Brain Structure & Function最新文献

{"title":"Thalamic projections from the cerebellar nuclei receiving proprioceptive signals from the jaw muscles in rats.","authors":"Atsushi Yoshida, Fumihiko Sato, Yumi Tsutsumi, Katsuro Uchino, Yuki Oi, Akiko Morita, Ayaka Oka, Takahiro Furuta, Jaerin Sohn, Yong Chul Bae, Yoshihisa Tachibana","doi":"10.1007/s00429-026-03185-7","DOIUrl":"10.1007/s00429-026-03185-7","url":null,"abstract":"<p><p>The neural mechanisms involved in transmission of proprioceptive information from muscles are not fully understood. Proprioceptive signals from jaw-closing muscle spindles (jcms) are relayed to the supratrigeminal nucleus (Su5), and, then, from the Su5 to the thalamus including the oval paracentral nucleus (OPC) via the trigeminal lemniscal pathway and to the jcms-IntDL and jcms-MedDL (the dorsolateral hump of interposed cerebellar nucleus [IntDL] and the dorsolateral protuberance of medial cerebellar nucleus [MedDL], which were electrophysiologically identified to receive jcms-proprioception). In this study, we investigated the cerebellothalamic projections from the jcms-IntDL and jcms-MedDL in rats by injecting an anterograde tracer into these two subnuclei. The thalamic projection sites from the jcms-IntDL and jcms-MedDL appeared bilaterally with a contralateral predominance and broadly overlapped, but with considerable differences. Namely, the jcms-IntDL principally projected to the ventrolateral (VL), ventromedial (VM), ventral anterior, paracentral (PC) thalamic nuclei, and OPC, whereas the jcms-MedDL mainly targeted the parafascicular and centrolateral thalamic nuclei as well as the VL, VM, and PC. Overall, these thalamic projections from the jcms-MedDL appeared stronger than those from the jcms-IntDL. In the OPC and VM, the size of axonal boutons from the jcms-IntDL was larger than that from the jcms-MedDL. We also investigated the cerebellar nucleus neurons projecting to the OPC by using retrograde tracer injections into the OPC, and confirmed that the cerebellothalamic and lemniscal pathways, which possibly transport the same proprioceptive information, converge on the OPC. Our findings demonstrate characteristics of thalamic projections from the cerebellar nuclei conveying muscle proprioceptive information.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between cerebral cortex volume and verbal fluency in community-dwelling adults using magnetic resonance imaging: a cross-sectional observational study.","authors":"Kentaro Akazawa, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Teruhide Koyama, Yukina Izumi, Keita Watanabe, Koji Sakai, Yoshinori Marunaka, Akihiro Takada, Toshiki Mizuno, Kei Yamada","doi":"10.1007/s00429-026-03183-9","DOIUrl":"10.1007/s00429-026-03183-9","url":null,"abstract":"<p><p>With the aging population, identifying the relationship between verbal fluency test (VFT) performance and brain atrophy is crucial for improving the early detection of cognitive decline. This study aimed to investigate the association between cerebral cortical volume and performance on VFTs, specifically category (CFT) and letter (LFT) fluency tests, to identify brain regions associated with verbal fluency. In this cross-sectional observational study, community-dwelling adults underwent brain magnetic resonance imaging (MRI) and completed CFTs and LFTs. Participants with organic brain anomalies on MRI were excluded. Using multiple linear regression, the relationship, adjusted for age, sex, Mini-Mental State Examination score, and total brain volume, between local gray matter volumes in 22 cortical regions in both hemispheres and VFT performance was analyzed. We included 267 community-dwelling adults (70 years and 0.8 months ± 6 years and 2.3 months; 178 men and 89 women). A significant association was found between CFT scores and volume of the left inferior frontal gyrus (R² = 0.1765, corrected-p = 0.0027), specifically the pars orbitalis (R² = 0.1520, corrected-p = 0.011) and pars triangularis (R² = 0.1452, corrected-p = 0.036). No significant associations were observed between LFT scores and cortical volumes. These findings align with previous lesion and functional MRI studies highlighting the left inferior frontal gyrus' role in language production. Lower CFT performance was associated with smaller left inferior frontal gyrus volume. Longitudinal and predictive studies are required before diagnostic or prognostic utility can be inferred.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing design students' inter-brain synchrony between face-to-face and online collaborations.","authors":"Luqian Wang, Clive Hy Wong, Kin Wai Michael Siu, Bolton Kh Chau, Zhen Yuan, Leanne Chang, Yi-Teng Shih","doi":"10.1007/s00429-026-03188-4","DOIUrl":"10.1007/s00429-026-03188-4","url":null,"abstract":"<p><p>The rapid digitalisation of design education has fundamentally altered how students collaborate; however, the cognitive and neurophysiological dynamics underlying online creative co-creation remain poorly understood. To address this, we conducted an exploratory pilot study (N = 11 dyads) employing a multimodal paradigm that integrated behavioural protocol analysis with fNIRS hyperscanning. Specifically, this study examined the effects of collaborative modality (face-to-face versus online via Zoom) and interactional behaviours between design students on neural coupling, utilising Phase Locking Value (PLV) to quantify