Brain Structure & Function最新文献

Dendritic allometry of neocortical pyramidal neurons across mammalian brain size. 新皮质锥体神经元在哺乳动物脑大小上的树突异速分布。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-11-05 DOI: 10.1007/s00429-026-03227-0

Young-Jin Jang, Dongchoon Ahn

{"title":"Dendritic allometry of neocortical pyramidal neurons across mammalian brain size.","authors":"Young-Jin Jang, Dongchoon Ahn","doi":"10.1007/s00429-026-03227-0","DOIUrl":"https://doi.org/10.1007/s00429-026-03227-0","url":null,"abstract":"Neuron number increases with mammalian brain size, but how the dendritic morphology of individual neocortical pyramidal neurons changes across this range remains unclear. To address this question, we examined 2,412 neocortical pyramidal neuron reconstructions from 23 mammalian species in NeuroMorpho.Org, spanning an approximately 11,000-fold range in brain weight. At the whole-neuron level, primary axis length, lateral extent, and Sholl critical radius increased with brain size but remained far below the isometric expectation, whereas total dendritic length showed no significant association. Mean remote bifurcation angle, section tortuosity, and maximum branch order decreased with brain size, suggesting that greater spatial reach was accompanied by a more streamlined arbor organization rather than by proportional increases in dendritic cable length or branching depth. Compartment-resolved analyses localized much of the spatial, cable-length, and fixed-radius Sholl signal to basal dendrites, whereas apical spatial expansion was weaker. By contrast, branch geometry associations were broadly similar between apical and basal compartments. Together, these patterns suggest that mammalian pyramidal neuron morphology varies with brain size through selective spatial expansion and basal-dominant compartmental scaling rather than through uniform enlargement of individual arbors.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149340778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstinence from heroin self-administration increases dendritic spine head diameter and the proportion of mushroom spines in rat prelimbic cortical neurons projecting to the paraventricular thalamus. 戒断海洛因会增加树突棘头直径和向室旁丘脑投射的边缘前皮质神经元中蘑菇棘的比例。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-11-05 DOI: 10.1007/s00429-026-03217-2

Maya A Nash, Giuseppe Giannotti

{"title":"Abstinence from heroin self-administration increases dendritic spine head diameter and the proportion of mushroom spines in rat prelimbic cortical neurons projecting to the paraventricular thalamus.","authors":"Maya A Nash, Giuseppe Giannotti","doi":"10.1007/s00429-026-03217-2","DOIUrl":"10.1007/s00429-026-03217-2","url":null,"abstract":"Relapse to opioid use remains the principal obstacle to recovery, often driven by enduring neuroadaptations that sustain vulnerability across abstinence. We have previously shown that the projection from the rat prelimbic cortex (PL) to the paraventricular thalamus (PVT) is functionally potentiated following abstinence from heroin self-administration and is necessary for cued heroin seeking, yet whether this pathway undergoes structural remodeling remains unknown. Using an intersectional viral strategy to selectively label PL neurons projecting to the PVT in rats, we reconstructed their apical tuft dendritic spines in three dimensions following 14 days of home-cage abstinence from heroin self-administration. We found that abstinence significantly increased spine head diameter (dH) and shifted the entire head-diameter distribution without altering overall spine density. Using an unsupervised model-based clustering to avoid arbitrary morphometric thresholds, we identified three distinct spine populations corresponding to classical thin, stubby, and mushroom categories. We found that abstinence reduced the density of thin-like spines and increased the density of mushroom-like spines. Overall, these findings identify the structural potentiation of excitatory inputs onto PL→PVT projection neurons as a fundamental component of the enduring circuit plasticity that sustains heroin seeking.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13740099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149340775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brainhack Rome 2025: connecting the dots between structure and function. Brainhack Rome 2025：连接结构和功能之间的点。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-11-05 DOI: 10.1007/s00429-026-03211-8

