Brain Structure & Function最新文献_第9页

Integrating brain function and structure in the study of the human attentional networks: a functionnectome study. 在人类注意力网络研究中整合大脑功能和结构：功能组研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-09-01 Epub Date: 2024-07-06 DOI: 10.1007/s00429-024-02824-1

Mar Martín-Signes, Pedro M Paz-Alonso, Michel Thiebaut de Schotten, Ana B Chica

{"title":"Integrating brain function and structure in the study of the human attentional networks: a functionnectome study.","authors":"Mar Martín-Signes, Pedro M Paz-Alonso, Michel Thiebaut de Schotten, Ana B Chica","doi":"10.1007/s00429-024-02824-1","DOIUrl":"10.1007/s00429-024-02824-1","url":null,"abstract":"Attention is a heterogeneous function theoretically divided into different systems. While functional magnetic resonance imaging (fMRI) has extensively characterized their functioning, the role of white matter in cognitive function has gained recent interest due to diffusion-weighted imaging advancements. However, most evidence relies on correlations between white matter properties and behavioral or cognitive measures. This study used a new method that combines the signal from distant voxels of fMRI images using the probability of structural connection given by high-resolution normative tractography. We analyzed three fMRI datasets with a visual perceptual task and three attentional manipulations: phasic alerting, spatial orienting, and executive attention. The phasic alerting network engaged temporal areas and their communication with frontal and parietal regions, with left hemisphere dominance. The orienting network involved bilateral fronto-parietal and midline regions communicating by association tracts and interhemispheric fibers. The executive attention network engaged a broad set of brain regions and white matter tracts connecting them, with a particular involvement of frontal areas and their connections with the rest of the brain. These results partially confirm and extend previous knowledge on the neural substrates of the attentional system, offering a more comprehensive understanding through the integration of structure and function.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1665-1679"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17. 恒河猴新皮层灰质层和表层白质的蛋白质组特征：前额叶区 46 和枕叶区 17 的比较。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-09-01 Epub Date: 2024-06-28 DOI: 10.1007/s00429-024-02819-y

Paola B Castro-Mendoza, Christina M Weaver, Wayne Chang, Maria Medalla, Kathleen S Rockland, Lisa Lowery, Elizabeth McDonough, Merina Varghese, Patrick R Hof, Dan E Meyer, Jennifer I Luebke

{"title":"Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17.","authors":"Paola B Castro-Mendoza, Christina M Weaver, Wayne Chang, Maria Medalla, Kathleen S Rockland, Lisa Lowery, Elizabeth McDonough, Merina Varghese, Patrick R Hof, Dan E Meyer, Jennifer I Luebke","doi":"10.1007/s00429-024-02819-y","DOIUrl":"10.1007/s00429-024-02819-y","url":null,"abstract":"In this novel large-scale multiplexed immunofluorescence study we comprehensively characterized and compared layer-specific proteomic features within regions of interest of the widely divergent dorsolateral prefrontal cortex (A46) and primary visual cortex (A17) of adult rhesus monkeys. Twenty-eight markers were imaged in rounds of sequential staining, and their spatial distribution precisely quantified within gray matter layers and superficial white matter. Cells were classified as neurons, astrocytes, oligodendrocytes, microglia, or endothelial cells. The distribution of fibers and blood vessels were assessed by quantification of staining intensity across regions of interest. This method revealed multivariate similarities and differences between layers and areas. Protein expression in neurons was the strongest determinant of both laminar and regional differences, whereas protein expression in glia was more important for intra-areal laminar distinctions. Among specific results, we observed a lower glia-to-neuron ratio in A17 than in A46 and the pan-neuronal markers HuD and NeuN were differentially distributed in both brain areas with a lower intensity of NeuN in layers 4 and 5 of A17 compared to A46 and other A17 layers. Astrocytes and oligodendrocytes exhibited distinct marker-specific laminar distributions that differed between regions; notably, there was a high proportion of ALDH1L1-expressing astrocytes and of oligodendrocyte markers in layer 4 of A17. The many nuanced differences in protein expression between layers and regions observed here highlight the need for direct assessment of proteins, in addition to RNA expression, and set the stage for future protein-focused studies of these and other brain regions in normal and pathological conditions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1495-1525"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From emotional arousal to executive action. Role of the prefrontal cortex 从情绪唤醒到执行行动。前额皮质的作用

