Brain Structure & Function最新文献_第5页

Enhanced structural brain connectivity analyses using high diffusion-weighting strengths. 使用高扩散加权强度增强结构脑连接分析。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-14 DOI: 10.1007/s00429-025-02916-6

Leyao Yu, Adeen Flinker, Jelle Veraart

{"title":"Enhanced structural brain connectivity analyses using high diffusion-weighting strengths.","authors":"Leyao Yu, Adeen Flinker, Jelle Veraart","doi":"10.1007/s00429-025-02916-6","DOIUrl":"https://doi.org/10.1007/s00429-025-02916-6","url":null,"abstract":"Tractography is a unique modality for the in vivo measurement of structural connectivity, crucial for understanding brain networks and neurological conditions. With increasing b-value, the diffusion-weighting signal becomes primarily sensitive to the intra-axonal signal. However, it remains unclear how tractography is affected by this observation. Here, using open-source datasets, we showed that at high b-values, DWI reduces the uncertainty in estimating fiber orientations. Specifically, we found the ratio of biologically-meaningful longer-range connections increases, accompanied with downstream impact of redistribution of connectome and network metrics. However, when going beyond b = 6000 s/mm2, the loss of SNR imposed a penalty. Lastly, we showed that the data reaches satisfactory reproducibility with b-values above 1200 s/mm2. Overall, the results suggest that using b-values above 2500 s/mm2 is essential for more accurate connectome reconstruction by reducing uncertainty in fiber orientation estimation, supporting the use of higher b-value protocols in standard diffusion MRI scans and pipelines.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"65"},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis. 拉斯穆森脑炎患者左半球切除术后语言重组的结构特征。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-09 DOI: 10.1007/s00429-025-02923-7

Anna Borne, Marcela Perrone-Bertolotti, Christine Bulteau, Emilie Cousin, Elise Roger, Monica Baciu

{"title":"Structural signatures of language reorganization after left hemispherotomy in patients with Rasmussen's encephalitis.","authors":"Anna Borne, Marcela Perrone-Bertolotti, Christine Bulteau, Emilie Cousin, Elise Roger, Monica Baciu","doi":"10.1007/s00429-025-02923-7","DOIUrl":"10.1007/s00429-025-02923-7","url":null,"abstract":"Rasmussen's encephalitis (RE) is a rare neurological disorder affecting a single cerebral hemisphere, often requiring hemispherotomy as a curative treatment. While significant brain plasticity occurs due to the pathology and surgical intervention, the mechanisms underlying cognitive functioning in the remaining hemisphere remain poorly understood. This multiple-case study longitudinally investigates neurocognitive reorganization in childhood after left hemispherotomy for RE and identifies structural patterns in the right hemisphere associated with language recovery. Indeed, the mechanisms that allow the right hemisphere to support language, after left hemispherotomy remain unclear. Cognitive trajectories were analyzed in three RE patients, and their cortical thickness (CT) changes were compared with data from a publicly available cohort of 393 healthy subjects. Language neuropsychological scores and T1-weighted MRI data were assessed in the healthy right hemisphere before hemispherotomy, one year, and five years post-surgery. Specifically, principal component analysis, structural covariance, and graph theory approaches were employed to investigate language network organization in patients and controls. Results reveal diverse language recovery trajectories among the three patients. Regarding CT, three potential signatures associated with favorable language outcomes were identified: (1) normal or below-normal CT values in cortical regions; (2) a more associative and integrative organization of the language network; and (3) increased global efficiency. These preliminary longitudinal findings provide novel insights into the mechanisms of neurocognitive reorganization following left hemispherotomy in childhood. By emphasizing structural patterns linked to favorable postoperative language recovery, this study highlights their value for guiding future research and clinical interventions.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"63"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding tractography in edematous brain regions: challenges and solutions. 了解脑水肿区域的神经束造影：挑战和解决方案。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-09 DOI: 10.1007/s00429-025-02925-5

