BMC Pediatrics最新文献

{"title":"How supportive care needs influence resilience and hope in mothers of children with cancer?","authors":"Maryam Alizadeh-Khanghahi, Azizeh Farshbaf-Khalili, Maedeh Alizadeh, Mahnaz Jabraeili","doi":"10.1186/s12887-025-06145-y","DOIUrl":"10.1186/s12887-025-06145-y","url":null,"abstract":"<p><strong>Background: </strong>Cancer is a leading cause of death among children and adolescents. This illness severely impacts families, particularly mothers, who often bear the primary responsibility for the child's care. Identifying the supportive care needs of mothers and the factors associated with these needs is of significant importance. Therefore, This study aimed to investigate the relationship between these needs and the resilience and hope of mothers.</p><p><strong>Methods: </strong>This cross-sectional correlational study was conducted in the hematology-oncology ward and clinic of a children's specialty hospital in Tabriz, Iran. The participants included 200 mothers of children under 18 years old with cancer, selected through convenient sampling. Data were collected using the Connor-Davidson Resilience Scale (CD-RISC-10), the Herth Hope Index (HHI), and the Supportive Care Needs Survey for Partners and Caregivers (SCNS-P&C). Data analysis was performed using statistical tests in SPSS version 26.</p><p><strong>Results: </strong>The mean total score for supportive care needs among mothers was 55.33 ± 12.68 (range 0-100), with the highest need in the psychological and emotional domain. The mean resilience score was 17.42 ± 8.04 (range 0-40) and the mean hope score was 31.29 ± 5.71 (range 12-48), indicating that the participating mothers had low resilience and moderate hope. There was an moderate negative correlation between supportive care needs and both resilience and hope in the mothers (P < 0.001).</p><p><strong>Conclusions: </strong>Meeting psychological and emotional needs is not only a clinical priority but also a psychological imperative. By implementing targeted interventions and enhancing support services, healthcare providers can improve resilience and hope.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"743"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic-assisted resection of long-segment small bowel duplication: a rare case report and review of literature.","authors":"Meng Kong, Yali Tian, Jinhua Jia, Chuanyang Liu, Hongzhen Liu","doi":"10.1186/s12887-025-06091-9","DOIUrl":"10.1186/s12887-025-06091-9","url":null,"abstract":"<p><strong>Background: </strong>Small bowel duplication is a rare congenital gastrointestinal malformation in children that can present in various ways and often lead to misdiagnosis. Laparoscopic surgery has gradually become the preferred treatment method because of its minimal invasive advantages. In this case, we report a child with small bowel duplication who underwent resection of the duplicated bowel segment with laparoscopic assistance.</p><p><strong>Case presentation: </strong>An 8-year-old male patient was admitted with \"abdominal pain for 20 days.\" After admission, abdominal ultrasound and computed tomography (CT) scans suggested a small bowel lesion, possibly Meckel's diverticulum. Following comprehensive preoperative evaluations, we performed single-site laparoscopic exploration via the umbilicus. Intraoperatively, long segment (60 cm) small bowel duplication was identified, and laparoscopic-assisted resection of the duplicated bowel was performed, with good postoperative recovery.</p><p><strong>Conclusions: </strong>Long segment small bowel duplication in children is extremely rare and poses significant diagnostic challenges. Complete surgical resection of the duplicated bowel is crucial. The single-site umbilical laparoscopic technique can be used to manage complex small bowel duplications safely and effectively, especially in pediatric patients.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"735"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of treprostinil in pediatric pulmonary hypertension following fontan surgery: a real-world analysis.","authors":"Mingjie Zhang, Xi Chen, Yahe Xu, Yijun Chen, Zhiyue Zhang, Jingru Zhou, Zhuoming Xu","doi":"10.1186/s12887-025-06097-3","DOIUrl":"10.1186/s12887-025-06097-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the efficacy and safety of treprostinil in managing pulmonary hypertension (PH) following Fontan surgery in children. The hypothesis was that early postoperative administration of treprostinil could reduce pulmonary arterial pressure and improve oxygenation, utilizing real-life data to better reflect clinical practice.</p><p><strong>Methods: </strong>A single-center, retrospective study was conducted at the Shanghai Children's Medical Center. The study included patients who underwent Fontan surgery between January 2015 and December 2023, comparing those treated with treprostinil (T Group) and those not treated (NT Group). Propensity-score matching was applied to adjust for baseline differences. Extracted demographic and clinical data included age, weight, height, type of cardiac defect, and surgical details. Postoperative variables included hemodynamic data, inotropic scores(IS), mean pulmonary arterial pressure(mPAP), pulmonary to systemic pressure ratio (Pp/Ps), PaO₂/FiO₂(P/F), volume of drainage and fluid balance. Statistical analysis was performed using SPSS software, with significance set at p<0.05.