BMC Pediatrics最新文献

{"title":"Global, regional, and National burden of childhood leukemia from 1990 to 2021.","authors":"Wenyuan Liu, Jing Fang, Meiping Zhu, Jing Zhou, Chen Yuan","doi":"10.1186/s12887-025-05847-7","DOIUrl":"https://doi.org/10.1186/s12887-025-05847-7","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"571"},"PeriodicalIF":2.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extremely rare case report of CEBALID syndrome presenting as congenital arthrogryposis.","authors":"Fatima A Dirani, Ghina Kahil, Rida Jaber, Zahraa Slim, Rabab El Hajj, Imad Chokr","doi":"10.1186/s12887-025-05949-2","DOIUrl":"https://doi.org/10.1186/s12887-025-05949-2","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"572"},"PeriodicalIF":2.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-midterm outcomes of preoperative extrauterine growth restriction in premature infants with critical congenital heart disease after surgery.","authors":"Yuan Li, Zhi-Ye Yao, Liang Chen, Jin Zhong, Man-Li Zheng, Xi-Meng Wang, Yan-Ling Chen, Xin Sun, Yu-Mei Liu, Shao-Ru He","doi":"10.1186/s12887-025-05892-2","DOIUrl":"https://doi.org/10.1186/s12887-025-05892-2","url":null,"abstract":"<p><strong>Objective: </strong>To assess the factors associated with early occurrence of extrauterine growth restriction (EUGR) in preterm infants with critical congenital heart disease (CCHD) and their short-midterm outcomes.</p><p><strong>Methods: </strong>This was a single-center retrospective study including a cohort of all premature infants (< 37weeks) undergoing surgery for CCHD at Guangdong Provincial People's Hospital from 2011 to 2022. According to the diagnostic and exclusion criteria, the subjects were divided into malnourished and un-malnourished groups. The clinical characteristics and nutrition outcomes of patients were collected and compared.</p><p><strong>Results: </strong>Among the entire cohort of 118 preterm neonates with critical congenital heart disease (CCHD), 46 (39.0%) were malnourished before the operation, and 72 (61.0%) were non-malnourished. The BWZ (birth weight Z-score) [OR = 0.041, (0.012, 0.143), P < 0.001] of preoperative extrauterine growth restriction (EUGR) was lower. In addition, the preoperational non-EUGR group had earlier operation age [OR = 1.076, (1.032, 1.122), P = 0.001] and less liquid volume [OR = 1.032, (1.000, 1.066), P = 0.050]. After surgery, the preoperative EUGR group fasted [(5.28 ± 0.933) vs. (3.92 ± 0.411) days, P = 0.021] and hospitalized [(43.10 ± 3.683) vs. (31.89 ± 2.301) days, P = 0.007] for a longer time. The WAZ (weight of age Z-score) of the preoperative EUGR group was lower at discharge [(-3.84 ± 0.166) vs. (-1.75 ± 0.138), P < 0.001] and more of them were still malnourished [13(38.2%) vs. 4(5.6%), P = 0.006] till 2-year follow-up. We found 14.41% mortality total, of which 11.86% was in hospital.</p><p><strong>Conclusion: </strong>Preoperative low weight-for-age, influenced by both congenital (e.g., SGA) and postnatal factors, predicts prolonged recovery and persistent growth deficits in preterm infants with CCHD. Comprehensive nutritional strategies must address both intrauterine and extrauterine contributors to growth failure.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"570"},"PeriodicalIF":2.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Incision paediatric laparoscopy-Assisted for the treatment of postnecrotizing enterocolitis colonic strictures: a single-centre retrospective study.","authors":"Aohua Song, Xunfeng Li, Xiao Xiang, Wei Feng, Zhenhua Guo","doi":"10.1186/s12887-025-05911-2","DOIUrl":"10.1186/s12887-025-05911-2","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"568"},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the combined impact of pesticide exposure and HIV/ART on child neurodevelopment in Eastern and Southern Africa: a systematic review.","authors":"Peter Martin Chilipweli, Msilikale Walter Manyiri, Namanya Basinda, Benson R Kidenya, Elias C Nyanza, Karim Manji, Aiwerasia Vera Ngowi","doi":"10.1186/s12887-025-05895-z","DOIUrl":"10.1186/s12887-025-05895-z","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"567"},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of TEACCH on social functioning in individuals with autism spectrum disorders: a systematic review and meta-analysis.","authors":"Shanshan Shi, Shuang Song, Huitong Wang, Pengfei Li, Xiaoying Zhang","doi":"10.1186/s12887-025-05921-0","DOIUrl":"10.1186/s12887-025-05921-0","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) on social functioning in individuals with autism spectrum disorders (ASD).</p><p><strong>Methods: </strong>Relevant studies on TEACCH intervention in ASD individuals were systematically searched in PubMed, The Cochrane Library, Embase, CNKI, and Wanfang from inception to March 2024. The main outcome measures were social, cognitive performance, fine motor, communication, daily living, imitation, and cognitive verbal skills. Data were meta-analyzed using R studio (4.1.2).