BMC Pediatrics最新文献

{"title":"Can PIM3 predict mortality adequately for patients admitted to Pediatric Intensive Care Unit in a resource limited setting? A single-center study.","authors":"Desy Rusmawatiningtyas, Renova Astriani Hutapea, Antonius H Pudjiadi, Firdian Makrufardi, Hennie Knoester, J B M van Woensel","doi":"10.1186/s12887-025-06114-5","DOIUrl":"https://doi.org/10.1186/s12887-025-06114-5","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"819"},"PeriodicalIF":2.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Term birth and levothyroxine dosage are significant factors associated with permanent congenital hypothyroidism: experience from a medical center in Taiwan.","authors":"Yu-En Kao, Wei-Hsin Ting, Yann-Jinn Lee, Chi-Yu Huang, Chao-Hsu Lin, Yi-Lei Wu, Lu-Ting Wang, Chin-Hui Tseng, Yi-Hsin Wu","doi":"10.1186/s12887-025-06199-y","DOIUrl":"10.1186/s12887-025-06199-y","url":null,"abstract":"<p><strong>Background: </strong>Before the introduction of newborn screening, congenital hypothyroidism was the leading cause of intellectual disability in infants and children. Patients with permanent congenital hypothyroidism require lifelong levothyroxine supplementation to prevent intellectual disability and growth failure. With progressively lower thyrotropin (TSH) cutoffs in newborn screening programs, more transient congenital hypothyroidism cases-requiring only temporary treatment-have also been identified. To avoid unnecessary medication use and reduce the burden on healthcare systems, early differentiation is essential.</p><p><strong>Methods: </strong>We retrospectively enrolled congenital hypothyroidism patients born between 2004 and 2018 and followed at MacKay Children's Hospital and classified them as permanent congenital hypothyroidism or transient congenital hypothyroidism based on levothyroxine dependence. Basic demographic data, including gender, gestational age, birth weight, newborn screening TSH levels, body height and weight, serum free T4, TSH levels, levothyroxine doses at every clinical visit, and age of TSH normalization were collected and compared between permanent and transient congenital hypothyroidism groups.</p><p><strong>Results: </strong>A total of 152 infants were enrolled in this study, with 73 (48%) classified as permanent congenital hypothyroidism. Term births were more common in permanent than transient congenital hypothyroidism (80% vs. 48%, p < 0.01). TSH normalization took longer in permanent congenital hypothyroidism (75 vs. 45 days, p < 0.01). Serum TSH and levothyroxine doses remained higher in permanent congenital hypothyroidism at 6 months, and at 1, 2, and 3 years. The levothyroxine dose that provided the best discrimination between permanent and transient congenital hypothyroidism was 2.5 𝛍g/kg/d at age 2 years (sensitivity: 73%, specificity: 90%), and 1.8 𝛍g/kg/d at age 3 years (sensitivity: 82%, specificity: 91%).</p><p><strong>Conclusions: </strong>Nearly half of the patients required lifelong levothyroxine supplements under the current newborn screening program. Permanent congenital hypothyroidism patients were more likely term-born, showed delayed TSH normalization, had higher TSH levels, and required higher levothyroxine doses during follow-up. The best cut-off level to discriminate permanent from transient congenital hypothyroidism was 2.5 and 1.8 µg/kg/day at the age of 2 and 3 years, respectively.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"814"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic spine injuries in paediatric and adolescent patients: a registry-based study of ICU needs and clinical outcomes.","authors":"Rayan Jafnan Alharbi, Sharfuddin Chowdhury, Hussin Albargi, Ateeq Almuwallad, Naif Harthi, Yahya H Khormi, Mohamed M Aly, Suliman Alghnam","doi":"10.1186/s12887-025-06102-9","DOIUrl":"10.1186/s12887-025-06102-9","url":null,"abstract":"<p><strong>Background: </strong>Traumatic spine injuries (TSIs) in paediatric and adolescent populations are uncommon but often result in serious morbidity and healthcare burden. In Saudi Arabia, limited population-based data exist to describe the epidemiology and outcomes of TSIs in this group.</p><p><strong>Methods: </strong>This retrospective cohort study included patients aged 1-18 years with TSIs admitted to King Saud Medical City in Riyadh between August 1, 2017, and December 31, 2022. Data were extracted from the Saudi TraumA Registry (STAR). Patients were categorised into three groups: pre-school (1-6 years), school-age (7-12 years), and adolescents (13-18 years). Demographic, injury, and outcome variables were analysed using descriptive and comparative statistics.