BMC Pediatrics最新文献

{"title":"Comparison of the epidemiological characteristics of mycoplasma pneumoniae infections among children during two epidemics in Wuhan from 2018 to 2024.","authors":"Jieyu Mao, Zhili Niu, Mengling Liu, Liangyu Li, Haiyue Zhang, Ruiyun Li, Pingan Zhang, Xiaojun Wu","doi":"10.1186/s12887-025-05435-9","DOIUrl":"https://doi.org/10.1186/s12887-025-05435-9","url":null,"abstract":"<p><strong>Background: </strong>Mycoplasma pneumoniae (M pneumoniae, MP) is a common pathogen causing respiratory tract infections, particularly in children. In 2023, a resurgence of MP epidemics was observed in Wuhan, Hubei Province, China. This study aims to examine the epidemiological trends and clinical characteristics of MP infections among children in Wuhan from 2018 to 2024, providing valuable scientific evidence to guide local prevention strategies.</p><p><strong>Methods: </strong>From January 1, 2018, to June 30, 2024, samples were collected from children under 14 years with Acute Respiratory Tract Infections (ARTI) at Renmin Hospital of Wuhan University. MP infections were diagnosed through MP-IgM antibody detection and MP-DNA detection. Results were analyzed and compared across distinct epidemic periods.</p><p><strong>Results: </strong>Of the 183 626 ARTI children, 57 393 (31.26%) tested positive for MP, with an average age of 4.87 ± 2.99 years and a male-to-female ratio of 1.12:1. The annual positive rates from 2018 to 2024 were 45.92%, 32.23%, 22.84%, 16.22%, 16.26%, and 42.93%, respectively. Across the study period, the highest positive rate was recored in autumn (35.13%, P < 0.05). Two distinct MP outbreaks were identified, in 2018-2019 and 2023. Significant differences were observed between the two outbreaks. The 2018-2019 epidemic peaked in summer, while the 2023 epidemic peaked in November and persisted into February 2024. By age, the 2018-2019 outbreaks predominantly affected pre-school children, whereas the 2023 outbreaks mainly involved school-aged children. In boths outbreaks, girls had higher positive rates. Antibody and DNA testing results followed similar trends.</p><p><strong>Conclusion: </strong>This study highlights the epidemiological trends and clinical characteristics of MP infections in Wuhan from 2018 to 2024, including two distinct outbreaks with differing seasonal patterns. The MP strain in 2023 appeared to predominantly affect older children.The trends observed suggest that MP infections may persist into the winter of 2024. Enhanced surveillance of respiratory pathogens and early diagnosis and prevention of MP infections in children remain critical in this region.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"71"},"PeriodicalIF":2.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White noise's effect on premature infants' physiological parameters during peripheral intravenous catheter insertion.","authors":"Omolbani Rahimi, FatemehSadat SeyedNematollah Roshan, Leila Nikrouz","doi":"10.1186/s12887-025-05431-z","DOIUrl":"https://doi.org/10.1186/s12887-025-05431-z","url":null,"abstract":"<p><strong>Background: </strong>Early and continuous exposure to painful stimuli in premature infants leads to short-and long-term complications. Listening to white noise is an accessible and inexpensive non-invasive method that can be used as a safe nursing intervention in hospitals. This study aimed to assess white noise's effect on premature Infants' physiological parameters during peripheral intravenous catheter insertion.</p><p><strong>Methods: </strong>The present experimental study was conducted on 40 premature Infants. From 5 min before Indwelling catheters to 10 min after, white noise was played through headphones to infants at a controlled volume in the test group. Using a monitor, physiological parameters were recorded from 10 min before to 30 min after the Indwelling catheter. Statistical analysis was done through the SPSS version 27 software program.</p><p><strong>Results: </strong>Regarding respiratory rate, there was no statistically significant difference between the two groups in the first, second, and sixth stages (p < 0.05). However, in the third, fourth, and fifth stages, RR in the control group was significantly higher than the test group (p ≤ 0.05). In terms of mean arterial blood pressure, there was no statistically significant difference between the two groups in any of the stages (p < 0.05). In terms of heart rate, there was no statistically significant difference between the two groups in the first, second, and sixth stages (p < 0.05). However, in the third, fourth, and fifth stages, HR in the control group was significantly higher than the test group (p ≤ 0.05). Regarding oxygen saturation percentage, there was no statistically significant difference between the two groups in the first, second, third, and sixth stages (p < 0.05). In contrast, in the fourth and fifth stages, the oxygen saturation percentage in the test group was significantly higher than in the control group (p < 0.05).