Brain Structure & Function最新文献_第6页

Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis. 拉斯穆森脑炎患者左半球切除术后语言重组的结构特征。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-09 DOI: 10.1007/s00429-025-02923-7

Anna Borne, Marcela Perrone-Bertolotti, Christine Bulteau, Emilie Cousin, Elise Roger, Monica Baciu

{"title":"Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis.","authors":"Anna Borne, Marcela Perrone-Bertolotti, Christine Bulteau, Emilie Cousin, Elise Roger, Monica Baciu","doi":"10.1007/s00429-025-02923-7","DOIUrl":"10.1007/s00429-025-02923-7","url":null,"abstract":"Rasmussen's encephalitis (RE) is a rare neurological disorder affecting a single cerebral hemisphere, often requiring hemispherotomy as a curative treatment. While significant brain plasticity occurs due to the pathology and surgical intervention, the mechanisms underlying cognitive functioning in the remaining hemisphere remain poorly understood. This multiple-case study longitudinally investigates neurocognitive reorganization in childhood after left hemispherotomy for RE and identifies structural patterns in the right hemisphere associated with language recovery. Indeed, the mechanisms that allow the right hemisphere to support language, after left hemispherotomy remain unclear. Cognitive trajectories were analyzed in three RE patients, and their cortical thickness (CT) changes were compared with data from a publicly available cohort of 393 healthy subjects. Language neuropsychological scores and T1-weighted MRI data were assessed in the healthy right hemisphere before hemispherotomy, one year, and five years post-surgery. Specifically, principal component analysis, structural covariance, and graph theory approaches were employed to investigate language network organization in patients and controls. Results reveal diverse language recovery trajectories among the three patients. Regarding CT, three potential signatures associated with favorable language outcomes were identified: (1) normal or below-normal CT values in cortical regions; (2) a more associative and integrative organization of the language network; and (3) increased global efficiency. These preliminary longitudinal findings provide novel insights into the mechanisms of neurocognitive reorganization following left hemispherotomy in childhood. By emphasizing structural patterns linked to favorable postoperative language recovery, this study highlights their value for guiding future research and clinical interventions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"63"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding tractography in edematous brain regions: challenges and solutions. 了解脑水肿区域的神经束造影：挑战和解决方案。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-09 DOI: 10.1007/s00429-025-02925-5

Shin Tai Chong, Joseph Yuan-Mou Yang, Ching-Po Lin

{"title":"Understanding tractography in edematous brain regions: challenges and solutions.","authors":"Shin Tai Chong, Joseph Yuan-Mou Yang, Ching-Po Lin","doi":"10.1007/s00429-025-02925-5","DOIUrl":"10.1007/s00429-025-02925-5","url":null,"abstract":"Fiber tractography is a powerful method for visualizing the complex network of neural connections in the brain, essential for understanding white matter architecture and guiding neurosurgical procedures. However, brain edema presents significant challenges for accurate tractography due to altered diffusion patterns that can obscure critical pathways. The increased isotropic diffusion in edematous regions disrupts traditional diffusion tensor imaging (DTI), limiting its ability to delineate fiber tracts reliably. This article explores the impact of edema on tractography and reviews recent advancements in diffusion models, including Free Water Imaging (FWI), Neurite Orientation Dispersion and Density Imaging (NODDI), Restriction Spectrum Imaging (RSI), Diffusion Basis Spectrum Imaging (DBSI), and Unscented Kalman Filter (UKF) tractography. These advanced techniques mitigate the limitations of conventional DTI by separating diffusion signals into multiple compartments, utilizing higher b-value encodings, and improving tract in heterogeneous environments. By enhancing the accuracy and reliability of fiber tracking, these approaches have significant implications for clinical applications, particularly in neurosurgical planning and connectivity analysis.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"64"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The scientific value of tractography: accuracy vs usefulness. 神经束造影的科学价值：准确性vs实用性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02921-9

Francois Rheault, Helen Mayberg, Michel Thiebaut de Schotten, Alard Roebroeck, Stephanie J Forkel

引用次数: 0

Rudolf Nieuwenhuys and the meaning of it all. Rudolf Nieuwenhuys和这一切的意义。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02926-4

R Jarrett Rushmore

引用次数: 0

Due to difference in anatomical definitions, population variability and tractography methods, it will not be possible to standardize brain tractography for users, or will it? 由于解剖学定义的不同、人群的差异性和脑束造影方法的不同，脑束造影是否可能对用户标准化？

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02924-6

Christian Beaulieu, Alessandro Daducci, Helen Mayberg, Alexander Leemans

引用次数: 0

Small brains but big challenges: white matter tractography in early life samples. 大脑小但挑战大：早期生命样本的白质束状图。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-28 DOI: 10.1007/s00429-025-02922-8

Jessica Dubois, Mareike Grotheer, Joseph Yuan-Mou Yang, Jacques-Donald Tournier, Christian Beaulieu, Catherine Lebel

