Brain Structure & Function最新文献_第6页

Sex differences in structural and functional connectivity in healthy young adults from the Amsterdam Open MRI Collection. 来自阿姆斯特丹开放MRI收集的健康年轻人结构和功能连接的性别差异。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-16 DOI: 10.1007/s00429-025-02965-x

Xiaojian Kang, Maheen M Adamson, Byung C Yoon

{"title":"Sex differences in structural and functional connectivity in healthy young adults from the Amsterdam Open MRI Collection.","authors":"Xiaojian Kang, Maheen M Adamson, Byung C Yoon","doi":"10.1007/s00429-025-02965-x","DOIUrl":"10.1007/s00429-025-02965-x","url":null,"abstract":"Understanding the structural and functional differences in the brain between sexes may provide insight into the sex differences in behaviors, cognition, and disorders. Structural (SC) and functional (FC) connectivity were examined in this study on 111 (Females = 56) right-handed, healthy, young adults controlled for brain size, using the cluster and region-of-interest (ROI) based algorithms. A nearly moderate correlation between SC and FC was observed for both male and female cohorts, but the degree of correlation was not significantly different between the sexes. Sex differences in SC were found in both intra- and inter-hemispheric clusters and connections, with more differences in the left hemisphere. Compared to males, females were found to have anatomical parcels with higher SC in the left hemisphere involving the language network. Females were also found to have anatomical parcels with higher FC than males in the left hemisphere, including connections to the somatomotor and default mode networks, and lower FC distributed symmetrically between the two hemispheres. These findings highlight the sex differences in the brain structure and function in healthy, young adult populations that may underly behavioral and cognitive differences, including language processing and somatomotor perception.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"98"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The bibliography of Rudolf Nieuwenhuys. 鲁道夫·纽文赫斯的参考书目。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-06-16 DOI: 10.1007/s00429-025-02954-0

Suzanne Bakker

引用次数: 0

Developmental changes of Reelin-expressing cell populations in the marginal zone of the neocortex of the European wild boar, Sus scrofa. 欧洲野猪新皮质边缘区表达reelin细胞群的发育变化。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-11 DOI: 10.1007/s00429-025-02958-w

Eric Sobierajski, Miriam González-Gómez, Emilio González-Arnay, Petra Wahle, Gundela Meyer

{"title":"Developmental changes of Reelin-expressing cell populations in the marginal zone of the neocortex of the European wild boar, Sus scrofa.","authors":"Eric Sobierajski, Miriam González-Gómez, Emilio González-Arnay, Petra Wahle, Gundela Meyer","doi":"10.1007/s00429-025-02958-w","DOIUrl":"10.1007/s00429-025-02958-w","url":null,"abstract":"Cortical Cajal-Retzius cells (CRc) are the main source of Reelin and essential for radial migration. We studied the development of cells expressing Reelin, Tbr1, p73 and calretinin in pig neocortex from E35 to P30. CRc originated around E35 from the cortical hem and filled the marginal zone (MZ). At E45, in an expanding cortex, CRc were more loosely arranged and more mature. At midgestation E60-E70, CRc with elongated horizontally oriented somata and long dendrites formed a dense network of processes in the upper MZ. Their axons were characterized by the presence of long axon initial segments and densely ramified in the lower MZ. Concurrently, the first GAD-positive/Reelin-positive as well as GAD-positive/Reelin-negative interneurons appeared in the MZ and in cortical layers. At E85, in an already highly gyrated cortex, the switch in Reelin-positive neuronal populations was largely completed. At E100 and P30, CRc were rare. A subpial granular layer was not detectable in pig. In sum, by form, distribution and the presence of a calretinin-positive axon plexus in the lower MZ, the pig CRc closely resembled the lagomorph and carnivore rather than the human morphotypes, and they become complemented by interneurons already after midgestation.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"96"},"PeriodicalIF":2.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tractography in brain tumor surgery: current clinical impact and future challenges. 脑肿瘤手术中的神经束造影：目前的临床影响和未来的挑战。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-10 DOI: 10.1007/s00429-025-02956-y

Silvio Sarubbo, Fracesco Vergani, Joseph Yuan-Mou Yang

引用次数: 0

Temporal progression of pathological features in an α-synuclein overexpression model of Parkinson's disease. α-突触核蛋白过表达模型帕金森病病理特征的时间进展

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-09 DOI: 10.1007/s00429-025-02959-9

Andrea Vaquero-Rodríguez, Jone Razquin, Ane Murueta-Goyena, Cristina Miguelez, José Ángel Ruíz-Ortega, José Vicente Lafuente, Harkaitz Bengoetxea, Naiara Ortuzar

