Brain Structure & Function最新文献

Microsurgical anatomy of the anterior commissure with special emphasis on the anterior limb: a comparative white matter fiber microdissection and tractography study. 前连合的显微外科解剖，特别强调前肢：白质纤维显微解剖和神经束造影的比较研究。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-09-10 DOI: 10.1007/s00429-025-03006-3

Pınar Kuru Bektaşoğlu, Serdar Rahmanov, Abuzer Güngör, Sima Cebecik Çakır, Zeynep Fırat, Fuat Pirinçci, Erhan Çelikoğlu, Wolfgang J Weninger, Uğur Türe

{"title":"Microsurgical anatomy of the anterior commissure with special emphasis on the anterior limb: a comparative white matter fiber microdissection and tractography study.","authors":"Pınar Kuru Bektaşoğlu, Serdar Rahmanov, Abuzer Güngör, Sima Cebecik Çakır, Zeynep Fırat, Fuat Pirinçci, Erhan Çelikoğlu, Wolfgang J Weninger, Uğur Türe","doi":"10.1007/s00429-025-03006-3","DOIUrl":"https://doi.org/10.1007/s00429-025-03006-3","url":null,"abstract":"The anterior commissure (AC) has an anterior and posterior limb. Despite comprehensive information about the posterior limb, there is limited and conflicting information about the anterior limb in the literature. We aimed to show the anatomical relationships of the AC with neighboring structures by using white matter microdissection and magnetic resonance (MR) tractography, primarily on the anterior limb of the AC. Twenty cadaveric human brains and three sheep brains were prepared according to Klingler's method. White matter fiber microdissections were performed. MR tractography was done in 20 specimens. This study defined the body and anterior and posterior limbs of the AC. The anterior limb leaves the body from the inferior side at the level of the anterior perforated substance and olfactory tract. It then courses anteroinferolaterally, curves towards the orbital gyri, and terminates at the olfactory trigone. The posterior limb of the AC divides into rostral (anterolateral) and caudal (posterolateral) parts. The anterior limb was more prominent in sheep than in human brains. This study accurately delineates the anatomy and variations of the anterior limb of the AC in human and sheep brains for the first time in the literature to the best of our knowledge. The anterior limb of the AC is larger in sheep than in humans. An increased importance of olfaction could be the evolutionary explanation for this difference. The MR tractography results shown are unique for this delicate anatomy.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 8","pages":"143"},"PeriodicalIF":2.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the effective segmentation of human lateral geniculate nucleus. 人外侧膝状核有效分割的评价。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-25 DOI: 10.1007/s00429-025-03000-9

Lauren E Welbourne, Joel T Martin, Federico G Segala, Anisa Y Morsi, Daniel H Baker, Alex R Wade

{"title":"Evaluating the effective segmentation of human lateral geniculate nucleus.","authors":"Lauren E Welbourne, Joel T Martin, Federico G Segala, Anisa Y Morsi, Daniel H Baker, Alex R Wade","doi":"10.1007/s00429-025-03000-9","DOIUrl":"https://doi.org/10.1007/s00429-025-03000-9","url":null,"abstract":"Important parts of the visual pathway occur in relatively small subcortical structures that are often difficult to identify and segment using standard structural scans in MRI (e.g. T1 and T2 scans). Studies of the Lateral Geniculate Nucleus (LGN) often use proton density (PD) scan protocols, repeated up to 40 times, then manually segment the LGN structure from the average image. Efficiency is crucial when conducting MRI scans: minimising time spent on structural scanning can increase time available for complementary functional MRI scans and/or reduce scanning costs. In this study we asked how segmentation accuracy depended on the number of PD repeats. Four raters segmented the LGN of five participants, using different numbers of PD scans in the average image (1, 2, 4, 8, 16, 24, 32, 40), and an additional experienced expert rater segmented the LGN for just the 40PD average for all participants. We compared how the rater LGN masks at each scan average level overlapped with the expert masks. One rater performed the segmentation for the 40PD average on four separate days, to measure intra-rater variability across repeats. We also used a state-of-the-art automated segmentation process to compare the reliability to manual segmentation. We found that the average overlap between rater masks and the expert masks increased up to the 16PD scan average level, after which there was no additional benefit to including more PD scans. The automated segmentation masks were comparable to the overlap between the raters (40PD) and expert masks.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"140"},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain. 人脑颅内脑电图寿命模式的多中心规范脑作图。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-21 DOI: 10.1007/s00429-025-02988-4

Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner, Gabrielle M Schroeder, Beate Diehl, John S Duncan, Jiajie Mo, Kai Zhang, Aswin Chari, Martin Tisdall, Friederike Moeller, Chris Petkov, Matthew A Howard, George M Ibrahim, Elizabeth Donner, Nebras M Warsi, Raheel Ahmed, Peter N Taylor, Yujiang Wang

{"title":"Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain.","authors":"Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner, Gabrielle M Schroeder, Beate Diehl, John S Duncan, Jiajie Mo, Kai Zhang, Aswin Chari, Martin Tisdall, Friederike Moeller, Chris Petkov, Matthew A Howard, George M Ibrahim, Elizabeth Donner, Nebras M Warsi, Raheel Ahmed, Peter N Taylor, Yujiang Wang","doi":"10.1007/s00429-025-02988-4","DOIUrl":"https://doi.org/10.1007/s00429-025-02988-4","url":null,"abstract":"Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality's invasive nature. This study substantially expands the subject pool compared to existing literature, to create a multi-centre, normative map of brain activity which considers the effects of age, sex and recording hospital. Using interictal icEEG recordings from [Formula: see text] subjects across 15 centres, we constructed a normative map of non-pathological brain activity by regressing age and sex on relative band power in five frequency bands. A linear mixed model was implemented to account for the hospital effect. Variable importance was assessed using standard statistical measures, and regression coefficients (and their standard errors) were analysed at both whole-brain and regional scales. Recording hospital significantly impacted normative icEEG maps in all frequency bands, and age was a more influential predictor of band power than sex. The age effect varied by frequency band, but no spatial patterns were observed at the region-specific level. Certainty about regression coefficients was also frequency band specific and moderately impacted by sample size. The concept of a normative map is well-established in neuroscience research and particularly relevant to the icEEG modality, which does not allow healthy control baselines. Our key results regarding the hospital site and age effect guide future work utilising normative maps in icEEG.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"138"},"PeriodicalIF":2.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gray matter abnormalities in sight deprivation and sight restoration. 视力剥夺和视力恢复中的灰质异常。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-12 DOI: 10.1007/s00429-025-02994-6

Caterina A Pedersini, Alessio Fracasso, Amna Dogar, Bas Rokers, Pawan Sinha

{"title":"Gray matter abnormalities in sight deprivation and sight restoration.","authors":"Caterina A Pedersini, Alessio Fracasso, Amna Dogar, Bas Rokers, Pawan Sinha","doi":"10.1007/s00429-025-02994-6","DOIUrl":"10.1007/s00429-025-02994-6","url":null,"abstract":"Blindness provides a unique model for investigating brain plasticity in response to sensory deprivation. While structural changes in both gray and white matter have been widely documented, particularly in cases of early or congenital visual deprivation, gray matter studies have traditionally focused on cortical thickness, often finding cortical thickening in posterior regions. However, other aspects of gray matter integrity, such as cortical myelin content, remain underexplored. In this study, we examined the effects of visual deprivation on cortical structure in a cohort of early blind individuals who received eye surgery during adolescence, expanding beyond conventional measures to include cortical thickness, curvature, and T1-weighted signal intensity. This multi-faceted approach offers a more comprehensive view of cortical adaptations to early sensory deprivation. While blindness offers valuable insights into sensory-driven brain plasticity, an intriguing and unresolved question is whether structural plasticity reverses after sight restoration, enabling typical visual processing circuits to develop despite the initial period of deprivation. To address this, we assessed the effect of sight-recovering eye surgery on gray matter changes. Critically, individuals in this cohort received surgery after the closure of the sensitive period for visual development. We did not find evidence of gray matter changes after surgery. However, in a previous study conducted on the same cohort, we reported that notable plasticity in white matter emerged in this same population. These results suggest that white matter may potentially serve as a biomarker of structural plasticity following sight restoration, even beyond the sensitive developmental window.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"133"},"PeriodicalIF":2.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the influence of musical sophistication, cognitive performance, and social skills on the Brain Age Gap Estimate (BrainAGE). 研究音乐成熟度、认知表现和社交技能对脑年龄差距估计（BrainAGE）的影响。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-11 DOI: 10.1007/s00429-025-03001-8