引用次数: 0

Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging. 老年性耳聋发病时听觉皮层的阳极直流电刺激可延缓皮层老化。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-25 DOI: 10.1007/s00429-025-02912-w

I S Fernández Del Campo, A J de la Fuente, I Díaz, I Plaza, M A Merchán

{"title":"Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging.","authors":"I S Fernández Del Campo, A J de la Fuente, I Díaz, I Plaza, M A Merchán","doi":"10.1007/s00429-025-02912-w","DOIUrl":"10.1007/s00429-025-02912-w","url":null,"abstract":"Presbycusis or age-related hearing loss (ARHL) affects millions of people worldwide, increasing their risk of cognitive decline and poor quality of life. However, ARHL remains an irreversible condition due to our inability to induce inner-ear hair cell regeneration. Nevertheless, multisession epidural stimulation of the auditory cortex (AC) at the onset of ARHL prevents hearing threshold elevation in naturally aging Wistar rats. Accordingly, we hypothesized that anodal direct current (DC) stimulation of the AC may also compensate for age-related maladaptive, activity-dependent changes. Here, we examined immunocytochemical markers in the AC, including early genes (c-fos and Arc), AMPA receptors (GluR2/3), parvalbumin (PV), and GAD67, along with auditory-evoked potentials (CAEPs) recorded in both auditory and visual (VC) cortices. When comparing 6 and 18.13-month-old rats without AC simulation, we observed loss of c-fos and Arc-positive neurons and decreased GluR2/3 expression, confirming altered AC neuronal network plasticity and activation. In addition, we noted changes in PV and decreased GAD67 immunoreactivity suggesting disrupted inhibition and significantly increased wave amplitudes in CAEPs, altered AC latencies, and decreased VC responses. By contrast, electrically stimulated rats showed no significant variations in early gene markers, GluR2/3, PV, or GAD67 with age, and the amplitudes and latencies of CAEPs recorded in their AC and VC resembled those of young rat. These findings indicate that anodal DC stimulation at the onset of ARHL delays AC aging by minimizing the loss of inhibition and preventing increases in cortical excitability in Wistar rats.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"56"},"PeriodicalIF":2.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Farewell Rudolf Nieuwenhuys, you neuroanatomical legend. 再见了，鲁道夫·纽文豪斯，你这个神经解剖学的传奇人物。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-23 DOI: 10.1007/s00429-025-02917-5

Michel Thiebaut de Schotten

引用次数: 0

Enhanced brain myelination and cognitive development in young children associated with milk fat globule membrane (MFGM) intake: a temporal cohort study. 与乳脂球膜（MFGM）摄入相关的幼儿脑髓鞘形成和认知发育增强：一项时间队列研究

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-19 DOI: 10.1007/s00429-025-02907-7

Sean C L Deoni, Jennifer Beauchemin, Viren D'Sa

{"title":"Enhanced brain myelination and cognitive development in young children associated with milk fat globule membrane (MFGM) intake: a temporal cohort study.","authors":"Sean C L Deoni, Jennifer Beauchemin, Viren D'Sa","doi":"10.1007/s00429-025-02907-7","DOIUrl":"10.1007/s00429-025-02907-7","url":null,"abstract":"Myelination is an important neurodevelopmental process that facilitates efficient brain messaging and connectivity, and contributes to the emergence and refinement of cognitive skills and abilities. Healthy maturation of the myelinated white matter requires coordinated delivery of key nutritional building blocks, including short and long-chain polyunsaturated fatty acids, phospholipids, and sphingolipids. While many of these nutrients are amply supplied by breastmilk, they may not be present in sufficient quantity in infant formula milk. Milk fat globule membrane (MFGM) is a rich source of phospholipids, including sphingomyelin and has been associated with improved cognitive development in infants and children when added to infant formula. To determine if added bovine MFGM is also associated with improved myelination, this study used myelin-sensitive MRI to compare myelination trends in healthy infants and toddlers, 0-2 years of age, who received the same branded infant formula with and without added bovine MFGM in two temporal cohorts: Without Added MFGM between 2010 and 2017; and With Added MFGM between 2018-2020. Concurrent with imaging, cognitive development was assessed using the Mullen Scales of Early Learning (MSEL). Matched for important demographic and socioeconomic characteristics, we found that children who received infant formula with added MFGM showed improved myelination in motor-related areas (motor cortices, internal capsule, and cerebellum) and improved MSEL gross and fine motor scores. No significant differences in verbal or overall cognitive ability scores were noted. These results support the importance of phospholipids, sphingolipids, and sphingomyelin in promoting brain myelination and cognitive development.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"52"},"PeriodicalIF":2.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rudolf Nieuwenhuys's later studies in neuroanatomy and functional neuroimaging. Rudolf Nieuwenhuys后来在神经解剖学和功能性神经成像方面的研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-18 DOI: 10.1007/s00429-025-02918-4

Robert Turner

引用次数: 0