BMC Pediatrics最新文献

{"title":"Congenital long QT syndrome caused by a KCNH2 pathogenic variant exhibiting \"motor seizures\": a case report and literature review.","authors":"Mei Jin, Fan Yang, Yakun Du, Libo Zhao, Xueran Zhao, Jing Liu, Jing Zhang, Suzhen Sun","doi":"10.1186/s12887-025-05545-4","DOIUrl":"10.1186/s12887-025-05545-4","url":null,"abstract":"<p><p>A retrospective analysis was conducted to evaluate the clinical characteristics, diagnostic challenges, and management strategies in a child with congenital long QT syndrome (cLQTS) caused by a KCNH2 gene pathogenic variant presenting as \"motor seizures\". The case involved a 10-year-old boy with a two-year history of recurrent loss of consciousness, which had worsened during the preceding week. Clinical manifestations included sudden episodes of unconsciousness, rightward strabismus of both eyes, cyanosis of the lips, guttural vocalizations, rigidity and shaking of the upper limbs, and urinary incontinence. These events typically lasted approximately two minutes, initially occurring semiannually but escalating to daily episodes over the past week, affecting both awake and sleep states. Video electroencephalography (VEEG) showed generalized slow waves and low voltage activity, while electrocardiography (ECG) demonstrated QTc prolongation, paired, and multi-source ventricular ectopy preceding torsades de pointes. Genetic testing identified a pathogenic c.1697G > A mutation in the KCNH2 gene corroborating the clinical diagnosis of cLQTS. Following confirmation, the patient was initiated on long-term oral therapy with propranolol and nicorandil. Under this regimen, the patient was seizure-free for 7-month. For patients with seizures or seizure-like episodes, such as extremity movement or rigidity, it is necessary to perform an ECG examination. Additionally, dynamic ECG and electrolyte assessments should be conducted when necessary to minimize the risk of misdiagnosis and inappropriate treatment. When VEEG shows a \"slow-flat-slow\" pattern, differentiation from A-S syndrome caused by malignant arrhythmias is critical. Once cLQTS is diagnosed, it is imperative to initiate prompt and aggressive treatment to mitigate the risks of syncope and sudden cardiac death.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"197"},"PeriodicalIF":2.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early predictors of induction of remission with exclusive enteral nutrition in children with Crohn's disease.","authors":"Yudie Hu, Yao Lv, Jingan Lou, Youyou Luo, Gan Yang, Yang Liu, Jiaying Zhou, Changjun Zhen, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Yan Ni, Jie Chen","doi":"10.1186/s12887-025-05497-9","DOIUrl":"10.1186/s12887-025-05497-9","url":null,"abstract":"<p><strong>Background: </strong>Exclusive enteral nutrition (EEN) is recommended as first-line therapy for children with mild to moderate Crohn's disease (CD), given its effectiveness in inducing clinical remission (CR) and promoting mucosal healing (MH). However, the identification of reliable early predictors of EEN response remains an area requiring further investigation.</p><p><strong>Methods: </strong>Patients with CD diagnosed between 2015 and 2024 were divided into training and validation cohorts. Baseline clinical and laboratory covariates were analyzed separately to evaluate their associations with CR and MH after 8 weeks of EEN therapy. Significant covariates were identified through univariate analysis and correlation tests, followed by their inclusion in stepwise logistic regression to develop separate predictive models for CR and MH. Model performance was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>A total of 56 patients were included in the derivation cohort, and 28 were included in the validation cohort. The CR diagnostic model achieved an Area Under Curve (AUC) of 0.93 in the derivation cohort (95% confidence interval (CI) 0.87-1.00; p < 0.05) and 0.82 in the validation cohort (95% CI 0.62-1.02; p < 0.05). Higher baseline levels of IBIL (> 4.95 µmol/L), T-cell cluster of differentiation 3 (CD3) (> 76.78%), and iron (> 9.025 mmol/L) were associated with reduced CR rates. The MH diagnostic model yielded an AUC of 0.87 in the derivation cohort (95% CI 0.73-1.00; p < 0.05) and 0.66 in the validation cohort (95% CI 0.43-0.89; p = 0.231). Factors associated with lower MH rates included an Interleukin 10 (IL-10) level > 4.35 µmol/L and a red cell distribution width (RDW) > 14.55%.</p><p><strong>Conclusion: </strong>IBIL, CD3 and iron levels are reliable predictors of the induction of CR with EEN, whereas the IL-10 level and RDW serve as early predictors of MH.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"206"},"PeriodicalIF":2.