Matteo Mancini, Maria Guidi, Alessandra Maiuro, Marco Palombo, Edoardo d'Andrea, Luca Cairone, Federico Calesella, Yikang Cao, Manuela Carriero, Angelina Catrambone, Daniele Cirulli, Marida De Maria, Matteo De Matola, Emanuele Di Giorgio, Chiara Ercolano, Ottavia Falconi, Michela Fratini, Giulio Iannelli, Flavia Liporace, Lorenzo Massimi, Anna Notaro, Fabrizio Parente, Tiziana Pedale, Margherita Premi, Veronica Rossi, Darvin Shehu, Tiago da Silva Alves de Nogueira Simões, Taljinder Singh, Ginevra Sperandio, Leonardo Spitoni, Luca Taffarello, Pablo Villegas, Marco Zenari, Federico Giove

{"title":"Brainhack Rome 2025: connecting the dots between structure and function.","authors":"Matteo Mancini, Maria Guidi, Alessandra Maiuro, Marco Palombo, Edoardo d'Andrea, Luca Cairone, Federico Calesella, Yikang Cao, Manuela Carriero, Angelina Catrambone, Daniele Cirulli, Marida De Maria, Matteo De Matola, Emanuele Di Giorgio, Chiara Ercolano, Ottavia Falconi, Michela Fratini, Giulio Iannelli, Flavia Liporace, Lorenzo Massimi, Anna Notaro, Fabrizio Parente, Tiziana Pedale, Margherita Premi, Veronica Rossi, Darvin Shehu, Tiago da Silva Alves de Nogueira Simões, Taljinder Singh, Ginevra Sperandio, Leonardo Spitoni, Luca Taffarello, Pablo Villegas, Marco Zenari, Federico Giove","doi":"10.1007/s00429-026-03211-8","DOIUrl":"10.1007/s00429-026-03211-8","url":null,"abstract":"Brainhack events provide a bottom-up approach to tackle challenges in neuroscience. In 2025, the Enrico Fermi Research Center in Rome hosted its first Brainhack, with the goal of fostering interdisciplinary collaborations bringing together the physics and neuroscience perspectives on the study of brain structure and function. Structured in four days, it gave the chance to the participants to propose their own idea and shape a project based on it, leading to six research avenues: the combination of X-ray imaging and diffusion MRI algorithms to pioneer ultra-high-resolution tractography; multivariate approaches to study the shared factors between brain metabolism and microstructure estimated from MRI data; development of transfer entropy analysis-based tools for effective connectivity estimation in fMRI data; identification of brain states through Markov models; deep learning approaches to predict task EEG time courses; multi-scale network models to study functional and cerebrovascular data. Each project led to promising results and marked the beginning of new collaborations.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13740103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149340776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complex 3D cytoarchitecture of the anterior horn of the human sacral spinal cord revealed by light sheet fluorescence microscopy. 光片荧光显微镜显示的人骶脊髓前角复杂的三维细胞结构。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-11-05 DOI: 10.1007/s00429-026-03219-0

G Glaudot, Z Delbaere, C Ferenc, M Martens, S Hildebrand, C Behets, A Jankovski

{"title":"Complex 3D cytoarchitecture of the anterior horn of the human sacral spinal cord revealed by light sheet fluorescence microscopy.","authors":"G Glaudot, Z Delbaere, C Ferenc, M Martens, S Hildebrand, C Behets, A Jankovski","doi":"10.1007/s00429-026-03219-0","DOIUrl":"10.1007/s00429-026-03219-0","url":null,"abstract":"This study provides a unique three-dimensional characterization of the cytoarchitecture of the anterior horn of the human sacral spinal cord, with a specific focus on the S2 segment. This region is of particular interest because it constitutes the transition between the motoneurons that innervate the muscles of the lower limbs and those that control the pelvic floor. The S2 segment also contains a distinct motor nucleus, Onuf's nucleus (ON), involved in sphincter control. Using a tissue clearing protocol combined with light sheet fluorescence microscopy, we analyzed samples of sacral spinal cords from ten human cadavers to obtain high-resolution 3D images. Segmentation revealed seven distinct motoneuron groups organized into medial and lateral divisions surrounding ON. ON itself displayed a complex, multilobed architecture, with a denser central region and more fragmented extremities. A robust cytoarchitectural pattern of specific neuron columns was identified along the rostrocaudal axis of ON and characterized by their progressive disappearance, fusion, or emergence. Notably, lateral columns predominated at the level of ON rostral half, whereas medial columns appeared more caudally. Additionally, a significant sexual dimorphism in ON length was observed, being longer in males. Overall, our findings demonstrate that the classical columnar model of spinal motoneuron organization underestimates the structural complexity of the anterior horn. This study highlights the interest of light sheet fluorescence microscopy for revealing fine anatomical organization and provides a framework for future investigations of SC cytoarchitecture.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13740047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149340777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projections from medial prefrontal cortex and hippocampus to midline thalamus and perirhinal cortex: a double retrograde tracing study in rats. 大鼠前额叶内侧皮层和海马向丘脑中线和鼻周皮层的投射：双逆行示踪研究。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-10-29 DOI: 10.1007/s00429-026-03218-1

