Brain Structure & Function最新文献_第5页

On the role of the arcuate fasciculus in word production and repetition: a reply to Van den Hoven et al. (2024). 论弧状筋膜在造词和复述中的作用：对 Van den Hoven 等人（2024 年）的答复。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-08-13 DOI: 10.1007/s00429-024-02849-6

Ardi Roelofs

引用次数: 0

Spatial-temporal representation of the astroglial markers in the developing human cortex. 发育中的人类大脑皮层中星形胶质细胞标记的空间-时间表示。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-08-17 DOI: 10.1007/s00429-024-02850-z

A Kharlamova, Yu Krivova, A Proshchina, O Godovalova, D Otlyga, E Andreeva, M Shachina, E Grushetskaya, S Saveliev

{"title":"Spatial-temporal representation of the astroglial markers in the developing human cortex.","authors":"A Kharlamova, Yu Krivova, A Proshchina, O Godovalova, D Otlyga, E Andreeva, M Shachina, E Grushetskaya, S Saveliev","doi":"10.1007/s00429-024-02850-z","DOIUrl":"10.1007/s00429-024-02850-z","url":null,"abstract":"Specific spatiotemporal patterns of the normal glial differentiation during human brain development have not been thoroughly studied. Immunomorphological studies on postmortem material have remained a basic method for human neurodevelopmental studies so far. The main problem for the immunohistochemical research of astrogliogenesis is that now there are no universal astrocyte markers, that characterize the whole mature astrocyte population or precursors at each stage of development. To define the general course of astrogliogenesis in the developing human cortex, 25 fetal autopsy samples at the stages from eight postconceptional weeks to birth were collected for the immunomorphological analysis. Spatiotemporal immunoreactivity patterns with the panel of markers (ALDH1L1, GFAP, S100, SOX9, and Olig-2), related to glial differentiation were described and compared. The early S100 + cell population of ventral origin was described as well. This S100 + cell distribution deviated from the SOX9-immunoreactivity pattern and was similar to the Olig-2 one. In the given material the dorsal gliogenic wave was characterized by ALDH1L1-, GFAP-, and S100-immunoreactivity manifestation in the dorsal proliferative niche at the end of the early fetal period. The time point of dorsal astrogliogenesis was agreed upon not later than the 17 GW stage. ALDH1L1 + , GFAP + , S100 + , and SOX9 + cell expansion patterns from the ventricular and subventricular zones to the intermediate zone, subplate, and cortical plate were described at the end of early fetal, middle, and late fetal periods. The ALDH1L1-, GFAP-, and S100-immunoreactivity patterns were shown to be not completely identical.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"2385-2403"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Music reward sensitivity is associated with greater information transfer capacity within dorsal and motor white matter networks in musicians. 音乐奖励敏感性与音乐家背侧和运动白质网络内更大的信息传递能力有关。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.1007/s00429-024-02836-x

Tomas E Matthews, Massimo Lumaca, Maria A G Witek, Virginia B Penhune, Peter Vuust