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake and determinants of routine vaccines among children aged 12-23 months in adansi South district of Ghana. a cross-sectional study.","authors":"Samuel Sem, Jacob Owusu Sarfo, Mustapha Amoadu, Thomas Hormenu","doi":"10.1186/s12887-025-05559-y","DOIUrl":"10.1186/s12887-025-05559-y","url":null,"abstract":"<p><strong>Background: </strong>Routine childhood vaccination (RCV) has demonstrated its effectiveness, saving millions of lives globally and reducing childhood mortality. However, several factors impede mothers from completing their children's vaccination schedule. The purpose of this study was to determine factors influencing RCV among children aged 12-23 months in the Adansi South District (ASD) of Ghana.</p><p><strong>Methods: </strong>A cross-sectional community-based survey with a census approach was conducted involving 3,312 mothers with children aged 12-23 months. Frequency and percentage, bivariate, and hierarchical binary logistic regression analyses were used to identify the factors related to RCV.</p><p><strong>Results: </strong>The number of fully vaccinated children was 56.8% with partially vaccinated being 43.2%, indicating a low full RCV. The factors that influenced RCV included the child's birth order (AOR = 0.653, [0.452--0.945], p = 0.024), maternal religious affiliation (AOR = 1.315, [1.098-1.575], p = 0.003), Antenatal care (ANC) contacts (AOR = 2.045, [1.315-3.179], p = 0.001), number of times ANC contacted (AOR = 0.597, [0.502-0.710], p = 0.000), and child (AOR = 1.842, [1.566-2.166], p = 0.000) and mother's age (AOR = 2.346, [1.369-4.019], p = 0.002). Maternal (AOR = 1.461, [1.143-1.866], p = 0.002) and spousal income adequacy (AOR = 1.590, [1.081-2.337], p = 0.018), spouse's income irregularity (AOR = 2.292, [1.757-2.987], p = 0.000), and if spouse's income is the sole source of livelihood (AOR = 1.751, [1.271-2.414], p = 0.001), type of material used for house construction (AOR = 1.459, [1.046-2.033], p = 0.026), and the type of housing for dwelling (AOR = 1.570, [1.310-1.881], p = 0.000), as well as mothers' perception of vaccines, and vaccination activities (AOR = 1.333, [1.137-1.562], p = 0.000) influence RCV in the district.</p><p><strong>Conclusions: </strong>The relatively low uptake of RCV is indicative of low herd immunity among these children and posing a potential risk of causing vaccine-preventable diseases (VPD) outbreaks and subsequent health issues among children. The Ghana Health Service should offer flexible scheduling and reminder systems for vaccination appointments in the district. The GHS should prioritise targeted interventions during child welfare clinics (CWC), ANC contacts, and community gatherings to educate mothers on the importance of childhood vaccinations.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"198"},"PeriodicalIF":2.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of child-specific activities in ambulatory children with and without developmental disabilities.","authors":"Barbara Engels, Manon A T Bloemen, Richard Felius, Karlijn Damen, Eline A M Bolster, Harriët Wittink, Raoul H H Engelbert, Jan Willem Gorter","doi":"10.1186/s12887-025-05489-9","DOIUrl":"10.1186/s12887-025-05489-9","url":null,"abstract":"<p><strong>Background: </strong>Pediatric healthcare professionals facilitate children to enhance and maintain a physically active lifestyle. Activity monitors (AM) can help pediatric healthcare professionals assess physical activity in everyday life. However, validation research of activity monitors has often been conducted in laboratories and insight into physical activity of children in their own everyday environment is lacking. Our goal was to study the criterion validity of a prototype AM (AM-p) model in a natural setting.</p><p><strong>Methods: </strong>Cross-sectional community-based study with ambulatory children (2-19 years) with and without developmental disability. Children wore the AM-p on the ankle and were filmed (gold standard) while performing an activity protocol in a natural setting. We labelled all videos per 5-second epoch with individual activity labels. Raw AM-p data were synchronized with activity labels. Using machine learning techniques, activity labels were subdivided in three pre-defined categories. Accuracy, recall, precision, and F1 score were calculated per category.</p><p><strong>Results: </strong>We analyzed data of 93 children, of which 28 had a developmental disability. Mean age was 11 years (SD 4.5) with 55% girls. The AM-p model differentiated between 'stationary', 'cycling' and 'locomotion' activities with an accuracy of 82%, recall of 78%, precision of 75%, and F1 score of 75%, respectively. Children older than 13 years with typical development can be assessed more accurately than younger children (2-12 years) with and without developmental disabilities.