Brain Structure & Function最新文献_第4页

Classifying athletes and non-athletes by differences in spontaneous brain activity: a machine learning and fMRI study. 根据自发脑活动的差异对运动员和非运动员进行分类：一项机器学习和功能磁共振成像研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-24 DOI: 10.1007/s00429-025-02941-5

Lei Peng, Lin Xu, Zheyuan Zhang, Zexuan Wang, Xiao Zhong, Letong Wang, Ziyi Peng, Ruiping Xu, Yongcong Shao

{"title":"Classifying athletes and non-athletes by differences in spontaneous brain activity: a machine learning and fMRI study.","authors":"Lei Peng, Lin Xu, Zheyuan Zhang, Zexuan Wang, Xiao Zhong, Letong Wang, Ziyi Peng, Ruiping Xu, Yongcong Shao","doi":"10.1007/s00429-025-02941-5","DOIUrl":"https://doi.org/10.1007/s00429-025-02941-5","url":null,"abstract":"Different types of sports training can induce distinct changes in brain activity and function; however, it remains unclear if there are commonalities across various sports disciplines. Moreover, the relationship between these brain activity alterations and the duration of sports training requires further investigation. This study employed resting-state functional magnetic resonance imaging (rs-fMRI) techniques to analyze spontaneous brain activity using the amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF) in 86 highly trained athletes compared to 74 age- and gender-matched non-athletes. Our findings revealed significantly higher ALFF values in the Insula_R (Right Insula), OFCpost_R (Right Posterior orbital gyrus), and OFClat_R (Right Lateral orbital gyrus) in athletes compared to controls, whereas fALFF in the Postcentral_R (Right Postcentral) was notably higher in controls. Additionally, we identified a significant negative correlation between fALFF values in the Postcentral_R of athletes and their years of professional training. Utilizing machine learning algorithms, we achieved accurate classification of brain activity patterns distinguishing athletes from non-athletes with over 96.97% accuracy. These results suggest that the functional reorganization observed in athletes' brains may signify an adaptation to prolonged training, potentially reflecting enhanced processing efficiency. This study emphasizes the importance of examining the impact of long-term sports training on brain function, which could influence cognitive and sensory systems crucial for optimal athletic performance. Furthermore, machine learning methods could be used in the future to select athletes based on differences in brain activity.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"74"},"PeriodicalIF":2.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activation patterns in male and female forebrain areas during habituation to food and context novelty. 在食物和环境新颖性习惯过程中，男性和女性前脑区域的激活模式。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-22 DOI: 10.1007/s00429-025-02927-3

Zoe R Irving, Eliza M Greiner, Mark Indriolo, Zhe Liu, Gorica D Petrovich

{"title":"Activation patterns in male and female forebrain areas during habituation to food and context novelty.","authors":"Zoe R Irving, Eliza M Greiner, Mark Indriolo, Zhe Liu, Gorica D Petrovich","doi":"10.1007/s00429-025-02927-3","DOIUrl":"https://doi.org/10.1007/s00429-025-02927-3","url":null,"abstract":"Novelty has significant effects on feeding behavior. New foods and unfamiliar environments suppress consumption, and adaptation to novelty is fundamental to survival. Yet, little is known about habituation to eating in a novel environment. The aim of the current study was to determine if context familiarity impacts habituation to novel food and to identify underlying neural substrates. Adult male and female rats were tested for consumption of a novel, palatable food in a novel or familiar environment across four habituation sessions and a final test session. Test-induced Fos expression was measured in amygdalar, thalamic, prefrontal, and hippocampal regions known to be recruited during the first exposure to novelty. Rats in the novel context ate less compared to rats in the familiar context during each habituation session and test, and females ate less than males during the first session. Habituation to eating in the novel context robustly induced Fos in the majority of regions analyzed, including the central, basolateral, and basomedial nuclei of the amygdala, thalamic paraventricular and reuniens nuclei, and the hippocampal field CA1. Females had overall higher Fos induction in most regions analyzed and higher in the novel condition in the reuniens nucleus. Bivariate correlation analyses of Fos induction between regions found a large number of correlations in the novel context condition. Females tested in the novel context had uniquely large number of correlations between all regions analyzed, except for one thalamic subregion. These results suggest that novelty from context remains relevant late in habituation and recruits a distinct and more interactive network in females than in males.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"73"},"PeriodicalIF":2.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The functional connectivity between the dorsolateral prefrontal cortex and the medial prefrontal cortex underlying the association between self-control and delay discounting. 背外侧前额叶皮层和内侧前额叶皮层之间的功能连接是自我控制和延迟折扣之间联系的基础。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02936-2