{"title":"Music reward sensitivity is associated with greater information transfer capacity within dorsal and motor white matter networks in musicians.","authors":"Tomas E Matthews, Massimo Lumaca, Maria A G Witek, Virginia B Penhune, Peter Vuust","doi":"10.1007/s00429-024-02836-x","DOIUrl":"10.1007/s00429-024-02836-x","url":null,"abstract":"There are pronounced differences in the degree to which individuals experience music-induced pleasure which are linked to variations in structural connectivity between auditory and reward areas. However, previous studies exploring the link between white matter structure and music reward sensitivity (MRS) have relied on standard diffusion tensor imaging methods, which present challenges in terms of anatomical accuracy and interpretability. Further, the link between MRS and connectivity in regions outside of auditory-reward networks, as well as the role of musical training, have yet to be investigated. Therefore, we investigated the relation between MRS and structural connectivity in a large number of directly segmented and anatomically verified white matter tracts in musicians (n = 24) and non-musicians (n = 23) using state-of-the-art tract reconstruction and fixel-based analysis. Using a manual tract-of-interest approach, we additionally tested MRS-white matter associations in auditory-reward networks seen in previous studies. Within the musician group, there was a significant positive relation between MRS and fiber density and cross section in the right middle longitudinal fascicle connecting auditory and inferior parietal cortices. There were also positive relations between MRS and fiber-bundle cross-section in tracts connecting the left thalamus to the ventral precentral gyrus and connecting the right thalamus to the right supplementary motor area, however, these did not survive FDR correction. These results suggest that, within musicians, dorsal auditory and motor networks are crucial to MRS, possibly via their roles in top-down predictive processing and auditory-motor transformations.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"2299-2313"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic causal modelling highlights the importance of decreased self-inhibition of the sensorimotor cortex in motor fatigability. 动态因果建模强调了感觉运动皮层自我抑制能力下降对运动性疲劳的重要性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-08-28 DOI: 10.1007/s00429-024-02840-1

Caroline Heimhofer, Marc Bächinger, Rea Lehner, Stefan Frässle, Joshua Henk Balsters, Nicole Wenderoth

{"title":"Dynamic causal modelling highlights the importance of decreased self-inhibition of the sensorimotor cortex in motor fatigability.","authors":"Caroline Heimhofer, Marc Bächinger, Rea Lehner, Stefan Frässle, Joshua Henk Balsters, Nicole Wenderoth","doi":"10.1007/s00429-024-02840-1","DOIUrl":"10.1007/s00429-024-02840-1","url":null,"abstract":"Motor fatigability emerges when challenging motor tasks must be maintained over an extended period of time. It is frequently observed in everyday life and affects patients as well as healthy individuals. Motor fatigability can be measured using simple tasks like finger tapping at maximum speed for 30 s. This typically results in a rapid decrease of tapping frequency, a phenomenon called motor slowing. In a previous study (Bächinger et al, eLife, 8 (September), https://doi.org/10.7554/eLife.46750 , 2019), we showed that motor slowing goes hand in hand with a gradual increase in blood oxygen level dependent signal in the primary sensorimotor cortex (SM1), supplementary motor area (SMA), and dorsal premotor cortex (PMd). It is unclear what drives the activity increase in SM1 caused by motor slowing and whether motor fatigability affects the dynamic interactions between SM1, SMA, and PMd. Here, we performed dynamic causal modelling (DCM) on data of 24 healthy young participants collected during functional magnetic resonance imaging to answer this question. The regions of interest (ROI) were defined based on the peak activation within SM1, SMA, and PMd. The model space consisted of bilateral connections between all ROI, with intrinsic self-modulation as inhibitory, and driving inputs set to premotor areas. Our findings revealed that motor slowing was associated with a significant reduction in SM1 self-inhibition, as uncovered by testing the maximum à posteriori against 0 (t(23)=-4.51, p < 0.001). Additionally, the model revealed a significant decrease in the driving input to premotor areas (t(23) > 2.71, p < 0.05) suggesting that structures other than cortical motor areas may contribute to motor fatigability.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"2419-2429"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Concise Language Paradigm (CLaP), a framework for studying the intersection of comprehension and production: electrophysiological properties. 简明语言范式 (CLaP)，研究理解与生产交叉的框架：电生理学特性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-05-15 DOI: 10.1007/s00429-024-02801-8