</p><p><strong>Conclusion: </strong>The single ankle-worn AM-p model can differentiate between three activity categories in children with and without developmental disabilities with good accuracy (82%). Because the AM-p can be used for a heterogenous group of ambulatory children with and without developmental disabilities, it may support the clinical assessment for pediatric healthcare professionals in the future.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"193"},"PeriodicalIF":2.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of croup severity and treatment in pediatric patient: a study of COVID-19 positive vs. negative cases during peak Omicron.","authors":"Fatemeh Pourjoula, Seyed Hossein Mirlohi, Niloufar Ghanbari","doi":"10.1186/s12887-025-05536-5","DOIUrl":"10.1186/s12887-025-05536-5","url":null,"abstract":"<p><strong>Background: </strong>The Omicron variant of SARS-CoV-2 has been associated with unique clinical presentations in children, including croup-like symptoms such as barking cough, hoarseness, and respiratory distress. This study aimed to compare the clinical, laboratory, and treatment characteristics of hospitalized pediatric patients with croup who tested positive or negative for COVID-19 during the Omicron wave.</p><p><strong>Methods: </strong>A retrospective, descriptive-analytical study was conducted on 111 pediatric patients hospitalized with croup at Bahrami Children's Hospital and the Children's Medical Center in Iran from January 21 to March 20, 2022. Patients were categorized into two groups: PCR-positive (Omicron group, n = 30) and PCR-negative (non-Omicron group, n = 81). Data on demographics, clinical severity, laboratory indices, treatments, and outcomes were extracted and analyzed using SPSS version 20.</p><p><strong>Results: </strong>The mean age of the Omicron group was significantly younger (16.93 ± 24.80 months) compared to the non-Omicron group (32.58 ± 37.26 months; p = 0.049). Symptom severity was higher in the Omicron group, with moderate to severe symptoms observed in 73.4% of patients, compared to 32.1% in the non-Omicron group (p = 0.001). The Omicron group had longer hospital stays (2.59 ± 3.93 vs. 2.11 ± 2.75 days; p = 0.016) and required more nebulized epinephrine (2.47 ± 1.27 vs. 1.77 ± 1.003 days; p = 0.003) and repeat corticosteroid doses (83.3% vs. 38.3%; p = 0.0001). Laboratory findings showed no significant differences between the groups (all p > 0.05).</p><p><strong>Conclusion: </strong>Children with croup during the Omicron surge exhibited increased symptom severity, required more intensive treatment, and experienced longer hospital stays compared to those without COVID-19. These findings emphasize the need for heightened clinical awareness and tailored management strategies for Omicron-related croup in pediatric populations.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"194"},"PeriodicalIF":2.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive functions in everyday life in children born small for gestational age - a pilot study of pre-term to full-term children 3 years and younger.","authors":"Ida Kongstad, Suzanne Petersson","doi":"10.1186/s12887-025-05564-1","DOIUrl":"10.1186/s12887-025-05564-1","url":null,"abstract":"<p><strong>Background: </strong>Children born small for gestational age (SGA) have shown an increased risk of developing cognitive impairment and more difficulties regarding academic performance later in life. However, it is not known whether cognitive impairment can be detected in very young children. This study aimed to investigate whether children born SGA, with a birthweight of ≤ 3 SD, aged 2:6-3:0 years, showed impairments of executive functions in everyday life based on parental ratings, compared to children born appropriate for gestational age (AGA).</p><p><strong>Methods: </strong>Thirty children with birth week 33-41, 15 in each group, were included. The children in the groups were matched based on gender, age at testing (± 3 months), and parental educational level. Cognitive development was measured with the Bayley-III assessment. The BRIEF-P was used for parental ratings of the children's executive functioning.</p><p><strong>Results: </strong>In terms of development a statistically significant difference between groups was shown regarding language ability, where the SGA group performed slightly worse compared to the AGA group (MD = -10.5 index points; 95% CI = -18.7-2.2; t(14) = -2.7; p = 0.02). No statistically significant differences were found between groups regarding parental ratings on the BRIEF-P.</p><p><strong>Conclusions: </strong>The study found no significant differences in EF between children born SGA and AGA based on parental ratings. Given the small sample the lower language ability in the SGA group suggests potential EF impairments, which could be detected at a younger age than is presently customary. These findings underscore the need for further research using varied assessment methods and larger samples to better understand EF development in this population. Early discovery of EF impairment is important for enabling adequate interventions for family, school, and health care.