IF 3.1 3区医学

Brain Structure & Function Pub Date : 2024-08-03 DOI: 10.1007/s00429-024-02837-w

Stefan M. Brudzynski, Jeffrey S. Burgdorf, Joseph R. Moskal

{"title":"From emotional arousal to executive action. Role of the prefrontal cortex","authors":"Stefan M. Brudzynski, Jeffrey S. Burgdorf, Joseph R. Moskal","doi":"10.1007/s00429-024-02837-w","DOIUrl":"https://doi.org/10.1007/s00429-024-02837-w","url":null,"abstract":"Emotional arousal is caused by the activity of two parallel ascending systems targeting mostly the subcortical limbic regions and the prefrontal cortex. The aversive, negative arousal system is initiated by the activity of the mesolimbic cholinergic system and the hedonic, appetitive, arousal is initiated by the activity of the mesolimbic dopaminergic system. Both ascending projections have a diffused nature and arise from the rostral, tegmental part of the brain reticular activating system. The mesolimbic cholinergic system originates in the laterodorsal tegmental nucleus and the mesolimbic dopaminergic system in the ventral tegmental area. Cholinergic and dopaminergic arousal systems have converging input to the medial prefrontal cortex. The arousal system can modulate cortical EEG with alpha rhythms, which enhance synaptic strength as shown by an increase in long-term potentiation (LTP), whereas delta frequencies are associated with decreased arousal and a decrease in synaptic strength as shown by an increase in long-term depotentiation (LTD). It is postulated that the medial prefrontal cortex is an adaptable node with decision making capability and may control the switch between positive and negative affect and is responsible for modifying or changing emotional state and its expression.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"9 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective well-being can be predicted by caudate volume and promotion focus 主观幸福感可通过尾状体体积和晋升重点进行预测

IF 3.1 3区医学

Brain Structure & Function Pub Date : 2024-07-27 DOI: 10.1007/s00429-024-02830-3

Masahiro Matsunaga, Yohsuke Ohtsubo, Keiko Ishii, Hirohito Tsuboi, Kohta Suzuki, Haruto Takagishi

{"title":"Subjective well-being can be predicted by caudate volume and promotion focus","authors":"Masahiro Matsunaga, Yohsuke Ohtsubo, Keiko Ishii, Hirohito Tsuboi, Kohta Suzuki, Haruto Takagishi","doi":"10.1007/s00429-024-02830-3","DOIUrl":"https://doi.org/10.1007/s00429-024-02830-3","url":null,"abstract":"It is well-known that the caudate nucleus is associated with motivational behaviors and subjective well-being. However, no longitudinal studies have examined the relationship between brain structure, behavioral orientations, and subjective well-being. This study analyzes data from our previous longitudinal study to examine whether future subjective well-being can be predicted by the volume of the caudate nucleus. We also examined whether behavioral orientation, based on the regulatory focus theory showing two orientations—promotion and prevention focus—was related to the volume of the caudate nucleus. Voxel-based morphometry analysis indicated that the left caudate volume was positively associated with rating scores for future subjective well-being and promotion orientation. Further, mediation analysis indicated that promotion orientation significantly mediated the relationship between future subjective well-being and left caudate volume. The findings indicate that future subjective well-being can be predicted by the volume of the left caudate nucleus, and that this relationship is mediated by promotion focus orientation.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"167 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective activations and functional connectivities to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus. 在通向人类海马体的视觉和非视觉皮层区域中，看到人脸、场景、身体部位和工具时的选择性激活和功能连接。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-01 Epub Date: 2024-06-05 DOI: 10.1007/s00429-024-02811-6

Edmund T Rolls, Jianfeng Feng, Ruohan Zhang

{"title":"Selective activations and functional connectivities to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus.","authors":"Edmund T Rolls, Jianfeng Feng, Ruohan Zhang","doi":"10.1007/s00429-024-02811-6","DOIUrl":"10.1007/s00429-024-02811-6","url":null,"abstract":"Connectivity maps are now available for the 360 cortical regions in the Human Connectome Project Multimodal Parcellation atlas. Here we add function to these maps by measuring selective fMRI activations and functional connectivity increases to stationary visual stimuli of faces, scenes, body parts and tools from 956 HCP participants. Faces activate regions in the ventrolateral visual cortical stream (FFC), in the superior temporal sulcus (STS) visual stream for face and head motion; and inferior parietal visual (PGi) and somatosensory (PF) regions. Scenes activate ventromedial visual stream VMV and PHA regions in the parahippocampal scene area; medial (7m) and lateral parietal (PGp) regions; and the reward-related medial orbitofrontal cortex. Body parts activate the inferior temporal cortex object regions (TE1p, TE2p); but also visual motion regions (MT, MST, FST); and the inferior parietal visual (PGi, PGs) and somatosensory (PF) regions; and the unpleasant-related lateral orbitofrontal cortex. Tools activate an intermediate ventral stream area (VMV3, VVC, PHA3); visual motion regions (FST); somatosensory (1, 2); and auditory (A4, A5) cortical regions. The findings add function to cortical connectivity maps; and show how stationary visual stimuli activate other cortical regions related to their associations, including visual motion, somatosensory, auditory, semantic, and orbitofrontal cortex value-related, regions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1471-1493"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered morphometric similarity networks in insomnia disorder. 失眠症中形态计量相似性网络的改变

