Brain Structure & Function最新文献_第6页

Katrin Amunts. 凯特琳Amunts。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02929-1

Katrin Amunts

引用次数: 0

Fixel-based evidence for preserved white matter asymmetry in human situs inversus totalis. 基于固定的证据，证明人类相对于整体位置保留的白质不对称性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02931-7

Emma M Karlsson, Helena Verhelst, Guy Vingerhoets

{"title":"Fixel-based evidence for preserved white matter asymmetry in human situs inversus totalis.","authors":"Emma M Karlsson, Helena Verhelst, Guy Vingerhoets","doi":"10.1007/s00429-025-02931-7","DOIUrl":"10.1007/s00429-025-02931-7","url":null,"abstract":"Situs inversus totalis (SIT), a rare condition involving the complete reversal of thoracic and abdominal organ placement, provides a unique model for investigating potential relationships between visceral and cerebral asymmetries. In this study, we examined whether white matter asymmetries are altered in a group of 21 SIT participants compared with 21 matched situs solitus (SO) controls. This sample represents the largest cohort of SIT individuals studied to date. Using fixel-based analysis, an advanced diffusion magnetic resonance imaging framework, we compared micro- and macrostructural white matter asymmetries across the whole brain between the two groups, specifically assessing fiber density and cross-section (FDC). Both groups showed extensive yet comparable patterns of white matter asymmetry, with no significant group differences. These asymmetry patterns were consistent with those reported in previous fixel-based studies. These results suggest that white matter lateralization is preserved despite complete visceral reversal. The observed divergence between brain and visceral asymmetry patterns suggests that symmetry breaking in visceral laterality relies on distinct mechanisms.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"69"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic inferior olive activation in a cognitive task: an fMRI study. 动态下橄榄在认知任务中的激活：fMRI研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02933-5

Annakarina Mundorf, Laura C Rice, Jutta Peterburs, John E Desmond

{"title":"Dynamic inferior olive activation in a cognitive task: an fMRI study.","authors":"Annakarina Mundorf, Laura C Rice, Jutta Peterburs, John E Desmond","doi":"10.1007/s00429-025-02933-5","DOIUrl":"10.1007/s00429-025-02933-5","url":null,"abstract":"The inferior olive provides powerful inputs to the cerebellum hypothesized to support cerebellar learning and error detection. Given cerebellar involvement in verbal working memory and the close interplay with the inferior olive, the inferior olive is likely also involved in verbal working memory. In order to elucidate the inferior olive's role in verbal working memory, we utilized an MRI-based Sternberg verbal working memory task which involved learning novel vs repeated sequences. As hypothesized, inferior olive activation was stronger during encoding and retrieval compared to maintenance, especially for novel compared to repeated sequences, indicative of diminished inferior olive activity with stimulus repetition. Results also revealed differential inferior olive activation during retrieval, with increased activation on matching probes for novel and on non-matching probes for repeated sequences. This underlines the crucial role of the inferior olive in novel information encoding and error feedback, and that conditions triggering strong inferior olive responses can change as a function of novelty.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"72"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study. 未破裂颅内动脉瘤患者的异常脑活动：静息状态功能MRI研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-20 DOI: 10.1007/s00429-025-02934-4

Wei Li, Weijie Fan, Si Zhang, Haiyu Zhang, Dong Zhang, Li Wen

{"title":"Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study.","authors":"Wei Li, Weijie Fan, Si Zhang, Haiyu Zhang, Dong Zhang, Li Wen","doi":"10.1007/s00429-025-02934-4","DOIUrl":"10.1007/s00429-025-02934-4","url":null,"abstract":"Patients carrying unruptured intracranial aneurysm (UIA) often experience emotional alterations and cognitive impairments. While the specific mechanisms underlying these impairments are still not fully understood. The study measured the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) to investigate the abnormal brain functional alterations in 49 UIA patients compared with 50 healthy controls, and also analyzed the correlations among neuroimaging indices, the clinical data, and the neuropsychological test results. UIA patients exhibited more active brain region activity in the right hippocampus than the healthy group and showed negatively activated brain regions, including the cuneus, left paracentral lobule, and right postcentral gyrus. Furthermore, the strength of FC decreased in the bilateral middle cingulate gyrus; right superior temporal gyrus and insula; and left parahippocampal gyrus, fusiform gyrus, lingual gyrus, inferior frontal gyrus, and middle frontal gyrus. The abnormal activities in the aforementioned brain regions were closely linked to worse performance in emotion and cognition. The study presents a potential neuroimaging-based mechanism of brain function that could explain the emotional alterations and cognitive impairments in UIA patients.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"68"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training. 脑瘫儿童平衡控制的脑结构相关性：基线相关性和训练效果。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-20 DOI: 10.1007/s00429-025-02937-1