Wenzhuo Gong, Hengyue Zhao, Zhuoran Wei, Tingyong Feng, Pan Feng

{"title":"The functional connectivity between the dorsolateral prefrontal cortex and the medial prefrontal cortex underlying the association between self-control and delay discounting.","authors":"Wenzhuo Gong, Hengyue Zhao, Zhuoran Wei, Tingyong Feng, Pan Feng","doi":"10.1007/s00429-025-02936-2","DOIUrl":"10.1007/s00429-025-02936-2","url":null,"abstract":"Delay discounting is the tendency for people to devalue future rewards as the time required to obtain them increases over time. Self-control is the ability to regulate behavior, emotions and cognition to achieve goals or adhere to social norms despite temptations, impulses or distractions. Previous studies have found that self-control was negatively correlated with delay discounting. However, the neural mechanism underlying the relationship between self-control and delay discounting remains unclear. To address this question, we examined the neural basis of the relationship between self-control and delay discounting using voxel-based morphometry(VBM) and resting-state functional connectivity analysis(RSFC). The behavioral results demonstrated a negative correlation between delay discounting and self-control. Furthermore, the voxel-based morphometry results showed a positive correlation between self-control and gray matter volume in the dorsolateral prefrontal cortex(dlPFC). Moreover, self-control was positively correlated with functional connectivity between the medial prefrontal cortex(mPFC) and the dorsolateral prefrontal cortex. More importantly, the association between self-control and delay discounting was shown to be partially mediated by the functional connectivity between the dlPFC and mPFC. These findings suggested that dlPFC-mPFC functional connectivity could be the neural basis underlying the association between self-control and delay discounting, which provided novel insights into how self-control affected delay discounting and offered new explanations from a neural perspective.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"71"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Katrin Amunts. 凯特琳Amunts。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02929-1

Katrin Amunts

引用次数: 0

Fixel-based evidence for preserved white matter asymmetry in human situs inversus totalis. 基于固定的证据，证明人类相对于整体位置保留的白质不对称性。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02931-7

Emma M Karlsson, Helena Verhelst, Guy Vingerhoets

{"title":"Fixel-based evidence for preserved white matter asymmetry in human situs inversus totalis.","authors":"Emma M Karlsson, Helena Verhelst, Guy Vingerhoets","doi":"10.1007/s00429-025-02931-7","DOIUrl":"10.1007/s00429-025-02931-7","url":null,"abstract":"Situs inversus totalis (SIT), a rare condition involving the complete reversal of thoracic and abdominal organ placement, provides a unique model for investigating potential relationships between visceral and cerebral asymmetries. In this study, we examined whether white matter asymmetries are altered in a group of 21 SIT participants compared with 21 matched situs solitus (SO) controls. This sample represents the largest cohort of SIT individuals studied to date. Using fixel-based analysis, an advanced diffusion magnetic resonance imaging framework, we compared micro- and macrostructural white matter asymmetries across the whole brain between the two groups, specifically assessing fiber density and cross-section (FDC). Both groups showed extensive yet comparable patterns of white matter asymmetry, with no significant group differences. These asymmetry patterns were consistent with those reported in previous fixel-based studies. These results suggest that white matter lateralization is preserved despite complete visceral reversal. The observed divergence between brain and visceral asymmetry patterns suggests that symmetry breaking in visceral laterality relies on distinct mechanisms.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"69"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic inferior olive activation in a cognitive task: an fMRI study. 动态下橄榄在认知任务中的激活：fMRI研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-21 DOI: 10.1007/s00429-025-02933-5