</p><p><strong>Results: </strong>A total of 264 patients were identified, with 126 in the T Group and 138 in the NT Group. After matching, 154 patients were enrolled in (77 patients in each group). Mortality rates were similar (T: 0% vs NT: 1.3%, p=0.375). The T group showed significantly higher effective rates at both POD1 (90.9% vs.75.3%, p=0.010) and POD2 (93.5% vs. 79.2%, p=0.005). In patients receiving treprostinil ≥20 ng/kg/min, both mPAP and Pp/Ps showed significant reductions (p<0.001). Compared with baseline, the T group had significantly lower mPAP (P=0.045) and Pp/Ps (P=0.009), and a higher P/F ratio (P=0.02) on POD1. Significant main effects of treprostinil were observed for Pp/Ps (p<0.001), IS (p = 0.012), and P/F (p<0.001).T group had longer mechanical ventilation (p = 0.001) and ICU stay (p = 0.031). No major adverse events were observed.</p><p><strong>Conclusion: </strong>Treprostinil treatment significantly reduced mPAP and Pp/Ps in the early postoperative period following Fontan surgery, with higher doses of treprostinil yielding more substantial hemodynamic improvements. But it did not significantly alter short-term clinical recovery, with no major adverse reactions observed.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"739"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crohn's disease-like perianastomotic ulcerations after neonatal necrotizing enterocolitis surgery: a case of successful anti-TNF therapy.","authors":"Sun Lina, Wang Xinyi, Ren Xiaoxia, Han Yanan","doi":"10.1186/s12887-025-06140-3","DOIUrl":"10.1186/s12887-025-06140-3","url":null,"abstract":"<p><strong>Background: </strong>Digestive perianastomotic ulcerations (DPAU) are rare Crohn's disease (CD)-like lesions that develop following intestinal surgery. Although enteral nutrition and anti-inflammatory agents constitute first-line therapies, 59% of refractory cases require advanced interventions. Emerging evidence implicates tumor necrosis factor (TNF)-α-driven inflammation as a key pathogenic mechanism, yet optimal therapeutic strategies remain undefined. A 12-year-old girl with a surgery history of neonatal necrotizing enterocolitis (NEC) presented with severe anemia (hemoglobin: 51 g/L) and chronic abdominal pain. Endoscopy revealed circumferential ulcers at the ileocolonic anastomosis, histologically confirmed as active inflammation without granulomas or evidence of infections. Initial therapy with 3 months enteral nutrition and mesalamine failed. Subcutaneous adalimumab induced endoscopic ulcer healing and hemoglobin normalization (111 g/L) within 3 months. At the 12-month follow-up, sustained clinical remission was observed (hemoglobin: 120 g/L, fecal calprotectin: 45 µg/g), with complete mucosal healing and no adverse events.</p><p><strong>Conclusions: </strong>Early anti-TNF therapy induced rapid and sustained remission in a pediatric patient with DPAU, reinforcing the mechanism that TNF-α-driven inflammation underlies disease pathogenesis. While promising, these findings require validation in larger cohorts. Individualized therapeutic decisions should weigh the risks of recurrence, cost, and long-term biologic safety.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"747"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Zealand school children's perspectives on influenza: listening to young voices in respiratory health.","authors":"Rajneeta Saraf, Tony Dowell, Maria Stubbe, Samantha Marsh, Nikki Turner","doi":"10.1186/s12887-025-06130-5","DOIUrl":"10.1186/s12887-025-06130-5","url":null,"abstract":"<p><strong>Background: </strong>Children play a crucial role in the transmission of influenza, yet their understanding of the virus and its prevention is often overlooked in public health messaging. This study aimed to explore, in the post COVID-19 pandemic era, children's perceptions of influenza, with a focus on understanding their perspectives and giving a voice to their views on the illness.</p><p><strong>Methods: </strong>Two focus groups were conducted in South Auckland, New Zealand, with a diverse sample of 27 children aged 5-13 years from two schools. Consent was obtained through parental approval and child assent. Using creative activities, including drawings and group discussions, children shared their understanding of influenza, its transmission, symptoms, and their views on non-pharmaceutical interventions (NPIs) and vaccination. Data were analysed qualitatively to identify key themes and insights.</p><p><strong>Results: </strong>While children generally recognise influenza as a severe illness with symptoms like fever, sore throat, and cough, a small proportion of younger children thought influenza was the same as common cold. Most children were aware of the airborne nature of transmission. Children showed strong awareness of how influenza impacts daily life, such as missing school and social events. Age-specific perceptions were evident in the drawings: younger children focused on symptoms, while older children had a broader view, including symptoms, transmission, prevention, and emotional and social impacts. Preferences for NPIs varied by age, with younger children emphasising coughing etiquette and older children prioritising handwashing and mask-wearing. Regarding vaccination, while children understood its protective role, many expressed fear of injections, preferring less invasive options like nasal sprays or patches.