Brain Structure & Function最新文献_第5页

Dynamic causal modelling highlights the importance of decreased self-inhibition of the sensorimotor cortex in motor fatigability. 动态因果建模强调了感觉运动皮层自我抑制能力下降对运动性疲劳的重要性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-08-28 DOI: 10.1007/s00429-024-02840-1

Caroline Heimhofer, Marc Bächinger, Rea Lehner, Stefan Frässle, Joshua Henk Balsters, Nicole Wenderoth

{"title":"Dynamic causal modelling highlights the importance of decreased self-inhibition of the sensorimotor cortex in motor fatigability.","authors":"Caroline Heimhofer, Marc Bächinger, Rea Lehner, Stefan Frässle, Joshua Henk Balsters, Nicole Wenderoth","doi":"10.1007/s00429-024-02840-1","DOIUrl":"https://doi.org/10.1007/s00429-024-02840-1","url":null,"abstract":"Motor fatigability emerges when challenging motor tasks must be maintained over an extended period of time. It is frequently observed in everyday life and affects patients as well as healthy individuals. Motor fatigability can be measured using simple tasks like finger tapping at maximum speed for 30 s. This typically results in a rapid decrease of tapping frequency, a phenomenon called motor slowing. In a previous study (Bächinger et al, eLife, 8 (September), https://doi.org/10.7554/eLife.46750 , 2019), we showed that motor slowing goes hand in hand with a gradual increase in blood oxygen level dependent signal in the primary sensorimotor cortex (SM1), supplementary motor area (SMA), and dorsal premotor cortex (PMd). It is unclear what drives the activity increase in SM1 caused by motor slowing and whether motor fatigability affects the dynamic interactions between SM1, SMA, and PMd. Here, we performed dynamic causal modelling (DCM) on data of 24 healthy young participants collected during functional magnetic resonance imaging to answer this question. The regions of interest (ROI) were defined based on the peak activation within SM1, SMA, and PMd. The model space consisted of bilateral connections between all ROI, with intrinsic self-modulation as inhibitory, and driving inputs set to premotor areas. Our findings revealed that motor slowing was associated with a significant reduction in SM1 self-inhibition, as uncovered by testing the maximum à posteriori against 0 (t(23)=-4.51, p < 0.001). Additionally, the model revealed a significant decrease in the driving input to premotor areas (t(23) > 2.71, p < 0.05) suggesting that structures other than cortical motor areas may contribute to motor fatigability.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative role of attention networks in frequency-dependent modular organization of human brain. 注意网络在人脑频率依赖性模块组织中的整合作用

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-08-19 DOI: 10.1007/s00429-024-02847-8

Hüden Neşe, Emre Harı, Ulaş Ay, Tamer Demiralp, Ahmet Ademoğlu

{"title":"Integrative role of attention networks in frequency-dependent modular organization of human brain.","authors":"Hüden Neşe, Emre Harı, Ulaş Ay, Tamer Demiralp, Ahmet Ademoğlu","doi":"10.1007/s00429-024-02847-8","DOIUrl":"https://doi.org/10.1007/s00429-024-02847-8","url":null,"abstract":"Despite converging evidence of hierarchical organization in the cerebral cortex, with sensory-motor and association regions at opposite ends, the mechanism of such hierarchical interactions remains elusive. This organization was primarily investigated regarding the spatiotemporal dynamics of intrinsic connectivity networks (ICNs). However, more effort is needed to investigate network dynamics in the frequency domain. We aimed to examine the integrative role of brain regions in the frequency domain with graph metrics. Phase-based connectivity estimation was performed in three frequency bands (0.011-0.038, 0.043-0.071, and 0.076-0.103 Hz) in the BOLD signal during rest. We applied modularity analysis to connectivity matrices and investigated those areas, which we called integrative regions, that showed frequency-domain flexibility. Integrative regions, mostly belonging to attention networks, were densely connected to higher-order cognitive ICNs in lower frequency bands but to sensory-motor ICNs in higher frequency bands. We compared the normalized participation coefficient (Pnorm) values of integrative and core regions with respect to their relation to higher-order cognition using a permutation-based t-test for multiple linear regression. Regression parameters of integrative regions in relation to three cognitive scores in executive functions, and working memory were significantly larger than those of core regions (Pfdr < 0.05) for salience ventral attention network. Parameters of integrative regions in relation to intelligence scores were significantly larger than those with core regions (Pfdr < 0.05) in dorsal attention network. Larger parameters of neuropsychological test scores in relation to these flexible parcels further indicate their essential role at an intermediate level in behavior. Results emphasize the importance of frequency-band analysis of brain networks.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial-temporal representation of the astroglial markers in the developing human cortex. 发育中的人类大脑皮层中星形胶质细胞标记的空间-时间表示。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-08-17 DOI: 10.1007/s00429-024-02850-z

