BMC Pediatrics最新文献

{"title":"Beyond the homozygous paradigm: symptomatic partial biotinidase deficiency in a heterozygous child-first case report from Nepal.","authors":"Jagdish Kunwar, Bijay Kunwar, Anup Ghimire, Aramva Bikram Adhikari, Binay Aryal, Sachchu Thapa, Bina Prajapati Manandhar","doi":"10.1186/s12887-025-05822-2","DOIUrl":"10.1186/s12887-025-05822-2","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"450"},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of bronchiolitis post-COVID-19 pandemic in children less than 2 years old in 2021-2024: experience from a tertiary center in Saudi Arabia.","authors":"Rawan Alrashed, Ibtihal Almeshawi, Asmaa Alshammari, Wateen Alhamoud, Reem AlShathri, Aliyah Alotaibi, Danyah Saja, Yara Algoraini","doi":"10.1186/s12887-025-05801-7","DOIUrl":"10.1186/s12887-025-05801-7","url":null,"abstract":"<p><strong>Background: </strong>Bronchiolitis, a common lower respiratory tract infection in children under 2, is primarily caused by respiratory syncytial virus (RSV). During the coronavirus disease (COVID-19) pandemic, respiratory infections initially decreased due to non-pharmaceutical interventions; however, patients with bronchiolitis have surged in the post-pandemic period. This study examined the burden and severity of bronchiolitis in the post-COVID era in a tertiary center in Saudi Arabia.</p><p><strong>Methods: </strong>This retrospective review was conducted on pediatric patients aged < 2 years who were diagnosed with bronchiolitis at a tertiary hospital in Riyadh between September 2021 and March 2024. The collected data included demographics, comorbidities, viral polymerase chain reaction results, clinical management, disposition, and outcomes. Statistical analysis was performed using SPSS, with statistical significance at p < 0.05.</p><p><strong>Results: </strong>Out of 482 patients, 56% were male, with a mean age of 6.37 months. RSV was the most common virus (53.79%) among the 132 tested patients. Oxygen therapy was administered to 93.15% of patients, with only 4.36% requiring high-flow nasal cannula and 0.41% requiring intubation. Pediatric Intensive Care Unit admission was necessary for 5.6%, with most managed with non-invasive support. Complications were infrequent; only 4.77% developed pneumonia.</p><p><strong>Conclusions: </strong>The findings reflect a significant increase in patients with bronchiolitis post-COVID, consistent with the global trends. Despite this increase, most patients required minimal intervention, aligning with pre-pandemic management practices. This study highlighted the post-pandemic resurgence of bronchiolitis. While the caseload has increased, outcomes remain favorable, reinforcing the importance of supportive care and judicious resource allocation during the bronchiolitis season.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"453"},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the impact of participation in a multidisciplinary family lifestyle intervention on exercise and diet quality during treatment for childhood cancer: the VIE program.","authors":"Ariane Levesque, Daniel Curnier, Valérie Marcil, Véronique Bélanger, Isabelle Bouchard, Josianne Delorme, Caroline Laverdière, Caroline Meloche, Melanie Napartuk, David Ogez, Émélie Rondeau, Katherine Péloquin, Daniel Sinnett, Maxime Caru, Serge Sultan","doi":"10.1186/s12887-025-05727-0","DOIUrl":"10.1186/s12887-025-05727-0","url":null,"abstract":"","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"452"},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in pulmonary microbiota of severe community-acquired pneumonia with different pathogenic microorganisms in children.","authors":"Yingying Luo, Ruxi Wu, Weiwei Wu, Deyu Zhao, Yazhou Jiang, Haiyan Gu","doi":"10.1186/s12887-025-05819-x","DOIUrl":"10.1186/s12887-025-05819-x","url":null,"abstract":"<p><strong>Background: </strong>Community-acquired pneumonia (CAP) is the leading cause of hospitalization and death in children under 5 years old. Recently, the number of children with severe CAP (SCAP) has increased significantly, and local or systemic complications may occur. However, changes in the pulmonary microbiota of SCAP with different pathogens and their relationship with the clinical features of SCAP remain unclear.</p><p><strong>Methods: </strong>This study collected bronchoalveolar lavage fluid (BALF) from 105 children with SCAP for metagenomics next generation sequencing (mNGS). According to the first pathogen of mNGS, the enrolled children were divided into the Streptococcus pneumoniae (SP), Mycoplasma pneumoniae (MP) and Haemophilus influenzae (HI) groups. We aimed to explore differences in clinical features and pulmonary microbiota of SCAP with different pathogens, and clarify the correlation between pulmonary microbiota and clinical features.</p><p><strong>Results: </strong>Fever days and the levels of C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), D-dimer and heparin-binding protein (HBP) of children in MP group were significantly higher than those in HI group. The level of LDH of children in MP group was significantly higher than that in SP group. The abundance of MP was also positively correlated with fever days and the levels of PCT, LDH and D-dimer. The α diversity of SP group was significantly increased compared to MP group and HI group.