Yen-Ling Huang, Chun-Hui Chang

{"title":"Projections from medial prefrontal cortex and hippocampus to midline thalamus and perirhinal cortex: a double retrograde tracing study in rats.","authors":"Yen-Ling Huang, Chun-Hui Chang","doi":"10.1007/s00429-026-03218-1","DOIUrl":"10.1007/s00429-026-03218-1","url":null,"abstract":"The nucleus reuniens (RE), paraventricular nucleus of the thalamus (PVT), and perirhinal cortex (PRC), which have reciprocal connections with both the medial prefrontal cortex (mPFC) and hippocampus (HPC), could act as the relays to regulate the interplay between the mPFC and HPC. To better understand the anatomical structure of neurons in the mPFC and HPC subregions projecting to the peri-reuniens nucleus (periRE), posterior PVT (pPVT), and PRC, fluorescent retrograde tracers of CTB-AF488 or CTB-AF594 were unilaterally injected into the pPVT and PRC (Experiment 1) or into the pPVT and periRE (Experiment 2), respectively. The cell labeling was examined in the region of interest of the mPFC-HPC network, including the prelimbic cortex (PL), infralimbic cortex (IL), dorsal and ventral CA1 (dCA1 and vCA1), and dorsal and ventral subiculum (dSub and vSub). Our results indicated that mPFC projections to the periRE or pPVT were more robust on the ipsilateral side in general, with the exception of IL projections to the pPVT showing no lateralization, and the majority of the projections originated from the deep layer. There was no lateralization of mPFC projections to the PRC. As for the HPC, the majority of PRC-projecting cells were found on the ipsilateral side of the vCA1 and dSub. There was in general no lateralization of HPC projections to the periRE or pPVT, with the exception of vSub projections to the pPVT more robust on the ipsilateral side. Finally, collateral projecting cells were sparse in all regions examined of the two experiments.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149294510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Comparative MRI analysis of the forebrain of three sauropsida models. 更正：三种蜥脚类动物模型的前脑对比MRI分析。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-10-25 DOI: 10.1007/s00429-026-03208-3

S Jiménez, I Santos-Álvarez, E Fernández-Valle, D Castejón, P Villa-Valverde, C Rojo-Salvador, P Pérez-Lloret, M J Ruiz-Fernández, S Ariza-Pastrana, R Martín-Orti, Juncal González-Soriano, Nerea Moreno

引用次数: 0

Quantifying dexterity and grip strength associations between age, cognitive function (MoCA), and cerebellar gray matter volume in healthy adults across the adult lifespan. 量化健康成人一生中年龄、认知功能（MoCA）和小脑灰质体积之间的灵巧性和握力关联

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-10-22 DOI: 10.1007/s00429-026-03213-6

Pranesh Rajesh Kannan, Raghav Pallapothu, Santosh Kudaravalli, Sriya Pallapothu, Roger D Newman-Norlund

