Brain Structure & Function最新文献

{"title":"Nieuwenhuys' timely, influential, and visionary work.","authors":"Alvaro Duque","doi":"10.1007/s00429-025-02949-x","DOIUrl":"10.1007/s00429-025-02949-x","url":null,"abstract":"","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"92"},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rudolf Nieuwenhuys (11 June 1927-4 November 2024): a scholarly life.","authors":"Suzanne Bakker, Hans J Ten Donkelaar, Jan Voogd, Charles Nicholson, Lawrence H Bannister, Loreta Medina, Ester Desfilis, Mario F Wullimann, Johannes Meek, Luis Puelles, Cees A J Broere, Robert Turner, Leonardo Cerliani, Matthew F Glasser","doi":"10.1007/s00429-025-02953-1","DOIUrl":"10.1007/s00429-025-02953-1","url":null,"abstract":"<p><p>This collective eulogy by colleagues, co-authors and friends is a tribute to the work and life of Rudolf Nieuwenhuys. 'Neurofascination' is an apt label for his scholarly life in the sciences from the start in 1955 until his last days in 2024. In addition, he had a broad interest in Roman and Gothic architecture, the history and politics of the twentieth century, religion and the music of Johann Sebastian Bach. Extensive discussions on one or more of these topics often led to long-lasting friendships, some of which inform the following pages. Rudolf is remembered for his highly didactical and remarkably illustrated presentations and publications, including the three-volume The Central Nervous System of Vertebrates and the four editions of The Human Central Nervous System. His research interests addressed an impressively wide range of topics concerning development and evolutionary neurobiology and a systematic approach to comparative brain structures in vertebrates. His almost endless fascination for neuromorphology included the invertebrates as well. But unfortunately, even his long life was not enough to write the book on the comparative neuroanatomy of invertebrates which he long had in mind. The many years of his career spanned the remarkable histology of the gigantocerebellum of mormyrids to an exploratory synthesis of subdivisions of the human cortex, as originally mapped by the Vogt-Vogt school of cortical architectonics.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"90"},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and structural plasticity induced by audiovisual associations and sensory experiences.","authors":"Fazilet Zeynep Yildirim-Keles, Pinar Demirayak, Hulusi Kafaligonul","doi":"10.1007/s00429-025-02951-3","DOIUrl":"10.1007/s00429-025-02951-3","url":null,"abstract":"<p><p>Crossmodal associations and correspondences play important roles in shaping perception and guiding our actions. However, we still have a limited understanding of association-induced changes in the adult human brain. An important question to address is to what extent passive exposure to crossmodal associations leads to functional and structural changes in the brain. Utilizing an audiovisual association paradigm in which motion stimuli presented in the left visual field were paired with auditory tones, we investigated experience-dependent crossmodal plasticity by examining resting-state functional connectivity and cortical thickness. Following the association phase, we observed widespread increases in functional connectivity between the trained region (e.g., right V1, V2, and V3) and higher-order frontal, temporal, and occipital areas. In contrast, functional connectivity changes in the untrained region (e.g., left V1, V2, and V3) were markedly reduced, indicating that the observed plasticity was largely specific to the cortical representation of the stimulated visual field. Consistent with the functional results, cortical thickness analysis revealed a clear hemispheric asymmetry, with significant changes observed exclusively in the right hemisphere. Moreover, both the functional and structural assessments showed widespread changes in high-level association cortices, whereas changes in low-level sensory areas were less pronounced. The overlap between functional and structural measures suggests that enhanced connectivity aligns with structural changes due to crossmodal associations. These results illustrate that associations formed without explicit training or feedback can lead to functional and structural changes in the adult human brain, providing important implications for perception and neural plasticity in daily life situations.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"89"},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The deep winding at the brain surface: replicating a historical report associating the 'bridged' central sulcus with the pli de passage fronto-pariétal moyen.","authors":"Renate Schweizer, Anna Marie Muellen, Julius Stropel","doi":"10.1007/s00429-025-02947-z","DOIUrl":"10.1007/s00429-025-02947-z","url":null,"abstract":"","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"87"},"PeriodicalIF":2.