BMC PediatricsPub Date : 2025-03-26DOI: 10.1186/s12887-025-05623-7
Shimlin Jahan Khanam, Badsha Alam, Awal Kabir, Nuruzzaman Khan
{"title":"Correction: Effects of disability on early childhood development in 3 to 4-year-old children in three South Asian countries: evidence from multiple indicators cluster surveys.","authors":"Shimlin Jahan Khanam, Badsha Alam, Awal Kabir, Nuruzzaman Khan","doi":"10.1186/s12887-025-05623-7","DOIUrl":"10.1186/s12887-025-05623-7","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"232"},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PediatricsPub Date : 2025-03-25DOI: 10.1186/s12887-025-05585-w
Ghayda Mohammad, Leen Abualhayja, Beesan Maraqa, Baraa Maraqa, Zaher Nazzal
{"title":"Prevalence and factors associated with nocturnal enuresis and social anxiety among Palestinian primary school children: a cross-sectional study.","authors":"Ghayda Mohammad, Leen Abualhayja, Beesan Maraqa, Baraa Maraqa, Zaher Nazzal","doi":"10.1186/s12887-025-05585-w","DOIUrl":"10.1186/s12887-025-05585-w","url":null,"abstract":"<p><strong>Background: </strong>Nocturnal enuresis (NE) is a prevalent pediatric condition with significant physical, psychological, and social impacts. This study aimed to determine the prevalence of NE among primary school children in Palestine and investigate its demographic and biopsychosocial associates.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from October 2023 to January 2024 in primary schools across the West Bank, Palestine. A sample of 1003 children from grades one to six were recruited using convenient sampling. Data were collected through an online questionnaire administered to parents, covering sociodemographic variables, NE, social anxiety and separational anxiety. Statistical analyses including Chi-square tests and binary logistic regression were performed.</p><p><strong>Results: </strong>The study reports a 27.9% prevalence of NE among 1,003 primary school children in the West Bank. The sample included 42.6% males and 57.4% females, with most attending public schools (65.3%) and 70.9% achieving excellent academic performance. Most fathers (79.3%) and mothers (94.9%) had higher education, and 37% of families reported a monthly income between 1,000 and 1,600 USD. NE was more prevalent in males (32.8%), children with lower academic performance (40.5%), and those from lower-income families. Significant factors associated with NE include being male (aOR: 1.6; 95% CI: 1.1-2.2), family history of NE (aOR: 6.1; 95% CI: 4.3-8.5), high fluid intake before bedtime (aOR: 1.6; 95% CI: 1.2-2.2), lower academic performance (aOR: 1.5; 95% CI: 1.1-2.1), daytime incontinence (aOR: 3.5; 95% CI: 1.4-8.5), and severe to extreme social anxiety (aOR: 7.4; 95% CI: 1.2-49.0).</p><p><strong>Conclusions: </strong>Considering the high prevalence of NE in the current study and its strong link with social anxiety, it underscores the need for integrated psychological support alongside medical management. Therefore, cooperation between health policymakers, healthcare providers, school staff, and families is essential to develop targeted interventions addressing both the physical and psychological impacts of NE, ultimately improving the quality of life for affected children and their families.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"231"},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PediatricsPub Date : 2025-03-25DOI: 10.1186/s12887-025-05446-6
Luis Blesa-Baviera, Ana Albors, Pedro Samblas, Úrsula Maraguat, Cristóbal Coronel-Rodríguez, Beatriz Abad, Elena Viciano, Francisco Javier Pérez-Sádaba, Cecilia Martínez-Costa
{"title":"Growth and gastrointestinal tolerance of healthy formula-fed infants: a multicentre, prospective observational study.","authors":"Luis Blesa-Baviera, Ana Albors, Pedro Samblas, Úrsula Maraguat, Cristóbal Coronel-Rodríguez, Beatriz Abad, Elena Viciano, Francisco Javier Pérez-Sádaba, Cecilia Martínez-Costa","doi":"10.1186/s12887-025-05446-6","DOIUrl":"10.1186/s12887-025-05446-6","url":null,"abstract":"<p><strong>Background: </strong>Infant formula with human milk oligosaccharides (HMOs) and increased β-palmitate mimics breast milk nutritional composition and clinical benefits. We aimed to assess formula-fed infant growth, gastrointestinal tolerance, infections, and parental satisfaction with a partly fermented infant formula with an improved lipid profile (enriched with β-palmitate and docosahexaenoic/arachidonic acid) and short and long-chain oligosaccharides (scGOS/lcFOS [9:1]) and HMOs.