</p><p><strong>Conclusion: </strong>Children's perceptions of influenza highlight both awareness and gaps in understanding, particularly regarding transmission and illness severity. Public health messaging that addresses both these strengths and gaps, while incorporating children's voices, could improve efforts to mitigate the impact of influenza and other respiratory illnesses. Strategies such as promoting alternative vaccination methods and reinforcing NPIs in a relatable way may enhance children's engagement with health behaviours, contributing to more effective influenza control in schools and communities.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"740"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percentile curve of balance development and network analysis with body shape and physical fitness in preschool children.","authors":"Deqiang Zhao, Xiaoxiao Chen, Aoyu Zhang, Yibei Wang, Yibo Gao, Jin He, Lupei Jiang, Haixia Hu, Yanfeng Zhang","doi":"10.1186/s12887-025-06163-w","DOIUrl":"10.1186/s12887-025-06163-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop age- and sex-specific percentile reference curves and evaluation criteria for balance ability in preschool children using the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) model. It also sought to analyze the influencing factors of balance ability through network analysis, providing evidence to support strategies for improving balance development in early childhood.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from April to July 2023, involving 5,559 preschool children aged 3 to 6 years from 12 districts (cities and counties) in Weifang City, Shandong Province, China. Participants were selected using a stratified, randomized, whole-cluster sampling method. Physical fitness tests and questionnaires on physical activity participation were administered. The GAMLSS model was used to generate balance ability percentile curves. Analysis of variance (ANOVA) and other statistical methods were employed to examine differences by age, sex, and urban-rural residence. Network analysis was conducted to identify key factors influencing balance ability.</p><p><strong>Results: </strong>Significant age-related differences in balance ability were observed (p < 0.05). Among 5-year-olds, girls demonstrated significantly better balance performance than boys (p < 0.01). Urban children outperformed rural peers in all age groups (p < 0.01). Balance beam completion time was significantly negatively correlated with height, weight, grip strength, and standing long jump performance (p < 0.01), while it was positively correlated with 10-meter shuttle run, 15-meter obstacle run, and two-legged continuous jump (p < 0.01).</p><p><strong>Conclusions: </strong>Girls exhibited earlier development in balance ability compared to boys, and urban children demonstrated superior balance performance relative to rural children. Physical morphology was closely related to balance ability, and various physical fitness components showed compensatory interactions, collectively influencing balance development in preschool children.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"749"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of elevated 1-hour post-load plasma glucose level in identifying risk of MAFLD in non-diabetic obese children and adolescents.","authors":"Xiaoxiao Liu, Zesheng Peng, Shifeng Ma, Fei Liu, Mingyue Liu, Xiaowen Li, Rongxiu Zheng","doi":"10.1186/s12887-025-05943-8","DOIUrl":"10.1186/s12887-025-05943-8","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the potential value of 1-h post-load plasma glucose level in patients who are prone to suffer from metabolic associated fatty liver disease (MAFLD) in a group of non-diabetic obese children and adolescents.</p><p><strong>Methods: </strong>Cardio-metabolic risk factors, oral glucose tolerance test outcomes, and Liver ultrasonic examination results were analyzed in 406 non-diabetic obese children and adolescents. Patients were divided into 4 groups: normal glucose tolerance with 1-h plasma glucose (NGT with 1-h PG) < 8.6 mmol/L, NGT with 1-h PG ≥ 8.6 mmol/L, impaired fasting glucose (IFG), and impaired glucose tolerance (IGT).</p><p><strong>Results: </strong>In this study, 406 non-diabetic children and adolescents with obesity (249 males, 157 females, mean age: 11.71 ± 2.22 years) were included. Among them, 286 (70.4%) had NGT, 30 (7.4%) had IFG, and 90 (22.2%) had IGT. As compared with NGT with 1-h PG < 8.6 mmol/L, NGT with 1-h PG ≥ 8.6 mmol/L and IGT groups demonstrated significantly higher body fat percentage, obesity family history, triglycerides, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST). After adjusting for age, sex, and BMI z-score, the 1-h PG level demonstrated significant positive correlations with ALT (Spearman's ρ = 0.12, P = 0.018), AST (ρ = 0.15, P = 0.003), and GGT (ρ = 0.21, P < 0.001). In the multivariable-adjusted logistic regression model controlling for age, sex, BMI z-score, body fat percentage, homeostatic model assessment of insulin resistance and glycosylated hemoglobin, individuals with NGT and 1-h PG ≥ 8.6 mmol/L exhibited 1.882-fold higher odds of MAFLD (95% CI 1.045-3.388), while the IGT group showed significantly elevated odds (OR = 1.980, 95% CI 1.056-3.709). No statistically significant association was observed in the IFG group.