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative tractography: joys and sorrows.","authors":"Alessandro Daducci, Simona Schiavi","doi":"10.1007/s00429-025-02939-z","DOIUrl":"10.1007/s00429-025-02939-z","url":null,"abstract":"<p><p>Quantitative tractography is the term used to indicate informing the estimation of the major axonal pathways of the brain from diffusion MRI with microstructural information (such as volume, myelin, axonal densities, etc.) to deliver veridical and biologically meaningful connectomes. The literature is replete with studies showing promising results obtained with such methods; however, did you know that these methods also have some subtle pitfalls that aren't immediately apparent but, if neglected, could result in incorrect or biased conclusions? This brief paper provides an overview of such pitfalls and solutions to mitigate them.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"88"},"PeriodicalIF":2.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DTI-based fiber tractography: why not?","authors":"Dogu Baran Aydogan, Alexander Leemans, Jessica Dubois, Flavio Dell'Acqua, Chiara Maffei","doi":"10.1007/s00429-025-02960-2","DOIUrl":"10.1007/s00429-025-02960-2","url":null,"abstract":"<p><p>Diffusion tensor imaging (DTI) has been fundamental in enabling the noninvasive exploration of the brain white matter architecture. However, the use of DTI for tractography remains challenging due to the known limitations of the tensor model in capturing complex fiber configurations. This short communication summarizes the key points of a debate held at the 2024 Tract-Anat Retreat sparked by the provocative statement: \"it is never acceptable to use DTI for tractography\". While we identified the advantages of moving towards more advanced orientation models that can provide more complete and accurate reconstructions of white matter pathways, we also highlighted the valuable contribution DTI-based tractography can make in clinical contexts, or when investigating simpler fiber architectures. These perspectives underscore the importance of the specific application when evaluating whether it is acceptable or not to use the tensor model for tractography.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"84"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of the motoneuronal pools controlling the hindlimb muscles in the lumbar spinal cord of the Acomys cahirinus.","authors":"Aleksandr Veshchitskii, Polina Shkorbatova, Natalia Merkulyeva","doi":"10.1007/s00429-025-02946-0","DOIUrl":"https://doi.org/10.1007/s00429-025-02946-0","url":null,"abstract":"<p><p>The motoneuron pools innervating major functionally distinct hindlimb muscles were mapped in the spinal cord of Acomys cahirinus using the fluorescent retrograde tracer Fast Blue. The dorsoventral, mediolateral, and rostrocaudal distributions of motoneuron pools in the lumbar spinal cord were characterized for the targeted muscles: (i) motoneuron pools innervating the m. iliacus (hip flexor) extend from the middle part of segment L1 to the caudal part of segment L3 and are located in the ventrolateral column; (ii) motoneuron pools innervating the m. vastus lateralis (knee extensor) extend from the caudal part of segment L2 to the caudal part of segment L3 and are located in the central column; (iii) motoneuron pools innervating the m. tibialis lateralis (ankle dorsiflexor) extend from the middle part of segment L3 to the middle part of segment L4 and are located in the dorsolateral column; (iv) motoneuron pools innervating the m. gracilis anterior (hip adductor, hip extensor) extend from the rostral part of segment L1 to the caudal part of segment L5 and are located in the central column; (v) motoneuron pools innervating the m. semitendinosus (hip extensor, knee flexor) extend from the caudal part of segment L2 to the middle part of segment L5 and are located in the central column; (vi) motoneuron pools innervating the m. soleus (ankle plantarflexor) extend from the caudal part of segment L3 to the middle part of segment L5 and are located in the dorsolateral column; (vii) motoneuron pools innervating the m. gastrocnemius medialis (knee flexor, ankle plantarflexor) extend from the middle part of segment L4 to the caudal part of L5 and are located in the dorsolateral column; and (viii) motoneuron pools innervating the m. gluteus medius (hip rotator, hip extensor) extend from the middle part of segment L3 to the caudal part of segment L5 and are located in the ventrolateral column. These findings represent the first detailed mapping of motoneuron pools in Acomys cahirinus and may prove valuable for studies investigating the locomotor system in precocial species.