The role of glucocorticoids in recurrent idiopathic intussusception: a retrospective cohort study.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-10-14 DOI:10.1186/s12887-025-06125-2

Jiyin Zhang, Tingting Liu, Dayong Wang, Xianling Li, Li Wang, Shuanling Li, Liuming Huang, Qiulong Shen

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引用次数: 0

Abstract

Background: This study aimed to evaluate the efficacy of glucocorticoids in reducing short-term recurrence rate of idiopathic intussusception in pediatric patients.

Methods: A retrospective cohort study was conducted on children with recurrent idiopathic intussusception treated at the Emergency Center of Beijing Children's Hospital from January 2015 to January 2024. Patients who experienced three episodes of intussusception within 5 days were included. After successful fluoroscopy-guided air enema (FGAE), some children received glucocorticoids (intervention group), while others did not (control group). Recurrence rates within 14 days were compared between the groups. Lastly, delayed complications and adverse effects related to glucocorticoid use were recorded.

Results: A total of 10,493 FGAE sessions were performed, with 206 patients initially enrolled. Ultimately, 183 patients (124 boys, 59 girls; aged 9 months to 9 years) were included. The recurrence rate was significantly lower in the intervention group compared to the control group (18.6% vs. 46.6%, P = 0.001). Finally, no delayed complications or adverse effects related to glucocorticoid therapy were observed.

Conclusions: Glucocorticoids effectively reduced recurrence rate in children with short-term recurrent idiopathic intussusception without eliciting significant adverse effects.

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糖皮质激素在复发性特发性肠套叠中的作用：一项回顾性队列研究。

背景：本研究旨在评价糖皮质激素对降低小儿特发性肠套叠短期复发率的疗效。方法：对2015年1月至2024年1月北京儿童医院急诊中心收治的复发性特发性肠套叠患儿进行回顾性队列研究。5天内出现3次肠套叠的患者纳入研究。透视引导下空气灌肠（FGAE）成功后，部分患儿给予糖皮质激素（干预组），部分患儿未给予糖皮质激素（对照组）。比较两组患者14天内的复发率。最后，记录与糖皮质激素使用相关的延迟并发症和不良反应。结果：总共进行了10493次FGAE治疗，最初招募了206名患者。最终纳入183例患者（124例男孩，59例女孩，年龄9个月至9岁）。干预组复发率明显低于对照组（18.6%比46.6%,P = 0.001）。最后，未观察到与糖皮质激素治疗相关的延迟并发症或不良反应。结论：糖皮质激素可有效降低短期复发性特发性肠套叠患儿的复发率，且无明显不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.