Brain Structure & Function最新文献

{"title":"Physiological fingerprinting of audiovisual warnings in assisted driving conditions: an investigation of fMRI and peripheral physiological indicators.","authors":"Ying Li, Halim Ibrahim Baqapuri, Micha Keller, Stefan Wolter, Chi Zhang, Fengyu Cong, Klaus Mathiak","doi":"10.1007/s00429-025-02891-y","DOIUrl":"10.1007/s00429-025-02891-y","url":null,"abstract":"<p><p>Physiological responses derived from audiovisual perception during assisted driving are associated with the regulation of the autonomic nervous system (ANS), especially in emergencies. However, the interaction of event-related brain activity and the ANS regulating peripheral physiological indicators (i.e., heart rate variability (HRV) and respiratory rate) is unknown, making it difficult to study the neural mechanism during takeover from the assistance system. In this paper, we established a mapping between the ANS regulation and brain activations of driving events in function magnetic resonance imaging (fMRI)-conditioned audiovisual warnings experiment to add physiological fingerprints for assisted driving. Firstly, we used the general linear model (GLM) to obtain brain activation clusters of driving events and brain activation clusters of peripheral physiological indicators in different frequency bands. Secondly, we redefined the input parameters based on the driving events to calculate the GLM to obtain the brain activation clusters of event-related physiological indicators. Finally, the relationship between the main activation clusters of driving events and the activation of event-related physiological indicators was quantified by the statistical test of the mean-time course of voxels within the region. The results showed that related areas of the brain responsible for movement, visceral autonomic regulation, auditory, and vision actively responded to the audiovisual warnings of automatic driving. The mappings created using them revealed that the correlation between driving event-related activation of brain regions and respiration worked at the onset of audiovisual warnings, especially between the intermediate (IM) and low frequency (LF) bands. For pre-emergency and takeover in audiovisual warnings, the correlations of HRV were dominant, with significant differences among LF, IM and high frequency (HF) bands. At different periods of audiovisual warnings, HRV and respiration play different roles in physiological fingerprints. Compared to respiratory indicators, HRV has higher sensitivity to emergency situations. This study investigates the interaction between driving-related network activity and ANS regulation, revealing the profound connection between driving behavior and neural activity, and contributing to the research of driving assistance systems.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 2","pages":"31"},"PeriodicalIF":2.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal forebrain innervation of the amygdala: an anatomical and computational exploration.","authors":"Tuğçe Tuna, Tyler Banks, Gregory Glickert, Cem Sevinc, Satish S Nair, Gunes Unal","doi":"10.1007/s00429-024-02886-1","DOIUrl":"10.1007/s00429-024-02886-1","url":null,"abstract":"<p><p>Theta oscillations of the mammalian amygdala are associated with processing, encoding and retrieval of aversive memories. In the hippocampus, the power of the network theta oscillation is modulated by basal forebrain (BF) GABAergic projections. Here, we combine anatomical and computational approaches to investigate if similar BF projections to the amygdaloid complex provide an analogous modulation of local network activity. We used retrograde tracing with fluorescent immunohistochemistry to identify cholinergic and non-cholinergic parvalbumin- or calbindin-immunoreactive BF neuronal subgroups targeting the input (lateral and basolateral nuclei) and output (central nucleus and the central bed nucleus of the stria terminalis) regions of the amygdaloid complex. We observed a dense non-cholinergic, putative GABAergic projection from the ventral pallidum (VP) and the substantia innominata (SI) to the basolateral amygdala (BLA). The VP/SI axonal projections to the BLA were confirmed using viral anterograde tracing and transsynaptic labeling. We tested the potential function of this VP/SI-BLA pathway in a 1000-cell biophysically realistic network model, which incorporated principal neurons and three major interneuron groups of the BLA, together with extrinsic glutamatergic, cholinergic, and VP/SI GABAergic inputs. We observed in silico that theta-modulation of VP/SI GABAergic projections enhanced theta oscillations in the BLA via their selective innervation of the parvalbumin-expressing local interneurons. Ablation of parvalbumin-, but not somatostatin- or calretinin-expressing, interneurons reduced theta power in the BLA model. These results suggest that long-range BF GABAergic projections may modulate network activity at their target regions through the formation of a common interneuron-type and oscillatory phase-specific disinhibitory motif.