BMC Pediatrics最新文献

{"title":"Lessons learned from the outbreak: the use of fomepizole in children with acute kidney injury due to ethylene glycol/diethylene glycol poisoning.","authors":"Yogi Prawira, Tartila Tartila, Nina Dwi Putri, Sharfina Fulki Adilla Hidayat, Niken Wahyu Puspaningtyas, Irene Yuniar, Rismala Dewi, Eka Laksmi Hidayati, Antonius Hocky Pudjiadi","doi":"10.1186/s12887-025-06107-4","DOIUrl":"10.1186/s12887-025-06107-4","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"748"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing assesment in children after intrauterine exposure to platinum-based treatment of pregnant cancer patients: A study from the International Network on Cancer, Infertility and Pregnancy.","authors":"Evangeline A Huis In 't Veld, Anna Babkova, Ľudmila Verespejova, Franciscus A Diepstraten, Annelot J M Meijer, Martine van Grotel, Mathilde van Gerwen, Indra A Van Assche, Kristel Van Calsteren, Harm van Tinteren, Marry M van den Heuvel-Eibrink, Frédéric Amant, Michael Halaska, Alexander E Hoetink","doi":"10.1186/s12887-025-05992-z","DOIUrl":"10.1186/s12887-025-05992-z","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"703"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal pneumocephalus secondary to meningitis: a case report and literature review.","authors":"Zongtai Feng, Zuming Yang, Lirong Shen, Jingjing Gao, Yan Cai, Meiying Zhu, Lili Li, Chuchu Gao, Yanan Wang","doi":"10.1186/s12887-025-06112-7","DOIUrl":"10.1186/s12887-025-06112-7","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"713"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of a case with short stature and Goltz syndrome with long-acting growth hormone: a case report and follow-up.","authors":"Jinghui Zhang, Nana Qiao, Xiaochun Li","doi":"10.1186/s12887-025-06129-y","DOIUrl":"10.1186/s12887-025-06129-y","url":null,"abstract":"<p><p>Goltz syndrome, also known as focal dermal hypoplasia, is an X-linked dominant genetic disorder caused by mutations in the PORCN gene, mainly characterized by developmental impairments affecting the skin, hair, bones, teeth, and eyes. This study reports a case with extensive skin dysplasia, limb malformations, and short stature. The genomic DNA whole exome sequencing of the child at 1 month of age revealed a mutation in the PORCN gene, confirming the diagnosis of Goltz syndrome. When she was 3 years old, she suffered from weight loss (W<-3SD) and was short for her age (H<-3SD). The growth hormone stimulation test confirmed growth hormone deficiency. She was treated with long-acting growth hormone (0.2 mg/Kg/week) for 2 years and 9 months, leading to a significant increase in height, with an average annual growth rate of 9.4 cm, without any side effects after three years of follow-up. Goltz syndrome with short stature may be associated with growth hormone deficiency, and long-term growth hormone therapy can achieve clinical benefit.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"733"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics for pediatric diarrhea and constipation: an umbrella meta-analysis.","authors":"Le Chen, Yan Wang, Xiao Liu, Haioun Wong, Chengjiao Huang","doi":"10.1186/s12887-025-06002-y","DOIUrl":"10.1186/s12887-025-06002-y","url":null,"abstract":"<p><strong>Background: </strong>The current evidence regarding the impact of probiotics on diarrhea and constipation outcomes in children is inconclusive. This umbrella review of systematic reviews and meta-analyses aims to deliver a comprehensive and conclusive summary of the effectiveness of probiotics in managing these conditions in pediatric populations.</p><p><strong>Methods: </strong>Meta-analyses were collected from Scopus, PubMed, Embase, and the Web of Science until May 2025. The overall effect size was calculated using a random effect model.</p><p><strong>Results: </strong>This umbrella study comprises a systematic review of 35 studies. Our findings illustrated that probiotics reduce diarrhea incidence (ES = 0.52; 95% CI: 0.40, 0.68, P < 0.001; I2 = 91.2%, p < 0.001) compared to the control group, meaningfully. Also, it is successful in reducing diarrhea duration (WMD = -1.85; 95% CI: -2.83, -0.86, P < 0.001; I² = 94.7%, p- <0.001; SMD = -0.94; 95% CI: -1.32, -0.56, P < 0.001; I² = 88.4%, p- <0.001) significantly. Probiotics had no significant effect on stool frequency (WMD = 0.22; 95% CI: -0.30, 0.74, P = 0.414, I² = 82.7%, P = 0.003; SMD= -0.22; 95% CI: -1.25, 0.81, P = 0.674). Probiotics prevent diarrhea by about 53% (ES = 0.47; 95% CI: 0.32, 0.71, P < 0.001).</p><p><strong>Conclusions: </strong>This meta-analyses highlights the potential benefits of probiotics in improving diarrhea outcomes in children, demonstrating a reduction in both the incidence and duration of diarrhea following probiotic supplementation.