Alisha D Davis, Negin Motamed Yeganeh, Nancy Hermiston, Janet F Werker, Lara A Boyd, Sarah N Kraeutner, Anja-Xiaoxing Cui

{"title":"Examining the influence of musical sophistication, cognitive performance, and social skills on the Brain Age Gap Estimate (BrainAGE).","authors":"Alisha D Davis, Negin Motamed Yeganeh, Nancy Hermiston, Janet F Werker, Lara A Boyd, Sarah N Kraeutner, Anja-Xiaoxing Cui","doi":"10.1007/s00429-025-03001-8","DOIUrl":"10.1007/s00429-025-03001-8","url":null,"abstract":"Brain age, an estimate of biological brain aging derived from neuroimaging, has been linked to cognitive and related factors. Metrics such as the Brain Age Gap Estimate (BrainAGE), depicting the discrepancy between predicted and chronological age, are commonly used to determine the influence of variables on brain aging. This study explored how cognitive ability, musical sophistication, and social skills contribute to BrainAGE in a sample of 81 healthy participants who underwent high-resolution magnetic resonance imaging and completed cognitive, musical, and social assessments. Following statistical analyses to fit the model, structural equation modelling was used to examine the influence of cognitive ability, assessed using the Delis-Kaplan Executive Function System, California Verbal Learning Test, and Wechsler Adult Intelligence Scale; musical sophistication, measured by the Goldsmiths Musical Sophistication Index; and social skills, evaluated using the Social Skills Inventory, on BrainAGE. Our findings demonstrated no significant influence of cognitive ability, musical expertise, or social skills on BrainAGE. These findings highlight the complexity of cognitive and social influences on brain age and underscore the need for further research into their interactive effects on neurobiological aging.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"132"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A thousand ways to tailor your tractography-based connectome. 一千种方法来定制你的基于神经束图的连接体。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-11 DOI: 10.1007/s00429-025-02998-2

Alessandra Griffa, Francois Rheault, Alessandro Daducci, Andrew Zalesky

引用次数: 0

Characterisation of putative retrotrapezoid nucleus (RTN) chemoreceptor neurons in the adult human brainstem. 成人脑干中假定的后梯形核（RTN）化学受体神经元的特征。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-11 DOI: 10.1007/s00429-025-02991-9