</p><p><strong>Conclusions: </strong>Although in both groups the painful procedure led to an increase in physiological variables (respiratory rate, heart rate, mean arterial blood pressure) and a decrease in blood oxygen saturation, in the test group these variables approached their initial state more quickly within half an hour after exposure to white noise. This confirms that the effect of white noise on the improvement of physiological variables is gradual.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"69"},"PeriodicalIF":2.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the clinical spectrum of 19p13.3 microduplication syndrome: a case report highlighting nephrotic syndrome and literature review.","authors":"Wenjie Sun, Hong Yan, Mengxin Sun, Jie Wang, Kunxia Li","doi":"10.1186/s12887-025-05394-1","DOIUrl":"https://doi.org/10.1186/s12887-025-05394-1","url":null,"abstract":"<p><strong>Background: </strong>Common clinical findings in patients with 19p13.3 duplication include intrauterine growth restriction, intellectual disability, developmental delay, microcephaly, and distinctive facial features. In this study, we report the case of a patient with 19p13.3 microduplication and novel clinical findings, specifically nephrotic syndrome.</p><p><strong>Case presentations: </strong>A 4-year-old girl was admitted to our hospital in December 2020 with a fever and cough that had persisted for 3 days. A series of treatments, chromosomal microarray analysis (CMA) and whole exome sequencing (WES) were performed. Relevant literature was reviewed using the search terms \"19p13.3\" and \"19p13.3 microduplication syndrome\" in the China Knowledge Network, Wanfang Database, Weipu Journal Service Platform, and PubMed (date range: database establishment to September 2023). In addition to common symptoms, such as developmental delay, microcephaly, distinctive facial features, and congenital heart defects, the patient also had nephrotic syndrome, a previously unreported phenomenon. CMA results showed a 3.6 Mb fragment duplication (copy number: 3) in the chr19p13.3 region, containing 127 protein-coding genes (including CELF5, NFIC, SMIM24, PIAS4, ATCAY, MAP2K2, and ZBTB7A). WES revealed a filamin C mutation (p.Glu309Valfs × 11). The mutation status of the patient and her father was heterozygous, whereas the mutation was not detected in the mother.</p><p><strong>Conclusion: </strong>Microduplication in the 19p13.3 region could be one of the genetic factors contributing to the observed clinical phenotypes. However, patients with developmental delay, microcephaly, distinctive facial features, congenital heart defects, and urogenital system disorders may exhibit these manifestations due to various genetic syndromes; therefore, simply considering the possibility of 19p13.3 microduplication syndrome based on these non-specific features is not sufficient. Further comprehensive evaluations, including CMA, should be conducted in conjunction with other genetic tests and detailed clinical examinations to accurately determine the underlying genetic causes.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"70"},"PeriodicalIF":2.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of LPCAT1-rs8352 genetic variant with susceptibility and severity of pediatric bronchial asthma: a case-control study.","authors":"Khalid M Mohany, Yasser Gamal, Yaser F Abdel Raheem","doi":"10.1186/s12887-025-05425-x","DOIUrl":"https://doi.org/10.1186/s12887-025-05425-x","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the possible association of LPCAT1-rs8352 genetic variant (single nucleotide change C to G) with the onset and severity of pediatric asthma. Additionally, the study examined the influence of LPCAT1-rs8352 genotypes on asthma-related biomarkers including blood eosinophils count (BEC), eosinophil cationic protein (ECP), high-sensitivity C-reactive protein (hs-CRP), and immunoglobulin E (IgE) and on lung function [forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC)].</p><p><strong>Patients and methods: </strong>The study included ninety-six participant grouped into two groups: G1 (46 asthmatics) and G2 (50 healthy controls). ECP, hs-CRP, and total IgE serum levels were measured using their corresponding ELISA kits. Neonatal blood DNA was extracted using the Gene JET™ Whole Blood Genomic DNA Purification Mini Kit. Genotyping was performed by RT-PCR.</p><p><strong>Results: </strong>A significantly higher proportion of individuals in G1 had the LPCAT1-rs8352 CC and GC genotypes compared to G2 (p < 0.001). Individuals with the CC genotype exhibited significantly more severe asthma, along with elevated levels of BEC, ECP, hs-CRP, and total IgE. Those with the GC genotype demonstrated a similar, though less severe, pattern, followed by individuals with the GG genotype. The FEV1 and FVC values showed the opposite trend, with individuals having the GG genotype exhibiting the highest lung function values.