</p><p><strong>Conclusion: </strong>Compared to SP-infected and HI-infected children with SCAP, children with SCAP infected with MP tend to have a more intense inflammatory response. The α diversity was higher in the lower airways of children with SCAP and SP infections compared to MP-infected and HI-infected children with SCAP.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"449"},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth in the first two years in children born to mothers infected with COVID-19 during pregnancy: a cohort study.","authors":"Habibe Nejad Biglari, Atefeh Ahmadi, Katayoun Alidousti, Malihe Pouredalati, Forouzandeh Kalantari, Effat Kargar, Farzaneh Salajegheh Tezerji, Sahebeh Dadshahi, Parya Jangipour Afshar, Hamid Sharifi, Masumeh Ghazanfarpour, Fatemeh Janipour, Fariba Heidari","doi":"10.1186/s12887-025-05663-z","DOIUrl":"10.1186/s12887-025-05663-z","url":null,"abstract":"<p><strong>Introduction: </strong>Because the impact of COVID-19 on the growth of infants whose mothers were infected with this virus during pregnancy is unclear, this study investigated the effect of mothers' infection with this virus during pregnancy on their infant's growth during the first two years of life.</p><p><strong>Method: </strong>In this prospective cohort study, the available information from 697 mothers referring to Iran's health care centers for pregnancy and breastfeeding care was used to compare the growth of 367 children born to mothers infected with COVID-19 during pregnancy with that of 330 children born to mothers who were not infected and not exposed to COVID-19 during pregnancy. Their growth was evaluated for two years.</p><p><strong>Results: </strong>Concerning the weight, height, and head circumference 6 months, 12 months, and 24 months after birth, although the values obtained in the exposed group were slightly higher than the non-exposed group, no statistically significant difference was observed (P > 0.05). Comparing the exposed group's growth indices (weight, height, and head circumference) based on whether the mother was infected with COVID-19 during the first, second, or third trimester showed no significant difference (P > 0.05). The birth height of the babies whose mothers infected with COVID-19 in the first and second trimesters of pregnancy was slightly lower than those whose mothers were infected in the third trimester (P = 0.019). Children in the exposed group weighed 76.61 g more than those in the non-exposed group (P = 0.018).</p><p><strong>Conclusion: </strong>More long-term studies in different populations about growth of children are needed to generalized the findings.</p><p><strong>Clinical trial number: </strong>Not applicable (A cohort study).</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"448"},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of social support on the social adaptive behaviors of children with acute leukemia in China: the mediating role of family functioning.","authors":"Shen Yuqing, Mo Lin, Yu Lu, Chen ZeFang, Liu Tao, Zeng Yan, Sabika","doi":"10.1186/s12887-025-05775-6","DOIUrl":"10.1186/s12887-025-05775-6","url":null,"abstract":"<p><strong>Background: </strong>Children with acute leukaemia often have adverse social adaptive behaviors during treatment, and good social support and family function are considered to be important protection factors. However, little is known about the interaction mechanism of social adaptive behaviors, social support and family function in children with acute leukaemia. This study aimed to explore the mediating role of family function in social support and social adaptive behaviors of children with acute leukemia in China.</p><p><strong>Methods: </strong>From August to December 2022, face-to-face data collection was conducted using convenience sampling in the Blood Department of a 3 A Children's Hospital in Chongqing, China. A total of 202 caregivers of children with acute leukemia participated in the questionnaire. Children's Adaptive Behavior Scale, family function scale and social support scale were used for evaluation. AMOS 26.0 structural equation modelling method was adopted, and Pearson correlation analysis and deviation-corrected centile Bootstrap method were adopted for analysis.</p><p><strong>Results: </strong>Among the 202 participants, 22.77% (46/202) of the children with acute leukaemia showed adverse social adaptive behaviors. Social support, family functioning and social adaptive behaviors demonstrated significant correlations(r = 0.318、-0.392,p < 0.05). It is worth noting that family functioning has a full mediating effect on social support and social adaptive behaviors.</p><p><strong>Conclusions: </strong>The evidence provided by this study indicates that social support can positively predict social adaptive behaviors, family functioning can negatively predict social adaptive behaviors, and family functioning mediates the relationship between social support and social adaptive behaviors.This study attributes to the development of precise interventions for caregivers for socially adapted behaviours in children with acute leukaemia and has important implications for policy development to improve the social adaptation of children with leukaemia.