":"10.1007/s00429-026-03121-9","DOIUrl":"10.1007/s00429-026-03121-9","url":null,"abstract":"Sex differences in stress-induced biobehavioral response and the sex-dependent effects of psychosocial stress on the vulnerability of stress-related psychiatric disorders have been well-acknowledged; however, sex differences in neural stress reactivity have not been sufficiently evaluated. The Montreal Imaging Stress Task was administered to 234 healthy controls (105 males, 129 females) during functional magnetic resonance imaging scanning to detect the effects of psychosocial stress on neural responses. Voxel-wise repeated-measures analysis of variance with stress exposure time as a within-subject variable was performed to detect sex differences in overall brain activation/functional connectivity and in dynamical neural changes during stress exposure when processing psychosocial stress. The males exhibited higher neural stress responses in the insula, inferior parietal lobule, dorsolateral prefrontal cortex, medial prefrontal cortex, and precuneus, and a stronger increase (stress vs. control) in the anti-correlation between amygdala/nucleus accumbens /hippocampus and cortex compared to the females. Additionally, the females exhibited increased deactivation (stress vs. control) in the amygdala, striatum, and medial orbitofrontal cortex (mOFC) during stress exposure, whereas the males did not show this neural dynamic pattern in these brain regions during stress exposure. Our findings highlight sex differences in neural stress responses, particularly in overall brain activation across several key regions involved in core brain networks, and in dynamic changes in limbic/striatal/mOFC regions during stress exposure.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons. 人类前额内侧被盖核和相关中脑抑制核调节多巴胺神经元的定位和定位。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-13 DOI: 10.1007/s00429-026-03103-x

Anastasia Filimontseva, YuHong Fu, Glenda M Halliday

{"title":"Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons.","authors":"Anastasia Filimontseva, YuHong Fu, Glenda M Halliday","doi":"10.1007/s00429-026-03103-x","DOIUrl":"10.1007/s00429-026-03103-x","url":null,"abstract":"Animal experiments reveal distinct GABAergic cell clusters within the dopaminergic midbrain regions in the rostromedial tegmental nucleus (RMTg) and retrorubral fields (RRF) that have yet to be clearly defined in humans. These neurons send prominent inhibitory projections to dopaminergic neurons in the substantia nigra and ventral tegmental area that impact motor, reward and threat processing. We have identified GABAergic RMTg and RRF cell clusters in 6 μm formalin-fixed paraffin-embedded transverse human midbrain sections from ten control cases obtained from the Sydney Brain Bank using immunohistochemistry for GABA and tyrosine hydroxylase. We determined the location and cell size of RMTg and RRF GABAergic neurons, further mapping these cell clusters in transverse 50 μm thick cresyl violet stained serial midbrain sections (every 750 μm) from previously published controls (Halliday et al. 1990). GABAergic neurons were cytoarchitecturally distinct, with the largest GABAergic neurons in the RRF, followed by RMTg neurons which were larger than GABAergic neurons in the well-defined interpedunclular nucleus (Kruskal-Wallis test, p < 0.0001). RMTg and RRF GABAergic neurons first appear in caudal transverse midbrain sections approximately 38 mm above the obex. RMTg moves rostrally and medially from underneath the decussation of the superior cerebellar peduncle to just lateral to the interpeduncular nucleus. The RRF cluster also moves rostrally and medially to the parabrachial pigmented nucleus (PBP) just under the red nucleus. The GABAergic neurons in RMTg and RRF/PBP that modulate dopamine neuronal excitability have distinct morphologies in humans. Identifying these inhibitory neurons is key to evaluating their role in neurodegenerative diseases.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal connectivity of the mouse mesocortical ring and functional implications. 小鼠中皮层环的内部连通性及其功能意义。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-08 DOI: 10.1007/s00429-026-03110-y

Luis Puelles, Elena Garcia-Calero

{"title":"Internal connectivity of the mouse mesocortical ring and functional implications.","authors":"Luis Puelles, Elena Garcia-Calero","doi":"10.1007/s00429-026-03110-y","DOIUrl":"10.1007/s00429-026-03110-y","url":null,"abstract":"The mammalian mesocortex (MCx) was redefined recently as a complete ring intercalated between the allo- and iso-cortex, attending to the consistent expression of 46 selective gene markers. The MCx exhibits various other characteristics such as low myelin content of its fibers, a property directly related to its function and susceptibility to degenerative disorders. Irrespective of its shared molecular profile, the MCx ring differentiates into different sectors with singular molecular and cytoarchitectonic characteristics, such as the posterior orbitary cortex, the cingulate cortex, and the insula. In the present study, using anterograde connectivity experiments published in an Allen Institute for Brain Science public database ( https://brain-map.org/our-research/connectivity ), we analyzed the internal connectivity of the mesocortical ring. We observed that its different sectors are multiply interconnected, possibly achieving integrative functions. The medial posterior orbitary cortex stands out; it appears to play a higher hierarchical role within the MCx ring by sending and receiving projections from all mesocortical sectors.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing neuronal cell bodies in white matter tracts of the human brain. 表征人脑白质束中的神经元细胞体。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-05 DOI: 10.1007/s00429-026-03112-w