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"30"},"PeriodicalIF":2.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early childhood stress and amygdala structure in children and adolescents with neurodevelopmental disorders.","authors":"Elizabeth Kuenzel, Sarah Al-Saoud, Michelle Fang, Emma G Duerden","doi":"10.1007/s00429-025-02890-z","DOIUrl":"10.1007/s00429-025-02890-z","url":null,"abstract":"<p><p>Children and adolescents with neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) may be more susceptible to early life stress compared to their neurotypical peers. This increased susceptibility may be linked to regionally-specific changes in the striatum and amygdala, brain regions sensitive to stress and critical for shaping maladaptive behavioural responses. This study examined early life stress and its impact on striatal and amygdala development in 62 children and adolescents (35 males, mean age = 10.12 years, SD = 3.6) with ASD (n = 14), ADHD (n = 28), or typical development (TD, n = 20) across two cohorts. We assessed stress from various sources, including from the family environment, loss of loved ones, social stress, and illness/injury. We further examined parenting styles as potential moderators of the effects of early life stress. Volumes of the striatum and amygdala were extracted using an automatic segmentation algorithm. Significant group differences in childhood stress exposure were observed (F = 3.29, df = 8, p = 0.002), with autistic children facing more early life stressors (social stress, illness/injury) compared to those with ADHD and neurotypical peers (both, p < 0.002). In autistic children, amygdala volumes were significantly associated with early life stress related to the familial environment, experiences of significant loss, and illness/injury (all, p < 0.03). Positive parenting moderated these effects. These findings suggest that autistic children are more likely to experience early life stress and exhibit region-specific changes in the amygdala, a key brain region implicated in emotional processing and stress responses. This underscores the need for targeted interventions to support autistic children in managing early life stress to potentially mitigate its impact on brain development.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"29"},"PeriodicalIF":2.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of auditory comprehension and integration of sanskrit verse: a functional MRI study.","authors":"Uttam Kumar, Himanshu Raj Pandey, Kalpana Dhanik, Prakash Padakannaya","doi":"10.1007/s00429-025-02892-x","DOIUrl":"10.1007/s00429-025-02892-x","url":null,"abstract":"<p><p>In this investigation, we delve into the neural underpinnings of auditory processing of Sanskrit verse comprehension, an area not previously explored by neuroscientific research. Our study examines a diverse group of 44 bilingual individuals, including both proficient and non-proficient Sanskrit speakers, to uncover the intricate neural patterns involved in processing verses of this ancient language. Employing an integrated neuroimaging approach that combines functional connectivity-multivariate pattern analysis (fc-MVPA), voxel-based univariate analysis, seed-based connectivity analysis, and the use of sparse fMRI techniques to minimize the interference of scanner noise, we highlight the brain's adaptability and ability to integrate multiple types of information. Our findings from fc-MVPA reveal distinct connectivity patterns in proficient Sanskrit speakers, particularly involving the bilateral inferior temporal, left middle temporal, bilateral orbitofrontal, and bilateral occipital pole. Voxel-based univariate analysis showed significant activation in the right middle frontal gyrus, bilateral caudate nuclei, bilateral middle occipital gyri, left lingual gyrus, bilateral inferior parietal lobules, and bilateral inferior frontal gyri. Seed-based connectivity analysis further emphasizes the interconnected nature of the neural networks involved in language processing, demonstrating how these regions collaborate to support complex linguistic tasks. This research reveals how the brain processes the complex syntactic and semantic elements of Sanskrit verse. Findings indicate that proficient speakers effectively navigate intricate syntactic structures and semantic associations, engaging multiple brain regions in coordination. By examining the cognitive mechanisms underlying Sanskrit verse comprehension, which shares rhythmic and structural features with music and poetry, this study highlights the neural connections between language, culture, and cognition.