Beyond tractography in brain connectivity mapping with dMRI morphometry and functional networks.

IF 2.9 3区 医学 Q1 ANATOMY & MORPHOLOGY
Jui-To Wang, Ching-Po Lin, Huei-Min Liu, Carlo Pierpaoli, Chun-Yi Zac Lo
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Abstract

Traditional brain connectivity studies have focused mainly on structural connectivity, often relying on tractography with diffusion MRI (dMRI) to reconstruct white matter pathways. In parallel, studies of functional connectivity have examined correlations in brain activity using fMRI. However, emerging methodologies are advancing our understanding of brain networks. Here we explore advanced connectivity approaches beyond conventional tractography, focusing on dMRI morphometry and the integration of structural and functional connectivity analysis. dMRI morphometry enables quantitative assessment of white matter pathway volumes through statistical comparison with normative populations, while functional connectivity reveals network organization that is not restricted to direct anatomical connections. More recently, approaches that combine diffusion tensor imaging (DTI) with functional correlation tensor (FCT) analysis have been introduced, and these complementary methods provide new perspectives into brain structure-function relationships. Together, such approaches have important implications for neurodevelopmental and neurological disorders as well as brain plasticity. The integration of these methods with artificial intelligence techniques have the potential to support both basic neuroscience research and clinical applications.

Abstract Image

Abstract Image

利用dMRI形态测量和功能网络进行脑连接映射的神经束造影研究。
传统的脑连接研究主要集中在结构连接上,通常依靠神经束成像与扩散MRI (dMRI)来重建白质通路。与此同时,功能性连通性的研究已经使用功能磁共振成像检查了大脑活动的相关性。然而,新兴的方法正在推进我们对大脑网络的理解。在这里,我们探索超越传统神经束造影的先进连接方法,重点是dMRI形态测量和结构和功能连接分析的整合。dMRI形态测定法可以通过与正常人群的统计比较来定量评估白质通路的体积,而功能连接则揭示了不局限于直接解剖连接的网络组织。最近,将扩散张量成像(DTI)与功能相关张量(FCT)分析相结合的方法被引入,这些互补的方法为研究大脑结构-功能关系提供了新的视角。总之,这些方法对神经发育和神经障碍以及大脑可塑性具有重要意义。这些方法与人工智能技术的整合有可能支持基础神经科学研究和临床应用。
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来源期刊
Brain Structure & Function
Brain Structure & Function 医学-解剖学与形态学
CiteScore
6.00
自引率
6.50%
发文量
168
审稿时长
8 months
期刊介绍: Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.
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