</p><p><strong>Methods: </strong>A prospective descriptive observational study in healthy infants with formula feeding or breastfeeding (reference population) was conducted in six Spanish primary care centres following routine clinical practice. In the first, second and fourth month of life visits sociodemographic, clinical, and anthropometric variables (weight, length, head circumference), stool consistency (Brussels Infant and Toddler Stool Scale [BITSS]), gastrointestinal symptoms, infections incidence and associated healthcare resource utilisation, and caregivers' satisfaction with formula were collected. A descriptive statistical analysis was performed (STATA-v.14). Growth was estimated as the mean (standard deviation) increase in the anthropometric variables and z-scores.</p><p><strong>Results: </strong>A total of 61 formula-fed and 65 breastfed infants were included in the study (50.8% male). The average increase in weight, length and head circumference in the formula feeding and in the breastfeeding groups from the first to the fourth month of life was 2,566 (496) g, 9.7 (1.7) cm and 4.4 (1.0) cm, and 2,571 (702) g, 9.8 (1.8) cm and 4.4 (1.1) cm, respectively. The weight z-score was -0.1 (0.7) for formula-fed and 0.1 (1.1) for breastfed infants. In all visits, more than 88% of infants had loose/watery stools and most infants suffered gastrointestinal symptoms with low/medium frequency. In the fourth month of life visit, 16 (26.2%) formula-fed and 16 (24.6%) breastfed infants had infections, mainly respiratory, with 16% of formula-fed and 12% of breastfed infants requiring treatment. Most formula-feeding caregivers had a good/very good opinion of formula (85.2%). 75.4% infants drank the whole feeding bottle.</p><p><strong>Conclusions: </strong>The growth, gastrointestinal tolerance, and incidence of infections of healthy formula-fed infants during the first four months of life were appropriate and in line with WHO standards. Formula feeding caregivers were satisfied with this partly fermented infant formula with an improved lipid profile and oligosaccharides.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"229"},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emotion regulation skills, brain-derived neurotrophic factor, cortisol hormone levels in primary school students in Türkiye: a cross-sectional and correlational analysis study.","authors":"Zila Özlem Kırbaş, Bülent Bayraktar, Elif Odabaşi Aktaş","doi":"10.1186/s12887-025-05576-x","DOIUrl":"10.1186/s12887-025-05576-x","url":null,"abstract":"<p><strong>Background: </strong>Hormones are molecules that contribute significantly to mental and physical health due to their role in emotion regulation (ER) processes. However, the role and effect of hormones on the ER has not yet been fully elucidated. In this study, it was aimed to examine the salivary Brain-derived neurotrophic factor (BDNF) and cortisol hormone response to support ERS in primary school students depending on some parameters.</p><p><strong>Method: </strong>This cross-sectional and correlational study was conducted in the Eastern Black Sea Region of Türkiye between April 2023 and June 2023. In the sample selection, after the number of students was determined in proportional stratification, the sample selection method was made by simple random selection from each class list, first according to the school and then the grade level of each school. A total of 177 healthy students between the ages of 8 and 10 who attended these schools, were allowed to participate in the research by their families, and were volunteers, were included in the study. Data were collected using the Personal Information Form and the Emotion Regulation Scale for Children and saliva collection cups. Human-specific Brain-derived neurotrophic factor ELISA Kit (BT LAB, Cat.No E1302Hu, CHINA) for measuring BDNF levels in saliva; In measuring the level of cortisol hormone in saliva, Human Cortisol ELISA Kit (BT LAB, Cat.No E 1 003Hu, CHINA) was used in accordance with the procedure specified in the manufacturer's catalogue. Data were evaluated using the SPSS 26.0 for Windows (SPSS, Chicago, Il, USA) package program. Independent Samples Test and One-Way ANOVA test, correlation and Multiple Linear Regression analysis were used to evaluate the data. P <.01 and p <.05 significance levels were used as statistical significance values.</p><p><strong>Results: </strong>A statistically significant correlation was found between the mean total score of the Emotion Regulation Skills Scale for Children and the mean level of salivary BDNF, and a negative correlation between the mean level of salivary cortisol (p˂0.01).