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"698"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of colostrum combined with non-nutritive sucking in non-invasive ventilated very low birth weight preterm infant.","authors":"Yanfen Tong, Yingying Chen, MaDing Zhao, Qingqing Li, Shenhui Jin","doi":"10.1186/s12887-025-06004-w","DOIUrl":"10.1186/s12887-025-06004-w","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"712"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal early-onset sepsis caused by Streptococcus Gallolyticus subsp. Pasteurianus with severe pulmonary hypertension and leukemoid reaction: a case report.","authors":"Xuelian Wang, Ling Wang, Yuan Yuan, Xiaopeng Zhao, Huayan Zhang","doi":"10.1186/s12887-025-06026-4","DOIUrl":"10.1186/s12887-025-06026-4","url":null,"abstract":"<p><strong>Background: </strong>Streptococcus gallolyticus subsp. pasteurianus (SGSP) is an uncommon cause of neonatal early-onset sepsis (EOS). We present a case of neonatal EOS attributed to SGSP in an infant complicated by meconium aspiration syndrome (MAS) and congenital pneumonia. The infant developed severe pulmonary hypertension and exhibited a leukemoid reaction during recovery. The clinical features of this case are rare, and a comprehensive review of her peripartum and follow-up data could enhance our understanding of this organism.</p><p><strong>Case presentation: </strong>This is a full-term female neonate born to a healthy mother via cesarean section due to suspected fetal distress with meconium-stained amniotic fluid. She required resuscitation in the delivery room and was subsequently admitted to the neonatal intensive care unit for respiratory distress. Both the mother and the baby exhibited fever after delivery, and cultures from the baby's blood and amniotic fluid revealed the same strain of SGSP. The baby had MAS and developed severe pulmonary hypertension, which was successfully treated with a comprehensive approach that included ampicillin, high-frequency oscillatory ventilation, inhaled nitric oxide, fluid resuscitation, and vasopressors. A significant increase in the white blood cell count was noted during her clinical improvement, followed by a spontaneous decline. The baby completed a 12-day course of ampicillin and was followed up to 1 year of age, during which she thrived. A systematic literature review on early-onset SGSP sepsis was also conducted.</p><p><strong>Conclusion: </strong>SGSP infection can be associated with life-threatening complications. This case underscores the importance of considering SGSP as a potential etiology in neonatal EOS.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"699"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of glycopyrrolate vs. atropine combined with neostigmine on heart rate dynamics and safety outcomes in pediatric patients: a prospective randomized controlled trial.","authors":"Tianxiao Zou, Xueting Yang, Lulu Ren, Sisi Wei, Guoqing Wang, Rong Wei, Shenghua Yu","doi":"10.1186/s12887-025-06092-8","DOIUrl":"10.1186/s12887-025-06092-8","url":null,"abstract":"<p><strong>Background: </strong>Neostigmine is a widely used muscle relaxant antagonist that requires combination with anticholinergic agents like atropine to mitigate its muscarinic effects. Glycopyrrolate exerts less influence on cardiac conduction than atropine, making it a preferable option. However, clinical research on its pediatric use is limited. This study aims to compare the effects of glycopyrrolate and atropine, in combination with neostigmine, on heart rate and adverse events in pediatric patients.</p><p><strong>Methods: </strong>Children undergoing penile flap surgery under general anesthesia combined with a caudal block were randomly assigned to either the glycopyrrolate group (Group G, n = 100) or the atropine group (Group A, n = 100). Postoperatively, patients in Group G received glycopyrrolate (8 µg/kg) and neostigmine (40 µg/kg), while those in Group A received atropine (20 µg/kg) and neostigmine (40 µg/kg) to reverse neuromuscular blockade. The baseline heart rate was defined as the heart rate measured before administering the trial drug, with heart rates recorded every minute thereafter, along with any adverse events noted within 24 h post-operation.</p><p><strong>Results: </strong>There were no statistically significant differences in age, surgery duration, or baseline heart rates between the two groups (p > 0.05). Heart rate changes within 15 min post-administration were less pronounced in the glycopyrrolate group compared to the atropine group (p < 0.05), indicating reduced fluctuation from baseline. Additionally, the area under the curve (AUC) for heart rate changes in the first 15 min post-administration was lower in the glycopyrrolate group (p < 0.05). No statistically significant differences in adverse events were observed between the two groups (p > 0.05).</p><p><strong>Conclusions: </strong>Compared to atropine, the combination of glycopyrrolate and neostigmine results in less fluctuation in heart rate but a higher incidence of dry mouth, with no significant differences in other complications. Therefore, glycopyrrolate may be preferred in scenarios where hemodynamic stability is prioritized, considering its higher risk of dry mouth.