BMC Pediatrics最新文献

{"title":"Inhalation of multiple pen caps causing bronchial foreign bodies: a rare case in an older child.","authors":"Jia Zhai, Yongsheng Guo, Chunlei Chen, Xuelin Wang, Yifan Wang, Ying-Xue Zou","doi":"10.1186/s12887-025-05401-5","DOIUrl":"10.1186/s12887-025-05401-5","url":null,"abstract":"<p><strong>Background: </strong>Foreign body inhalation is rare in older children, often leading to underdiagnosis and delayed treatment. Most cases involve a single foreign body, but instances of multiple foreign bodies are exceedingly uncommon. This report presents a case of an elder child who inhaled two pen caps, emphasizing the need for clinical vigilance and thorough medical history collection.</p><p><strong>Case presentation: </strong>A twelve-year-old boy was admitted with a persistent cough lasting over two months, accompanied by sputum with a peculiar odor. Previous treatments with oral Cefdinir (0.1 g, three times daily) and inhaled Budesonide Suspension had not improved his condition. Physical examination revealed decreased breath sounds on the right side without signs of respiratory distress or wheezing. Imaging studies, including chest X-ray and CT scan, along with bronchoscopy, confirmed the presence of two foreign bodies in the right bronchus. The patient was started on anti-infective therapy to address any underlying infection before proceeding with removal. A combination of flexible bronchoscopy and rigid bronchoscopy, supplemented by a cryotherapy instrument, successfully extracted the pen caps. Post-procedure assessments indicated that the patient's body temperature returned to normal, cough symptoms resolved, and lung ventilation significantly improved.</p><p><strong>Conclusion: </strong>This case highlights the critical need for clinicians to remain vigilant regarding bronchial foreign bodies in older children. The rare occurrence of multiple foreign bodies, particularly resulting from active inhalation, necessitates a comprehensive medical history during patient evaluation. Early recognition and intervention can lead to significant improvements in patient outcomes, underscoring the importance of thorough clinical assessment in similar cases.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"43"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of miR-200b in diagnosis and prognosis of childhood pneumonia.","authors":"Weiwei Qi, Beibei Teng, Fan Zhang, Ying Chen, Jinmei Xu, Jinling Luan","doi":"10.1186/s12887-024-05370-1","DOIUrl":"10.1186/s12887-024-05370-1","url":null,"abstract":"<p><strong>Background: </strong>Childhood pneumonia (CP) is a common respiratory infectious disease in children with high morbidity and mortality. However, differential changes in miRNAs may interact with the regulation of CP. The aim of this paper was to discuss the miR-200b expression in CP and its diagnostic and prognostic value.</p><p><strong>Methods: </strong>RT-qPCR was used to measure the miR-200b expression in venous blood. ROC curve was adopted to assess the diagnostic ability of miR-200b in children with CP. Logistic analysis was adopted to study the risk factors are related to CP. Kaplan-Meier was employed to analyze the prognostic ability of miR-200b in CP. Transfection of MRC-5 cells in vitro was used to verify the impact of miR-200b on cell proliferation and apoptosis.</p><p><strong>Results: </strong>The expression of miR-200b in serum of CP children was upregulated. ROC analysis prompted that upregulation of miR-200b could be effective in distinguishing between CP and healthy children. Compared with the good prognosis group, miR-200b expression was elevated in the poor prognosis group. Kaplan-Meier reminded that high expression of miR-200b led to a poor prognosis in CP. Cells experiments demonstrated that transfection with miR-200b inhibitor encouraged cell proliferation and inhibited apoptosis, whereas transfection with miR-200b mimic had the contrary result.