inter-brain synchrony (IBS). The results revealed an inversion between observable behaviour and underlying neural synchrony. In face-to-face settings, dyads spent the majority of their time communicating verbally, yet their highest levels of IBS were associated with sketching. Conversely, although participants sketched significantly more often in the online environment, the neural coupling previously associated with sketching collapsed. Instead, verbal communication emerged as the primary correlate of enhanced IBS in the digital space. These initial findings indicate that online collaborative dyads may rely more heavily on explicit verbal channels to maintain cognitive alignment. Crucially, because generative \"Solution Space\" activities inherently demand the visual externalisation of ideas, this disruption of sketching-associated neural coupling raises the theoretical hypothesis that remote environments may leave students more susceptible to misaligned mental models or design fixation during the solution exploration phases. It also highlights a critical avenue for future outcome-based research.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orchestrating neuroimaging data processing using the 'Snakemake' workflow manager.","authors":"Damien J Mannion, Maria Del Mar Quiroga, Jacob M Paul, Marta I Garrido","doi":"10.1007/s00429-026-03189-3","DOIUrl":"10.1007/s00429-026-03189-3","url":null,"abstract":"<p><p>The processing of neuroimaging data typically involves a complicated set of operations, which often require different software packages and have intensive computational and storage demands. Although there are many options available for the neuroimaging researcher to establish their preferred set of processing operations, there is relatively little guidance on how to orchestrate such operations within a coherent data processing workflow. Here, by describing the construction of a simplified neuroimaging processing workflow, we demonstrate how the established general-purpose workflow manager 'Snakemake' can be used to facilitate neuroimaging data processing. Snakemake allows researchers to use a Python-based markup language to describe how input files are transformed into output files. Snakemake then uses these rules to schedule and execute the computational jobs that are required to generate the output files, without unnecessary recreation of existing output files. This allows the complete processing workflow to be executed with a single command and creates workflows that are interpretable, efficient, and reproducible.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of acute, chronic, and social defeat stress on microglial morphology in the basolateral and central amygdala, and the medial and lateral habenula.","authors":"A Nieto-Quero, J Munoz-Martin, M I Infantes-López, S Tabbai, A Arjona, E Zambrana-Infantes, P Chaves-Peña, M J Blanca, M Pérez-Martín, C Pedraza","doi":"10.1007/s00429-026-03172-y","DOIUrl":"10.1007/s00429-026-03172-y","url":null,"abstract":"<p><p>Effective stress regulation is essential for emotional health, whereas maladaptive stress responses contribute to neuropsychiatric disorders such as depression and post-traumatic stress disorder. Because neuron-microglia interactions are increasingly recognized as key modulators of neuroplasticity under physiological conditions, stress-related microglial dysregulation may contribute to aberrant neuronal responses implicated in mental health disorders. This exploratory study examined region-specific microglial morphometric responses to acute intense stress, chronic restraint stress, and social defeat stress (SDS) in the amygdala and habenula, focusing on the BLA, CeA, LHb, and MHb. Microglial morphology was assessed using animal-level morphometric comparisons and exploratory cluster-based profiling. Acute stress was associated with limited animal-level morphometric differences, while exploratory cluster distributions suggested subregion-dependent shifts, particularly in the CeA and LHb. Chronic stress was associated with larger soma-related parameters in the BLA and CeA, together with a descriptive redistribution toward large-soma/low-process profiles in both amygdalar subregions. In the habenula, chronic stress induced selective MHb morphometric changes, while cluster profiles remained comparatively constrained. SDS was associated with the most pronounced remodelling in the amygdala, including increased soma-related measures, reduced circularity/solidity in the CeA, altered spatial organization, and a strong redistribution toward large-soma/ high-process profile. SDS also shifted LHb cluster profiles, whereas the MHb showed comparatively limited sensitivity. Overall, these exploratory findings suggest that different stressors are associated with region- and subregion-dependent microglial remodelling, with the amygdala showing greater stress-related plasticity than the habenula. These patterns support further investigation of microglial morphological adaptation as a potential contributor to stress-related psychopathology.