</p><p><strong>Results: </strong>A total of 353 patients were included, with males comprising 84.7%. Motor vehicle crashes (MVCs) were the leading cause of injury (69.3%). Overall, thoracic spine injuries were most common (43.8%), while high cervical injuries predominated in pre-school children (40.8%). Polytrauma occurred in 72.5% of cases, and a third of the patients required ICU admission. Among those admitted to ICU or who died, head injuries were the most frequent associated injury. Common procedures included spinal internal fixation (25%), craniotomy/craniectomy (20%), and lower-limb fixation (19.5%). Mechanical ventilation was required in 23.8% of patients, and in-hospital mortality was 3.4%. Mortality was associated with higher Injury Severity Scores, lower Glasgow Coma Scale, and increased need for trauma team activation, blood transfusion, and respiratory support.</p><p><strong>Conclusion: </strong>This study highlights the burden of TSIs among children and adolescents in Saudi Arabia, particularly those caused by MVCs and frequently associated with polytrauma. The findings highlight the pressing need for targeted prevention strategies, improved trauma system infrastructure, and multidisciplinary management. Future research should investigate long-term outcomes and evaluate the effectiveness of preventive initiatives.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"815"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute severe hypernatremia complicated by osmotic demyelination syndrome in a 13-day-old infant.","authors":"Mélanie Bonet, Nail Benallegue, Patrick Desbordes De Cepoy, François Buisson, Marie Moreau","doi":"10.1186/s12887-025-06179-2","DOIUrl":"10.1186/s12887-025-06179-2","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"813"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the diagnostic value of the pediatric critical care observation tool (P-CPOT) among children hospitalized in the pediatric intensive care unit in 2021- a comparative study.","authors":"Mohammad Salehpoor-Emran, Mojgan Panjo, Roghieh Nazari","doi":"10.1186/s12887-025-06231-1","DOIUrl":"10.1186/s12887-025-06231-1","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"817"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of glucocorticoids in recurrent idiopathic intussusception: a retrospective cohort study.","authors":"Jiyin Zhang, Tingting Liu, Dayong Wang, Xianling Li, Li Wang, Shuanling Li, Liuming Huang, Qiulong Shen","doi":"10.1186/s12887-025-06125-2","DOIUrl":"10.1186/s12887-025-06125-2","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the efficacy of glucocorticoids in reducing short-term recurrence rate of idiopathic intussusception in pediatric patients.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on children with recurrent idiopathic intussusception treated at the Emergency Center of Beijing Children's Hospital from January 2015 to January 2024. Patients who experienced three episodes of intussusception within 5 days were included. After successful fluoroscopy-guided air enema (FGAE), some children received glucocorticoids (intervention group), while others did not (control group). Recurrence rates within 14 days were compared between the groups. Lastly, delayed complications and adverse effects related to glucocorticoid use were recorded.</p><p><strong>Results: </strong>A total of 10,493 FGAE sessions were performed, with 206 patients initially enrolled. Ultimately, 183 patients (124 boys, 59 girls; aged 9 months to 9 years) were included. The recurrence rate was significantly lower in the intervention group compared to the control group (18.6% vs. 46.6%, P = 0.001). Finally, no delayed complications or adverse effects related to glucocorticoid therapy were observed.</p><p><strong>Conclusions: </strong>Glucocorticoids effectively reduced recurrence rate in children with short-term recurrent idiopathic intussusception without eliciting significant adverse effects.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"816"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between screen time and anxiety/depression symptoms in preschool children with autism spectrum disorder: the mediating role of cortical volume.","authors":"Ren Chen, Miao-Shui Bai, Tong Zhao, Yang Xue, Zakaria Ahmed Mohamed, Fei-Yong Jia","doi":"10.1186/s12887-025-06203-5","DOIUrl":"10.1186/s12887-025-06203-5","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"818"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonoperative treatment of neonatal appendicitis.","authors":"Yakun Liu, Shuai Chen, Yang Li, Lulu Chen, Shungen Huang","doi":"10.1186/s12887-025-06201-7","DOIUrl":"10.1186/s12887-025-06201-7","url":null,"abstract":"<p><strong>Background: </strong>Neonatal appendicitis (NA) is a rare but potentially fatal condition with diagnostic challenges and limited management evidence. This study evaluates the efficacy of nonoperative treatment compared to surgical intervention.