Placental histology for infants with hypoxic ischaemic encephalopathy compared with healthy controls: a case-control study.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-04-14 DOI:10.1186/s12887-025-05652-2

Áine Fox, Emma Doyle, Adam Reynolds, Michael Geary, Rocco Cuzzilla, Breda Hayes

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Abstract

Background: The role of the placenta in the development of hypoxic ischaemic encephalopathy (HIE) remains undefined. There is limited research comparing placental histology for infants with HIE and healthy controls. This is limiting our ability to understand its role in HIE. This study hypothesised that placental pathology is more common in infants with HIE compared with healthy infants and aimed to report the differences in placental histology between infants with HIE and healthy controls.

Methods: A case-control study of infants with moderate andsevere HIE and healthy controls at a single tertiary Neonatal Intensive Care Unit. Placental histology was reviewed by one perinatal histopathologist using consensus guidelines.

Results: Seventy-four cases and 98 controls were included. Cases had a higher incidence of pathology, including fetal vascular malperfusion, histological chorioamnionitis and delayed villous maturation.

Conclusion: This study demonstrates a higher incidence of placental pathology for infants born with HIE suggesting that the placenta is an important factor in the pathogenesis of HIE. Further research is required to delineate this relationship.

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低氧缺血性脑病患儿胎盘组织学与健康对照：一项病例对照研究

背景：胎盘在缺氧缺血性脑病（HIE）发展中的作用尚不明确。比较HIE婴儿和健康对照组胎盘组织学的研究有限。这限制了我们理解它在HIE中的作用。本研究假设，与健康婴儿相比，胎盘病理在HIE婴儿中更常见，旨在报告HIE婴儿和健康对照组之间胎盘组织学的差异。方法：在单一三级新生儿重症监护病房对中度和重度HIE婴儿和健康对照进行病例对照研究。胎盘组织学由一位围产期组织病理学家使用共识指南进行审查。结果：纳入74例病例和98例对照。病例有较高的病理发生率，包括胎儿血管灌注不良，组织学绒毛膜羊膜炎和绒毛成熟延迟。结论：本研究显示先天性HIE患儿胎盘病理发生率较高，提示胎盘是HIE发病的重要因素。需要进一步的研究来描述这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.