</p><p><strong>Conclusion: </strong>The LPCAT1-rs8352 allele C is associated with pediatric asthma onset and severity. Further research on the LPCAT1 genetic variants may provide a deeper understanding of pediatric bronchial asthma mechanisms and lead to improved management strategies.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"68"},"PeriodicalIF":2.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis.","authors":"Fatma Atia, Hafez Bazaraa, Yara Abdelatty, Sarah Lotfy, Eman Eryan","doi":"10.1186/s12887-025-05386-1","DOIUrl":"https://doi.org/10.1186/s12887-025-05386-1","url":null,"abstract":"<p><strong>Background: </strong>Anemia is prevalent among pediatric patients diagnosed with end-stage kidney disease (ESKD). In addition, erythropoiesis-stimulating agents (ESA) and iron supplementation are considered the cornerstones in the management of anemia. However, a significant proportion of patients remain anemic. Vitamin B6 plays a vital role in the biosynthesis of heme and may be deficient in children with chronic kidney disease (CKD), particularly those on regular hemodialysis (HD). We aimed to evaluate serum vitamin B6 concentration in those children and determine its correlation with anemia indices.</p><p><strong>Methods: </strong>The current cross-sectional study included 39 children on regular HD and 43 healthy controls. Clinical data were collected, including anthropometric measurements, blood pressure, iron, and erythropoietin therapy. Laboratory investigations included hemoglobin (Hb) indices, iron profile, and vitamin B6 level.</p><p><strong>Results: </strong>The median Hb level in our cohort was 10.5 g/dL, and nine patients had Hb levels at or above the target Hb of 11 g/dl. They had a median Serum Vitamin B6 concentration of 28.2 ng/ml (IQR = 22.8-52.9) compared to a median of 27.5 ng/ml(IQR = 20-34) in controls, with no substantial differences between both groups. There was no statistically significant correlation between vitamin B6 and Hb levels or erythropoietin dose.</p><p><strong>Conclusion: </strong>It is evident that the majority of our patients did not meet the desired threshold for anemia control. However, it is noteworthy that the average hemoglobin (Hb) level approached the intended target. The incidence of Vitamin B6 deficiency was not found to be statistically significant within our study population. Therefore, we could not establish a correlation between vitamin B6 deficiency and anemia in children on HD.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"64"},"PeriodicalIF":2.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for visual-acoustic intervention with service delivery in-person and via telepractice (VISIT) non-inferiority trial for residual speech sound disorder.","authors":"Tara McAllister, Jonathan L Preston, Elaine R Hitchcock, Nina R Benway, Jennifer Hill","doi":"10.1186/s12887-024-05364-z","DOIUrl":"https://doi.org/10.1186/s12887-024-05364-z","url":null,"abstract":"<p><strong>Background: </strong>Residual speech sound disorder (RSSD) is a high-prevalence condition that negatively impacts social and academic participation. Telepractice service delivery has the potential to expand access to technology-enhanced intervention methods that can help remediate RSSD, but it is not known whether remote service delivery is associated with a reduction in the efficacy of these methods. This project will systematically measure the outcomes of visual-acoustic biofeedback intervention when delivered in-person or online.</p><p><strong>Methods/design: </strong>This project, Visual-acoustic Intervention with Service delivery In-person and via Telepractice (VISIT), aims to treat 76 children in a parallel randomized controlled clinical trial in which children with RSSD will receive visual-acoustic biofeedback treatment either in person or via telepractice. Eligible children will be speakers of American English aged 9-17 years who exhibit RSSD affecting /ɹ/ but otherwise show cognitive-linguistic and hearing abilities within the typical range. All participants will receive twenty sessions of visual-acoustic biofeedback; they will be randomized, with stratification by pre-treatment speech production ability and site, to complete their treatment sessions either in the laboratory setting or at home via telepractice. For the primary outcome measure, blinded listeners will evaluate changes in the perceived accuracy of /ɹ/ production after the end of treatment.</p><p><strong>Discussion: </strong>By comparing outcomes in children randomized to receive a standard course of biofeedback treatment either via telepractice or in-person, this study will provide evidence-based guidance for clinicians seeking flexible service delivery options for a challenging and prevalent condition.