Altered white matter architecture in patients with isolated congenital anosmia.

IF 2.7 3区 医学 Q1 ANATOMY & MORPHOLOGY
Yun-Ting Chao, Yin-Chun Liao, Pei-Shan Hsu, Divesh Thaploo
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引用次数: 0

Abstract

Isolated Congenital Anosmia (ICA) is a rare condition characterized by the absence of the sense of smell due to the underdevelopment of the olfactory bulbs and a corresponding lifelong lack of olfactory input to the brain. Previous studies have reported that ICA patients exhibit structural and volumetric alterations in both gray and white matter regions as well as slightly elevated fractional anisotropy (FA) in the orbitofrontal cortex. This study expanded on these findings by utilizing whole-brain diffusion tensor imaging (DTI) with a 3T MR scanner to investigate microstructural changes in the white matter of 8 ICA patients and 14 age- and gender-matched healthy controls (HCs). Tract-based spatial statistics revealed significantly lower FA values in the right superior corona radiata (SCR) of ICA patients compared to HCs (p = 0.001), indicating compromised white matter integrity in this region. Elevated mean diffusivity and radial diffusivity values in the right SCR (p = 0.009 and p = 0.002, respectively) suggest underlying demyelination. In the HC group, FA values in the SCR cluster were positively correlated with odor identification scores (rho = 0.59, p = 0.026), highlighting the functional relevance of SCR in processing olfactory information and semantic formation of odor perception. These findings underscore the critical role of early sensory input in shaping the architecture of white matter, and illustrate the impact of congenital olfactory deprivation on the structural integrity and functional organization of neural pathways.

孤立性先天性嗅觉缺失患者的白质结构改变。
孤立性先天性嗅觉缺失(ICA)是一种罕见的疾病,其特征是由于嗅球发育不全以及相应的终身缺乏大脑嗅觉输入而导致嗅觉缺失。先前的研究报道,ICA患者在灰质和白质区域均表现出结构和体积的改变,并且眼窝前额皮质的分数各向异性(FA)略有升高。本研究通过利用全脑弥散张量成像(DTI)和3T MR扫描仪对8例ICA患者和14例年龄和性别匹配的健康对照(hc)的白质微结构变化进行了研究,进一步扩展了这些发现。基于通道的空间统计显示,ICA患者右侧上放射状冠(SCR)的FA值明显低于hcc患者(p = 0.001),表明该区域白质完整性受损。右侧SCR平均扩散率和径向扩散率升高(分别为p = 0.009和p = 0.002)提示潜在脱髓鞘。在HC组中,SCR集群FA值与气味识别得分呈正相关(rho = 0.59, p = 0.026),突出了SCR在嗅觉信息加工和气味感知语义形成中的功能相关性。这些发现强调了早期感觉输入在形成白质结构中的关键作用,并说明了先天性嗅觉剥夺对神经通路结构完整性和功能组织的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain Structure & Function
Brain Structure & Function 医学-解剖学与形态学
CiteScore
6.00
自引率
6.50%
发文量
168
审稿时长
8 months
期刊介绍: Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.
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