A Kharlamova, Yu Krivova, A Proshchina, O Godovalova, D Otlyga, E Andreeva, M Shachina, E Grushetskaya, S Saveliev

{"title":"Spatial-temporal representation of the astroglial markers in the developing human cortex.","authors":"A Kharlamova, Yu Krivova, A Proshchina, O Godovalova, D Otlyga, E Andreeva, M Shachina, E Grushetskaya, S Saveliev","doi":"10.1007/s00429-024-02850-z","DOIUrl":"https://doi.org/10.1007/s00429-024-02850-z","url":null,"abstract":"Specific spatiotemporal patterns of the normal glial differentiation during human brain development have not been thoroughly studied. Immunomorphological studies on postmortem material have remained a basic method for human neurodevelopmental studies so far. The main problem for the immunohistochemical research of astrogliogenesis is that now there are no universal astrocyte markers, that characterize the whole mature astrocyte population or precursors at each stage of development. To define the general course of astrogliogenesis in the developing human cortex, 25 fetal autopsy samples at the stages from eight postconceptional weeks to birth were collected for the immunomorphological analysis. Spatiotemporal immunoreactivity patterns with the panel of markers (ALDH1L1, GFAP, S100, SOX9, and Olig-2), related to glial differentiation were described and compared. The early S100 + cell population of ventral origin was described as well. This S100 + cell distribution deviated from the SOX9-immunoreactivity pattern and was similar to the Olig-2 one. In the given material the dorsal gliogenic wave was characterized by ALDH1L1-, GFAP-, and S100-immunoreactivity manifestation in the dorsal proliferative niche at the end of the early fetal period. The time point of dorsal astrogliogenesis was agreed upon not later than the 17 GW stage. ALDH1L1 + , GFAP + , S100 + , and SOX9 + cell expansion patterns from the ventricular and subventricular zones to the intermediate zone, subplate, and cortical plate were described at the end of early fetal, middle, and late fetal periods. The ALDH1L1-, GFAP-, and S100-immunoreactivity patterns were shown to be not completely identical.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the role of the arcuate fasciculus in word production and repetition: a reply to Van den Hoven et al. (2024). 论弧状筋膜在造词和复述中的作用：对 Van den Hoven 等人（2024 年）的答复。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-08-13 DOI: 10.1007/s00429-024-02849-6

Ardi Roelofs

引用次数: 0

Neonatal amygdala volumes, procedural pain and the association with social-emotional development in children born very preterm. 早产儿的新生儿杏仁核体积、程序性疼痛以及与社会情感发育的关系。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-08-06 DOI: 10.1007/s00429-024-02845-w

Megan E Mueller, Myriam Bickle Graz, Anita C Truttmann, Juliane Schneider, Emma G Duerden

{"title":"Neonatal amygdala volumes, procedural pain and the association with social-emotional development in children born very preterm.","authors":"Megan E Mueller, Myriam Bickle Graz, Anita C Truttmann, Juliane Schneider, Emma G Duerden","doi":"10.1007/s00429-024-02845-w","DOIUrl":"https://doi.org/10.1007/s00429-024-02845-w","url":null,"abstract":"Very preterm birth (< 32 weeks' gestational age) is associated with later social and emotional impairments, which may result from enhanced vulnerability of the limbic system during this period of heightened vulnerability. Evidence suggests that early procedural pain may be a key moderator of early brain networks. In a prospective cohort study, neonates born very preterm (< 30 weeks' gestation) underwent MRI scanning at term-equivalent age (TEA) and clinical data were collected (mechanical ventilation, analgesics, sedatives). Procedural pain was operationalized as the number of skin breaking procedures. Amygdala volumes were automatically extracted. The Strengths and Difficulties questionnaire was used to assess social-emotional outcomes at 5 years of age (mean age 67.5 months). General linear models were employed to examine the association between neonatal amygdala volumes and social-emotional outcomes and the timing and amount of procedural pain exposure (early within the first weeks of life to TEA) as a moderator, adjusting for biological sex, gestational age, 5-year assessment age, days of mechanical ventilation and total cerebral volumes. A total of 42 preterm infants participated. Right amygdala volumes at TEA were associated with prosocial behaviour at age 5 (B = -0.010, p = 0.005). Procedural pain was found to moderate the relationship between right amygdala volumes in the neonatal period and conduct problems at 5 years, such that early skin breaking procedures experienced within the first few weeks of life strengthened the association between right amygdala volumes and conduct problems (B = 0.005, p = 0.047). Late skin breaking procedures, experienced near TEA, also strengthened the association between right amygdala volumes and conduct problems (B = 0.004, p = 0.048).","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging. 通过突触发生的时空耦合模式以及微观结构和宏观尺度的活体磁共振成像，揭示人类胎儿新皮层电路基本结构的发展。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-08-05 DOI: 10.1007/s00429-024-02838-9