Natascha Marie Roos, Julia Chauvet, Vitória Piai

{"title":"The Concise Language Paradigm (CLaP), a framework for studying the intersection of comprehension and production: electrophysiological properties.","authors":"Natascha Marie Roos, Julia Chauvet, Vitória Piai","doi":"10.1007/s00429-024-02801-8","DOIUrl":"10.1007/s00429-024-02801-8","url":null,"abstract":"Studies investigating language commonly isolate one modality or process, focusing on comprehension or production. Here, we present a framework for a paradigm that combines both: the Concise Language Paradigm (CLaP), tapping into comprehension and production within one trial. The trial structure is identical across conditions, presenting a sentence followed by a picture to be named. We tested 21 healthy speakers with EEG to examine three time periods during a trial (sentence, pre-picture interval, picture onset), yielding contrasts of sentence comprehension, contextually and visually guided word retrieval, object recognition, and naming. In the CLaP, sentences are presented auditorily (constrained, unconstrained, reversed), and pictures appear as normal (constrained, unconstrained, bare) or scrambled objects. Imaging results revealed different evoked responses after sentence onset for normal and time-reversed speech. Further, we replicated the context effect of alpha-beta power decreases before picture onset for constrained relative to unconstrained sentences, and could clarify that this effect arises from power decreases following constrained sentences. Brain responses locked to picture-onset differed as a function of sentence context and picture type (normal vs. scrambled), and naming times were fastest for pictures in constrained sentences, followed by scrambled picture naming, and equally fast for bare and unconstrained picture naming. Finally, we also discuss the potential of the CLaP to be adapted to different focuses, using different versions of the linguistic content and tasks, in combination with electrophysiology or other imaging methods. These first results of the CLaP indicate that this paradigm offers a promising framework to investigate the language system.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"2097-2113"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter connectivity linked to novel word learning in children. 白质连通性与儿童新词学习有关。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1007/s00429-024-02857-6

Clara Ekerdt, Willeke M Menks, Guillén Fernández, James M McQueen, Atsuko Takashima, Gabriele Janzen

{"title":"White matter connectivity linked to novel word learning in children.","authors":"Clara Ekerdt, Willeke M Menks, Guillén Fernández, James M McQueen, Atsuko Takashima, Gabriele Janzen","doi":"10.1007/s00429-024-02857-6","DOIUrl":"10.1007/s00429-024-02857-6","url":null,"abstract":"Children and adults are excellent word learners. Increasing evidence suggests that the neural mechanisms that allow us to learn words change with age. In a recent fMRI study from our group, several brain regions exhibited age-related differences when accessing newly learned words in a second language (L2; Takashima et al. Dev Cogn Neurosci 37, 2019). Namely, while the Teen group (aged 14-16 years) activated more left frontal and parietal regions, the Young group (aged 8-10 years) activated right frontal and parietal regions. In the current study we analyzed the structural connectivity data from the aforementioned study, examining the white matter connectivity of the regions that showed age-related functional activation differences. Age group differences in streamline density as well as correlations with L2 word learning success and their interaction were examined. The Teen group showed stronger connectivity than the Young group in the right arcuate fasciculus (AF). Furthermore, white matter connectivity and memory for L2 words across the two age groups correlated in the left AF and the right anterior thalamic radiation (ATR) such that higher connectivity in the left AF and lower connectivity in the right ATR was related to better memory for L2 words. Additionally, connectivity in the area of the right AF that exhibited age-related differences predicted word learning success. The finding that across the two age groups, stronger connectivity is related to better memory for words lends further support to the hypothesis that the prolonged maturation of the prefrontal cortex, here in the form of structural connectivity, plays an important role in the development of memory.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"2461-2477"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gray matter based spatial statistics framework in the 1-month brain: insights into gray matter microstructure in infancy. 基于灰质的 1 个月大脑空间统计框架：对婴儿期灰质微观结构的洞察。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI: 10.1007/s00429-024-02853-w

Marissa A DiPiero, Patrik Goncalves Rodrigues, McKaylie Justman, Sophia Roche, Elizabeth Bond, Jose Guerrero Gonzalez, Richard J Davidson, Elizabeth M Planalp, Douglas C Dean