</p><p><strong>Conclusions: </strong>miR-200b had high diagnostic and prognostic value for children with CP and may become a biomarker for clinical diagnosis and prognosis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"42"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review.","authors":"Shulin Hou, Zeyao Shi, Xiaowen Li, Ru Yang, Yan Song, Zhaolan Zeng","doi":"10.1186/s12887-024-05261-5","DOIUrl":"10.1186/s12887-024-05261-5","url":null,"abstract":"<p><strong>Background: </strong>Current treatment of giant omphalocele in newborns is not standardized. The main treatments include one-time repair and staged surgery using synthetic and biologic mesh, or silos. However, surgery can lead to various postoperative complications. Recently, negative pressure wound therapy (NPWT) has been recommended as an effective method for giant omphalocele. We adopted NPWT and some new wound dressings for a case of ruptured giant omphalocele. Vaseline gauze (VG), followed by silver-containing sodium carboxymethylcellulose dressing(CMC-Ag)was used to control infection. NPWT was mainly performed to promote granulation and accelerated healing. Recombinant human basic fibroblast growth factor (Rh-bFGF) was used to heal the wound. No studies have conducted NPWT and new wound dressings healing the wound of ruptured giant omphalocele. Therefore, we present our management experience in this case.</p><p><strong>Case presentation: </strong>The patient was a baby boy aged 2 days, weighing 2930 g. He was diagnosed with a giant omphalocele with a partial intestine exposed. Two hours after admission, the baby underwent a silo placement. The herniation of the bowel was gradually reduced into the abdominal cavity. At the age of 13 days, the stitches at the bottom of the silo fell off, and the liver was exposed with the defect size about 8 cm x 10 cm. The hole failed to be repaired by surgery. We used VG and CMC-Ag patched on the defect hole. After creating a moist and fresh environment, NPWT was then applied mainly to extract excess fluid and promote granulation. CMC-Ag was performed for 19 days when the wound showed no exudate or infection. NPWT was stopped at the age of 47 days when the granulation tissue was fully formed with the defect size reduced to 4.5 cm x 3.5 cm. After halting the NPWT, the wound was managed with Rh-bFGF and VG. At the age of 2 months, the wound was reduced to 1 cm x 1 cm with satisfactory epithelialization.</p><p><strong>Conclusions: </strong>NPWT is a safe and effective alternative therapy for the repair of giant omphalocele. CMC-Ag can help control wound infection and manage exudate and Rh-bFGF promotes wound healing. NPWT combined with new wound dressings can effectively manage ruptured giant omphalocele.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"44"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of functional constipation and analysis of intestinal microbiota in children aged 0-4 in Zunyi region.","authors":"Shungang Gong, Zhengbo Yu, Yuan Ding, Yue Wang, Xi Li, Shengli Gu","doi":"10.1186/s12887-024-05383-w","DOIUrl":"10.1186/s12887-024-05383-w","url":null,"abstract":"<p><strong>Background: </strong>Functional constipation (FC) significantly impacts children's health. This study investigates the prevalence and microbiota characteristics of FC in children aged 0-4 years in Zunyi area.</p><p><strong>Methods: </strong>From October to December 2023, 2039 children aged 0-4 years in Zunyi were selected using stratified sampling and cross-sectional survey methods. A questionnaire based on Rome IV diagnostic criteria was used. Twenty-nine children with FC were randomly selected as the functional constipation group (FCG), and 26 healthy children, matched for age, sex, and area, were selected as the control group (CG).</p><p><strong>Results: </strong>A total of 2051 questionnaires were collected, with 2039 valid responses. Among them, 151 children had FC, resulting in a prevalence rate of 7.4%. The prevalence rates in boys and girls were 6.6% and 8.5%, respectively, with no significant gender difference (P > 0.05). Alpha diversity analysis revealed higher richness and diversity of intestinal flora in the FCG compared to the CG. At the phylum level, Actinobacteria, Firmicutes, Proteobacteria, and Bacteroidetes were dominant in both groups. The FCG showed a higher relative abundance of Firmicutes, Actinobacteria, and Proteobacteria compared to the CG (P < 0.05).</p><p><strong>Conclusions: </strong>The prevalence of FC in children aged 0-4 years in Zunyi is 7.4%. Disease characteristics vary with age and living environment but are unrelated to gender. The gut microbiota of children with FC shows significant alterations, with higher diversity and specific phyla abundance.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"45"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surviving prematurity: retrospective longitudinal study of multisystem consequences in preterm-born individuals from infancy to adolescence.","authors":"Ruta Morkuniene, Ruta Levuliene, Vilmantas Gegzna, Egle Marija Jakimaviciene, Janina Tutkuviene","doi":"10.1186/s12887-025-05393-2","DOIUrl":"10.1186/s12887-025-05393-2","url":null,"abstract":"<p><strong>Background: </strong>Prematurity is linked to diverse and significant health outcomes, but a comprehensive understanding of its long-term multisystem impacts remains limited.