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"196"},"PeriodicalIF":2.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial.","authors":"Mao-Wei Xing, Yue Zhang, Hui-Ting Zhu, Chang Liu, Zhi-Yu Geng, Lin-Lin Song, Dong-Xin Wang","doi":"10.1186/s12887-025-05543-6","DOIUrl":"10.1186/s12887-025-05543-6","url":null,"abstract":"<p><strong>Background: </strong>Whether intraoperative isotonic balanced maintenance fluid is associated with less variation in sodium homeostasis in small children undergoing major neurosurgery remains unknown.</p><p><strong>Methods: </strong>Patients aged up to 6 years undergoing major neurosurgery were randomly assigned to receive either isotonic balanced solution (IB) or 0.2% hypotonic solution (H) as intraoperative maintenance fluid. Serum electrolyte levels were measured from preoperative baseline to 6 d following surgery.</p><p><strong>Results: </strong>Eighty patients were included in the primary analysis. Serum sodium change was significantly less in the IB patients from the end of surgery continuing to 24 h following surgery (at the end of surgery: -1.4 ± 3.6 versus - 4.6 ± 3.5 mmol/l, P < 0.001; 24 h post: -1.2 ± 4.8 versus - 3.4 ± 2.5 mmol/l, P = 0.028). Twenty (50%) of the IB patients and 25 (63%) of the H patients had serum sodium change > 2.5 mmol/l 24 h following surgery (6.0 ± 3.4 versus 4.8 ± 2.1 mmol/l), with 13 (33%) of the IB patients and 25 (63%) of the H patients having sodium decrease > 2.5 mmol/l (6.4 ± 3.7 versus 4.8 ± 2.1 mmol/l) (P = 0.007). Seven patients in group IB experienced an increase in blood sodium levels exceeding 2.5 mmol/l (median, 4.1 [range 2.7 ∼ 9.2] mmol/l). Notably, 10 (25%) of the IB patients and 6 (15%) of the H patients had sodium variation > 5 mmol/l (median, 8.5 [range 5.1 ∼ 14.6] versus 7.2 [range 5.5 ∼ 11.1] mmol/l). Immediately following surgery till 24 h postoperatively, hyponatremia was less observed in the IB patients compared with that in the H patients. The IB patients had higher hemoglobin levels and less diuresis 48 h postoperatively. No symptoms including altered mental status, seizure, and circulatory overload were observed in all patients.</p><p><strong>Conclusion: </strong>Intraoperative isotonic balanced solution infusion resulted in statistically but not clinically minimal variation of sodium homeostasis and hemoglobin level postoperatively in small children undergoing major neurosurgery, compared to the use hypotonic solution. Potentially excessive sodium fluctuation following isotonic balanced maintenance fluid infusion should be cautioned, even for a brief period of infusion.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ).</p><p><strong>Registration number: </strong>ChiCTR2100046539. Registration date: May 21, 2021. Principal investigator: Lin-Lin Song.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"195"},"PeriodicalIF":2.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBV associated epiglottitis in an immunocompetent child.","authors":"Sharareh Babaei, Azin Momeni","doi":"10.1186/s12887-025-05547-2","DOIUrl":"10.1186/s12887-025-05547-2","url":null,"abstract":"<p><strong>Background: </strong>The article presents a case report of subacute epiglottitis in a healthy three-year-old child, secondary to Epstein-Barr Virus (EBV) infection. This case is particularly significant as EBV-related epiglottitis is extremely rare, with only one prior reported case in a pediatric patient.</p><p><strong>Case presentation: </strong>A previously healthy three-year-old boy developed fever, cough, and difficulty breathing, initially diagnosed as croup but worsened, leading to hospital admission with respiratory distress, odynophagia and dysphagia. He had a hoarse voice, inspiratory stridor, swollen neck lymph nodes, increased work of breathing and hypoxemia, but was otherwise alert and nontoxic. Laboratory tests confirmed acute EBV infection, and imaging showed an enlarged epiglottis. The patient received supportive care, including oxygen therapy, and did not require intubation.</p><p><strong>Conclusions: </strong>The case highlights the importance of considering EBV as a potential cause of epiglottitis in pediatric patients.