Brain Structure & Function最新文献

{"title":"Consistent neural evidence to support novelty and appropriateness processing for creative thinking: a coordinated meta-analysis using activation likelihood estimation.","authors":"Jiabao Lin, Yuanyun He, Siying Zhang, Lei Mo, Changyi Kuang, Yajue Chen","doi":"10.1007/s00429-026-03127-3","DOIUrl":"10.1007/s00429-026-03127-3","url":null,"abstract":"<p><p>Creative thinking is characterized by novelty and appropriateness. Previous research has focused on consistent neural mechanisms across specific creative tasks, leaving the general brain bases of novelty and appropriateness unclear. Therefore, this study used activation likelihood estimation to identify coherent neural activity underlying these two features. After robust selection, forty studies were recruited for novelty analysis, while fifteen were for appropriateness. Two single meta-analyses were performed, followed by contrast and conjunction analyses. Results revealed that novelty processing involved the fusiform gyrus, parahippocampal gyrus, precuneus, inferior parietal lobule, precentral gyrus, inferior frontal gyrus, and middle frontal gyrus. Appropriateness processing engaged the superior occipital gyrus, middle temporal gyrus, anterior cingulate cortex, and medial frontal gyrus. These findings offer robust evidence for understanding independent neural roles that support novelty and appropriateness in creativity. And we also proposed a newly-developed dual model to better understand how these brain regions might interact to serve creative thinking.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the neural patterns of verbal repetition: an activation likelihood estimation meta-analysis.","authors":"Ariane Awana, Marcelo L Berthier, María José Torres-Prioris, Diana López-Barroso","doi":"10.1007/s00429-026-03119-3","DOIUrl":"10.1007/s00429-026-03119-3","url":null,"abstract":"<p><p>Verbal repetition involves transforming heard speech into articulatory motor output and constitutes a core language function integrating receptive and expressive processes within tight temporal constraints. This integrative nature underlies its importance for language acquisition and learning and accounts for its diagnostic relevance in acquired and developmental language disorders. Despite extensive investigation, the consistent neural architecture supporting verbal repetition has remained insufficiently established due to methodological heterogeneity across studies. Here, we conducted a coordinate-based meta-analysis using Activation Likelihood Estimation (ALE) on 27 neuroimaging experiments (380 participants; 440 activation foci) to identify brain regions consistently engaged during verbal repetition in healthy adults, to compare word and pseudoword repetition, and to assess hemispheric lateralization. Across all conditions, verbal repetition consistently engaged a robust, bilaterally distributed fronto-temporo-parietal network encompassing auditory-phonological regions of the superior temporal cortex, sensorimotor cortices of the precentral and postcentral gyri, and medial frontal motor regions including the SMA and the preSMA. Lateralization analyses revealed a predominant left-hemispheric contribution across conditions, with a stronger leftward bias for pseudoword than for word repetition, despite largely bilateral engagement. Direct contrasts indicated stimulus-dependent modulation within this partially shared dorsal network: pseudoword repetition showed greater involvement of auditory associative, premotor, and subcortical regions, whereas word repetition preferentially engaged primary auditory and medial frontal motor regions. Together, these findings provide a comprehensive overview of the neural systems supporting verbal repetition, highlighting a shared dorsal auditory-motor network that is flexibly modulated as a function of stimulus familiarity.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13221332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside the frontal face network: multimodal evidence for distinct emotional and motor resonance circuits.","authors":"Beatrice De Negri, Luciano Simone, Fausto Caruana, Marzio Gerbella","doi":"10.1007/s00429-026-03125-5","DOIUrl":"10.1007/s00429-026-03125-5","url":null,"abstract":"<p><p>The perception of emotional facial expressions engages widespread cortical networks, extending beyond occipito-temporal visual areas to multiple frontal and perisylvian regions. While the connectivity of the occipito-temporal territories involved in visual processing of faces has been extensively mapped, the frontal and perisylvian pathways, comprising motor, emotional, and cognitive-attentional components, remain less understood. Building on intracranial recordings, electrical stimulation, and cortico-cortical evoked potentials, our