Ivica Kostović

{"title":"Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging.","authors":"Ivica Kostović","doi":"10.1007/s00429-024-02838-9","DOIUrl":"https://doi.org/10.1007/s00429-024-02838-9","url":null,"abstract":"In humans, a quantifiable number of cortical synapses appears early in fetal life. In this paper, we present a bridge across different scales of resolution and the distribution of synapses across the transient cytoarchitectonic compartments: marginal zone (MZ), cortical plate (CP), subplate (SP), and in vivo MR images. The tissue of somatosensory cortex (7-26 postconceptional weeks (PCW)) was prepared for electron microscopy, and classified synapses with a determined subpial depth were used for creating histograms matched to the histological sections immunoreacted for synaptic markers and aligned to in vivo MR images (1.5 T) of corresponding fetal ages (maternal indication). Two time periods and laminar patterns of synaptogenesis were identified: an early and midfetal two-compartmental distribution (MZ and SP) and a late fetal three-compartmental distribution (CP synaptogenesis). During both periods, a voluminous, synapse-rich SP was visualized on the in vivo MR. Another novel finding concerns the phase of secondary expansion of the SP (13 PCW), where a quantifiable number of synapses appears in the upper SP. This lamina shows a T2 intermediate signal intensity below the low signal CP. In conclusion, the early fetal appearance of synapses shows early differentiation of putative genetic mechanisms underlying the synthesis, transport and assembly of synaptic proteins. \"Pioneering\" synapses are likely to play a morphogenetic role in constructing of fundamental circuitry architecture due to interaction between neurons. They underlie spontaneous, evoked, and resting state activity prior to ex utero experience. Synapses can also mediate genetic and environmental triggers, adversely altering the development of cortical circuitry and leading to neurodevelopmental disorders.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From emotional arousal to executive action. Role of the prefrontal cortex 从情绪唤醒到执行行动。前额皮质的作用

IF 3.1 3区医学

Brain Structure & Function Pub Date : 2024-08-03 DOI: 10.1007/s00429-024-02837-w

Stefan M. Brudzynski, Jeffrey S. Burgdorf, Joseph R. Moskal

{"title":"From emotional arousal to executive action. Role of the prefrontal cortex","authors":"Stefan M. Brudzynski, Jeffrey S. Burgdorf, Joseph R. Moskal","doi":"10.1007/s00429-024-02837-w","DOIUrl":"https://doi.org/10.1007/s00429-024-02837-w","url":null,"abstract":"Emotional arousal is caused by the activity of two parallel ascending systems targeting mostly the subcortical limbic regions and the prefrontal cortex. The aversive, negative arousal system is initiated by the activity of the mesolimbic cholinergic system and the hedonic, appetitive, arousal is initiated by the activity of the mesolimbic dopaminergic system. Both ascending projections have a diffused nature and arise from the rostral, tegmental part of the brain reticular activating system. The mesolimbic cholinergic system originates in the laterodorsal tegmental nucleus and the mesolimbic dopaminergic system in the ventral tegmental area. Cholinergic and dopaminergic arousal systems have converging input to the medial prefrontal cortex. The arousal system can modulate cortical EEG with alpha rhythms, which enhance synaptic strength as shown by an increase in long-term potentiation (LTP), whereas delta frequencies are associated with decreased arousal and a decrease in synaptic strength as shown by an increase in long-term depotentiation (LTD). It is postulated that the medial prefrontal cortex is an adaptable node with decision making capability and may control the switch between positive and negative affect and is responsible for modifying or changing emotional state and its expression.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"9 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective well-being can be predicted by caudate volume and promotion focus 主观幸福感可通过尾状体体积和晋升重点进行预测

IF 3.1 3区医学

Brain Structure & Function Pub Date : 2024-07-27 DOI: 10.1007/s00429-024-02830-3

Masahiro Matsunaga, Yohsuke Ohtsubo, Keiko Ishii, Hirohito Tsuboi, Kohta Suzuki, Haruto Takagishi