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"86"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI and non-MRI quantifiable neuroanatomical and functional parameters are useful for tractography.","authors":"Simona Schiavi, Elena Borra, Alberto De Luca, Derek K Jones, Laurent Petit, Diego Szczupak","doi":"10.1007/s00429-025-02932-6","DOIUrl":"10.1007/s00429-025-02932-6","url":null,"abstract":"<p><p>Tractography provides a powerful framework to reconstruct white matter pathways from diffusion magnetic resonance imaging (dMRI) but remains challenged by its inherent ambiguity and lack of direct biological specificity. This short communication summarizes the key points of a debate held at the 2024 Tract-Anat Retreat on the utility of MRI and non-MRI quantifiable neuroanatomical and functional parameters for improving tractography. During the discussion, concerns were raised about the availability of histological properties only on post-mortem tissues, the disparity in scale between MRI and other modalities and the additional costs (both in time and money) of such additional parameters. However, we identified several areas that enhance the anatomical accuracy of tractography including the potential value of histological priors, functional imaging constraints, and microstructural metrics in guiding or validating tract reconstructions. These perspectives underscore the need for multimodal frameworks that bridge imaging and biology, enabling tractography towards a more anatomically grounded representation of white matter organization.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"83"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional brain network correlates of cardiorespiratory fitness and moderation by depression symptoms.","authors":"Lauren R Borrell, Andrew C Venezia, J Carson Smith","doi":"10.1007/s00429-025-02952-2","DOIUrl":"10.1007/s00429-025-02952-2","url":null,"abstract":"<p><p>Cardiorespiratory fitness may protect against or alleviate depression through neuroplastic mechanisms within disrupted brain networks underlying cognitive and affective symptoms. There is a scarcity of research examining the effects of cardiorespiratory fitness on functional brain networks in representative samples spanning adulthood. Further, little is known about the interaction of cardiorespiratory fitness with depression in these networks. To address this problem, this study made use of the NKI-Rockland sample dataset and magnetic resonance imaging to examine whether functional brain network features associated with cardiorespiratory fitness were moderated by depression symptom severity in a community sample of 217 participants (134 females, 83 males) between the ages of 18 and 71 (M = 43.8 years, SD = 16.2). Cardiorespiratory fitness was positively associated with whole-brain modularity, between-network connectivity of the central executive and salience networks, and within-network connectivity of the default mode, central executive, and salience networks. The association of cardiorespiratory fitness and default mode network connectivity was stronger in the presence of moderate-to-severe depression symptoms. Taken together, these observations lend support to prior work that has demonstrated the associations of cardiorespiratory fitness with reduced concurrent and prospective depression risk and symptom severity. Depression symptoms moderated default mode network connectivity, suggesting that cardiorespiratory fitness may differentially impact neural substrates for those with moderate-to-severe depression symptoms.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 6","pages":"85"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition to synchronization in functional brain networks of children suffering from ADHD.","authors":"Sheida Ansarinasab, Atiyeh Bayani, Fatemeh Parastesh, Farnaz Ghassemi, Karthikeyan Rajagopal, Sajad Jafari","doi":"10.1007/s00429-025-02935-3","DOIUrl":"10.1007/s00429-025-02935-3","url":null,"abstract":"<p><p>The synchronization phenomenon is one of the crucial collective behaviors of the brain network, with its abnormal patterns in the brain networks of individuals with mental disorders like attention deficit hyperactivity disorder (ADHD) capturing the interest of researchers. ADHD is a prevalent disorder among children, which is linked to adverse outcomes such as impaired recognition of others' emotional facial expressions, leading to awkward social interactions. Despite numerous studies focusing on the synchronization analysis of brain networks in ADHD children while observing emotional facial expressions, the path to synchronization in these networks has been overlooked. For this reason, this research aims to investigate the differences in the synchronization transition of brain networks between healthy and ADHD children while processing emotional facial expressions based on their electroencephalogram signals. The analysis of synchronization cluster sequences in children's brain networks reveals that the formation and progression of synchronization clusters toward complete synchronization follow a more organized and goal-directed pattern in the healthy group than in the ADHD group. Furthermore, examining synchronization clusters with significant differences in stability (P-values < 0.05) during the clustering sequence between the two groups highlights abnormal synchronization in the frontal brain region during the early stages of neural processing in the ADHD group. This finding may contribute to deficits in attentional control and emotional regulation observed in ADHD children. Moreover, the classification results indicate the high potential of synchronization transition-based features to distinguish between ADHD and healthy children, with maximum accuracy, precision, and sensitivity of 82%, 77%, and 90%, respectively.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"82"},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}