Annakarina Mundorf, Laura C Rice, Jutta Peterburs, John E Desmond

{"title":"Dynamic inferior olive activation in a cognitive task: an fMRI study.","authors":"Annakarina Mundorf, Laura C Rice, Jutta Peterburs, John E Desmond","doi":"10.1007/s00429-025-02933-5","DOIUrl":"10.1007/s00429-025-02933-5","url":null,"abstract":"The inferior olive provides powerful inputs to the cerebellum hypothesized to support cerebellar learning and error detection. Given cerebellar involvement in verbal working memory and the close interplay with the inferior olive, the inferior olive is likely also involved in verbal working memory. In order to elucidate the inferior olive's role in verbal working memory, we utilized an MRI-based Sternberg verbal working memory task which involved learning novel vs repeated sequences. As hypothesized, inferior olive activation was stronger during encoding and retrieval compared to maintenance, especially for novel compared to repeated sequences, indicative of diminished inferior olive activity with stimulus repetition. Results also revealed differential inferior olive activation during retrieval, with increased activation on matching probes for novel and on non-matching probes for repeated sequences. This underlines the crucial role of the inferior olive in novel information encoding and error feedback, and that conditions triggering strong inferior olive responses can change as a function of novelty.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"72"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study. 未破裂颅内动脉瘤患者的异常脑活动：静息状态功能MRI研究。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-20 DOI: 10.1007/s00429-025-02934-4

Wei Li, Weijie Fan, Si Zhang, Haiyu Zhang, Dong Zhang, Li Wen

{"title":"Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study.","authors":"Wei Li, Weijie Fan, Si Zhang, Haiyu Zhang, Dong Zhang, Li Wen","doi":"10.1007/s00429-025-02934-4","DOIUrl":"10.1007/s00429-025-02934-4","url":null,"abstract":"Patients carrying unruptured intracranial aneurysm (UIA) often experience emotional alterations and cognitive impairments. While the specific mechanisms underlying these impairments are still not fully understood. The study measured the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) to investigate the abnormal brain functional alterations in 49 UIA patients compared with 50 healthy controls, and also analyzed the correlations among neuroimaging indices, the clinical data, and the neuropsychological test results. UIA patients exhibited more active brain region activity in the right hippocampus than the healthy group and showed negatively activated brain regions, including the cuneus, left paracentral lobule, and right postcentral gyrus. Furthermore, the strength of FC decreased in the bilateral middle cingulate gyrus; right superior temporal gyrus and insula; and left parahippocampal gyrus, fusiform gyrus, lingual gyrus, inferior frontal gyrus, and middle frontal gyrus. The abnormal activities in the aforementioned brain regions were closely linked to worse performance in emotion and cognition. The study presents a potential neuroimaging-based mechanism of brain function that could explain the emotional alterations and cognitive impairments in UIA patients.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"68"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training. 脑瘫儿童平衡控制的脑结构相关性：基线相关性和训练效果。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-20 DOI: 10.1007/s00429-025-02937-1

Nina P T Jacobs, Marjolein M van der Krogt, Annemieke I Buizer, Laura A van de Pol, Chloé E C Bras, Frederik Barkhof, Pieter Meyns, Petra J W Pouwels

{"title":"Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training.","authors":"Nina P T Jacobs, Marjolein M van der Krogt, Annemieke I Buizer, Laura A van de Pol, Chloé E C Bras, Frederik Barkhof, Pieter Meyns, Petra J W Pouwels","doi":"10.1007/s00429-025-02937-1","DOIUrl":"10.1007/s00429-025-02937-1","url":null,"abstract":"Structural brain abnormalities likely underlie impaired balance control in cerebral palsy (CP). This study investigated whether balance measures were associated with measures derived from conventional MRI and diffusion tensor imaging (DTI), and whether an X-Box One Kinect balance training (6 weeks, 5 days/week, 30 min/session) could induce neuroplastic changes in CP. Twelve children with spastic CP (age:11.3 ± 2.3y) underwent balance evaluation and MRI examination, at baseline and after training. Nine age-matched typically developing (TD) children underwent baseline measurements. Balance control was evaluated testing advanced motor skills (Challenge score) and during gait (medio-lateral Margin of Stability, MoS). With conventional MRI, but especially with DTBM (DTI-based VBM), we found smaller volumes of several deep grey matter structures and within the right inferior parietal cortex, right supramarginal cortex, and left postcentral cortex, and lower fractional anisotropy (FA) and smaller volumes of various white matter regions in CP compared to TD. Within the CP group alone, no correlations within brain tissue were found. After training, Challenge scores of children with CP improved. In an exploratory analysis DTBM showed a trend for volume increase within the right inferior parietal cortex, volume decrease within the right retrolenticular limb of the internal capsule, and an increase of FA within the right corticospinal tract. This indicates that a 6-week balance intervention may induce neuroplastic changes in children with CP. CP-RehOP (trial registration number: NTR6034/NL5854, date of registration: August 26th 2016).","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"67"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased rubidium levels in brain regions involved in food intake in obese rats. 肥胖大鼠大脑中与食物摄入有关的区域铷含量增加。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-15 DOI: 10.1007/s00429-025-02930-8