</p><p><strong>Results: </strong>Eleven studies involving 701 ASD individuals were included in this study. The TEACCH group had significantly higher socialization score [MD = 0.6, 95% CI(0.2, 1.0)], Cognitive Performance Scale score [MD = 1.34, 95% CI(0.09, 2.58)], and fine motor score [MD = 0.7, 95% CI(0.4, 1.0)] but significantly lower Autism Behavior Checklist score [MD = -1.57, 95% CI(-2.11, -1.02)], Childhood Autism Rating Scale score [MD= -0.7, 95%CI(-1.0, -0.3)], and Autism Treatment Evaluation Checklist score [MD= -0.7, 95% CI(-1.0, -0.3)] compared to the control group. There were no significant differences in other outcome measures.</p><p><strong>Conclusion: </strong>TEACCH is a promising intervention for improving the social skills, cognitive performance, and fine motor functions of ASD individuals. However, further studies are warranted to confirm the effectiveness of TEACCH on ASD core symptoms.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"569"},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of 20 cases of brain injury caused by diabetic ketoacidosis in children.","authors":"Bin Zhou, Weiwei Chen, Shengxin Zhang, Yukun Huang, Chunzhi Chen, Yali Cai","doi":"10.1186/s12887-025-05927-8","DOIUrl":"https://doi.org/10.1186/s12887-025-05927-8","url":null,"abstract":"<p><strong>Objective: </strong>To analyse clinical features and identify risk factors for brain injury in paediatric diabetic ketoacidosis (DKA), aiming to support early recognition and intervention.</p><p><strong>Methods: </strong>A retrospective study was conducted on 20 children with DKA-related brain injury and 14 children with DKA without brain injury admitted to Xiamen Children's Hospital between January 2022 and April 2024. Clinical data, laboratory findings, electroencephalography and magnetic resonance imaging (MRI) results were reviewed. Logistic regression analyses were used to identify influencing factors.</p><p><strong>Results: </strong>Among the 20 children with DKA-related brain injury, 75% were girls, the median age was 7.3 years and 70% had severe DKA. Impaired consciousness was the primary symptom, presenting as lethargy (75%), dizziness (10%), somnolence (10%) and delirium (5%). Electroencephalography abnormalities were observed in 8 cases, and MRI changes were noted in 3 cases. Multivariate analysis identified a longer time to blood glucose stabilisation (odds ratio [OR] = 1.047, 95% confidence interval [CI]: 1.014-1.080, P = 0.005) and elevated insulin levels (OR = 1.217, 95% CI: 1.048-1.413, P = 0.010) as independent risk factors. Higher pH (OR = 0.002, P = 0.003), partial pressure of carbon dioxide (OR = 0.790, P = 0.007), serum bicarbonate (OR = 0.836, P = 0.010) and base excess (OR = 0.665, P = 0.015) were found to be protective.</p><p><strong>Conclusions: </strong>Brain injury in paediatric DKA is associated with delayed metabolic correction. Early monitoring and timely regulation of acid-base balance and glucose levels may reduce the risk and improve outcomes.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"566"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare resource utilization and caregiver burden associated with rotavirus gastroenteritis hospitalizations in Taiwan.","authors":"Yhu-Chering Huang, Chih-Hsien Chuang, Chia-Jung Hsieh, Chiu-Mei Hsieh, Ying Hui Wu, Questa Lin, Joanne Lin, Fei Qin, Janine Verstraete, Michael Herdman, Cristina Carias","doi":"10.1186/s12887-025-05711-8","DOIUrl":"10.1186/s12887-025-05711-8","url":null,"abstract":"<p><strong>Background: </strong>Rotavirus infection is a leading cause of acute gastroenteritis in children aged < 5 years. However, few studies assessed the spillover effect on caregivers' health-related quality of life (HRQoL) and out-of-pocket costs associated with rotavirus gastroenteritis (RGE) in Taiwan.</p><p><strong>Methods: </strong>This is a prospective, observational, survey-based study conducted in Northern Taiwan between March 2021-September 2023. Caregivers were interviewed during the RGE-hospitalization episode and after patient discharge. One caregiver per child aged ≤ 9 years with clinical presentation of a new RGE hospitalization was enrolled. Outcomes assessed included caregiver HRQoL, emotional state, impact on daily routine, healthcare resource utilization (HCRU), and direct and indirect costs.</p><p><strong>Results: </strong>The mean age of inpatients was 3.03 years and 69.0% were male. Rotavirus genotype G3P[8] was detected in 61.2% of patients. Caregivers' mean age was 33.7 years, 79.3% were female, and 65.5% had monthly household income < NT$80,000. Caregivers reported significantly higher health state (EQ visual analog scale) after discharge (86.21) than during RGE hospitalization (74.48) (p = 0.049). Among the caregivers, 65.5% and 69.0% experienced disruptions in sleep and leisure activities, respectively. About 45% were worried about complications and 41.4% were concerned about their child's recovery. The total medical costs associated with hospitalization, reimbursed by National Health Insurance, averaged US$575.56. Additional out-of-pocket costs included US$82.51 for medical visits, US$44.95 for transportation, US$5.47 for medication, and US$90.41 for meals outside the home. The caregivers also reported taking an average of 0.12, 1.18, and 1.82 days of child/parental, paid, and unpaid leave, respectively. The estimated wage loss associated with the days not working was US$246.67.