Nina P T Jacobs, Marjolein M van der Krogt, Annemieke I Buizer, Laura A van de Pol, Chloé E C Bras, Frederik Barkhof, Pieter Meyns, Petra J W Pouwels

{"title":"Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training.","authors":"Nina P T Jacobs, Marjolein M van der Krogt, Annemieke I Buizer, Laura A van de Pol, Chloé E C Bras, Frederik Barkhof, Pieter Meyns, Petra J W Pouwels","doi":"10.1007/s00429-025-02937-1","DOIUrl":"10.1007/s00429-025-02937-1","url":null,"abstract":"Structural brain abnormalities likely underlie impaired balance control in cerebral palsy (CP). This study investigated whether balance measures were associated with measures derived from conventional MRI and diffusion tensor imaging (DTI), and whether an X-Box One Kinect balance training (6 weeks, 5 days/week, 30 min/session) could induce neuroplastic changes in CP. Twelve children with spastic CP (age:11.3 ± 2.3y) underwent balance evaluation and MRI examination, at baseline and after training. Nine age-matched typically developing (TD) children underwent baseline measurements. Balance control was evaluated testing advanced motor skills (Challenge score) and during gait (medio-lateral Margin of Stability, MoS). With conventional MRI, but especially with DTBM (DTI-based VBM), we found smaller volumes of several deep grey matter structures and within the right inferior parietal cortex, right supramarginal cortex, and left postcentral cortex, and lower fractional anisotropy (FA) and smaller volumes of various white matter regions in CP compared to TD. Within the CP group alone, no correlations within brain tissue were found. After training, Challenge scores of children with CP improved. In an exploratory analysis DTBM showed a trend for volume increase within the right inferior parietal cortex, volume decrease within the right retrolenticular limb of the internal capsule, and an increase of FA within the right corticospinal tract. This indicates that a 6-week balance intervention may induce neuroplastic changes in children with CP. CP-RehOP (trial registration number: NTR6034/NL5854, date of registration: August 26th 2016).","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"67"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased rubidium levels in brain regions involved in food intake in obese rats. 肥胖大鼠大脑中与食物摄入有关的区域铷含量增加。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-15 DOI: 10.1007/s00429-025-02930-8

Magdalena Szczerbowska-Boruchowska, Aleksandra Chenczke, Blazej Ruszczycki, Pawel Wrobel, Wiktoria Tokarczyk, Patryk Stec, Katarzyna M Sowa, Agata Ziomber-Lisiak

{"title":"Increased rubidium levels in brain regions involved in food intake in obese rats.","authors":"Magdalena Szczerbowska-Boruchowska, Aleksandra Chenczke, Blazej Ruszczycki, Pawel Wrobel, Wiktoria Tokarczyk, Patryk Stec, Katarzyna M Sowa, Agata Ziomber-Lisiak","doi":"10.1007/s00429-025-02930-8","DOIUrl":"10.1007/s00429-025-02930-8","url":null,"abstract":"The hypothalamus, particularly its ventromedial and lateral regions, plays a pivotal role in homeostatic appetite regulation and is therefore a significant brain structure in the development of obesity. Additionally, the development of obesity can be caused by improper hedonic regulation, which involves neural circuits and systems associated with pleasure and reward. Several studies indicate a possible link between rubidium (Rb) and obesity, despite this element is not being typically considered influential in vital life processes. The present study, therefore, aims to investigate whether excessive body fat in obese animals alters rubidium levels in brain regions directly or indirectly involved in appetite regulation. The research was conducted on high-calorie diet (HCD)-induced obese rats (OB, n = 8) and their lean counterparts (L, n = 8). The determination of Rb levels in brain areas was performed using synchrotron radiation-based X-ray fluorescence microanalysis (SRXRF). The obtained results show a significantly higher level of Rb in all brain areas examined, although the increase in this element in obese individuals was not the same in all structures. The largest relative difference (over 70%) was observed for the orbitofrontal cortex, and the smallest (about 35%) for the amygdala. Principal component analysis with linear projections demonstrated a clear differentiation between the brain structures of obese and non-obese individuals based on the full elemental composition of tissues, while Rb was the only element that distinguished the obese group in each of the examined brain structures. The results obtained clearly confirm the increase in Rb levels in the brain structures responsible for regulating appetite in obesity.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"66"},"PeriodicalIF":2.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced structural brain connectivity analyses using high diffusion-weighting strengths. 使用高扩散加权强度增强结构脑连接分析。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-14 DOI: 10.1007/s00429-025-02916-6