previous work identified two frontal-perisylvian clusters: a premotor cluster (constituted by Rolandic operculum and a region between the frontal eye fields and the ventral premotor cortex) supporting motor resonance, and a limbic/prefrontal cluster (composed by prefrontal and cingulate territories) supporting emotional resonance. Here, combining diffusion tractography (DTI) and resting-state fMRI (rsfMRI), we provide a detailed anatomical and functional connectivity framework for these regions. DTI revealed seven principal fiber tracts organizing the clusters into three coherent networks, while rsfMRI demonstrated shared and dissociable connectivity patterns among them partially consistent with Default Mode, Ventral Attention, Dorsal Attention, Frontoparietal, and Sensorimotor networks. The first two networks here identified largely correspond to the limbic/prefrontal and premotor clusters described in our previous study, while the third appears to serve as a nexus between the first two and as a source of visual information for them. These findings outline a tripartite architecture-emotional, premotor, and cognitive networks-through which facial emotion recognition may operates via parallel, functionally specialized streams, enabling both motor and emotional resonance and supporting adaptive social behavior.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences modulate olfactory bulb volume-function relationships but not olfactory training-induced plasticity.","authors":"Yi-Ting Hsieh, Yin-Chun Liao, Heather Grace Piluden Dulnuan, Jiing-Feng Lirng, Yun-Ting Chao","doi":"10.1007/s00429-026-03126-4","DOIUrl":"10.1007/s00429-026-03126-4","url":null,"abstract":"<p><p>Men typically display larger olfactory bulb (OB) volumes, while women demonstrate superior olfactory performance. Olfactory training (OT) has been shown to induce structural changes in OB, but whether sex influences OT-related plasticity remains unclear. This study aimed to examine how sex differences modulate OB volume-function relationships and OT-related OB neuroplasticity. Participants included 27 women and 11 men with acquired olfactory dysfunction who underwent Sniffin' Sticks Test and T2-weighted MRI before and after a 12-week OT program of twice-daily exposure to four odorants. OB volume was measured by ITK-SNAP. Pooled baseline analysis revealed no significant correlation between OB volume and composite threshold-discrimination-identification (TDI) score. Women showed a significant correlation between baseline OB volume and TDI on both sides (left: r = 0.458, p = 0.016; right: r = 0.413, p = 0.032), whereas no significant associations were observed in men. Following OT, the overall sample showed bilateral OB volume increases (left: mean difference = 4.70 ± 2.16, p = 0.036; right: mean difference = 5.64 ± 1.91, p = 0.005) and improvements in odor discrimination (t = 2.12, p = 0.040) and composite TDI score (t = 2.13, p = 0.040). Men consistently presented larger OB volumes (F(1, 36) = 6.63, p = 0.014), and no sex-by-session interaction effects were observed. It appears that sex can mask cross-sectional associations between OB volume and olfactory performance, supporting sex-aware analysis when interpreting baseline OB morphometry. In contrast, OT elicits comparable OB volume increases across sexes, suggesting a similar pattern of training-induced structural plasticity.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anatomical basis of morpho-syntactic computation reflected in gray matter volume and pattern of the inferior frontal gyrus.","authors":"Jeahong Kim, Joonwoo Kim, Solbin Lee, Kichun Nam","doi":"10.1007/s00429-026-03120-w","DOIUrl":"10.1007/s00429-026-03120-w","url":null,"abstract":"<p><p>This study examined whether gray matter (GM) volume in the inferior frontal gyrus (IFG)-specifically the pars triangularis and pars orbitalis-could predict individual sensitivity to morpho-syntactic violations. Native speakers of Korean performed a lexical decision task involving transposed syllable stimuli that either preserved or violated morphological boundaries. Behavioral efficiency was measured using inverse efficiency scores (IES), and structural brain data were analyzed via voxel-based morphometry. Univariate partial correlation analysis showed a significant negative association between GM volume in the left pars triangularis and IES difference scores (across-boundary minus replaced-control), suggesting that individuals with greater volume in this region are more sensitive to morpho-syntactic structure. No such effect was observed for the pars orbitalis. Multivariate pattern analysis (MVPA) further revealed that distributed GM patterns in both IFG subregions significantly predicted morpho-syntactic sensitivity. These findings remained robust under permutation testing that controlled for demographic and anatomical covariates. While the present study examined morpho-syntactic processing in participants' native language, the findings offer insight into inter-individual variability in IFG morphology, which may support language-specific computations.