{"title":"Quantifying dexterity and grip strength associations between age, cognitive function (MoCA), and cerebellar gray matter volume in healthy adults across the adult lifespan.","authors":"Pranesh Rajesh Kannan, Raghav Pallapothu, Santosh Kudaravalli, Sriya Pallapothu, Roger D Newman-Norlund","doi":"10.1007/s00429-026-03213-6","DOIUrl":"10.1007/s00429-026-03213-6","url":null,"abstract":"Cerebellar Crus I/II gray matter volume (GMV) is a structural marker of cognitive aging, and motor performance predicts age-related cognitive decline. Whether grip strength and manual dexterity dissociate in their cerebellar and cognitive correlates is unknown. We computed Pearson partial correlations (age, sex, and race covaried) between grip strength, Nine-Hole Peg Test (9HPT) dexterity, cerebellar Crus I/II GMV, and Montreal Cognitive Assessment (MoCA) subscores in 304 healthy adults aged 20-79 from the University of South Carolina Aging Brain Cohort. GMV was derived from T1-weighted MRI using CAT12 with the AAL3 atlas. After false discovery rate (FDR) correction, dominant 9HPT time correlated with MoCA total score (r=-.240) and memory index (r=-.220; both pFDR<0.001). Grip strength was unrelated to any MoCA measure but correlated bilaterally with Crus II GMV (r=.156-.224, all pFDR≤0.041). Bootstrapped mediation indicated that dexterity statistically accounted for 28.8% of the age-cognition association and Crus II volume for 34.4-41.4% of the age-grip association. Dichotomizing at the MoCA cut-off of 26, each additional second of peg time carried 17.6% higher odds of scoring below cut-off (odds ratio = 1.176, 95% CI [1.062,1.302]) while grip strength carried none. Grip strength, but not dexterity, was independently associated with Crus II GMV, whereas dexterity, but not grip, was associated with cognition. Grip strength and dexterity are therefore not interchangeable indices of motor function. Because the design is cross-sectional, mediation estimates describe shared variance rather than causal pathways, and the pronounced MoCA ceiling likely attenuated the cognitive associations.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency-dependent, asymmetric, and dynamic alterations of white matter function in primary hemifacial spasm: a multiband resting-state fMRI study. 原发性面肌痉挛中白质功能的频率依赖、不对称和动态改变：一项多波段静息状态fMRI研究。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-10-17 DOI: 10.1007/s00429-026-03207-4

Haiqi Ye, Luoyu Wang, Juncheng Yan, Lei Pan, Yuting Zhang, Lidan Fang, Fenyang Chen, Ding Wang, Xiuhong Ge

{"title":"Frequency-dependent, asymmetric, and dynamic alterations of white matter function in primary hemifacial spasm: a multiband resting-state fMRI study.","authors":"Haiqi Ye, Luoyu Wang, Juncheng Yan, Lei Pan, Yuting Zhang, Lidan Fang, Fenyang Chen, Ding Wang, Xiuhong Ge","doi":"10.1007/s00429-026-03207-4","DOIUrl":"https://doi.org/10.1007/s00429-026-03207-4","url":null,"abstract":"Primary hemifacial spasm involves central network reorganization, but white matter functional alterations remain unclear. We acquired resting-state functional magnetic resonance imaging data from 89 left-sided patients, 92 right-sided patients, and 124 healthy controls. Patients exhibited widespread abnormalities in tracts including the corpus callosum, superior longitudinal fasciculus, and corona radiata. Notably, this remodeling was highly asymmetric: left-sided patients primarily showed increased local neural activity in prefrontal pathways, whereas right-sided patients exhibited increased global network centrality across interhemispheric tracts. Furthermore, these alterations displayed distinct frequency preferences, and certain functional instabilities were exclusively captured by dynamic metrics rather than static analyses. These findings demonstrate that the disorder is associated with time-varying, frequency-specific, and asymmetric white matter functional reorganization, highlighting the value of dynamic and multi-frequency approaches in decoding its pathophysiology.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facial emotion recognition of sadness relates to superior parietal gray matter volume in mild cognitive impairment. 轻度认知障碍患者悲伤面部情绪识别与顶叶上灰质体积有关。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-10-17 DOI: 10.1007/s00429-026-03215-4

Rachana Mahadevan, Naomi Kristin Giesers, Thomas Liman, Karsten Witt, Andrea Hildebrandt, Mandy Roheger, Stephanie Rosemann

