The tractographer's dilemma: understanding sources of variability in tractography.

IF 2.7 3区医学 Q1 ANATOMY & MORPHOLOGY

Brain Structure & Function Pub Date : 2025-06-16 DOI:10.1007/s00429-025-02964-y

Flavio Dell'Acqua, Alexander Leemans, Fan Zhang, Francois Rheault, Shawna Farquharson, Alberto De Luca

引用次数: 0

Abstract

Tractography involves many steps, and as such can be heavily affected by data quality, operator decisions such as algorithm and parameter selection and/or biological variables - in addition to random effects such as noise and motion. Due to the interplay between sources of variability, even seemingly minor decisions or overlooked assumptions can lead to major variations in output that can potentially confound tractography results. This article summarizes the main sources of variability in tractography to remind both new and experienced users of the importance of making informed decisions at all stages of the tractography pipeline.

查看原文本刊更多论文

牵导仪的困境：了解牵导术可变性的来源。

神经束造影涉及许多步骤，因此可能受到数据质量、操作员决策（如算法和参数选择）和/或生物变量的严重影响，此外还有噪声和运动等随机效应。由于变异性来源之间的相互作用，即使是看似微小的决定或被忽视的假设也可能导致输出的重大变化，从而可能混淆导管造影结果。本文总结了导管造影变异性的主要来源，以提醒新手和有经验的用户在导管造影管道的所有阶段做出明智决策的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Structure & Function 医学-解剖学与形态学

CiteScore

6.00

自引率

6.50%

发文量

168

审稿时长

8 months

期刊介绍： Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.