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the impact of tactile processing on motor cortex: how touch shapes motor behaviour.","authors":"Antonio Zafarana, Dollyane Muret, Alessandro Farnè, Luigi Tamè","doi":"10.1007/s00429-026-03128-2","DOIUrl":"10.1007/s00429-026-03128-2","url":null,"abstract":"<p><p>The ability to manipulate objects is a fundamental human skill that relies primarily on the motor system. However, effective object manipulation would not be possible without the continuous information provided by the somatosensory system. Cutaneous tactile feedback is particularly important when a movement must be adjusted while performing an action. Efficient interactions between the tactile and motor systems are therefore paramount for fine motor behaviour, as clearly demonstrated by the profound impairments observed following lesions to sensorimotor brain regions. However, somatosensory deficits following cortical damage have received considerably less attention than motor impairments, even though substantial evidence shows that such deficits are typically associated with poorer motor recovery and that preserved somatosensation is a strong predictor of motor outcome. This disconnect highlights a significant gap in the literature: despite the critical role of touch in shaping motor behaviour, the functional relationships between the tactile and motor systems remain inadequately characterized. In this review, we provide a unified (though not exhaustive) synthesis of the evidence pointing towards the substantial role of cutaneous tactile information in modulating motor cortical processing and, consequently, motor behaviour. We first describe, across species, the anatomical and neurophysiological connections linking somatosensory and motor systems and the nature of their interactions. We then review evidence from neuropathological studies demonstrating the severe consequences of disrupted tactile signals on motor performance. Finally, we examine the impact of short- and long-term tactile learning on motor function, highlighting its potential for developing novel tactile-to-motor rehabilitation strategies for individuals suffering from brain injury and other neurological conditions. Table of contents. Introduction 4. Anatomical connections between the somatosensory and motor cortices 8. Functional nature of sensorimotor interactions 13. Neuropathological evidence of sensorimotor interactions 19. Tactile and motor interactions in the context of motor planning and motor learning 26. Effects of tactile training on motor and sensorimotor performance 29. Conclusion and future perspectives 34. References 37.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stronger right-hemispheric involvement in language processing is associated with greater functional connectivity between the left-lateralized language-related network and the cingulo-opercular network.","authors":"Victor Karpychev, Svetlana Malyutina, Olga Dragoy","doi":"10.1007/s00429-026-03116-6","DOIUrl":"10.1007/s00429-026-03116-6","url":null,"abstract":"<p><p>Language comprehension and production are predominantly supported by the left-lateralized language-related network (LRN). However, right-hemispheric homologs of the language regions can also contribute to language processing, resulting in reduced left-hemispheric language lateralization. To date, it remains unclear whether less left-hemispheric language lateralization is associated with the recruitment of other non-language networks and their interaction with the LRN during language processing. In this study, we investigated how the degree of left-hemispheric language lateralization in healthy adults relates to the activation of non-language networks and the LRN connectivity to those networks. We applied independent component analysis to task-based functional magnetic resonance imaging data with sentence completion collected from 50 healthy adults. Instead of a single network, we identified the left-lateralized LRN and a mirror right-lateralized LRN. During language processing, the salience network was co-activated alongside the left-lateralized LRN and the right-lateralized LRN, regardless of individual language lateralization. We found that a weaker degree of lateralization was not associated with either domain-general network activation or left-lateralized LRN connectivity to domain-general networks. However, we present novel evidence that stronger right-hemispheric involvement in language processing is associated with greater left-lateralized LRN connectivity to the cingulo-opercular network (CON). Given the role of the CON in the action mode, this result might indicate greater cognitive control to support language processing in people with stronger right-hemispheric involvement in language processing.