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"28"},"PeriodicalIF":2.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternally activated connections of the ventral lateral septum reveal input from the posterior intralaminar thalamus.","authors":"Gina Puska, Vivien Szendi, Máté Egyed, Diána Dimén, Melinda Cservenák, Árpád Dobolyi","doi":"10.1007/s00429-024-02870-9","DOIUrl":"10.1007/s00429-024-02870-9","url":null,"abstract":"<p><p>The lateral septum (LS) demonstrates activation in response to pup exposure in mothers, and its lesions eliminate maternal behaviors suggesting it is part of the maternal brain circuitry. This study shows that the density of pup-activated neurons in the ventral subdivision of the LS (LSv) is nearly equivalent to that in the medial preoptic area (MPOA), the major regulatory site of maternal behavior in rat dams. However, when somatosensory inputs including suckling were not allowed, pup-activation was markedly reduced in the LSv. Retrograde tract tracing identified various brain regions potentially influencing LSv neuronal activation through their projections. Among all, anterograde tract tracing confirmed that the posterior intralaminar thalamic nucleus (PIL), implicated in processing touch-related stimuli, targets the pup-activated region of the LSv. Moreover, nerve terminals containing the maternally induced PIL neuropeptide parathyroid hormone 2 (PTH2), were found to form synaptic connections with c-Fos activated LSv neurons using electron microscopy. Confirmation of PTH2 + PIL fibers projecting to LSv was achieved by retrograde tract tracing methods. Furthermore, double retrograde injections revealed that neurons within the PIL can project to both LSv and MPOA, suggesting their simultaneous regulation by PIL input. We also established that septal neurons activated by the pups in the mother are GABAergic and send inhibitory projections to the MPOA and other components of the maternal brain circuitry. This implies that the LSv and MPOA form an interconnected subcircuit in the maternal brain network, which is primarily driven by somatosensory input from the pups via the PIL PTH2 + neurons.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"27"},"PeriodicalIF":2.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there something sexual in the ventral midline thalamus?","authors":"Jean-Christophe Cassel, Elodie Panzer, Isabella Guimaraes-Olmo, Brigitte Cosquer, Anne Pereira de Vasconcelos, Aline Stephan","doi":"10.1007/s00429-024-02869-2","DOIUrl":"10.1007/s00429-024-02869-2","url":null,"abstract":"<p><p>This mini-review explores sexual dimorphism in the ventral midline thalamus, focusing on the reuniens nucleus and its role in behavioral functions. Traditionally linked to tasks such as working memory, cognitive flexibility, fear generalization, and memory consolidation, most studies have been conducted in male rodents. Research comparing the effects of ventral midline thalamus manipulations between female and male rodents is limited. Emerging evidence suggests sex-specific differences, particularly in response to stress, pharmacological manipulations, and memory processes. Studies reveal distinct c-Fos expression patterns in the reuniens nucleus between females and males, especially under stress, with females often showing different neural activation. Additionally, females exhibit different recruitment of the reuniens nucleus in object recognition tasks, indicating possible sex-dependent cognitive strategies. While evidence suggests functional differences between sexes in the reuniens nucleus, current data are limited. Further research is needed to understand how sex influences brain function and cognition, particularly in the ventral midline thalamus, which is crucial for various cognitive processes.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"26"},"PeriodicalIF":2.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.","authors":"Pauline Ali, Mickaël Dinomais, Matthieu Labriffe, Frederico Pieruccini-Faria, Manuel Montero-Odasso, Robert Bartha, Cédric Annweiler","doi":"10.1007/s00429-024-02873-6","DOIUrl":"10.1007/s00429-024-02873-6","url":null,"abstract":"<p><p>The dual task cost of gait (DTC) is an accessible and cost-effective test that can help identify individuals with cognitive decline and dementia. However, its neural substrate has not been widely described. This study aims to investigate the neural substrate of the high DTC in older adults across the spectrum of cognitive decline. A total of 336 individuals from the GAIT study cohort were analyzed, including cognitively healthy (N = 122, 71 ± 3.6 years), those with mild cognitive impairment (N = 168, 71 ± 5.3 years), and those with dementia (N = 46, 80 ± 5.7 years). A DTC of 20% or greater was considered to indicate a high level of slowing down while performing successively two verbal tasks (counting backwards task by ones and naming animals). Voxel-based morphometry was employed to investigate differences in gray matter volume (GMV) between groups, which were dichotomized according to the DTC. A high DTC in the whole population (N = 336) was associated with a smaller GMV in the bilateral temporal lobe across both dual-task conditions. A moderation analysis was employed to compare the neural substrate between cognitive status groups. This revealed that the dementia group exhibited an additional cluster located in the left precentral gyrus with GMV loss associated with a high naming animals DTC, in contrast to the other cognitive groups. These results provide new evidence on why dual-task gait capabilities deteriorate in normal and pathological cognitive aging. A more precise understanding of the neural substrate associated with high DTC and cognitive status would help elucidate its use in clinical and research settings.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"25"},"PeriodicalIF":2.7,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance.","authors":"David J Madden, Jenna L Merenstein, Hollie A Mullin, Shivangi Jain, Marc D Rudolph, Jessica R Cohen","doi":"10.1007/s00429-024-02887-0","DOIUrl":"10.1007/s00429-024-02887-0","url":null,"abstract":"","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"23"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the fMRI analysis of the default mode network: a review.","authors":"Emilio Sanz-Morales, Helena Melero","doi":"10.1007/s00429-024-02888-z","DOIUrl":"10.1007/s00429-024-02888-z","url":null,"abstract":"<p><p>The default mode network (DMN) is a singular pattern of synchronization between brain regions, usually observed using resting-state functional magnetic resonance imaging (rs-fMRI) and functional connectivity analyses. In comparison to other brain networks that are primarily involved in attentional-demanding tasks (such as the frontoparietal network), the DMN is linked with self-referential activities, and alterations in its pattern of connectivity have been related to a wide range of disorders. Structural connectivity analyses have highlighted the vital role of the posterior cingulate cortex and the precuneus as integrative hubs, and advanced parcellation methods have further contributed to elucidate the DMN's regions, enriching its explanatory potential across cognitive functions and dysfunctions. Interestingly, the study of its temporal characteristics - the specific frequency spectrum of BOLD signal oscillations -, its developmental trajectory over the course of life, and its interaction with other networks, provides new insight into the DMN's defining features. In this context, this review aims to synthesize the state of the art in the study of the DMN to provide the most updated findings to anyone interested in its research. Finally, some weaknesses in the current state of knowledge and some interesting lines of work for further progress in the study of the DMN are presented.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"22"},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tribute to Laszlo Zaborszky: pioneering discoveries in the basal forebrain and inspiring generations of neuroscientists.","authors":"Erika Gyengesi","doi":"10.1007/s00429-024-02881-6","DOIUrl":"10.1007/s00429-024-02881-6","url":null,"abstract":"<p><p>This editorial celebrates the 80th birthday of Distinguished Professor Laszlo Zaborszky, co-founder of Brain Structure and Function, and reflects on his monumental contributions to neuroscience, particularly his pioneering work on the cholinergic basal forebrain. Professor Zaborszky's research has reshaped our understanding of this brain region's organization and function, uncovering its critical role in cognitive processes such as learning, memory, and attention. His findings have challenged longstanding assumptions, demonstrating that the cholinergic projections to the cortex are highly organized, with implications for neurodegenerative diseases like Alzheimer's. Beyond his scientific achievements, Professor Zaborszky has made lasting contributions through his mentorship, shaping the careers of many neuroscientists, including the author. This editorial pays tribute to his remarkable legacy, both as a researcher and mentor and highlights his enduring impact on the field of neuroscience.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 1","pages":"21"},"PeriodicalIF":2.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}