{"title":"Subjective well-being can be predicted by caudate volume and promotion focus","authors":"Masahiro Matsunaga, Yohsuke Ohtsubo, Keiko Ishii, Hirohito Tsuboi, Kohta Suzuki, Haruto Takagishi","doi":"10.1007/s00429-024-02830-3","DOIUrl":"https://doi.org/10.1007/s00429-024-02830-3","url":null,"abstract":"It is well-known that the caudate nucleus is associated with motivational behaviors and subjective well-being. However, no longitudinal studies have examined the relationship between brain structure, behavioral orientations, and subjective well-being. This study analyzes data from our previous longitudinal study to examine whether future subjective well-being can be predicted by the volume of the caudate nucleus. We also examined whether behavioral orientation, based on the regulatory focus theory showing two orientations—promotion and prevention focus—was related to the volume of the caudate nucleus. Voxel-based morphometry analysis indicated that the left caudate volume was positively associated with rating scores for future subjective well-being and promotion orientation. Further, mediation analysis indicated that promotion orientation significantly mediated the relationship between future subjective well-being and left caudate volume. The findings indicate that future subjective well-being can be predicted by the volume of the left caudate nucleus, and that this relationship is mediated by promotion focus orientation.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"167 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional and structural brain connectivity in disorders of consciousness. 意识障碍中的大脑功能和结构连接。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-25 DOI: 10.1007/s00429-024-02839-8

Victor Altmayer, Aude Sangare, Charlotte Calligaris, Louis Puybasset, Vincent Perlbarg, Lionel Naccache, Jacobo Diego Sitt, Benjamin Rohaut

{"title":"Functional and structural brain connectivity in disorders of consciousness.","authors":"Victor Altmayer, Aude Sangare, Charlotte Calligaris, Louis Puybasset, Vincent Perlbarg, Lionel Naccache, Jacobo Diego Sitt, Benjamin Rohaut","doi":"10.1007/s00429-024-02839-8","DOIUrl":"https://doi.org/10.1007/s00429-024-02839-8","url":null,"abstract":"Brain connectivity, allowing information to be shared between distinct cortical areas and thus to be processed in an integrated way, has long been considered critical for consciousness. However, the relationship between functional intercortical interactions and the structural connections thought to underlie them is poorly understood. In the present work, we explore both functional (with an EEG-based metric: the median weighted symbolic mutual information in the theta band) and structural (with a brain MRI-based metric: fractional anisotropy) connectivities in a cohort of 78 patients with disorders of consciousness. Both metrics could distinguish patients in a vegetative state from patients in minimally conscious state. Crucially, we discovered a significant positive correlation between functional and structural connectivities. Furthermore, we showed that this structure-function relationship is more specifically observed when considering structural connectivity within the intra- and inter-hemispheric long-distance cortico-cortical bundles involved in the Global Neuronal Workspace (GNW) theory of consciousness, thus supporting predictions of this model. Altogether, these results support the interest of multimodal assessments of brain connectivity in refining the diagnostic evaluation of patients with disorders of consciousness.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship evolution shapes inter-brain synchrony in affective sharing: The role of self-expansion. 关系演变塑造了情感分享中的脑间同步：自我扩张的作用

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-07-25 DOI: 10.1007/s00429-024-02841-0

Dan Wang, Yong Ren, Wenfeng Chen

{"title":"Relationship evolution shapes inter-brain synchrony in affective sharing: The role of self-expansion.","authors":"Dan Wang, Yong Ren, Wenfeng Chen","doi":"10.1007/s00429-024-02841-0","DOIUrl":"https://doi.org/10.1007/s00429-024-02841-0","url":null,"abstract":"The development of social relationships influences a person's self-concept, which in turn affects their perceptions and neural correlates in social interactions. This study employed an EEG-based hyperscanning technique and a longitudinal design to investigate how the evolution of interpersonal relationships impacts inter-brain synchrony during nonverbal social-emotional interactions. The framework for this study is based on the self-expansion model. We found that dyads exhibited enhanced affective sharing abilities and increased brain-to-brain synchrony, particularly in the gamma rhythm across the frontal, parietal, and left temporoparietal regions, after seven months together compared to when they first met. Additionally, the results indicate that inter-brain coupling evolves as relationships develop, with synchrony in nonverbal social-emotional interactions increasing as self-expansion progresses. Crucially, in the deep learning model, interpersonal closeness can be successfully classified by inter-brain synchrony during emotional-social interactions. The longitudinal EEG-hyperscanning design of our study allows for capturing dynamic changes over time, offering new insights into the neurobiological foundations of social interaction and the potential of neural synchrony as a biomarker for relationship dynamics.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0