Leyao Yu, Adeen Flinker, Jelle Veraart

{"title":"Enhanced structural brain connectivity analyses using high diffusion-weighting strengths.","authors":"Leyao Yu, Adeen Flinker, Jelle Veraart","doi":"10.1007/s00429-025-02916-6","DOIUrl":"10.1007/s00429-025-02916-6","url":null,"abstract":"Tractography is a unique modality for the in vivo measurement of structural connectivity, crucial for understanding brain networks and neurological conditions. With increasing b-value, the diffusion-weighting signal becomes primarily sensitive to the intra-axonal signal. However, it remains unclear how tractography is affected by this observation. Here, using open-source datasets, we showed that at high b-values, DWI reduces the uncertainty in estimating fiber orientations. Specifically, we found the ratio of biologically-meaningful longer-range connections increases, accompanied with downstream impact of redistribution of connectome and network metrics. However, when going beyond b = 6000 s/mm2, the loss of SNR imposed a penalty. Lastly, we showed that the data reaches satisfactory reproducibility with b-values above 1200 s/mm2. Overall, the results suggest that using b-values above 2500 s/mm2 is essential for more accurate connectome reconstruction by reducing uncertainty in fiber orientation estimation, supporting the use of higher b-value protocols in standard diffusion MRI scans and pipelines.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"65"},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis. 拉斯穆森脑炎患者左半球切除术后语言重组的结构特征。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-09 DOI: 10.1007/s00429-025-02923-7

Anna Borne, Marcela Perrone-Bertolotti, Christine Bulteau, Emilie Cousin, Elise Roger, Monica Baciu

{"title":"Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis.","authors":"Anna Borne, Marcela Perrone-Bertolotti, Christine Bulteau, Emilie Cousin, Elise Roger, Monica Baciu","doi":"10.1007/s00429-025-02923-7","DOIUrl":"10.1007/s00429-025-02923-7","url":null,"abstract":"Rasmussen's encephalitis (RE) is a rare neurological disorder affecting a single cerebral hemisphere, often requiring hemispherotomy as a curative treatment. While significant brain plasticity occurs due to the pathology and surgical intervention, the mechanisms underlying cognitive functioning in the remaining hemisphere remain poorly understood. This multiple-case study longitudinally investigates neurocognitive reorganization in childhood after left hemispherotomy for RE and identifies structural patterns in the right hemisphere associated with language recovery. Indeed, the mechanisms that allow the right hemisphere to support language, after left hemispherotomy remain unclear. Cognitive trajectories were analyzed in three RE patients, and their cortical thickness (CT) changes were compared with data from a publicly available cohort of 393 healthy subjects. Language neuropsychological scores and T1-weighted MRI data were assessed in the healthy right hemisphere before hemispherotomy, one year, and five years post-surgery. Specifically, principal component analysis, structural covariance, and graph theory approaches were employed to investigate language network organization in patients and controls. Results reveal diverse language recovery trajectories among the three patients. Regarding CT, three potential signatures associated with favorable language outcomes were identified: (1) normal or below-normal CT values in cortical regions; (2) a more associative and integrative organization of the language network; and (3) increased global efficiency. These preliminary longitudinal findings provide novel insights into the mechanisms of neurocognitive reorganization following left hemispherotomy in childhood. By emphasizing structural patterns linked to favorable postoperative language recovery, this study highlights their value for guiding future research and clinical interventions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"63"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding tractography in edematous brain regions: challenges and solutions. 了解脑水肿区域的神经束造影：挑战和解决方案。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-09 DOI: 10.1007/s00429-025-02925-5

Shin Tai Chong, Joseph Yuan-Mou Yang, Ching-Po Lin

{"title":"Understanding tractography in edematous brain regions: challenges and solutions.","authors":"Shin Tai Chong, Joseph Yuan-Mou Yang, Ching-Po Lin","doi":"10.1007/s00429-025-02925-5","DOIUrl":"10.1007/s00429-025-02925-5","url":null,"abstract":"Fiber tractography is a powerful method for visualizing the complex network of neural connections in the brain, essential for understanding white matter architecture and guiding neurosurgical procedures. However, brain edema presents significant challenges for accurate tractography due to altered diffusion patterns that can obscure critical pathways. The increased isotropic diffusion in edematous regions disrupts traditional diffusion tensor imaging (DTI), limiting its ability to delineate fiber tracts reliably. This article explores the impact of edema on tractography and reviews recent advancements in diffusion models, including Free Water Imaging (FWI), Neurite Orientation Dispersion and Density Imaging (NODDI), Restriction Spectrum Imaging (RSI), Diffusion Basis Spectrum Imaging (DBSI), and Unscented Kalman Filter (UKF) tractography. These advanced techniques mitigate the limitations of conventional DTI by separating diffusion signals into multiple compartments, utilizing higher b-value encodings, and improving tract in heterogeneous environments. By enhancing the accuracy and reliability of fiber tracking, these approaches have significant implications for clinical applications, particularly in neurosurgical planning and connectivity analysis.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"64"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time tractography: computation and visualization. 实时轨迹成像：计算和可视化。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-06 DOI: 10.1007/s00429-025-02928-2

Maxime Chamberland, Joseph Yuan-Mou Yang, Dogu Baran Aydogan

引用次数: 0