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"447"},"PeriodicalIF":2.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric pancreatectomy for neoplasms: indications, outcomes, and implementation of minimally invasive surgery in a Ukrainian tertiary center.","authors":"Veronika Rozhkova, Anton Burlaka, Oleksandr Kvasivka, Ivan Lisnyy, Andriy Beznosenko, Kostiantyn Kopchak, Dmytro Cheverdiuk, Andrii Lukashenko","doi":"10.1186/s12887-025-05802-6","DOIUrl":"10.1186/s12887-025-05802-6","url":null,"abstract":"<p><strong>Purpose: </strong>Pancreatic neoplasms are rare in children, resulting in limited data on pancreatectomy within this population. Our case series aims to contribute to the understanding of the indications, long- and short-term outcomes of surgical treatment for both benign and malignant pancreatic neoplasms in children.</p><p><strong>Methods: </strong>This is a retrospective review of pediatric patients (≤ 18 years old) who underwent resection for pancreatic neoplasms in a single tertiary referral center from July 2003 to November 2023.</p><p><strong>Results: </strong>Overall, 31 patients with a median age of 13 years (range 1-15) were included in the study. Solid pseudopapillary neoplasm was diagnosed in 15 (48%) patients, neuroendocrine tumor- 7 (23%), serous cystadenoma- 2 (6%), pancreatic ductal adenocarcinoma- 2 (6%), pancreatoblastoma- 2 (6%), and lymphoma- 1 (3%). There were two rare cases of mature cystic teratoma and pancreatic paraganglioma. 20 (65%) distal pancreatectomies, 7 (23%) pancreaticoduodenectomies, and 4 (13%) tumor enucleations were performed. The laparoscopic approach was applied in 9 (29%) cases in the last seven years. There were 4 (13%) complications Clavien-Dindo ≥ 3, and no cases of perioperative mortality. The median follow-up was 114 months (range 10-131 months). 87% (27/31) of patients were alive without tumor recurrence.</p><p><strong>Conclusions: </strong>Surgical treatment remains the best chance for cure in patients with pancreatic neoplasms. These complex surgeries can be safely performed in the pediatric population with good long-term results. Advances in minimally invasive technique allow transition to less traumatic surgery in these patients.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"441"},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein and serum amyloid A protein as complementary biomarkers in differentiating viral and bacterial community-acquired pneumonia in children.","authors":"Juan Cheng, Ying Wu, Hui Ma, Mingyu Tang, Yufen Wu, Yong Yin, Qiuhui Pan, Qizhi Diao, Jing Zhang","doi":"10.1186/s12887-025-05770-x","DOIUrl":"10.1186/s12887-025-05770-x","url":null,"abstract":"<p><strong>Objective: </strong>Distinguishing between viral and bacterial community-acquired pneumonia (CAP) in children is crucial for guiding targeted management and antibiotic use. This study aimed to evaluate the efficacy of serum amyloid A protein(SAA) and C-reactive protein (CRP) as biomarkers to differentiate viral from bacterial CAP in children.</p><p><strong>Methods: </strong>A total of 441 hospitalized children with a confirmed diagnosis of CAP were initially selected. Of these, 206 met the inclusion and exclusion criteria, including 132 cases of viral pneumonia and 74 cases of bacterial pneumonia. Baseline data and clinical characteristics were collected. Respiratory pathogen detection and blood biomarker measurements, including SAA and CRP levels, were completed within 24 h of admission. Receiver operating characteristic (ROC) curves were plotted to evaluate the effectiveness of SAA, CRP, and their combination in differentiating between viral and bacterial CAP.</p><p><strong>Results: </strong>Fever (body temperature ≥ 38 °C) was more frequently observed in the bacterial CAP group (95.9%) compared to the viral CAP group (75%, P = 0.000). Wheezing was more prevalent in the viral CAP group (40.2% vs. 24.3%, P = 0.022). CRP and SAA levels were significantly higher in the bacterial CAP group (CRP: 27.6 (6.5, 49.4) mg/L vs. 3 (0.7, 8.4) mg/L, P = 0.000; SAA: 190.1 (70, 297.4) mg/L vs. 13.5 (1.4, 48.2) mg/L, P = 0.000). The area under the ROC curve for CRP and SAA was 0.84 (0.78 ∼ 0.90) and 0.85 (0.79 ∼ 0.91), respectively. The cutoff points were 86.55 mg/L for SAA and 19.65 mg/L for CRP, with sensitivities of 86.9% and 94.6%, and specificities of 73.0% and 63.5%, respectively. Combining SAA and CRP detection with clinical symptoms increases specificity to 93.2% and 97.3% but reduces sensitivity to 31.3% and 22.7% in distinguishing viral from bacterial pneumonia. Multivariate regression analysis confirmed that CRP was an independent predictor of bacterial pneumonia (OR = 1.098, P < 0.001) and was strongly correlated with SAA (Pearson r = 0.816, P < 0.001).