</p><p><strong>Conclusions: </strong>Within the scope of the data obtained in our current study, BDNF levels were found to be high and cortisol hormone levels to be low in children with high ERS.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"230"},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Swenson-like pull-through for treatment of the rare association between Hirschsprung's disease and anorectal malformation.","authors":"Mohamed Abdelmalak, Mohamed Mansy, Hazem Khafaga, Yasmine Ghazaly, Reem Saeed, Nada Yakout, Saber Waheeb, Mostafa Zain","doi":"10.1186/s12887-025-05549-0","DOIUrl":"10.1186/s12887-025-05549-0","url":null,"abstract":"<p><strong>Background: </strong>Anorectal malformations and Hirschsprung's disease are congenital conditions impacting the digestive system, with a particularly uncommon co-occurrence, estimated at 2-3% of all ARM cases. This case series explores this rare association through three distinct cases, each presenting unique clinical challenges and insights.</p><p><strong>Methods: </strong>We report a series of five patients with ARM who were concurrently diagnosed with HD based on clinical and radiological evaluations, with definitive confirmation obtained through rectal biopsy. In cases where HD was diagnosed after the complete surgical repair of ARM, the patients underwent a Swenson-like pull-through procedure. Notably, the anastomosis was created approximately 3 cm from the anal verge, rather than the conventional 3 cm from the dentate line.</p><p><strong>Results: </strong>This study reviewed the records of 136 ARM patients treated at our center over five years, identifying five cases with concurrent HD. In three of these cases, HD was initially overlooked and diagnosed only after ARM repair. These patients underwent a Swenson-like pull-through procedure. During follow-up, two patients achieved good bowel control without fecal soiling, while the third had regular bowel movements and satisfactory growth, albeit with occasional episodes of enterocolitis managed medically. The remaining two cases were identified earlier, following colostomy, which led to a different management approach.</p><p><strong>Conclusion: </strong>This case series underscores the critical importance of considering HD in patients with ARM who present with persistent, atypical gastrointestinal symptoms post-surgical repair of their ARM. Preservation of the aganglionic neoanal canal with a subsequent Swenson pull-through appeared beneficial to achieve good postoperative continence.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"228"},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PediatricsPub Date : 2025-03-24DOI: 10.1186/s12887-025-05567-y
Qiong Wang, Min Yang, Kening Chen, Fangjieyi Zheng, Zhixin Zhang, Wenquan Niu
{"title":"Clustering unhealthy lifestyle factors in Chinese children and adolescents with overweight or obesity.","authors":"Qiong Wang, Min Yang, Kening Chen, Fangjieyi Zheng, Zhixin Zhang, Wenquan Niu","doi":"10.1186/s12887-025-05567-y","DOIUrl":"10.1186/s12887-025-05567-y","url":null,"abstract":"<p><strong>Background: </strong>This study used latent class analysis (LCA) to examine the potential patterns of unhealthy lifestyle factors (ULFs) and their association with overweight and obesity in children and adolescents with overweight or obesity in China.</p><p><strong>Methods: </strong>We conducted three cross-sectional surveys, recruiting 7,927 children with obesity or overweight from September 2019 to January 2022. We used LCA to identify patterns of co-occurrence of ULFs based on seven types of behaviors. Multinomial logistic regression model was constructed to examine the association of fetal and neonatal factors with the clusters of ULFs.</p><p><strong>Results: </strong>Of 7,927 participants, 7,627 (96.78%) had at least one ULF, and 6,942 (87.57%) had two or more ULFs concurrently. Using LCA, four distinct clusters were identified based on the elbow point of the Akaike's information criterion (AIC), that is, \"unhealthy food intake but long sleeping\", \"relative health\", \"healthy food intake but unhealthy eating-sleeping-sitting habits\", and \"unhealthy food intake and unhealthy sitting-activity habits\". Moreover, several factors including sex, age, infancy feeding, parental obesity, and parental age were significantly associated with the clusters of ULFs.