</p><p><strong>Methods: </strong>A retrospective study included infants ≤ 28 days with clinically and sonographically confirmed NA treated at four institutions between January 2010 and May 2022. The nonoperative group received antibiotics and supportive care, compared to a control group of 34 surgically treated neonates. The primary outcome was nonoperative treatment failure (death or delayed appendectomy), while secondary outcomes included severe infectious complications, hospital stay, costs, and readmission.</p><p><strong>Results: </strong>Twenty-eight neonates (median age 11 days; 35.7% female) received nonoperative therapy. The failure rate was 25%, with 3 deaths (10.7%) and 5 delayed appendectomies (17.9%). Severe infectious complications occurred in 28.6% of cases, higher than the surgical group, but not statistically significant (P = 0.10). Hospital costs were significantly lower for the nonoperative group (P < 0.05). No recurrence was observed over 6.2 years of follow-up.</p><p><strong>Conclusions: </strong>Nonoperative treatment of NA was associated with a high failure rate, mortality, and complication rate, despite lower costs. Given limited power for several comparisons, our findings suggest early surgical intervention may be preferable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"812"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12522754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rate and time of recovery and its predictors among children aged 6-59 months admitted to inpatient therapeutic feeding centers for the treatment of severe acute malnutrition in Sana'a, Yemen: a prospective cohort study.","authors":"Mohammed Abdullah Al Amad, Salwa Yahya Al-Eryani, Khaled Algendari, Yahia Ahmed Raja'a","doi":"10.1186/s12887-025-06166-7","DOIUrl":"10.1186/s12887-025-06166-7","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"811"},"PeriodicalIF":2.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical impact of Vitamin A Deficiency (VAD) in critically ill children with sepsis.","authors":"Amany Mohammed El-Rebigi, Ahmed Shaheen Dabour, Sara Hosny El-Farargy, Amr Ahmed Aly Ibrahim, Ola Samir El-Shimi, Rasha Mohammed Zakaria","doi":"10.1186/s12887-025-06143-0","DOIUrl":"10.1186/s12887-025-06143-0","url":null,"abstract":"<p><strong>Background: </strong>Data on vitamin A deficiency (VAD) among critically ill pediatric patients with sepsis and its impact remain limited. This study aimed to determine the prevalence of VAD in septic children and evaluate its association with clinical outcomes.</p><p><strong>Methods: </strong>This prospective cohort included 180 children with sepsis admitted to the Pediatric Intensive Care Unit (PICU) of Benha University Hospital, and 40 healthy controls. Using ELISA, serum vitamin A (VA) levels were measured upon admission. Clinical parameters, including the Pediatric Risk of Mortality (PRISM) scores, sepsis progression, ventilation duration, PICU stay, and mortality were assessed. Multivariate regression evaluated the relationship between VAD and sepsis severity.</p><p><strong>Results: </strong>VAD was significantly more prevalent among septic patients than controls (61.7% vs. 20%, P < 0.001). ROC analysis identified serum VA ≤ 21.4 µg/dl as a significant predictor of sepsis (AUC = 0.699, P < 0.001). While VAD was more frequent in non-survivors (71.4%), the association with mortality was not statistically significant. VAD was linked to higher PRISM scores, longer PICU stays, and greater sepsis severity.</p><p><strong>Conclusion: </strong>Our cohort found that VAD is more prevalent in pediatric sepsis patients compared to controls and correlated with higher PRISM scores, sepsis severity and prolonged stays in PICUs. Nevertheless, VAD did not demonstrate a statistically significant association with 28-days mortality. These findings highlight the necessity for additional large-scale research to determine if routine screening of VAD and potential supplementation could improve outcomes in these patients.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"810"},"PeriodicalIF":2.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}