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Improving tractography in peri-lesional oedema using constrained spherical deconvolution in paediatric neurosurgery patients.","authors":"Joseph Yuan-Mou Yang, Oscar Alateras, Jacques-Donald Tournier, Sila Genc","doi":"10.1007/s00429-026-03123-7","DOIUrl":"10.1007/s00429-026-03123-7","url":null,"abstract":"","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Receptor architecture of the macaque lateral geniculate nucleus.","authors":"Marina Saito, Lucija Rapan, Meiqi Niu, Ling Zhao, Sei-Ichi Tsujimura, Hiromasa Takemura, Nicola Palomero-Gallagher","doi":"10.1007/s00429-026-03109-5","DOIUrl":"10.1007/s00429-026-03109-5","url":null,"abstract":"<p><p>The lateral geniculate nucleus (LGN) is a key thalamic nucleus in the primate visual system that relays visual information from the retina to cortical visual areas. While functional and microanatomical characteristics of the LGN and its layers have been extensively studied, previous investigations on its receptor architecture have been restricted to a small subset of neurotransmitter receptors. To characterise the receptor architecture of the macaque LGN in greater detail, we analysed in vitro autoradiography data to quantify the density of 15 neurotransmitter receptors at the sublayer level, thus improving our understanding of the molecular architecture supporting primate visual function. For comparison, we also determined the densities of these receptors in the primary visual cortex (V1) at a laminar level. Though comparable in shape, the receptor fingeprints of magnocellular layers were larger than those of parvocellular layers. In contrast, receptor fingerprints of cytoarchitectonic layers in V1 differed in both shape and size. Ionotropic/metabotropic and excitatory/inhibitory receptor ratios were significantly larger in V1 than in the LGN, suggesting a greater prominence of inhibitory neurotransmission in the latter region. The nicotinic α₄β₂ receptor was the only receptor type with a higher density in the LGN compared to V1, highlighting the particular importance of acetylcholine in the modulation of visual stimuli. These findings provide insights into the receptor architecture underlying functions of the LGN, with implications for mechanisms such as visual signal encoding and surround suppression.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13186819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neuroanatomy and connectivity of the ventral striatum and ventral capsule area in the Göttingen minipig.","authors":"Anna Sofie R B Poulsen, Hamed Zaer, Bjarke Søgaard, Andreas N Glud, Jens Christian H Sørensen, Dariusz Orlowski","doi":"10.1007/s00429-026-03115-7","DOIUrl":"10.1007/s00429-026-03115-7","url":null,"abstract":"<p><p>A considerable proportion of patients with major depressive disorder (MDD) do not respond to current treatments. Deep brain stimulation has shown promise as an intervention but has yielded inconsistent outcomes, potentially due to the complex biopsychosocial nature of MDD and the lack of standardized large animal models. The ventral striatum/ventral capsule brain area (VS/VC), involved in emotional and behavioral regulation, is a proposed DBS target. The Göttingen minipig (GM) is an emerging non-primate large animal model; however, the anatomy and connectivity of the GM VS/VC remain poorly characterized. To characterize the neuroanatomy and connectivity of the GM VS/VC region, we have used four female minipigs, which underwent MRI-guided stereotaxic unilateral injection of retrograde (FluoroGold) and anterograde (Biotinylated Dextran Amine) tracers into the VS/VC. Postmortem brains were coronally cryosectioned into 40 µm-thick sections, Nissl-stained, and analyzed for tracer distribution. Additional non-injected GM brains were immunostained using antibodies against calbindin, substance P, myelin basic protein, DARPP-32, tyrosine hydroxylase, and choline acetyltransferase to describe cytoarchitecture. The GM VS/VC exhibited bidirectional connectivity with limbic, associative, and sensorimotor regions, paralleling human nigrostriatal and mesolimbic circuits. The cytoarchitecture, particularly of the nucleus accumbens, is similar to that of primates, including the human brain. The GM VS/VC demonstrates anatomical and connectivity features similar to those found in humans and rodents, supporting its translational potential for modeling neuropsychiatric conditions and testing interventions such as DBS.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 5","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}