Magdalena Szczerbowska-Boruchowska, Aleksandra Chenczke, Blazej Ruszczycki, Pawel Wrobel, Wiktoria Tokarczyk, Patryk Stec, Katarzyna M Sowa, Agata Ziomber-Lisiak

{"title":"Increased rubidium levels in brain regions involved in food intake in obese rats.","authors":"Magdalena Szczerbowska-Boruchowska, Aleksandra Chenczke, Blazej Ruszczycki, Pawel Wrobel, Wiktoria Tokarczyk, Patryk Stec, Katarzyna M Sowa, Agata Ziomber-Lisiak","doi":"10.1007/s00429-025-02930-8","DOIUrl":"10.1007/s00429-025-02930-8","url":null,"abstract":"The hypothalamus, particularly its ventromedial and lateral regions, plays a pivotal role in homeostatic appetite regulation and is therefore a significant brain structure in the development of obesity. Additionally, the development of obesity can be caused by improper hedonic regulation, which involves neural circuits and systems associated with pleasure and reward. Several studies indicate a possible link between rubidium (Rb) and obesity, despite this element is not being typically considered influential in vital life processes. The present study, therefore, aims to investigate whether excessive body fat in obese animals alters rubidium levels in brain regions directly or indirectly involved in appetite regulation. The research was conducted on high-calorie diet (HCD)-induced obese rats (OB, n = 8) and their lean counterparts (L, n = 8). The determination of Rb levels in brain areas was performed using synchrotron radiation-based X-ray fluorescence microanalysis (SRXRF). The obtained results show a significantly higher level of Rb in all brain areas examined, although the increase in this element in obese individuals was not the same in all structures. The largest relative difference (over 70%) was observed for the orbitofrontal cortex, and the smallest (about 35%) for the amygdala. Principal component analysis with linear projections demonstrated a clear differentiation between the brain structures of obese and non-obese individuals based on the full elemental composition of tissues, while Rb was the only element that distinguished the obese group in each of the examined brain structures. The results obtained clearly confirm the increase in Rb levels in the brain structures responsible for regulating appetite in obesity.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"66"},"PeriodicalIF":2.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced structural brain connectivity analyses using high diffusion-weighting strengths. 使用高扩散加权强度增强结构脑连接分析。

IF 2.7 3区医学

Brain Structure & Function Pub Date : 2025-05-14 DOI: 10.1007/s00429-025-02916-6

Leyao Yu, Adeen Flinker, Jelle Veraart

{"title":"Enhanced structural brain connectivity analyses using high diffusion-weighting strengths.","authors":"Leyao Yu, Adeen Flinker, Jelle Veraart","doi":"10.1007/s00429-025-02916-6","DOIUrl":"https://doi.org/10.1007/s00429-025-02916-6","url":null,"abstract":"Tractography is a unique modality for the in vivo measurement of structural connectivity, crucial for understanding brain networks and neurological conditions. With increasing b-value, the diffusion-weighting signal becomes primarily sensitive to the intra-axonal signal. However, it remains unclear how tractography is affected by this observation. Here, using open-source datasets, we showed that at high b-values, DWI reduces the uncertainty in estimating fiber orientations. Specifically, we found the ratio of biologically-meaningful longer-range connections increases, accompanied with downstream impact of redistribution of connectome and network metrics. However, when going beyond b = 6000 s/mm2, the loss of SNR imposed a penalty. Lastly, we showed that the data reaches satisfactory reproducibility with b-values above 1200 s/mm2. Overall, the results suggest that using b-values above 2500 s/mm2 is essential for more accurate connectome reconstruction by reducing uncertainty in fiber orientation estimation, supporting the use of higher b-value protocols in standard diffusion MRI scans and pipelines.","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"230 5","pages":"65"},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0