</p><p><strong>Conclusion: </strong>These data suggest that NGT with 1-h PG ≥ 8.6 mmol/L in non-diabetic obese pediatric patients can facilitate identifying individuals at higher risk of MAFLD.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"700"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of serum creatinine changes on surgical timing and prognosis in progressive necrotizing Enterocolitis.","authors":"JinBao Han, JianYing Cao, Gang Liu, Lian Duan, MengNan Yu, Guang Li, LiuMing Huang","doi":"10.1186/s12887-025-06122-5","DOIUrl":"10.1186/s12887-025-06122-5","url":null,"abstract":"<p><strong>Introduction: </strong>To explore the effect of elevated serum creatinine on the timing of surgery and prognosis in patients with progressive necrotizing enterocolitis.</p><p><strong>Methods: </strong>A total of 367 children who underwent surgery for necrotizing enterocolitis(NEC) from May 2008 to April 2024 were collected, and 156 patients with incomplete data were excluded. Among the remaining 211 surgical cases, 168 patients (before August 14, 2019) were included in the statistical analysis, and 43 patients (after August 14, 2019) were used as the validation set. The basic data of the patients, including gender, gestational age, birth weight, age at onset, the length of ICU stay, cardiac ultrasound results, Bell's stage, whether they were small for gestational age, urine volume in the 24 h before operation, preoperative blood routine (white blood cells, platelets), C-reactive protein (CRP), blood gas analysis, renal function (serum creatinine, blood urea nitrogen) and weight at the time of surgery were collected for statistical analysis.</p><p><strong>Results: </strong>A total of 98 (26.7%) patients died among the 367 patients, of which 47 (48%) had acute kidney injury. Between the 211 patients included in the statistical analysis, 47 (22.3%) died, and among the 168 patients in the data set, 39 (23.2%) died. Of the 43 patients in the validation set, 8 (18.6%) died. There were statistically significant differences in birth weight, length of ICU stay, preoperative serum creatinine, urine volume, white blood cell count, lactate, HCO3-, heart malformations, and small for gestational age status in the collected data, p < 0.05. After ROC-AUC analysis, it was found that when serum creatinine cutoff = 60.5ummol/L, the area under the curve AUC = 0.842, sensitivity = 0.795, specificity = 0.705, and after COX regression analysis, the serum creatinine HR value = 7.242, 95% CI [2.852-18.388]. Log Rank in the K-M curve of SGA = 42.958, p < 0.001. Among the 43 cases in the validation set, 35 survived, sensitivity = 0.75, specificity = 0.771.</p><p><strong>Conclusion: </strong>In addition to clinical manifestations, imaging, and infection indicators as factors for determining surgical indications in progressive NEC, more active intervention should be considered when serum creatinine begins to rise to 60.5ummol/L.</p><p><strong>Level of evidence: </strong>Level III Retrospective Comparative Cohort Study.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"734"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian modelling of oxygen saturation (SpO₂) of cardiac patients using the asymmetric generalized error distribution.","authors":"Tayu Nigusie Abebe, Ayele Taye Goshu","doi":"10.1186/s12887-025-06094-6","DOIUrl":"10.1186/s12887-025-06094-6","url":null,"abstract":"<p><strong>Background: </strong>Oxygen saturation (SpO₂) is a crucial parameter for monitoring the health of cardiac patients. It measures the percentage of hemoglobin in the blood that is saturated with Oxygen. The study aims to analyze longitudinal Oxygen saturation (SpO₂) levels and identify its determinants among cardiac patients.</p><p><strong>Methods: </strong>Bayesian linear mixed-effects model with the asymmetric generalized error distribution (AGED) was used to analyze the data. The data comprises 323 children diagnosed with cardiac disease. AGED outperforms the others distributions and indicates robust and effective choice to analysis the data.</p><p><strong>Results: </strong>The estimated shape parameters of AGED are significant [Formula: see text] (95% CI: 2.31, 2.58) which is degree of asymmetry, and [Formula: see text] (95% CI: 3.18, 3.46) is associated with peakedness of the distribution. The finding reveals that corrective surgery, pulmonary hypertension, cardiomyopathy, anemia, nutritional status, and hemoglobin levels are significantly associated with Oxygen saturation (SpO₂). Pulmonary hypertension, cardiomyopathy, and under nutrition are found to lower SpO₂. In contrast, higher hemoglobin and corrective surgery are significantly associated with higher SpO₂. The AGED fitted to the data, and found to be important for analyzing data characterized by asymmetry and excess kurtosis.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"727"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal pulmonary hypertension in the NICU: a 10-year single-center experience.","authors":"Oguzhan Ay, Sezgin Gunes, Erkan Erfidan, Ayse Simsek","doi":"10.1186/s12887-025-05928-7","DOIUrl":"10.1186/s12887-025-05928-7","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"724"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}