{"title":"Gray matter based spatial statistics framework in the 1-month brain: insights into gray matter microstructure in infancy.","authors":"Marissa A DiPiero, Patrik Goncalves Rodrigues, McKaylie Justman, Sophia Roche, Elizabeth Bond, Jose Guerrero Gonzalez, Richard J Davidson, Elizabeth M Planalp, Douglas C Dean","doi":"10.1007/s00429-024-02853-w","DOIUrl":"10.1007/s00429-024-02853-w","url":null,"abstract":"The neurodevelopmental epoch from fetal stages to early life embodies a critical window of peak growth and plasticity in which differences believed to be associated with many neurodevelopmental and psychiatric disorders first emerge. Obtaining a detailed understanding of the developmental trajectories of the cortical gray matter microstructure is necessary to characterize differential patterns of neurodevelopment that may subserve future intellectual, behavioral, and psychiatric challenges. The neurite orientation dispersion density imaging (NODDI) Gray-Matter Based Spatial Statistics (GBSS) framework leverages information from the NODDI model to enable sensitive characterization of the gray matter microstructure while limiting partial volume contamination and misregistration errors between images collected in different spaces. However, limited contrast of the underdeveloped brain poses challenges for implementing this framework with infant diffusion MRI (dMRI) data. In this work, we aim to examine the development of cortical microstructure in infants. We utilize the NODDI GBSS framework and propose refinements to the original framework that aim to improve the delineation and characterization of gray matter in the infant brain. Taking this approach, we cross-sectionally investigate age relationships in the developing gray matter microstructural organization in infants within the first month of life and reveal widespread relationships with the gray matter architecture.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"2445-2459"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No sex difference in maturation of brain morphology during the perinatal period. 围产期大脑形态的成熟没有性别差异。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI: 10.1007/s00429-024-02828-x

Yucen Sheng, Ying Wang, Xiaomin Wang, Zhe Zhang, Dalin Zhu, Weihao Zheng

{"title":"No sex difference in maturation of brain morphology during the perinatal period.","authors":"Yucen Sheng, Ying Wang, Xiaomin Wang, Zhe Zhang, Dalin Zhu, Weihao Zheng","doi":"10.1007/s00429-024-02828-x","DOIUrl":"10.1007/s00429-024-02828-x","url":null,"abstract":"Accumulating evidence have documented sex differences in brain anatomy from early childhood to late adulthood. However, whether sex difference of brain structure emerges in the neonatal brain and how sex modulates the development of cortical morphology during the perinatal stage remains unclear. Here, we utilized T2-weighted MRI from the Developing Human Connectome Project (dHCP) database, consisting of 41 male and 40 female neonates born between 35 and 43 postmenstrual weeks (PMW). Neonates of each sex were arranged in a continuous ascending order of age to capture the progressive changes in cortical thickness and curvature throughout the developmental continuum. The maturational covariance network (MCN) was defined as the coupled developmental fluctuations of morphology measures between cortical regions. We constructed MCNs based on the two features, respectively, to illustrate their developmental interdependencies, and then compared the network topology between sexes. Our results showed that cortical structural development exhibited a localized pattern in both males and females, with no significant sex differences in the developmental trajectory of cortical morphology, overall organization, nodal importance, and modular structure of the MCN. Furthermore, by merging male and female neonates into a unified cohort, we identified evident dependencies influences in structural development between different brain modules using the Granger causality analysis (GCA), emanating from high-order regions toward primary cortices. Our findings demonstrate that the maturational pattern of cortical morphology may not differ between sexes during the perinatal period, and provide evidence for the developmental causality among cortical structures in perinatal brains.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1979-1994"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new map of the rat isocortex and proisocortex: cytoarchitecture and M₂ receptor distribution patterns. 大鼠等皮层和前等皮层的新地图：细胞结构和 M2 受体分布模式。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-11-01 Epub Date: 2023-06-15 DOI: 10.1007/s00429-023-02654-7