{"title":"Facial emotion recognition of sadness relates to superior parietal gray matter volume in mild cognitive impairment.","authors":"Rachana Mahadevan, Naomi Kristin Giesers, Thomas Liman, Karsten Witt, Andrea Hildebrandt, Mandy Roheger, Stephanie Rosemann","doi":"10.1007/s00429-026-03215-4","DOIUrl":"10.1007/s00429-026-03215-4","url":null,"abstract":"Mild cognitive impairment (MCI) is associated with early, regionally selective neurodegenerative changes that may affect socioemotional functioning before atrophy becomes widespread. This study examined whether structural brain alterations in MCI relate to facial emotion recognition performance. Sixty adults (30 MCI, 30 healthy controls), aged 50-86 years, completed neuropsychological testing, the Facial emotion composite Task, and structural MRI. Whole-brain voxel-based morphometry revealed no significant gray matter volume differences between groups. However, targeted region-of-interest ROI analyses demonstrated lower right amygdala and bilateral hippocampal volumes in patients with MCI. Cortical thickness analyses identified two regions with lower thickness in MCI: the right superior parietal lobule and the left posterior insula. A significant Group × Sadness interaction indicated that the association between left superior parietal gray matter volume and sadness recognition differed between groups. Follow-up analyses of the extracted values showed a positive association in MCI, although this within-group association did not reach statistical significance, and a significant inverse association in HCs. These findings suggest that early MCI involves selective thinning in association cortices supporting attention and salience processing. The sadness-specific interaction indicates that patients with MCI may rely on preserved superior parietal structure during sadness recognition, a pattern that is consistent with structural reserve accounts, although this interpretation remains speculative given the cross-sectional design.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reward sensitivity is negatively associated with future self-continuity: the mediation role of functional connectivity between the dorsomedial prefrontal cortex and ventrolateral prefrontal cortex. 奖励敏感性与未来自我连续性呈负相关：背内侧前额叶皮层和腹外侧前额叶皮层之间功能连接的中介作用。

IF 3 3区医学

Brain Structure & Function Pub Date : 2026-10-17 DOI: 10.1007/s00429-026-03212-7

Hongjie Shen, Liang Chen, Hengyue Zhao, Jicheng Huang, Chenxu Yang, Zixiao Xiong, Zhonghui Zhang, Yanlin Ren, Yanhong Liu, Tingyong Feng, Pan Feng

{"title":"Reward sensitivity is negatively associated with future self-continuity: the mediation role of functional connectivity between the dorsomedial prefrontal cortex and ventrolateral prefrontal cortex.","authors":"Hongjie Shen, Liang Chen, Hengyue Zhao, Jicheng Huang, Chenxu Yang, Zixiao Xiong, Zhonghui Zhang, Yanlin Ren, Yanhong Liu, Tingyong Feng, Pan Feng","doi":"10.1007/s00429-026-03212-7","DOIUrl":"https://doi.org/10.1007/s00429-026-03212-7","url":null,"abstract":"Reward Sensitivity refers to individual differences in the perception, evaluation, and emotional response to potential or acquired rewarding stimuli. Future self-continuity refers to the degree of psychological connection, identification, and consistency that individuals perceive between their present self and future self. Although both constructs are known to critically influence intertemporal decision-making and self-control, the shared neurobiological mechanisms linking them remain largely unexplored. To address this question, we used voxel-based morphometry and resting-state functional connectivity analyses to investigate the neural basis underlying the association between reward sensitivity and future self-continuity. Behavioral results showed reward sensitivity exhibited a significant negative correlation with future self-continuity. Moreover, voxel-based morphometry (VBM) revealed that reward sensitivity was negatively associated with gray matter volume in the dorsomedial prefrontal cortex (dmPFC). Furthermore, resting-state functional connectivity (RSFC) analysis demonstrated that the functional connectivity between the dmPFC and the ventrolateral prefrontal cortex (vlPFC) was positively correlated with reward sensitivity. Ultimately, mediation analysis revealed a positive indirect effect, indicating that this dmPFC-vlPFC connectivity acted as a protective neural factor in the negative relationship between reward sensitivity and future self-continuity. In conclusion, the current research offered novel insights into the impact of reward sensitivity on future self-continuity, advancing our understanding of this behavioral connection from a neurobiological perspective.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0