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"714"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and determinants of early neonatal mortality in Ethiopia: evidence from the Ethiopian demographic and health survey data.","authors":"Tsion Mulat Tebeje, Beminate Lemma Seifu, Yordanos Sisay Asgedom, Kusse Urmale Mare, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Abdu Hailu Shibeshi, Afework Alemu Lombebo, Kebede Gemeda Sabo, Bezawit Melak Fente, Bizunesh Fantahun Kase","doi":"10.1186/s12887-025-06022-8","DOIUrl":"10.1186/s12887-025-06022-8","url":null,"abstract":"<p><strong>Background: </strong>Early neonatal mortality (ENM) accounts for three-fourths of all neonatal deaths and one-third of overall child mortality. While previous studies have primarily focused on neonatal and under-five mortality, ENM has received comparatively less attention. This study aims to address this gap by analyzing trends and identifying factors associated with ENM in Ethiopia.</p><p><strong>Methods: </strong>Data from the Ethiopian Demographic and Health Survey (EDHS) conducted between 2005 and 2016 were analyzed, comprising a total weighted sample of 22,310 participants. To account for the hierarchical structure of the EDHS data, a mixed-effects binary logistic regression model was applied to identify associated factors. In the multivariable analysis, adjusted odds ratios with 95% confidence intervals (CI) were reported to demonstrate the statistical relationship between ENM and explanatory variables.</p><p><strong>Results: </strong>The early neonatal mortality in Ethiopia increased from 20.4 per 1,000 live births (95% CI: 17.4-23.9) in 2005 to 21.4 per 1,000 live births (95% CI: 18.3-24.9) in 2011 before declining to 16.7 per 1,000 live births (95% CI: 14.0-19.9) in 2016. The multilevel analysis revealed that the odds of ENM were lower among mothers of female newborns, those who initiated breastfeeding within two days after delivery, mothers who attended antenatal care at least once to three times, and those residing in the Afar, SNNPR, and Gambela regions. In contrast, cesarean section delivery and multiple pregnancy were significantly associated with increased odds of ENM.</p><p><strong>Conclusions: </strong>Given the slow decline in ENM, sustained efforts are essential to improve access to quality healthcare, strengthen the health system, and address key health determinants to achieve better neonatal outcomes. Implementing evidence-based strategies, including enhancing antenatal care services, promoting early initiation of breastfeeding, and providing specialized care for multiple pregnancies and cesarean deliveries, can play a crucial role in reducing ENM and ensuring healthier outcomes for newborns.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"704"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The timing of using IVIG for neonatal ABO hemolytic disease.","authors":"Na Ma, Feihong Zhang, Yong Hu, Bin Xia","doi":"10.1186/s12887-025-06062-0","DOIUrl":"10.1186/s12887-025-06062-0","url":null,"abstract":"<p><strong>Background: </strong>ABO hemolytic disease of the newborn (ABO HDN) is the most prevalent cause of hemolytic disease of the newborn, often leading to hyperbilirubinemia. In some cases, ABO HDN can progress to significant hyperbilirubinemia. The role of intravenous immunoglobulin (IVIG) in treating ABO HDN remains controversial. Several key questions regarding significant hyperbilirubinemia remain unanswered: What are the risk factors of ABO HDN with significant hyperbilirubinemia? Can IVIG provide benefits for ABO HDN with significant hyperbilirubinemia? Where do we place IVIG in the treatment sequence paradigm of ABO HDN? How do we best stratify ABO HDN with significant hyperbilirubinemia for IVIG therapy?</p><p><strong>Methods: </strong>We conducted a retrospective cohort study include 948 newborns from West China Second University Hospital, divided into two groups according to the use/nonuse of IVIG. The maternal and neonatal baseline clinical data were collected from digital medical record system. The risk factors of the significant hyperbilirubinemia associated with ABO HDN were investigated using univariate and multivariate analysis. The generalized additive mixed model (GAMM) was used to analyze the nonlinear relationship of bilirubin level with different treatment over time.</p><p><strong>Results: </strong>A total of 948 newborns fulfilled the inclusion criteria, with 143 (15.1%) in the IVIG group, and 805 (84.9%) in the non-IVIG group. (1) The multivariate analysis found that gestational age ≥ 37 weeks (OR 4.19; p = 0.019), age at admission range 24-48 h (OR 9.69; p = 0.03) and age at admission >48 h (OR 50.31; p < 0.0001) were affect significant hyperbilirubinemia in neonates. (2) The total serum bilirubin (TSB) descent speed of IVIG group (0.69µmol/L/h, 95%CI, 0.48-0.89µmol/L/h) was higher than non-IVIG group (0.21µmol/L/h, 95%CI, 0.14-0.29µmol/L/h) among the neonates with age at admission ≤ 48 h (p < 0.0001);No adverse effects related to IVIG treatment were recorded in either group.</p><p><strong>Conclusion: </strong>Regular monitoring of TSB levels starting 24 h after birth is an effective strategy to prevent severe hyperbilirubinemia in ABO HDN. For southwest Chinese neonates, IVIG should not be routinely used to treat ABO HDN in those admitted > 48 h after birth.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"731"},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}