Yazhou Liu, Rita Machaalani, Irit Markus, Claire E Shepherd, Natasha N Kumar

{"title":"Characterisation of putative retrotrapezoid nucleus (RTN) chemoreceptor neurons in the adult human brainstem.","authors":"Yazhou Liu, Rita Machaalani, Irit Markus, Claire E Shepherd, Natasha N Kumar","doi":"10.1007/s00429-025-02991-9","DOIUrl":"10.1007/s00429-025-02991-9","url":null,"abstract":"The retrotrapezoid nucleus (RTN) of rodents is located ventral to the facial motor nucleus (7N) and consists of acid-sensitive neurons that activate breathing and mediate the central component of the ventilatory response to hypercapnia. In rodents, RTN neurons can be histologically identified by the presence of paired-like homeobox 2B positive nuclei (Phox2b +) and the absence of cytoplasmic choline acetyltransferase (ChAT-) and tyrosine hydroxylase (TH-). Up to 50% of rodent RTN neurons synthesise galanin, and 88% express pituitary adenylate cyclase activating polypeptide (PACAP). The human RTN (hRTN) has not been mapped to date. This study aimed to map the location and cytoarchitecture of the adult hRTN and compare the findings to the homologies of rodents, macaques and human infants. Formalin-fixed, paraffin-embedded tissue blocks from two adult cases, spanning the medulla-pons, were serially sectioned (10 µm thick) and every four in thirty sections was assayed for immunohistochemistry for ChAT, or double-labelled Phox2b/TH, Phox2b/galanin and Phox2b/PACAP, followed by analysis using QuPath software. hRTN neurons, identified as Phox2b + /TH-/ChAT-, were located ventral to 7N and lateral to the superior olive, overlapped with the C1 or A5 catecholaminergic population and extended rostrocaudally from Obex + 13 to + 17 mm. In the parafacial area, 90% of Phox2b immunoreactive (-ir) neurons are hRTN neurons, totaling around 5000 bilaterally, and were surrounded by numerous TH-ir fibers. Galanin- and PACAP-ir was identified in 43% and 39% of Phox2b-ir parafacial neurons, respectively. This is the first study to characterise and quantitatively map the adult human RTN using a series of neurochemical markers.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"131"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic brain changes in post-acute COVID-19: systematic review and meta-analysis of [18F]-FDG-PET findings. COVID-19急性后脑代谢性变化：[18F]-FDG-PET结果的系统回顾和meta分析

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-07 DOI: 10.1007/s00429-025-02997-3

Izabella Fernanda Bastos Siqueira, Lais Almeida Figueiredo, Camila Emanuele Moreira Fernandes, Leandro Pinheiro Cintra, Glauber Fernandes de Oliveira, Maria Angélica Rios, Ricardo Maciel, Rodrigo Ferretjans, Nathalia Sernizon Guimarães, Luiz Alexandre Viana Magno

{"title":"Metabolic brain changes in post-acute COVID-19: systematic review and meta-analysis of [18F]-FDG-PET findings.","authors":"Izabella Fernanda Bastos Siqueira, Lais Almeida Figueiredo, Camila Emanuele Moreira Fernandes, Leandro Pinheiro Cintra, Glauber Fernandes de Oliveira, Maria Angélica Rios, Ricardo Maciel, Rodrigo Ferretjans, Nathalia Sernizon Guimarães, Luiz Alexandre Viana Magno","doi":"10.1007/s00429-025-02997-3","DOIUrl":"10.1007/s00429-025-02997-3","url":null,"abstract":"Individuals with long COVID exhibit neurological and psychiatric symptoms that often persist well beyond the initial SARS-CoV-2 infection. Studies using [18F]-FDG positron emission tomography (FDG-PET) have revealed diverse abnormalities in brain glucose metabolism during the post-acute phase of COVID-19. We conducted a systematic review and meta-analysis to assess the spatial distribution and heterogeneity of brain metabolic changes in patients in the post-acute phase of COVID-19 relative to controls. We searched the MEDLINE, EMBASE, and CENTRAL databases in June 2025 for studies reporting FDG-PET data in patients with post-acute COVID-19 who have persistent neurological symptoms. Of the 14 eligible studies (584 scans), 13 reported glucose hypometabolism across frontoparietal regions, with the frontal cortex being the most consistently affected. This finding was confirmed by meta-analysis, which revealed a large and significant effect in the frontal cortex (Hedges' g = 1.34; 95% CI: 0.79-1.88; p < 0.001), despite high heterogeneity (I2 = 93.6%). The systematic review indicates that brain metabolism generally improves over time, with widely varying recovery timelines, and consistently correlates hypometabolism with neurological symptom burden. These findings underscore the clinical relevance of frontoparietal hypometabolism in post-acute COVID-19 and its association with neurocognitive deficits, highlighting the need for longitudinal, quantitative PET studies to elucidate temporal dynamics and inform therapeutic development.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"128"},"PeriodicalIF":2.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase. 大鼠纹状体区按性别和发情周期分类的神经元体积和密度测量。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-06 DOI: 10.1007/s00429-025-02995-5