</p><p><strong>Methods: </strong>Retrospective longitudinal cohort study on 417 preterm children born between 2000 and 2015 explores the incidence, dynamics, and interrelationships of health conditions from infancy to adolescence. Data on 1818 diagnoses, categorised by birth weight (BW) and gestational age (GA) and documented according to ICD-10, were analysed using non-parametric tests and negative binomial regression models.</p><p><strong>Results: </strong>Most diagnoses occurred by age 7, with eye diseases, congenital malformations, and infections most prevalent, but the greatest disparities with the general population were in blood, nervous system, mental, and neoplastic diseases. Lower BW significantly correlated with higher mean disease counts and greater diversity of health conditions across various ICD-10 chapters, while GA showed less pronounced associations. Children in \"Extremely and very low,\" \"Low,\" and \"Sub-optimal\" BW categories exhibited 1.77, 1.50, and 1.34 times more diseases, respectively, than those in the \"Normal\" BW category. Unique and highly individual patterns of disease co-occurrence were observed, increasing in complexity as BW decreased.</p><p><strong>Conclusions: </strong>The highest disease burden for preterm-born individuals occurred by age 7, with lower BW linked to greater health complexity and unique comorbidities.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"46"},"PeriodicalIF":2.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and outcomes of neonatal group B streptococcal sepsis in Qatar-a multicentre study.","authors":"Sajid Salim Thyvilayil, Anvar Paraparambil Vellamgot, Khalil Salameh, Sudheer Babu Kurunthattilthazhe, Abdurahiman Elikkottil, Liliana Llerena Dominguez, Dhanya Banarjee","doi":"10.1186/s12887-025-05398-x","DOIUrl":"10.1186/s12887-025-05398-x","url":null,"abstract":"<p><strong>Background: </strong>Group B Streptococcus (GBS) is the most common cause of neonatal early onset sepsis in term infants and a major cause of late onset sepsis in both term and preterm infants.</p><p><strong>Aim: </strong>To estimate the incidence of GBSS among neonates born in Qatar between July 2015 and June 2020 (5 years). A secondary aim was to describe the outcomes of the affected babies.</p><p><strong>Materials and methods: </strong>A retrospective chart review of all neonates born during the study period was performed with the help of medical records departments of the four main maternity hospitals in Qatar, where > 90% of the births occurred.</p><p><strong>Results: </strong>From 123,878 live births, 113 babies grew GBS in blood culture, during the first 90 days. 72 cases of early-onset GBS sepsis (EOGBSS) and 41 cases of late-onset GBS sepsis (LOGBSS) were identified. The estimated incidence of EOGBSS and LOGBSS were 0.58/1000 live births (95% CI 0.46- 0.73) and 0.33/1000 live births (95% CI 0.24- 0.45) respectively. The overall mortality was 7%, and the chart review identified severe neurodisability among at least 11% of survivors.</p><p><strong>Conclusion: </strong>The incidences of EOGBSS and LOGBSS in Qatar are 0.58/1000 live births (LB) and 0.33/1000 LB, respectively. The relatively high incidence of EOGBSS probably reflects the high rate of carrier state among pregnant mothers. We did not observe any significant change in incidence after introducing the universal maternal screening for GBS. The overall mortality was similar to previously published data. Further prospective studies are recommended.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"41"},"PeriodicalIF":2.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of active play interventions on children's fundamental movement skills: a systematic review.","authors":"Xinmiao Zhang, Changhao Tang, Miao Geng, Kai Li, Cong Liu, Yujun Cai","doi":"10.1186/s12887-024-05385-8","DOIUrl":"10.1186/s12887-024-05385-8","url":null,"abstract":"<p><strong>Background: </strong>Many countries worldwide face the problem of underdeveloped fundamental movement skills (FMS) in children. Active play (AP) holds significant potential for enhancing children's FMS based on its free-choice and unstructured nature, as well as its ease of implementation and dissemination. Therefore, the primary objective of this systematic review was to determine the effects of AP interventions on FMS in typically developing children.