</p><p><strong>Conclusions: </strong>We provide evidence on how multiple ULFs in combination may influence health among Chinese children and adolescents with overweight or obesity, and we agree that further external validations are warranted.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"226"},"PeriodicalIF":2.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lactescent urine following pediatric cardiac surgery due to catheter migration.","authors":"Violette Suc, Mathilde Grapin, Ayman Haydar, Olivier Raisky, Ségolène Bernheim","doi":"10.1186/s12887-025-05589-6","DOIUrl":"10.1186/s12887-025-05589-6","url":null,"abstract":"<p><strong>Background: </strong>Central venous catheterization is crucial for the perioperative and postoperative management of neonatal cardiac surgery patients. The procedure can be challenging due to the small size of the vessels, and it carries a high risk of morbidity and mortality. The most common sites for catheter insertion are the jugular or femoral veins; however, jugular access is typically avoided in patients with univentricular heart disease. The most frequent complications associated with central venous catheters are thromboembolic events and infections. Here, we present a case of lactescent urine in the postoperative period following cardiac surgery, attributed to the migration of a central venous catheter into the renal vein.</p><p><strong>Case presentation: </strong>We report the case of a newborn with an antenatal diagnosis of type B aortic arch interruption, who underwent complete surgical correction on day 9 of life. The infant presented with lactescent urine on postoperative day 5. Extensive investigations revealed that the central venous catheter had migrated into the right renal vein.</p><p><strong>Conclusion: </strong>Lactescent urine is an uncommon presentation in children and is most often associated with parasitic infections. In our case, this condition was related to the diffusion of parenteral nutrition into the renal vein. This case illustrates a rare postoperative complication, where a central venous catheter migrated into the renal vein following cardiac surgery.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"227"},"PeriodicalIF":2.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PediatricsPub Date : 2025-03-22DOI: 10.1186/s12887-025-05592-x
Ipek Altunoz, Ozcan Aygun
{"title":"Validity and reliability of the European health literacy child form in Turkish children.","authors":"Ipek Altunoz, Ozcan Aygun","doi":"10.1186/s12887-025-05592-x","DOIUrl":"10.1186/s12887-025-05592-x","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to assess the validity and reliability of the European Health Literacy Scale Child Form in Turkish children and to examine the instrument's psychometric properties.</p><p><strong>Design and methods: </strong>A total of 843 students aged 9-11 years in primary and secondary school were included in this scale adaptation study. In the validity analyses of the Health Literacy Scale Child Form-Turkish form (HLS-Child-Q15-TR), language and content validity were used to determine cultural compatibility, and exploratory and confirmatory factor analysis were used in structural analyses. Reliability was investigated by examining internal consistency and test-retest reliability.</p><p><strong>Results: </strong>The content validity of the HLS-Child-Q15-TR was found to be high. The model fit values of the confirmatory factor analysis results of the three-factor model consisting of health care, disease prevention and health promotion dimensions of the HLS-Child-Q15-TR were found to be satisfactory (x2/df = 2.68, CFI = 0.945, GFI = 0.965, and RMSEA = 0.045). HLS-Child-Q15-TR item-total correlations were above 0.30 and Cronbach's alpha coefficient was 0.831. The test-retest correlation coefficient of the HLS-Child-Q15-TR was 0.98 and stable over time.</p><p><strong>Conclusions: </strong>HLS-Child-Q15-TR is valid and reliable in Turkish children aged 9-11 years. It is recommended that the valid and reliable HLS-Child-Q15-TR be used to measure the health literacy levels of Turkish children under 12 years of age.</p><p><strong>Practice implications: </strong>HLS-Child-Q15-TR valid and reliable instrument for use with Turkish children aged 9-11 years. HLS-Chıld-Q15-TR will make an important contribution to the Turkish culture in evaluating the health literacy levels of children 9-11 years age in Turkey.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"225"},"PeriodicalIF":2.