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"192"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infant development at 14 months in the context of maternal objective and subjective birth experience and infant hair glucocorticoids.","authors":"Isabel Jaramillo, Luisa Bergunde, Corinna Müller-Stark, Marlene Karl, Victoria Weise, Clemens Kirschbaum, Susan Garthus-Niegel, Susann Steudte-Schmiedgen","doi":"10.1186/s12887-025-05528-5","DOIUrl":"10.1186/s12887-025-05528-5","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests maternal birth experience impacts infant health. Alterations of the infant's hypothalamus-pituitary-adrenal (HPA) axis are discussed as one possible underlying mechanism. This study aimed to investigate both objective and subjective birth experience as potential predictors of offspring's hair glucocorticoid concentrations (GCs) and infant development, respectively. Further, we examined the role of hair GCs for prospective infant development in different domains.</p><p><strong>Methods: </strong>n = 263 mothers participating in the prospective cohort study DREAM_HAIR completed questionnaires about their objective and subjective birth experience approximately eight weeks after birth. Additionally, hair samples from n = 286 infants were taken around ten days (neonatal hair GCs) and eight weeks after birth (infant hair GCs) and long-term integrated hair cortisol and cortisone levels were measured in scalp-near 2-cm segments. Infant development (communication, gross motor, fine motor, problem-solving, personal-social) was assessed 14 months after birth using the Ages and Stages Questionnaire - 3 (ASQ-3).</p><p><strong>Results: </strong>No significant associations were found between objective or subjective birth experience and most domains of infant development, except that a more negative objective birth experience predicted poorer fine motor skills. Additionally, a more negative objective birth experience was linked to lower infant hair cortisone levels and a higher cortisol/cortisone ratio, while a more negative subjective experience was associated with higher neonatal hair cortisol. Lower neonatal hair cortisone showed a link to poorer personal-social development. However, after correction for multiple testing, only the associations between a more negative objective birth experience and lower hair cortisone and a higher cortisol/cortisone ratio at eight weeks remained significant.</p><p><strong>Conclusions: </strong>Objective aspects of the birth experience may have a more enduring impact on infant hair GCs than maternal subjective perceptions, particularly with higher birth complications being linked to lower infant cortisone and a higher infant cortisol/cortisone ratio. Given that this ratio may indicate reduced enzymatic activity in converting cortisol to its inactive form, results suggest that birth complications could affect the infant's glucocorticoid metabolism. No robust associations were found between birth experiences or hair GCs and infant development. Further research in more diverse, at-risk populations is needed to clarify these complex relationships.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"191"},"PeriodicalIF":2.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of thrombospondin 1 as a novel biomarker in pediatric-onset systemic lupus erythematosus.","authors":"Chenxi Liu, Menglan Zhang, Lingyi Yan, Jie Luo, Zhijun Liu, Ting Liu, Yongmei Jiang","doi":"10.1186/s12887-025-05542-7","DOIUrl":"10.1186/s12887-025-05542-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the potential of thrombospondin 1 (TBS-1) as a biomarker for pediatric-onset systemic lupus erythematosus (pSLE) and investigated its association with clinical characteristics and other laboratory tests in pSLE.</p><p><strong>Methods: </strong>A total of 112 pSLE and 50 age-matched and gender-matched healthy controls (HCs) were recruited in this study from January 2022 to June 2023 at West China Second University Hospital, Sichuan university. Plasma TBS-1 levels were measured, and clinical and laboratory findings were collected from the medical database.</p><p><strong>Results: </strong>The plasma TBS-1 level was significantly lower in pSLE patients (26778 ng/mL, IQR: 9875-59011) compared to HCs (100583 ng/mL, IQR: 58327-189547) (P < 0.0001). ROC analysis demonstrated that TBS-1 could effectively differentiate pSLE patients and HCs (AUC: 0.845, 95%CI: 0.785-0.905, P < 0.0001) with an optimal cut-off was 49,937 ng/mL, yielding a sensitivity of 84% and specificity of 70.5% based on the Youden index. Compared to TBS-1 positive patients, TBS-1 negative patients exhibited significant reductions in hemoglobin, IgM, and fibrinogen levels.</p><p><strong>Conclusion: </strong>In light of the current data, the efficacy of TBS-1 as a biomarker in pSLE diverged from its performance in adult SLE. In summary, TBS-1 shows potential as a biomarker for pSLE, particularly in hematological manifestations. Further investigations are essential to delve into the immunomodulatory roles of TBS-1 in the autoimmune pathways of pSLE.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"190"},"PeriodicalIF":2.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}