</p><p><strong>Conclusion: </strong>CRP and SAA are effective biomarkers for distinguishing between viral and bacterial CAP in children, with CRP demonstrating independent predictive value. The combined detection of CRP and SAA, along with clinical symptoms (such as fever or wheezing), significantly enhances diagnostic specificity but requires a trade-off with reduced sensitivity. This finding provides important evidence for the early precise classification of pediatric CAP and the rational use of antibiotics, but its clinical value still needs to be validated through larger-scale multicenter studies.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"445"},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Single surgeon\" and \"single site\" total thoracoscopic surgery for paediatric extralobular pulmonary sequestration.","authors":"Rui Guo, Yunpeng Zhai, Huashan Zhao, Gang Shen, Sai Huang, Longfei Lv, Honghao Song, Shisong Zhang","doi":"10.1186/s12887-025-05806-2","DOIUrl":"10.1186/s12887-025-05806-2","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical outcomes of \"Single Surgeon\" and \"Single Site\" total thoracoscopic surgery with multi-portal video-assisted thoracic surgery (M-VATS) in the treatment of paediatric extralobar sequestration (ELS), and to evaluate its safety and feasibility in routine practice.</p><p><strong>Methods: </strong>We retrospectively analysed 51 paediatric ELS cases treated thoracoscopically at our institution from January 2020 to March 2025. Patients were grouped by surgical approach: 18 underwent single-site thoracoscopy, and 33 underwent M-VATS. Clinical parameters were compared between groups.</p><p><strong>Results: </strong>Compared to M-VATS, the single-site group showed significantly reduced operative time (P = 0.02), blood loss (P < 0.01), hospital stay (P < 0.01), and expenses (P < 0.01). No bronchopleural fistulas, postoperative pneumonia, or conversions to open surgery occurred in either group.</p><p><strong>Conclusions: </strong>\"Single Surgeon\" and \"Single Site\" thoracoscopic surgery offers distinct advantages, including minimized incisions, faster recovery, and reduced resource consumption, aligning with modern minimally invasive and enhanced recovery practices. The technique demonstrates safety, efficiency, and cost-effectiveness, supporting its broader clinical adoption.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"446"},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In their eyes: parental experiences navigating pediatric glaucoma diagnosis, treatment, and care in Turkey - a qualitative study.","authors":"Cansu Yuksel Elgin, Ceyhun Elgin","doi":"10.1186/s12887-025-05813-3","DOIUrl":"10.1186/s12887-025-05813-3","url":null,"abstract":"<p><strong>Background: </strong>Pediatric glaucoma is a rare but vision-threatening condition requiring complex, lifelong management. While clinical outcomes have been well-documented, little is known about the lived experiences of families navigating this condition, particularly in middle-income countries. This study aimed to explore how parents in Turkey experience and navigate the diagnosis, treatment, and ongoing care of a child with pediatric glaucoma.</p><p><strong>Methods: </strong>We conducted a qualitative exploratory study using semi-structured interviews with parents of children diagnosed with pediatric glaucoma in Turkey. Twenty-two parents (17 mothers, 5 fathers) representing 20 children with various forms of pediatric glaucoma participated. Participants were recruited through pediatric ophthalmology clinics, social media, and snowball sampling. Interviews were conducted remotely, audio-recorded, transcribed verbatim, and analyzed using thematic analysis.</p><p><strong>Results: </strong>Six major themes emerged: (1) Diagnosis Journey: Shock, Confusion, and the Search for Answers; (2) Treatment Burden: Managing Complex Care Regimens; (3) Navigating the Healthcare System: Structural Barriers and Facilitators; (4) Impact on Family Life: Adjustments, Limitations, and Emotional Tolls; (5) Coping and Resilience: Finding Strength Amid Challenges; and (6) Unmet Needs and Recommendations for System Improvement. Parents reported significant geographical disparities in access to specialist care, substantial financial burdens despite universal health coverage, and lack of psychological support and Turkish-language information resources. Parents demonstrated remarkable resilience through peer support networks, religious faith, and sophisticated medication management strategies, but identified critical gaps in the healthcare system that impeded optimal care.</p><p><strong>Conclusions: </strong>Pediatric glaucoma affects not only vision but all aspects of family life, including finances, sibling relationships, and parental wellbeing. Findings highlight the need for family-centered care models that address both clinical and psychosocial dimensions of pediatric glaucoma. Implementing teleophthalmology services, developing regional expertise through hub-and-spoke models, integrating psychological support, and creating accessible educational resources in Turkish could significantly improve family experiences. This first qualitative study from Turkey provides insights relevant to other middle-income countries with similar healthcare systems.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"444"},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}