</p><p><strong>Conclusion: </strong>RGE poses a significant burden on caregivers' HRQoL, daily activities, and out-of-pocket costs. Interventions aimed at mitigating the spillover effects of RGE on caregivers are essential to improve family well-being.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"565"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic features of axial torsion of Meckel's diverticulum in 12 pediatric patients: a retrospective analysis and literature review.","authors":"Yanxiu Hu, Liqun Jia, Yu Wang, Yue Xin, Xiaoman Wang","doi":"10.1186/s12887-025-05826-y","DOIUrl":"https://doi.org/10.1186/s12887-025-05826-y","url":null,"abstract":"<p><strong>Background: </strong>As described in isolated case reports, axial torsion is an extremely rare complication of Meckel's diverticulum (MD). Diagnosis based on preoperative imaging alone is challenging for clinicians.</p><p><strong>Objective: </strong>The aim of this study was to investigate the clinical and sonographic characteristics of axial torsion of MD in Chinese pediatric patients treated at a single center and to review the published literature on this condition.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of pediatric patients (< 18 years) who underwent surgical treatment for MD torsion between November 2008 and January 2023 at our institution, focusing on clinical presentation and ultrasound findings. In addition, a systematic review of English-language articles in PubMed (1989-2023) was performed to summarize reported cases of MD torsion in pediatric populations.</p><p><strong>Results: </strong>Twelve patients (10 males, 2 females; male-to-female ratio 5:1; median age 4 years, range 2-15) were included. The predominant symptoms were abdominal pain (91.7%) and vomiting (75.0%). Preoperative ultrasound revealed key findings: a cystic mass with digestive wall structure (83.3%), the 'whirlpool' sign (58.3%), and small bowel obstruction (75.0%). There were nine cases of MD gangrene, but no cases of intestinal necrosis. The diagnostic accuracy of preoperative ultrasound was 75.0% for MD and 41.7% for axial torsion of MD. A review of 18 pediatric cases from the English literature showed that our ultrasound detection rates exceeded those of previous reports-83.3% vs. 27.3% for cystic masses and 58.3% vs. 18.2% for the 'whirlpool' sign.</p><p><strong>Conclusion: </strong>The characteristic sonographic features of MD torsion include a cystic mass with digestive tract wall structure, the 'whirlpool' sign, and bowel obstruction. Early recognition of these features may expedite preoperative diagnosis, enable timely surgical intervention and improve clinical outcomes. While experienced sonographers utilizing multi-frequency probes can enhance detection accuracy, preoperative ultrasound diagnosis of this condition remains challenging.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"564"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different modalities of combat sports on the motor skills of children and adolescents.","authors":"Bruna Thamyres Ciccotti Saraiva, William Rodrigues Tebar, Amanda Barbosa Dos Santos, Ewerton Pegorelli Antunes, Stefany Carolaine Bezerra Silva, Débora Toshimi Furuta, Gerson Ferrari, Leandro Dragueta Delfino, Diego Giulliano Destro Christofaro","doi":"10.1186/s12887-025-05814-2","DOIUrl":"10.1186/s12887-025-05814-2","url":null,"abstract":"<p><strong>Purpose: </strong>Motor skills are essential for carrying out daily tasks and the practice of physical activities can help to increase these skills. Being combat sports, it can be an alternative practice with this objective. However, it is not known which is the ideal modality. Therefore, the aim was to analyze the effects of nine months of practicing Muay Thai (MT) and Judo on the motor skills of children and adolescents.</p><p><strong>Methods: </strong>A sample of 109 young people from a Philanthropic Institution was distributed into: control (n = 36), Judo (n = 29) and MT (n = 44). The following motor skills tests were carried out: balance on the beam, side jumps, single-leg jump and transfer onto the platform. The intervention lasted nine months, twice a week for one hour.</p><p><strong>Results: </strong>After nine months, the Judo and Muay Thai groups showed increased values ​​in lateral jumps (Judo p-value < 0.001; Muay Thai p-value < 0.001), and transfer platform (Judo p-value = 0.007; Muay Thai p-value < 0.001) from the pre-moment compared to the post-moment. In the single-leg jump, the Judo (p-value = 0.011) and MT (p-value < 0.001) groups were different compared to the control group.</p><p><strong>Conclusion: </strong>The practice of combat sports was effective in causing improvements in the motor skills of young.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"562"},"PeriodicalIF":2.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}