Shin Tai Chong, Joseph Yuan-Mou Yang, Ching-Po Lin

{"title":"Understanding tractography in edematous brain regions: challenges and solutions.","authors":"Shin Tai Chong, Joseph Yuan-Mou Yang, Ching-Po Lin","doi":"10.1007/s00429-025-02925-5","DOIUrl":"https://doi.org/10.1007/s00429-025-02925-5","url":null,"abstract":"Fiber tractography is a powerful method for visualizing the complex network of neural connections in the brain, essential for understanding white matter architecture and guiding neurosurgical procedures. However, brain edema presents significant challenges for accurate tractography due to altered diffusion patterns that can obscure critical pathways. The increased isotropic diffusion in edematous regions disrupts traditional diffusion tensor imaging (DTI), limiting its ability to delineate fiber tracts reliably. This article explores the impact of edema on tractography and reviews recent advancements in diffusion models, including Free Water Imaging (FWI), Neurite Orientation Dispersion and Density Imaging (NODDI), Restriction Spectrum Imaging (RSI), Diffusion Basis Spectrum Imaging (DBSI), and Unscented Kalman Filter (UKF) tractography. These advanced techniques mitigate the limitations of conventional DTI by separating diffusion signals into multiple compartments, utilizing higher b-value encodings, and improving tract in heterogeneous environments. By enhancing the accuracy and reliability of fiber tracking, these approaches have significant implications for clinical applications, particularly in neurosurgical planning and connectivity analysis.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"64"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time tractography: computation and visualization. 实时轨迹成像：计算和可视化。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-06 DOI: 10.1007/s00429-025-02928-2

Maxime Chamberland, Joseph Yuan-Mou Yang, Dogu Baran Aydogan

引用次数: 0

The scientific value of tractography: accuracy vs usefulness. 神经束造影的科学价值：准确性vs实用性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02921-9

Francois Rheault, Helen Mayberg, Michel Thiebaut de Schotten, Alard Roebroeck, Stephanie J Forkel

引用次数: 0

Rudolf Nieuwenhuys and the meaning of it all. Rudolf Nieuwenhuys和这一切的意义。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02926-4

R Jarrett Rushmore

引用次数: 0

Due to difference in anatomical definitions, population variability and tractography methods, it will not be possible to standardize brain tractography for users, or will it? 由于解剖学定义的不同、人群的差异性和脑束造影方法的不同，脑束造影是否可能对用户标准化？

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-29 DOI: 10.1007/s00429-025-02924-6

Christian Beaulieu, Alessandro Daducci, Helen Mayberg, Alexander Leemans

引用次数: 0

Small brains but big challenges: white matter tractography in early life samples. 大脑小但挑战大：早期生命样本的白质束状图。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-28 DOI: 10.1007/s00429-025-02922-8

Jessica Dubois, Mareike Grotheer, Joseph Yuan-Mou Yang, Jacques-Donald Tournier, Christian Beaulieu, Catherine Lebel

引用次数: 0

Fascinated by brain evolution. 对大脑进化着迷。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-26 DOI: 10.1007/s00429-025-02920-w

Loreta Medina

引用次数: 0

Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging. 老年性耳聋发病时听觉皮层的阳极直流电刺激可延缓皮层老化。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-04-25 DOI: 10.1007/s00429-025-02912-w

I S Fernández Del Campo, A J de la Fuente, I Díaz, I Plaza, M A Merchán

{"title":"Anodal direct current stimulation of the auditory cortex at the onset of presbycusis delays cortical aging.","authors":"I S Fernández Del Campo, A J de la Fuente, I Díaz, I Plaza, M A Merchán","doi":"10.1007/s00429-025-02912-w","DOIUrl":"10.1007/s00429-025-02912-w","url":null,"abstract":"Presbycusis or age-related hearing loss (ARHL) affects millions of people worldwide, increasing their risk of cognitive decline and poor quality of life. However, ARHL remains an irreversible condition due to our inability to induce inner-ear hair cell regeneration. Nevertheless, multisession epidural stimulation of the auditory cortex (AC) at the onset of ARHL prevents hearing threshold elevation in naturally aging Wistar rats. Accordingly, we hypothesized that anodal direct current (DC) stimulation of the AC may also compensate for age-related maladaptive, activity-dependent changes. Here, we examined immunocytochemical markers in the AC, including early genes (c-fos and Arc), AMPA receptors (GluR2/3), parvalbumin (PV), and GAD67, along with auditory-evoked potentials (CAEPs) recorded in both auditory and visual (VC) cortices. When comparing 6 and 18.13-month-old rats without AC simulation, we observed loss of c-fos and Arc-positive neurons and decreased GluR2/3 expression, confirming altered AC neuronal network plasticity and activation. In addition, we noted changes in PV and decreased GAD67 immunoreactivity suggesting disrupted inhibition and significantly increased wave amplitudes in CAEPs, altered AC latencies, and decreased VC responses. By contrast, electrically stimulated rats showed no significant variations in early gene markers, GluR2/3, PV, or GAD67 with age, and the amplitudes and latencies of CAEPs recorded in their AC and VC resembled those of young rat. These findings indicate that anodal DC stimulation at the onset of ARHL delays AC aging by minimizing the loss of inhibition and preventing increases in cortical excitability in Wistar rats.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 4","pages":"56"},"PeriodicalIF":2.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12031871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0