{"title":"Temporal progression of pathological features in an α-synuclein overexpression model of Parkinson's disease.","authors":"Andrea Vaquero-Rodríguez, Jone Razquin, Ane Murueta-Goyena, Cristina Miguelez, José Ángel Ruíz-Ortega, José Vicente Lafuente, Harkaitz Bengoetxea, Naiara Ortuzar","doi":"10.1007/s00429-025-02959-9","DOIUrl":"10.1007/s00429-025-02959-9","url":null,"abstract":"Parkinson's disease (PD) is a common neurodegenerative disorder, affecting 1-5% of individuals over 60, with a higher incidence in men. It is clinically characterized by progressive motor impairments, including rigidity, bradykinesia, tremors, and gait disturbances. The neuropathological hallmark of PD is the aggregation of α-synuclein (α-syn) into Lewy bodies (LB) and neurites (LN). Although α-syn plays essential physiological roles, its misfolding and accumulation drive neurodegeneration. In this study, we investigated the temporal progression and anatomical distribution of α-syn pathology using a bilateral adeno-associated virus serotype-9 (AAV9)-mediated α-syn overexpression model in rats. Disease-related features were analyzed at one, two and four months post-injection. Neuronal α-syn overexpression was confirmed as it co-localized predominantly with tyrosine hydroxylase (TH)-positive neurons, distinctly separate from glial markers. Behavioral assessment, immunofluorescence assays, stereological quantification, and optical densitometry revealed progressive motor impairments, dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc), and decreased TH + fibers in the striatum and dendrites of the substantia nigra pars reticulata (SNpr). These changes were accompanied by increased microglial activation. Furthermore, axonal swellings in the striatum increased progressively over time, correlating with reductions in striatal TH optical density. By characterizing the temporal dynamics of α-syn-induced pathology, this study underscores the model's relevance for PD research and highlights critical time windows for evaluating therapeutic interventions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"91"},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nieuwenhuys' timely, influential, and visionary work. Nieuwenhuys的及时、有影响力和有远见的工作。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-09 DOI: 10.1007/s00429-025-02949-x

Alvaro Duque

引用次数: 0

Rudolf Nieuwenhuys (11 June 1927-4 November 2024): a scholarly life. 鲁道夫·纽文赫斯（1927年6月11日- 2024年11月4日）：学术生涯。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-06-08 DOI: 10.1007/s00429-025-02953-1

Suzanne Bakker, Hans J Ten Donkelaar, Jan Voogd, Charles Nicholson, Lawrence H Bannister, Loreta Medina, Ester Desfilis, Mario F Wullimann, Johannes Meek, Luis Puelles, Cees A J Broere, Robert Turner, Leonardo Cerliani, Matthew F Glasser

{"title":"Rudolf Nieuwenhuys (11 June 1927-4 November 2024): a scholarly life.","authors":"Suzanne Bakker, Hans J Ten Donkelaar, Jan Voogd, Charles Nicholson, Lawrence H Bannister, Loreta Medina, Ester Desfilis, Mario F Wullimann, Johannes Meek, Luis Puelles, Cees A J Broere, Robert Turner, Leonardo Cerliani, Matthew F Glasser","doi":"10.1007/s00429-025-02953-1","DOIUrl":"10.1007/s00429-025-02953-1","url":null,"abstract":"This collective eulogy by colleagues, co-authors and friends is a tribute to the work and life of Rudolf Nieuwenhuys. 'Neurofascination' is an apt label for his scholarly life in the sciences from the start in 1955 until his last days in 2024. In addition, he had a broad interest in Roman and Gothic architecture, the history and politics of the twentieth century, religion and the music of Johann Sebastian Bach. Extensive discussions on one or more of these topics often led to long-lasting friendships, some of which inform the following pages. Rudolf is remembered for his highly didactical and remarkably illustrated presentations and publications, including the three-volume The Central Nervous System of Vertebrates and the four editions of The Human Central Nervous System. His research interests addressed an impressively wide range of topics concerning development and evolutionary neurobiology and a systematic approach to comparative brain structures in vertebrates. His almost endless fascination for neuromorphology included the invertebrates as well. But unfortunately, even his long life was not enough to write the book on the comparative neuroanatomy of invertebrates which he long had in mind. The many years of his career spanned the remarkable histology of the gigantocerebellum of mormyrids to an exploratory synthesis of subdivisions of the human cortex, as originally mapped by the Vogt-Vogt school of cortical architectonics.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"90"},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The deep winding at the brain surface: replicating a historical report associating the 'bridged' central sulcus with the pli de passage fronto-pariétal moyen. 大脑表面的深层弯曲：复制了一份历史报告，将“桥接”的中央沟与前额-顶节通道联系起来。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-06 DOI: 10.1007/s00429-025-02947-z

Renate Schweizer, Anna Marie Muellen, Julius Stropel

引用次数: 0

Quantitative tractography: joys and sorrows. 定量气管造影：喜怒哀乐。

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-06 DOI: 10.1007/s00429-025-02939-z

Alessandro Daducci, Simona Schiavi

引用次数: 0

DTI-based fiber tractography: why not? 基于dti的纤维束状图：为什么不呢？

IF 2.9 3区医学

Brain Structure & Function Pub Date : 2025-06-05 DOI: 10.1007/s00429-025-02960-2

Dogu Baran Aydogan, Alexander Leemans, Jessica Dubois, Flavio Dell'Acqua, Chiara Maffei

引用次数: 0