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-01 Epub Date: 2024-05-27 DOI: 10.1007/s00429-024-02809-0

Yulin Wang, Jingqi Yang, Haobo Zhang, Debo Dong, Dahua Yu, Kai Yuan, Xu Lei

{"title":"Altered morphometric similarity networks in insomnia disorder.","authors":"Yulin Wang, Jingqi Yang, Haobo Zhang, Debo Dong, Dahua Yu, Kai Yuan, Xu Lei","doi":"10.1007/s00429-024-02809-0","DOIUrl":"10.1007/s00429-024-02809-0","url":null,"abstract":"Previous studies on structural covariance network (SCN) suggested that patients with insomnia disorder (ID) show abnormal structural connectivity, primarily affecting the somatomotor network (SMN) and default mode network (DMN). However, evaluating a single structural index in SCN can only reveal direct covariance relationship between two brain regions, failing to uncover synergistic changes in multiple structural features. To cover this research gap, the present study utilized novel morphometric similarity networks (MSN) to examine the morphometric similarity between cortical areas in terms of multiple sMRI parameters measured at each area. With seven T1-weighted imaging morphometric features from the Desikan-Killiany atlas, individual MSN was constructed for patients with ID (N = 87) and healthy control groups (HCs, N = 84). Two-sample t-test revealed differences in MSN between patients with ID and HCs. Correlation analyses examined associations between MSNs and sleep quality, insomnia symptom severity, and depressive symptoms severity in patients with ID. The right paracentral lobule (PCL) exhibited decreased morphometric similarity in patients with ID compared to HCs, mainly manifested by its de-differentiation (meaning loss of distinctiveness) with the SMN, DMN, and ventral attention network (VAN), as well as its decoupling with the visual network (VN). Greater PCL-based de-differentiation correlated with less severe insomnia and fewer depressive symptoms in the patients group. Additionally, patients with less depressive symptoms showed greater PCL de-differentiation from the SMN. As an important pilot step in revealing the underlying morphometric similarity alterations in insomnia disorder, the present study identified the right PCL as a hub region that is de-differentiated with other high-order networks. Our study also revealed that MSN has an important potential to capture clinical significance related to insomnia disorder.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1433-1445"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligence and cortical morphometry: caveats in brain-behavior associations. 智力与皮层形态测量：大脑与行为关联的注意事项。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-01 Epub Date: 2024-05-25 DOI: 10.1007/s00429-024-02792-6

John D Lewis, Vandad Imani, Jussi Tohka

{"title":"Intelligence and cortical morphometry: caveats in brain-behavior associations.","authors":"John D Lewis, Vandad Imani, Jussi Tohka","doi":"10.1007/s00429-024-02792-6","DOIUrl":"10.1007/s00429-024-02792-6","url":null,"abstract":"It is well-established that brain size is associated with intelligence. But the relationship between cortical morphometric measures and intelligence is unclear. Studies have produced conflicting results or no significant relations between intelligence and cortical morphometric measures such as cortical thickness and peri-cortical contrast. This discrepancy may be due to multicollinearity amongst the independent variables in a multivariate regression analysis, or a failure to fully account for the relationship between brain size and intelligence in some other way. Our study shows that neither cortical thickness nor peri-cortical contrast reliably improves IQ prediction accuracy beyond what is achieved with brain volume alone. We show this in multiple datasets, with child data, developmental data, and with adult data; we show this with data acquired either at multiple sites, or at a single site; we show this with data acquired with different MRI scanner manufacturers, or with all data acquired on a single scanner; and we show this with fluid intelligence, full-scale IQ, performance IQ, and verbal IQ. But our point is not really even about IQ; rather we proffer a methodological caveat and potential explanation of the discrepancies in previous results, and which applies broadly.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1417-1432"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141096806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organization of enkephalinergic neuronal system in the central nervous system of the gecko Hemidactylus frenatus. 壁虎脑啡肽能神经元系统在壁虎中枢神经系统中的组织结构