Drew VanderBerg, Kelly Perlman, Maria Antonietta Davoli, Gustavo Turecki, Naguib Mechawar

{"title":"Characterizing neuronal cell bodies in white matter tracts of the human brain.","authors":"Drew VanderBerg, Kelly Perlman, Maria Antonietta Davoli, Gustavo Turecki, Naguib Mechawar","doi":"10.1007/s00429-026-03112-w","DOIUrl":"10.1007/s00429-026-03112-w","url":null,"abstract":"Until the discovery of white matter neurons (WMN) in the 19th century, white matter (WM) was considered to be completely devoid of neuronal cell bodies. Despite evidence consistently showing neuronal soma within cortical WM and their purported implication in neuropsychiatric disorders, these neurons are understudied and have not been characterized in human long-range WM tracts. Using postmortem human brain tissue, we investigated the presence, densities and proportions of excitatory/inhibitory neurons in the uncinate fasciculus (UF) and corpus callosum (CC). We also investigated the ventromedial prefrontal cortex (vmPFC) to validate our methods by comparing our results with previously reported densities of neurons in cortical WM. To identify WMN, we employed fluorescence in situ hybridization with excitatory (SLC17A7) and inhibitory (GAD1) neuronal markers and subsequently validated these neurons at the protein level with NeuN immunohistochemistry. We found that the density of WMN in the vmPFC corresponded with previous independent estimates. The UF displayed a similar, though slightly lower density of WMN compared to the vmPFC, while the CC had a far lower density of WMN than both of these regions. Due to the higher-than-expected density of WMN in the UF, we validated the findings at a second location along the UF temporal segment and confirmed the presence of substantial numbers of WMN in this tract. This research constitutes the first ever validated observation of WMN in human long-range WM tracts, laying the foundation for future research on the phenotype and function of these neurons, and how they may be affected in brain disorders.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direction selectivity in naturalistic action observation: distributed representations across the action observation network. 自然行为观察中的方向选择性：跨行为观察网络的分布式表示。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-05 DOI: 10.1007/s00429-026-03111-x

Zelal Eltaş, Murat B Tunca, Burcu A Urgen

{"title":"Direction selectivity in naturalistic action observation: distributed representations across the action observation network.","authors":"Zelal Eltaş, Murat B Tunca, Burcu A Urgen","doi":"10.1007/s00429-026-03111-x","DOIUrl":"10.1007/s00429-026-03111-x","url":null,"abstract":"Perceiving the direction of observed actions is critical for interpreting intentions and understanding everyday actions. While direction selectivity has been extensively studied with simple stimuli such as dots, gratings, or point-light displays (PLDs), little is known about how the brain encodes direction in naturalistic, repetitive actions that are seen frequently in daily life. The present fMRI study investigated direction-selective representations during observation of complex actions performed along three bidirectional dimensions (left-right, up-down, front-back) within a 96-video stimulus set. The brain activity was analyzed using multivariate pattern analysis (MVPA) and multiple regression representational similarity analysis (RSA). MVPA revealed above-chance classification of action direction across occipital, parietal, and motor cortices, with the highest decoding in occipital, primary motor, and somatosensory regions. Crucially, RSA demonstrated that when accounting for low-level and motor features, direction information was still represented in early visual cortex, occipito-temporal areas, parietal regions, and motor-related regions. These findings indicate that action direction is represented across multiple levels of the action observation network (AON), extending from early sensory regions to higher-order parietal and frontal cortices. By using naturalistic, repetitive action videos, this study provides new evidence that the coding of action direction in the human brain is broadly distributed, reflecting the complexity of perceiving actions in everyday life. These findings suggest that direction selectivity is a core feature of the action observation network, linking basic motion processing with higher-level action understanding.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective alterations in CA1 spine morphology following dietary fructose intake. 膳食果糖摄入后CA1脊柱形态的选择性改变。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-05 DOI: 10.1007/s00429-026-03102-y

Mátyás Kapiller, G Mark Marcello, Diána Hazai, Emese Andrásovszky, Péter Sótonyi, József Szabó, Bence Rácz