Nathan J Dale, Jinyan Cao, David M Dorris, Ashtin B Crawford, John Meitzen

{"title":"Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase.","authors":"Nathan J Dale, Jinyan Cao, David M Dorris, Ashtin B Crawford, John Meitzen","doi":"10.1007/s00429-025-02995-5","DOIUrl":"10.1007/s00429-025-02995-5","url":null,"abstract":"In the adult mammalian nervous system, sex differences can be manifested independently or in concert with sex-specific hormone cycles, such as the rat estrous cycle. Biological sex and related cycles influence neuronal properties in many brain regions, including the striatum, encompassing the nucleus accumbens (NAc) core, NAc shell, and caudate-putamen (CPu). While neuron soma size and density are commonly assessed in the context of biological sex, these attributes have never been investigated in the striatal regions of adult gonad-intact rodents disaggregated by sex and estrous cycle phase. Thus, we tested the hypothesis that neuron soma size and density would vary by striatal region, sex, and estrous cycle phase. Neuron soma size and density were measured in NAc core, NAc shell, and CPu from adult male rats and female rats in diestrus, proestrus, and estrus phases. Overall, neuron soma size was larger in the CPu than the NAc core and shell. Neuron density was greatest in the NAc shell, followed by the NAc core and CPu. Regarding sex, soma size was larger in male than female NAc shell and did not differ in other regions. Soma density did not sexually differ. Neither soma size nor density differed across estrous cycle phases. These results provide, for the first time, striatal neuron size and density measurements disaggregated by sex and estrous cycle phase and an indication of a sex difference in NAc shell soma size. In contrast, the estrous cycle appears to influence striatal function via other mechanisms than neuronal soma attributes.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"127"},"PeriodicalIF":2.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic bias in surface area asymmetry measurements from automatic cortical parcellations. 从自动皮层包块测量表面积不对称的系统偏差。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-08-05 DOI: 10.1007/s00429-025-02989-3

Yinuo Liu, Ja Young Choi, Tyler K Perrachione

{"title":"Systematic bias in surface area asymmetry measurements from automatic cortical parcellations.","authors":"Yinuo Liu, Ja Young Choi, Tyler K Perrachione","doi":"10.1007/s00429-025-02989-3","DOIUrl":"10.1007/s00429-025-02989-3","url":null,"abstract":"Anatomical asymmetry is a hallmark of the human brain and may reflect hemispheric differences in its functional organization. Widely used software like FreeSurfer can automate neuroanatomical measurements and facilitate studies of hemispheric asymmetry. However, patterns of surface area lateralization measured using FreeSurfer are curiously consistent across diverse samples. Here, we demonstrate systematic biases in these measurements obtained from the default processing pipeline. We compared surface area asymmetry measured from reconstructions of original brains vs. the same scans after flipping their left-right orientation. The default pipeline returned implausible asymmetry patterns between the original and flipped brains: Many structures were always left- or right-lateralized. Notably, these biases occur prominently in key speech and language regions. In contrast, manual labeling and curvature-based parcellations of key structures both yielded the expected reversals of left/right lateralization in flipped brains. We determined that these biases result from discrepancies in how regional labels are defined between the cortical parcellation atlases' left and right hemispheres. These biases are carried into individual parcellations because the parcellation algorithm prioritizes vertex correspondence to the template over individual neuroanatomical variation, meaning such biases could exist in any asymmetric atlas-based parcellation. We further demonstrate several straightforward, bias-free approaches to measuring surface area asymmetry, including using symmetric registration templates and parcellation atlases, vertex-wise analyses, and within-subject curvature-based parcellations. These results highlight theoretical concerns about using only atlas-based parcellations to make inferences about population-level brain asymmetry and underscore the need for validating bias-free neuroanatomical measurements, particularly to better examine how structural lateralization underlies functional lateralization.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 7","pages":"126"},"PeriodicalIF":2.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0