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1007/s00429-024-02805-4

Ananya Ganeyan, C B Ganesh

{"title":"Organization of enkephalinergic neuronal system in the central nervous system of the gecko Hemidactylus frenatus.","authors":"Ananya Ganeyan, C B Ganesh","doi":"10.1007/s00429-024-02805-4","DOIUrl":"10.1007/s00429-024-02805-4","url":null,"abstract":"Enkephalins are endogenous opioid pentapeptides that play a role in neurotransmission and pain modulation in vertebrates. However, the distribution pattern of enkephalinergic neurons in the brains of reptiles has been understudied. This study reports the organization of the methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK) neuronal systems in the central nervous system of the gecko Hemidactylus frenatus using an immunofluorescence labeling method. Although M-ENK and L-ENK-immunoreactive (ir) fibers extended throughout the pallial and subpallial subdivisions, including the olfactory bulbs, M-ENK and L-ENK-ir cells were found only in the dorsal septal nucleus. Enkephalinergic perikarya and fibers were highly concentrated in the periventricular and lateral preoptic areas, as well as in the anterior and lateral subdivisions of the hypothalamus, while enkephalinergic innervation was observed in the hypothalamic periventricular nucleus, infundibular recess nucleus and median eminence. The dense accumulation of enkephalinergic content was noticed in the pars distalis of the hypophysis. In the thalamus, the nucleus rotundus and the dorsolateral, medial, and medial posterior thalamic nuclei contained M-ENK and L-ENK-ir fibers, whereas clusters of M-ENK and L-ENK-ir neurons were observed in the pretectum, mesencephalon, and rhombencephalon. The enkephalinergic fibers were also seen in the area X around the central canal, as well as the dorsal and ventral horns. The widespread distribution of enkephalin-containing neurons within the central nervous system implies that enkephalins regulate a variety of functions in the gecko, including sensory, behavioral, hypophysiotropic, and neuroendocrine functions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1365-1395"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strong direct link from the layer 3/4 border to layer 6 of cat primary visual cortex. 从第 3/4 层边界到猫的初级视觉皮层第 6 层之间有很强的直接联系。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1007/s00429-024-02806-3

Kevan A C Martin, Franziska D Sägesser

{"title":"A strong direct link from the layer 3/4 border to layer 6 of cat primary visual cortex.","authors":"Kevan A C Martin, Franziska D Sägesser","doi":"10.1007/s00429-024-02806-3","DOIUrl":"10.1007/s00429-024-02806-3","url":null,"abstract":"The cat primary visual cortex (V1) is a cortical area for which we have one of the most detailed estimates of the connection 'weights' (expressed as number of synapses) between different neural populations in different layers (Binzegger et al in J Neurosci 24:8441-8453, 2004). Nevertheless, the majority of excitatory input sources to layer 6, the deepest layer in a local translaminar excitatory feedforward loop, was not accounted for by the known neuron types used to generate the quantitative Binzegger diagram. We aimed to fill this gap by using a retrograde tracer that would label neural cell bodies in and outside V1 that directly connect to layer 6 of V1. We found that more than 80% of labeled neurons projecting to layer 6 were within V1 itself. Our data indicate that a substantial fraction of the missing input is provided by a previously unidentified population of layer 3/4 border neurons, laterally distributed and connecting more strongly to layer 6 than the typical superficial layer pyramidal neurons considered by Binzegger et al. (Binzegger et al in J Neurosci 24:8441-8453, 2004). This layer 3/4 to layer 6 connection may be a parallel route to the layer 3 - layer 5 - layer 6 feedforward pathway, be associated with the fast-conducting, movement-related Y pathway and provide convergent input from distant (5-10 degrees) regions of the visual field.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1397-1415"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings. 人类大脑结构和功能的代际传递：对设计、方法和研究结果的叙述性回顾。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1007/s00429-024-02804-5

Charlotte Constant-Varlet, Tomoya Nakai, Jérôme Prado

{"title":"Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings.","authors":"Charlotte Constant-Varlet, Tomoya Nakai, Jérôme Prado","doi":"10.1007/s00429-024-02804-5","DOIUrl":"10.1007/s00429-024-02804-5","url":null,"abstract":"Children often show cognitive and affective traits that are similar to their parents. Although this indicates a transmission of phenotypes from parents to children, little is known about the neural underpinnings of that transmission. Here, we provide a general overview of neuroimaging studies that explore the similarity between parents and children in terms of brain structure and function. We notably discuss the aims, designs, and methods of these so-called intergenerational neuroimaging studies, focusing on two main designs: the parent-child design and the multigenerational design. For each design, we also summarize the major findings, identify the sources of variability between studies, and highlight some limitations and future directions. We argue that the lack of consensus in defining the parent-child transmission of brain structure and function leads to measurement heterogeneity, which is a challenge for future studies. Additionally, multigenerational studies often use measures of family resemblance to estimate the proportion of variance attributed to genetic versus environmental factors, though this estimate is likely inflated given the frequent lack of control for shared environment. Nonetheless, intergenerational neuroimaging studies may still have both clinical and theoretical relevance, not because they currently inform about the etiology of neuromarkers, but rather because they may help identify neuromarkers and test hypotheses about neuromarkers coming from more standard neuroimaging designs.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1327-1348"},"PeriodicalIF":2.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0