{"title":"Selective alterations in CA1 spine morphology following dietary fructose intake.","authors":"Mátyás Kapiller, G Mark Marcello, Diána Hazai, Emese Andrásovszky, Péter Sótonyi, József Szabó, Bence Rácz","doi":"10.1007/s00429-026-03102-y","DOIUrl":"10.1007/s00429-026-03102-y","url":null,"abstract":"High fructose intake has been linked to metabolic and cognitive disturbances, yet its effects on hippocampal synaptic architecture remain unclear. We examined whether four weeks of fructose feeding alter metabolic parameters or CA1 synaptic ultrastructure in adult rats maintained on isocaloric AIN-93G diets containing fructose, glucose, or starch as the primary carbohydrate source. Serum biochemical and hormonal profiles showed only modest, diet-specific differences without major metabolic disruption. Quantitative electron microscopy revealed similar dendritic spine density, postsynaptic density length, perforated synapse frequency, and multisynaptic bouton density across groups, whereas fructose-fed rats displayed a small but significant reduction in spine area and an alteration in circularity. These localized geometric changes occurred without broader synaptic remodeling. Overall, our findings indicate that short-term fructose exposure under metabolically controlled, solid-diet conditions produces minimal metabolic and ultrastructural effects, in contrast to the pronounced disturbances reported in metabolically stressful paradigms, suggesting that structural consequences of fructose depend strongly on dietary context and metabolic load.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter fibers mediate the relationship between workload, resource use, and burnout: a new attempt to apply the conservation of resources theory to neuroscience. 白质纤维介导工作负荷、资源使用和倦怠之间的关系：将资源保护理论应用于神经科学的新尝试。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2026-05-05 DOI: 10.1007/s00429-026-03099-4

Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa

{"title":"White matter fibers mediate the relationship between workload, resource use, and burnout: a new attempt to apply the conservation of resources theory to neuroscience.","authors":"Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa","doi":"10.1007/s00429-026-03099-4","DOIUrl":"10.1007/s00429-026-03099-4","url":null,"abstract":"As global competition intensifies, work-related stress and burnout have become increasingly prevalent, yet their neural correlates remain poorly understood. Drawing on the Conservation of Resources (COR) theory as a conceptual framework, this study examined whether white-matter integrity in executive-function-related brain tracts statistically mediates the associations between workload, resource use, and burnout. Using cross-sectional diffusion MRI data from 188 healthy adults in Japan, we focused on fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF), internal capsule (IC), and external capsule (EC), which have been consistently linked to executive functioning. Correlation and mediation analyses revealed that higher workload was negatively associated with FA in the SLF, IC, and EC, whereas FA in these tracts was negatively associated with cynicism, a core dimension of burnout. Resource use was positively associated with FA in the SLF. Mediation analyses further indicated that FA in the SLF, IC, and EC partially mediated the association between workload and cynicism, and that FA in the SLF fully mediated the association between resource use and cynicism. No comparable mediation effects were observed for exhaustion or professional efficacy. These findings should be interpreted as associative rather than causal. FA is not conceptualized as a resource itself, but as a neural correlate of executive-function capacity that covaries with psychological resource dynamics. By integrating a well-established stress-behavior framework with structural neuroimaging, this study provides an initial interdisciplinary perspective on how work-related demands, resource utilization, and burnout-related attitudes align with individual differences in white-matter integrity.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotive language activates right temporoparietal junction, while referential language activates the left hemispheric network. 情感语言激活右侧颞顶叶网络，而指称语言激活左侧半球网络。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-05-05 DOI: 10.1007/s00429-026-03122-8

Qiong Ma, Michiru Makuuchi

{"title":"Emotive language activates right temporoparietal junction, while referential language activates the left hemispheric network.","authors":"Qiong Ma, Michiru Makuuchi","doi":"10.1007/s00429-026-03122-8","DOIUrl":"10.1007/s00429-026-03122-8","url":null,"abstract":"Language has referential and emotive uses. Referential language depicts events and can be verified or falsified by comparison with the event, whereas emotive language lacks the events upon which one can determine the truth value of the sentence. Using functional magnetic resonance imaging (fMRI), we investigated the brain mechanisms of the processing of the two semantically distinct forms of language in a paradigm of empathy for pain conveyed through single short sentences. In the emotive condition, subjective expressions of pain, such as \"I have a toothache\", were used. In the referential condition, an objective description of events in which an individual would experience pain, such as \"I cut my finger\", were presented. Assuming each stimulus elicits activation proportional to pain intensity ratings, we combined referential and emotive conditions and performed an analysis with a parametric modulation model. It revealed activation in the anterior cingulate cortex and, slightly below the threshold, the anterior insula, that are involved in the perception of one's own pain. Without pooling the two conditions, only the referential condition yielded activation in the two regions. Crucially, although both emotive and referential language activated multiple regions, emotive sentences activated the right temporoparietal junction, whereas referential sentences activated the precuneus/retrosplenial cortex, parahippocampal cortex, and the language network in the left hemisphere. These results suggest that a complementary interhemispheric network supports the processing of both types of language.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0