</p><p><strong>Methods: </strong>A systematic literature search was conducted in six electronic databases, Web of Science, PubMed, Embase, Scopus, China National Knowledge Infrastructure (CNKI), and Wan Fang Data, from database inception to May 30, 2024. The main inclusion criteria for literature screening included the intervention modality being AP, the outcome indicator as FMS, and the intervention being for typically developing children. Information on countries and regions, study types, experimental designs, sample characteristics, measurement methods, and intervention effects of the included literature were extracted for the included literature. To assess the risk of bias in the literature, the RoB2.0 tool was used for RCTs, while the ROBINS-I 2.0 tool was applied to non-RCTs.</p><p><strong>Result: </strong>Of the 3,672 articles retrieved, 9 studies were ultimately included in this review. The risk of bias assessment identified 3 studies as having a low risk of bias and 6 as having a moderate risk. The AP interventions in these 9 studies exhibited varying characteristics, with individual intervention durations ranging from 45 to 60 min, intervention frequencies ranging from once a week to four times per week, and intervention periods spanning from 4 weeks to 6 months. FMS were assessed using the Test of Gross Motor Development-2 (TGMD-2), the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP), the Peabody Development Motor Scales-2 (PDMS-2), and the Movement Assessment Battery for Children (MABC). Regarding the effects of AP interventions on children's FMS, seven studies reported a significant effect, while two others reported no significant effect.</p><p><strong>Conclusion: </strong>Although the results of the included studies are inconsistent, AP interventions generally demonstrate a positive effect on FMS in typically developing children. To better understand the potential of AP in developing FMS in children, high-quality AP interventions and more in-depth studies across diverse populations, settings, and timeframes are needed. Additionally, greater clarity is needed regarding the components of AP interventions and their quantitative relationships with FMS efficacy.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"40"},"PeriodicalIF":2.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quality improvement initiative to improve growth monitoring of children attending immunization clinic in an urban primary health centre in Delhi.","authors":"Ravneet Kaur, Udita Singh, K Srinath, Anjusha Ranjith, Baridalyne Nongkynrih","doi":"10.1186/s12887-024-05373-y","DOIUrl":"10.1186/s12887-024-05373-y","url":null,"abstract":"<p><strong>Background: </strong>Immunization clinics present an opportunity for passive screening for malnutrition among young children through plotting of growth charts. Passive screening for malnutrition can enable timely interventions and improve morbidity and mortality of under-five children. Therefore, we aimed to increase the plotting of growth charts (weight-for-age) to 90%, among under-five children attending immunization clinics in an Urban Health Centre (UHC) in south Delhi over three months.</p><p><strong>Methodology: </strong>A Quality Improvement (QI) initiative was undertaken in the immunization clinic of an urban primary health centre in southern Delhi, from January to March 2024. A multi-faceted QI team was formed. The baseline coverage of weight-for-age growth chart plotting in the immunization clinic was 31%. The process flow was mapped, and critical gaps identified by root cause analysis (Fish Bone technique). Change ideas were discussed and prioritized using a prioritization matrix to implement these through sequential PDSA cycles. The main change ideas implemented were training of health workers, allotting regular supervisors for the session, and appending a stamp for quick identification of underweight children. Run chart was used to assess the changes over time. We considered the outcome achieved if the plotting coverage was more than 90% sustained for at least six consecutive immunization sessions.</p><p><strong>Results: </strong>Multiple change ideas were implemented over a period of three months. The coverage of growth chart plotting increased to more than 90%. Lack of motivation among stakeholders was a challenge for some change ideas. Monitoring of immunization sessions for plotting of growth chart was continued post the implementation of all change ideas to assess sustainability which showed positive results. Post-implementation of the change ideas, a meeting was held with the members of the QI team to get feedback on this activity.