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural alterations in early auditory cortex in borderline personality disorder with auditory verbal hallucinations.","authors":"Yéléna Le Prieult, Marie-Luise Otte, Mike M Schmitgen, Mert Koc, Chantal Tech, Robert Christian Wolf","doi":"10.1007/s00429-026-03162-0","DOIUrl":"10.1007/s00429-026-03162-0","url":null,"abstract":"<p><p>Auditory Verbal Hallucinations (AVH) are not exclusive to schizophrenia but also occur in other psychiatric disorders, including Borderline Personality Disorder (BPD). While AVH in SZ has been extensively studied, their neurobiological underpinnings in BPD remain poorly understood. Preliminary evidence suggests structural anomalies in auditory regions among BPD patients experiencing AVH, indicating potential neuroanatomical vulnerabilities. This study examined structural brain differences in female BPD patients with (BPD-AVH n = 20) and without (BPD-nAVH n = 27) a lifetime history of AVH, as well as healthy controls (HC, n = 30), using high-resolution structural MRI. Cortical thickness (CTh), gyrification (CG), and gray matter volume (GMV) were assessed in frontotemporal regions implicated in auditory and speech processing, including the inferior frontal gyrus and superior, middle, and transverse temporal gyri. Region-of-interest (ROI) analyses were performed via CAT12, with supplementary segmentation of Heschl's gyrus using the TASH toolbox. Group comparisons were conducted using SPM12. Compared to both HC and BPD-nAVH, BPD-AVH patients showed significantly reduced CG in the right transverse temporal gyrus (rTTG), a region encompassing early auditory cortex. No significant group differences emerged in other ROI analyses, for GMV, CG or CTh. Reduced gyrification in the rTTG suggests aberrant cortical folding in early auditory regions among BPD patients with AVH. This may reflect disrupted neurodevelopmental processes that impair auditory signal encoding and internal vs. external sound source discrimination. These findings highlight the role of primary auditory cortex abnormalities in AVH and support transdiagnostic models emphasizing early sensory processing deficits.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-brain coupling during naturalistic collaborative Tangram solving in child dyads: an exploratory fNIRS hyperscanning study.","authors":"Raimundo da Silva Soares Junior, João Ricardo Sato","doi":"10.1007/s00429-026-03187-5","DOIUrl":"10.1007/s00429-026-03187-5","url":null,"abstract":"<p><p>Collaborative problem solving plays a central role in children's cognitive and social development, yet how neural activity relates to real-time peer coordination remains poorly understood. Using functional near-infrared spectroscopy (fNIRS) hyperscanning, we simultaneously recorded brain activity from 15 dyads of school-aged children during a naturalistic Tangram puzzle task, including rest, solo problem-solving, observation, and collaboration. We examined task-related neural activation and inter-brain connectivity (IBC) to assess how interpersonal neural dynamics relate to task context and behavior. No prespecified region-of-interest activation effect survived correction for multiple comparisons. At the exploratory channel level, a posterior-parietal channel showed a positive HbO response during collaboration relative to baseline. The global IBC did not differ significantly across experimental conditions, indicating that inter-brain synchrony was not determined solely by collaboration or social presence. Nevertheless, an exploratory association between global HbO coupling during Duo and total manual activity showed a relevant magnitude (Spearman rho = 0.581), a bootstrap 95% confidence interval excluding zero [0.038, 0.891], positive coefficients in every leave-one-dyad-out analysis, and a similar magnitude after excluding the first 8 s of each block (rho = .538), although it did not meet the FDR threshold across the broader sensitivity family, q = 0.131. Building on the emerging literature on dual-child portable fNIRS hyperscanning, the study reinforces the viability of this approach in an ecologically valid, hands-on task and suggests that block-wise inter-brain coupling may capture meaningful variation in dyad-level behavioral engagement.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACPC-MAP: a protocol for manually aligning structural T1-weighted magnetic resonance images to the anterior commissure - posterior commissure plane according to clinical standards.","authors":"Ashok K Selvaraj, Ronald H M A Bartels, Christian F Beckmann, R Saman Vinke, Koen V Haak","doi":"10.1007/s00429-026-03171-z","DOIUrl":"10.1007/s00429-026-03171-z","url":null,"abstract":"<p><p>Realigning structural MR images to stereotactic AC-PC space is a standard procedure that enhances anatomical consistency both within and across neuroimaging studies, allowing for precise spatial localization and reliable cross-subject comparisons in both clinical and research contexts. However, different versions of AC-PC spaces, stemming from varying definitions of the AC-PC axis as outlined in common stereotactic atlases like Talairach and Schaltenbrand, often lead to discrepancies between the neurosurgical and neuroimaging communities. Manual realignment of structural MR images to the clinically used version of the AC-PC plane is often necessary to validate the results of automated methods or to realign the image when these methods fail. Furthermore, manual realignment provides a critical 'ground truth' for the development of new automated tools. However, such manual interventions are typically performed in a non-standardised manner by domain experts who possess the specialized knowledge of neuroanatomy and neuroimaging required to ensure accurate alignment. To address these challenges, we have developed and validated a standardized protocol for manually realigning structural MR images to the clinically used Schaltenbrand AC-PC plane, using a set of visual criteria to ensure accurate realignment. This protocol can be used to manually align images, verify results, validate existing automated methods, or generate ground truth data for developing new automated techniques.