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier NCT06517225, 07/23/2024. URL: https://clinicaltrials.gov/study/NCT06517225 .</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"65"},"PeriodicalIF":2.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2.","authors":"Liuzhao Zhang, Quanwang Chu, Shuyue Jiang, Bo Shao","doi":"10.1186/s12887-025-05424-y","DOIUrl":"https://doi.org/10.1186/s12887-025-05424-y","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the genetic characteristics of pediatric sepsis through a combined analysis of multiple methods, including Mendelian Randomization (MR), differential gene expression analysis, and immune cell infiltration assessment. It explores their potential as biomarkers for sepsis risk and their involvement in immune-related pathways.</p><p><strong>Methods: </strong>Differential expression analysis was performed using public datasets to identify genes with significant expression changes between pediatric sepsis patients and healthy controls. MR analysis utilized genome-wide significant SNPs as instrumental variables to assess causal relationships between gene expression and sepsis risk. Bi-directional MR was conducted to assess both forward and reverse causality. FDR correction was applied to adjust for multiple comparisons in MR results. Immune cell infiltration analysis was performed to investigate the genes' roles in immune responses, and findings were validated with independent datasets. ROC curves were constructed to assess predictive performance.</p><p><strong>Results: </strong>Differential expression analysis identified significant changes in RGL4,ATP9A,MAP3K7CL, and DDX11L2. MR analysis revealed causal associations between these genes and sepsis risk, with RGL4 and ATP9A upregulated (inflammatory roles), and MAP3K7CL and DDX11L2 downregulated (protective roles). Bi-directional MR found no significant reverse causality. Immune cell analysis showed associations with key immune cell types, and ROC analysis demonstrated strong predictive potential.</p><p><strong>Conclusion: </strong>RGL4,ATP9A,MAP3K7CL, and DDX11L2 play important roles in pediatric sepsis risk and immune response regulation, offering insights into genetic and immune mechanisms that may inform future sepsis research and treatment.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"66"},"PeriodicalIF":2.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe central nervous system injury in 9 children with COVID-19.","authors":"Peipei Zhang, Meiyun Xin, Yingge Bai, Xueyun Ren, Na Li","doi":"10.1186/s12887-025-05436-8","DOIUrl":"https://doi.org/10.1186/s12887-025-05436-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical features and prognosis of severe central nervous system (CNS) injury in children caused by coronavirus disease 2019 (COVID-19).</p><p><strong>Method: </strong>We retrospectively studied confirmed pediatric cases of COVID-19 complicated with CNS injury.</p><p><strong>Results: </strong>Nine patients diagnosed with COVID-19 complicated with severe CNS injury were admitted to the pediatric intensive care unit of the Affiliated Hospital of Jining University from December 1, 2022 to January 12, 2023. Of the nine patients, seven were male (77.78%). Five children were aged ≥ 10 years, and the others were 1-2 years old. All children had fever, eight had convulsions, seven had progressed to multiple organ failure, and all suffered varying degrees of coma. Most of the children had elevated interleukin-6 (100%), lactic acid (100%), alanine transaminase (87.5%), aspartate transaminase (87.5%), creatine kinase MB (87.5%), and lactate dehydrogenase (85.7%) levels. Four children had cerebrospinal fluid proteinnacell separation. The cranial imaging results of five children were abnormal. One child had lost his vital signs when admitted to hospital, and the remaining eight received hormonal shock, human immunoglobulin transfusion, antinainfection, cranial pressure reduction, and tracheal intubation, among others, during hospitalization. Ultimately, eight children died, and the remaining child has serious neurological sequelae and is undergoing rehabilitation.</p><p><strong>Conclusions: </strong>Severe CNS injury caused by COVID-19 has an acute onset, rapid progression, high disability rate, and high fatality rate. A low cerebrospinal fluid protein level may be a protective factor for children with severe nervous system injury caused by COVID-19.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"63"},"PeriodicalIF":2.