Hossein Haghir, Anika Kuckertz, Ling Zhao, Javad Hami, Nicola Palomero-Gallagher

{"title":"A new map of the rat isocortex and proisocortex: cytoarchitecture and M2 receptor distribution patterns.","authors":"Hossein Haghir, Anika Kuckertz, Ling Zhao, Javad Hami, Nicola Palomero-Gallagher","doi":"10.1007/s00429-023-02654-7","DOIUrl":"10.1007/s00429-023-02654-7","url":null,"abstract":"Neurotransmitters and their receptors are key molecules in information transfer between neurons, thus enabling inter-areal communication. Therefore, multimodal atlases integrating the brain's cyto- and receptor architecture constitute crucial tools to understand the relationship between its structural and functional segregation. Cholinergic muscarinic M2 receptors have been shown to be an evolutionarily conserved molecular marker of primary sensory areas in the mammalian brain. To complement existing rodent atlases, we applied a silver cell body staining and quantitative in vitro receptor autoradiographic visualization of M2 receptors to alternating sections throughout the entire brain of five adult male Wistar rats (three sectioned coronally, one horizontally, one sagittally). Histological sections and autoradiographs were scanned at a spatial resolution of 1 µm and 20 µm per pixel, respectively, and files were stored as 8 bit images. We used these high-resolution datasets to create an atlas of the entire rat brain, including the olfactory bulb, cerebellum and brainstem. We describe the cyto- and M2 receptor architectonic features of 48 distinct iso- and proisocortical areas across the rat forebrain and provide their mean M2 receptor density. The ensuing parcellation scheme, which is discussed in the framework of existing comprehensive atlasses, includes the novel subdivision of mediomedial secondary visual area Oc2MM into anterior (Oc2MMa) and posterior (Oc2MMp) parts, and of lateral visual area Oc2L into rostrolateral (Oc2Lr), intermediate dorsolateral (Oc2Lid), intermediate ventrolateral (Oc2Liv) and caudolateral (Oc2Lc) secondary visual areas. The M2 receptor densities and the comprehensive map of iso-and proisocortical areas constitute useful tools for future computational and neuroscientific studies.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1795-1822"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9630816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary scaling and cognitive correlates of primate frontal cortex microstructure. 灵长类动物额叶皮层微观结构的进化尺度和认知相关性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2024-11-01 Epub Date: 2023-10-27 DOI: 10.1007/s00429-023-02719-7

Cheryl D Stimpson, Jeroen B Smaers, Mary Ann Raghanti, Kimberley A Phillips, Bob Jacobs, William D Hopkins, Patrick R Hof, Chet C Sherwood

{"title":"Evolutionary scaling and cognitive correlates of primate frontal cortex microstructure.","authors":"Cheryl D Stimpson, Jeroen B Smaers, Mary Ann Raghanti, Kimberley A Phillips, Bob Jacobs, William D Hopkins, Patrick R Hof, Chet C Sherwood","doi":"10.1007/s00429-023-02719-7","DOIUrl":"10.1007/s00429-023-02719-7","url":null,"abstract":"Investigating evolutionary changes in frontal cortex microstructure is crucial to understanding how modifications of neuron and axon distributions contribute to phylogenetic variation in cognition. In the present study, we characterized microstructural components of dorsolateral prefrontal cortex, orbitofrontal cortex, and primary motor cortex from 14 primate species using measurements of neuropil fraction and immunohistochemical markers for fast-spiking inhibitory interneurons, large pyramidal projection neuron subtypes, serotonergic innervation, and dopaminergic innervation. Results revealed that the rate of evolutionary change was similar across these microstructural variables, except for neuropil fraction, which evolves more slowly and displays the strongest correlation with brain size. We also found that neuropil fraction in orbitofrontal cortex layers V-VI was associated with cross-species variation in performance on experimental tasks that measure self-control. These findings provide insight into the evolutionary reorganization of the primate frontal cortex in relation to brain size scaling and its association with cognitive processes.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":" ","pages":"1823-1838"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54227665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0