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical diagnostic value of throat swabs in pediatric acute lower respiratory tract infections using targeted next-generation sequencing.","authors":"Di Lian, Chenye Lin, ZhiNan Zhang, JianXing Wei, Dong Wang, QiuYu Tang","doi":"10.1186/s12887-024-05380-z","DOIUrl":"10.1186/s12887-024-05380-z","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the clinical utility of targeted next-generation sequencing (tNGS) for pathogen detection of pediatric acute lower respiratory tract infections (ALRTIs), with a particular focus on the use of throat swab samples.</p><p><strong>Methods: </strong>In this diagnostic accuracy study involving 132 children, throat swabs and bronchoalveolar lavage fluid (BALF) samples were collected and analyzed by tNGS, and the results were compared with those obtained from conventional diagnostic methods. The impact of prior antibiotic use on the detection rate of tNGS was evaluated, the consistency between throat swabs and BALF was assessed, and the economic cost and invasiveness of the sampling methods were examined.</p><p><strong>Results: </strong>This study enrolled 132 children, of whom 79 (60%) were boys and 53 (40%) were girls. Ninety-two (70%) of the patients had fever, and 128 (97%) had a cough. The detection rates of bacteria, viruses, and atypical pathogens in BALF samples by tNGS were 89.5% (n = 68), 98.2% (n = 108), and 77.8% (n = 63), respectively. Compared to traditional detection methods, tNGS showed significantly higher detection rates for bacteria and viruses (P < 0.001), but there was no statistically significant difference in the detection of atypical pathogens (P = 0.59). The use of antibiotics had no significant effect on bacterial detection by tNGS (P = 0.237). Using BALF-tNGS as the \"gold standard,\" the sensitivities of tNGS of throat swabs for detecting bacteria, viruses, and atypical pathogens were 95.83%, 88.16%, and 92.06%, respectively, with specificities of 55.95%, 83.93%, and 100%. In the analysis of economic costs and invasiveness, the cost of throat swab sampling was significantly lower than that of BALF sampling, and the associated pain score and complication rate were significantly lower (P < 0.05).</p><p><strong>Conclusions: </strong>tNGS with throat swabs offers higher sensitivity and specificity than traditional methods for diagnosing pediatric ALRTIs. As such, it offers a less invasive, more cost-effective alternative to BALF sampling.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"224"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut microbiota signatures in food allergy children without and with malnutrition: a cross-sectional study.","authors":"Xiaojiao Zhang, Hengying Chen, Yiyuan Wang, Qiujin Xu, Xinzu Qiu, Li Cheng, Qizhi Xiao, Yanhong Liu, Jianduan Zhang, Hongzhong Zhang, Hongyuan Wu","doi":"10.1186/s12887-025-05578-9","DOIUrl":"10.1186/s12887-025-05578-9","url":null,"abstract":"<p><strong>Background: </strong>Altered gut microbiota (GM) profiles have been documented in children with food allergies (FA) and experiencing malnutrition. This study explored the GM composition in children with FA across varying degrees of malnutrition including those without malnutrition and those with different severity levels.</p><p><strong>Methods: </strong>Fresh faecal samples were collected from 120 children aged 1-6 years, including 40 FA children with adequate weight (FANM), 40 FA children with malnutrition (FAM), and 40 healthy controls. The hypervariable region of the 16 S rDNA gene was subsequently sequenced to assess bacterial communities.</p><p><strong>Results: </strong>Compared with healthy controls, the FANM group displayed a greater increase in the alpha diversity index. The FAM group exhibited an increase in seven genera, including Alistipes and Parabacteroides, compared to the control group, whereas nine genera were enriched in the FANM group. An analysis of clinical characteristics revealed a positive correlation between the relative abundance of the genus Faecalibacterium and the total IgE level. Fourteen pivotal microbial markers demonstrated substantial classification potential (AUC: 89.86%, 95% CI: 76.40-99.73% for FAM; AUC: 88.92%, 95% CI: 73.58-99.65% for FANM).</p><p><strong>Conclusion: </strong>FA children exhibit distinct GM profiles depending on the presence of malnutrition, which suggests the need for tailored microbiota-targeted therapies.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"220"},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}