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a comprehensive intervention on anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight.","authors":"Fatemeh Sadat Hashemi Javaheri, Zahra Mousavi, Saeideh Mohammadi, Arezoo Amjadi, Khadijeh Abbasi Mobarakeh, Seyedeh Hayedeh Mousavi Shalmani, Mahdieh Torkaman, Masoomeh Alsadat Mirshafaei, Sara Khoshdooz, Zahra Saeedirad, Naser Kalantari, Parmis Mirzaei, Saeid Doaei, Nastaran Keshavarz Mohammadi, Maryam Gholamalizadeh","doi":"10.1186/s12887-025-05396-z","DOIUrl":"https://doi.org/10.1186/s12887-025-05396-z","url":null,"abstract":"<p><strong>Background: </strong>Non-communicable diseases in adulthood are reported to be strongly associated with adolescent obesity. The present study aimed to assess the effect of a comprehensive lifestyle modification intervention on the anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight.</p><p><strong>Methods: </strong>This pragmatic trial was conducted on 126 adolescent boys with overweight. A comprehensive school-based intervention was carried out at two levels for four months: at the school level based on the Ottawa Charter framework and at the personal level including individualized diet and physical activity.</p><p><strong>Results: </strong>The percentage of mean difference of BMI and BF loss in the intervention group were 1.20% (P < 0.05) and 6.41% (P < 0.01), respectively. The intervention group had a lower intake of calorie (2350 ± 861 vs. 2634 ± 917 kcal/d), carbohydrate (255.68 ± 41 vs. 286.97 + 47 g/d), and fat (112.67 ± 78 vs. 217.72 ± 86 g/d) after the intervention compared to the control group (All P < 0.05). The intervention resulted in a significant increase in physical activity parameters including distance (3501 ± 287 vs. 614 ± 56 m/d), duration (203 ± 35 vs. 72 ± 10 min/d), and calorie expenditure (359.24 ± 62.4 vs. 46.74 ± 7.5 kcal/d) in the intervention group compared to the control group (P < 0.01).</p><p><strong>Conclusion: </strong>A comprehensive lifestyle modification intervention which covers both school and individual levels may positively influence BMI, body fat, calorie intake, and distance and duration of physical activity in adolescents. Thus, adopting multifaceted strategies using the Ottawa Charter framework may be considered as an effective approach to managing obesity in adolescents.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"67"},"PeriodicalIF":2.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors for clinical omphalitis among neonates in Eastern Uganda using chlorhexidine gel for cord care: a community-cohort study.","authors":"John Wogabaga, Kathy Burgoine, Abel Kakuru, Brendah Nambozo, Martin Chebet, Josephine Tumuhamye, Benon Wanume, Faith Oguttu, Milton W Musaba, Agnes Napyo, Solomon Wani, Peter Olupot-Olupot, Andrew D Weeks, Thorkild Tylleskär, David Mukunya","doi":"10.1186/s12887-025-05428-8","DOIUrl":"10.1186/s12887-025-05428-8","url":null,"abstract":"<p><strong>Background: </strong>Omphalitis is a bacterial infection of the umbilicus and/or surrounding tissues, occurring primarily in the neonatal period. Whereas it is known to be a major route of localized and often systemic infection, studies describing incidence and risk factors remain scanty, especially in resource limited settings where the condition is thought to be common. We assessed the incidence and risk factors for omphalitis among neonates born to women who received a birth kit containing chlorhexidine for umbilical cord care after birth in Eastern Uganda.</p><p><strong>Trial registration for the parent study: </strong>The BabyGel trial was registered in the Pan African Clinical Trial Registry -(PACTR202004705649428 Registered 1 April 2020, https://pactr.samrc.ac.za/ ).</p><p><strong>Methods: </strong>We conducted a community-based cohort study between January 2021 and June 2023. This study was nested within the BabyGel trial. Our outcome of interest was clinical omphalitis, defined as purulent discharge from the umbilical cord stump within the first twenty-eight days of life as witnessed by a study midwife. Data were analyzed using Stata version 17.0. Bivariable and multivariable analyses were conducted using Cox proportional hazard regression models to estimate hazard ratios (HR) of selected exposures and time to omphalitis.</p><p><strong>Results: </strong>A total of 2052 neonates were enrolled; half of which were female (51.1%). The incidence of omphalitis was 3.0% (62/2052; 95% confidence interval (CI): 1.9%, 4.4%). The incidence rate of omphalitis was 1.6 cases per 1000 person days (95% CI: 1.1, 2.3). Neonates born at home were twice as likely to develop omphalitis as those born in a health facility (adjusted hazards ratio (AHR) 1.99; 95% CI: 1.01, 3.9).</p><p><strong>Conclusion: </strong>The incidence of omphalitis among neonates in Eastern Uganda was low. Home births carried twice the risk for omphalitis. Use of chlorhexidine coupled with close follow-up of neonates in the community by health workers and community health workers might have reduced the risk of omphalitis.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"55"},"PeriodicalIF":2.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}