</p><p><strong>Conclusion: </strong>There is potential for improving growth monitoring at immunization clinics, which can be beneficial in strengthening passive screening for malnutrition in primary care settings.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"39"},"PeriodicalIF":2.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pediatric COVID-19 isolation on children's well-being and caregiver mental health.","authors":"Song I Yang, Chi-Hyun Choi, Eun Joo Lee, Sun Hee Jee, Mi Seon Han","doi":"10.1186/s12887-025-05399-w","DOIUrl":"10.1186/s12887-025-05399-w","url":null,"abstract":"<p><strong>Background: </strong>The Korean government implemented mandatory hospital isolation in the early phase of the COVID-19 pandemic. This study investigated the mental health of children and caregivers who underwent mandatory hospital isolation due to COVID-19.</p><p><strong>Methods: </strong>This prospective study examined the physical condition and mental health of children under 7 years of age with COVID-19 and the mental health of their caregivers who underwent isolation in negative pressure rooms at two hospitals in Korea from April to September 2021. Caregivers received a self-report questionnaire via text message. Their responses were analyzed to compare the physical condition and mental health of children with COVID-19 and the mental health of their caregivers during and after isolation and identify factors influencing caregivers' mental health.</p><p><strong>Results: </strong>Sixty caregivers participated in the study. More than half of the caregivers perceived their children's disease severity as mild. During hospital isolation, 36.4% of the children experienced decreased oral intake, which improved significantly post-isolation (8.7%, P = 0.014). During isolation, approximately 22.2% of the children frequently awoke from sleep, 20.0% displayed irritability, and 70.8% had symptoms of depression. Approximately 36.7% of caregivers showed at least moderate levels of depression during isolation, which significantly decreased to 14.3% three months after discharge (P = 0.032). Factors associated with caregivers' mental health included child-related issues, such as difficulty concentrating, frequent awakenings, and irritability.</p><p><strong>Conclusion: </strong>Mandatory hospital isolation has a significantly negative psychological impact on children and caregivers during pandemics. Isolation decisions must be carefully considered during pandemics, especially those concerning young children. Heightened vigilance is warranted for the early detection and intervention of mental health issues in children and their caregivers.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"37"},"PeriodicalIF":2.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic multicentric Castleman disease in children: a single-center retrospective analysis.","authors":"Junye Du, Jiafeng Yao, Honghao Ma, Li Li, Ang Wei, Liping Zhang, Dong Wang, Zhigang Li, Rui Zhang, Tianyou Wang","doi":"10.1186/s12887-024-05347-0","DOIUrl":"https://doi.org/10.1186/s12887-024-05347-0","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical features, pathological phenotype, treatment and prognosis of idiopathic multicenter Castleman disease (iMCD)in children.</p><p><strong>Methods: </strong>From January 2017 to September 2023, basic information, laboratory tests, treatment and prognosis of children diagnosed with iMCD who attended Beijing Children's Hospital of Capital Medical University were collected.</p><p><strong>Results: </strong>A total of 9 children were enrolled, with a median age of onset of median 11 (2-15) years, 6 males and 3 female. 3 cases were pathologically typed as plasma cell type, 1 case was mixed type, and the remaining 5 cases were hyaline vascular type. 9 children received different regimens of chemotherapy. The median follow-up time was 26 (13, 58) months, with no deaths, 7/9 cases showing improvement, 1/9 cases showing stable condition, and 1/9 cases showing active condition.</p><p><strong>Conclusion: </strong>Children with multicentric CD often have systemic symptoms, lymph node enlargement and related compression symptoms are the most common manifestations, followed by fever, malaise and other systemic symptoms. Anti-IL-6-based therapy combined with hormones lenalidomide and other medications have a specific therapeutic effect on multicentric CD.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"38"},"PeriodicalIF":2.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}