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structural pathways linking dietary patterns and cognitive performance in adolescents.","authors":"Isabelle Brocas, Liam Kirwin, Matthew Kuloszewski","doi":"10.1007/s00429-026-03190-w","DOIUrl":"10.1007/s00429-026-03190-w","url":null,"abstract":"<p><p>Dietary patterns covary with cognitive performance during adolescence, but the structural brain features associated with this covariance remain incompletely characterized. To identify structural brain correlates of cognition-aligned dietary patterns in adolescents while addressing adiposity, ethnicity adjustment, family relatedness, and multiple testing. We analyzed 3,308 adolescents from ABCD Release 5.1. Ten food-group measures were summarized by five dietary principal components (PCs). We constructed sample-derived, cognition-aligned dietary scores (PolyIQ) and used repeated five-fold family-level cross-fitting so that each participant's score was calculated using cognition-derived weights estimated without that participant or members of the same family. The original PCs provided an outcome-independent benchmark. Primary models adjusted for age, sex, pubertal stage, socioeconomic status, income-to-needs ratio, sleep, and age- and sex-standardized BMI; ethnicity was excluded from primary models and added in sensitivity analyses. Brain-cognition models and family-cluster bootstrap indirect-effect models examined fractional anisotropy (FA), cortical thickness, surface area, and regional volume. All pre-specified indirect-effect models, including nonsignificant results, were retained. Cross-fitted dietary scores were associated with crystallized cognition (β = 0.099, SE = 0.018, P < 0.001) and fluid cognition (β = 0.064, SE = 0.015, P < 0.001); the five original dietary PCs were jointly associated with both domains. Brain-cognition associations in the bilateral fornix and hippocampal cingulum remained after BMI adjustment. In the all-ROI analysis, indirect associations through right and left fornix FA survived false-discovery-rate correction for both crystallized cognition (right: 0.0067, 95% CI [0.0016, 0.0134]; left: 0.0063, [0.0013, 0.0126]) and fluid cognition (right: 0.0061, [0.0019, 0.0127]; left: 0.0052, [0.0011, 0.0106]). No gray-matter indirect effect survived correction across all tested regions. A sample-derived dietary pattern aligned with cognition covaried with FA in bilateral fornix pathways. The findings were robust to adiposity adjustment and were similar when ethnicity was added, but the cross-sectional design supports only a decomposition of shared variance, not a causal or temporally ordered mechanism.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale network reorganization during the multidimensional recollection of naturalistic events.","authors":"Federica Procida, Maria Giulia Tullo, Matteo Frisoni, Annalisa Tosoni, Mauro Gianni Perrucci, Antonello Baldassarre, Carlo Sestieri","doi":"10.1007/s00429-026-03184-8","DOIUrl":"10.1007/s00429-026-03184-8","url":null,"abstract":"<p><p>The recollection of complex events is multidimensional. Recent work has gathered evidence for varying degrees of functional specialization for different memory dimensions across the main cortical networks involved in cued recollection. However, how functional brain network topology reorganizes to support the retrieval of different types of information remains largely unexplored. Here, we applied graph theoretical analysis to task-related fMRI functional connectivity data from 22 participants engaged in cued recollection of specific details from naturalistic movie scenes. A beta series correlation approach was used to identify the pattern of whole-brain regional co-activation for cued recollection in general, and separately for each memory dimension of interest (object and character details, spatial layouts, temporal sequences, and verbal dialogues). Subsequently, using graph theory, we investigated the association between indices of brain network topology and cued recollection performance, as well as differences in functional brain network architecture across memory dimensions at the multiscale level. Successful recollection was associated with higher global efficiency and lower modularity at the whole-network level, as well as with lower system segregation within the Frontoparietal control network. Crucially, retrieval conditions placing greater demands on relational integration (i.e., temporal order judgments), compared to those emphasizing single-item details, were associated with more integration in the Default Mode network and increased degree centrality, efficiency, and reduced path length in the right hippocampus. Together, these findings reinforce the idea that successful retrieval requires system integration, especially when accessing complex relational representations like temporal sequences.</p>","PeriodicalId":9145,"journal":{"name":"Brain Structure & Function","volume":"231 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}