BMC Pediatrics最新文献

{"title":"Osteopathic treatment of infants with infantile colic/excessive crying: a prospective, multicentric, randomized controlled trial and nested observational trial.","authors":"Florian Schwerla, Marlen Zimmer, Janine Göpfert, Petra Laux, Simone Langenmair, Michaela Rütz, Karl-Ludwig Resch","doi":"10.1186/s12887-025-05413-1","DOIUrl":"10.1186/s12887-025-05413-1","url":null,"abstract":"<p><strong>Background: </strong>Colic in infants is defined as excessive crying in an otherwise healthy and thriving baby. Colic is a common but poorly understood and often frustrating problem for caregivers.</p><p><strong>Objective: </strong>To study whether osteopathic treatments of infants with infantile colic / excessive crying (IC/EC) have an impact on the subjectively perceived psychological stress of caregivers compared to usual care.</p><p><strong>Methods: </strong>The study was designed as a prospective, multicenter, randomized controlled trial. Infants aged 1 week to 3 months and who met Rome IV criteria for IC/EC were included. By means of external randomization, infants were allocated to an intervention group or a control group. Infants in the intervention group received three osteopathic treatments at intervals of one weeks. The treatments were custom-tailored and based on osteopathic principles. Controls received their osteopathic treatment after a 3 week untreated period. The primary outcome parameter was the assessment of parental psychological stress (three questions), measured using a numeric rating scale (NRS; 0-10). Furthermore, the average daily crying time (measured using the Likert scale), the crying intensity (measured using the NRS) and the parents' self-confidence (measured using the Karitane Parenting Confidence Scale) were assessed.</p><p><strong>Results: </strong>A total of 103 infants (average age 39.4 ±19.2 days) were included, 52 in the intervention group and 51 in the control group. An inter-group comparison of changes revealed clinically relevant improvements in favor of the intervention group for the main outcome - parameter psychological stress - for all 3 questions (e.g., for question 2 respectively 3, NRS: between group difference of means 3.5; 95% CI: 2.6 to 4.4; p < 0.001). For the secondary outcome parameters of crying intensity and crying time/day, the changes were of similar magnitude.</p><p><strong>Conclusion: </strong>Three osteopathic treatments given over a period of two weeks led to statistically significant and clinically relevant positive changes of parental psychological stress.</p><p><strong>Trial registration: </strong>German Clinical Trials Register: DRKS00025867, registration date 10.08.21.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"77"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphisms and dental age in non-syndromic cleft lip and palate: a cross-sectional study.","authors":"Gabriela Fonseca-Souza, Lhorrany Alves-Souza, Maria Angélica Hueb de Menezes-Oliveira, Nikolaos Daratsianos, Svenja Beisel-Memmert, Christian Kirschneck, Rafaela Scariot, Juliana Feltrin-Souza, Erika Calvano Küchler","doi":"10.1186/s12887-025-05444-8","DOIUrl":"10.1186/s12887-025-05444-8","url":null,"abstract":"<p><strong>Background: </strong>Children with non-syndromic cleft lip with or without palate (CL ± P) may present alterations in dental development. The purpose of this cross-sectional study was to compare the dental age (DA) between children with and without CL ± P, and whether single nucleotide polymorphisms (SNPs) in genes encoding growth factors are associated with DA variations.</p><p><strong>Methods: </strong>Children aged between 5 and 14 years with and without CL ± P were recruited to participate in this study. DA was evaluated by calibrated examiners (kappa > 0.80) using the method proposed by Demirjian et al. (1973). Genomic DNA was extracted from buccal cells, and SNPs in Epidermal Growth Factor (EGF) - rs4444903 and rs2237051, Epidermal Growth Factor Receptor (EGFR) - rs2227983 -, Transforming Growth Factor Beta 1 (TGFB1) - rs1800470 and rs4803455 -, and Transforming Growth Factor Beta Receptor 2 (TGFBR2) - rs3087465 - were genotyped by real-time polymerase chain reactions using the TaqMan assay. The Student T-test was used to compare the variations in DA between the phenotypes \"with CL ± P\" and \"without CL ± P\", and the ANOVA two-way test was performed to compare the variations in DA among the genotypes (α = 0.05). A post-hoc analysis was performed using Bonferroni correction.</p><p><strong>Results: </strong>Two hundred and nine (n = 209) children (100 with CL ± P and 109 without CL ± P) with a mean chronological age of 8.66 years - standard deviation (SD) = 1.92 - were included. The group with CL ± P demonstrated a significantly delayed DA (mean=-0.23; SD = 0.71) compared to the group without CL ± P (mean=-0.01; SD = 0.88) (p = 0.049). Genotype distributions were in Hardy-Weinberg equilibrium. The SNP rs4803455 in TGFB1 was significantly associated with DA variations in children without CL ± P (p < 0.01). In the group with CL ± P, no significant differences in DA were observed among the genotypes.</p><p><strong>Conclusion: </strong>Children with CL ± P presented delayed DA compared with children without CL ± P. The SNP rs4803455 in TGFB1 is associated with variations in DA in children without CL ± P.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"80"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorder.","authors":"Amanda Aparecida Alves Cunha Nascimento, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Gabriela Silva Oliveira, Vitor Geraldi Haase","doi":"10.1186/s12887-025-05422-0","DOIUrl":"10.1186/s12887-025-05422-0","url":null,"abstract":"<p><strong>Background: </strong>Understanding the priorities of parents of children and adolescents with autism spectrum disorder (ASD) is crucial for implementing evidence-based programs. This study aims to identify the functional priorities of parents of Brazilian children and adolescents with ASD, analyze variations in priorities according to the levels of support and age groups of the participants, and categorize the goals according to the categories of the International Classification of Functioning, Disability, and Health (ICF). Additionally, this study aimed to evaluate changes in parents' performance and satisfaction with functional priorities after intervention with the Global Integration Method (Métodode Integração Global - MIG).</p><p><strong>Methods: </strong>A total of 241 children/adolescents with ASD (mean age, 6.92 ± 3.61 years) were recruited from different regions of Brazil. 76% (76%) were male, and 40.7% were classified as having support level 2. The Canadian Occupational Performance Measure was administered to parents/caregivers to identify their priorities for their children and to assess changes in performance and satisfaction with priorities after intervention with MIG. The MIG protocol consisted of functional task training in a naturalistic environment (City of Tomorrow) combined with the use of a flexible therapeutic suit (MIG Flex) and was conducted for 3 months, five times a week, for 3-4 h per day. Descriptive statistics were used to provide the priority profile. Pre- and post-intervention data were analyzed using paired t-test.</p><p><strong>Results: </strong>Parents established 1,203 functional priorities. Activities of daily living, behavioral difficulties, communication, play, and social interactions were the main functional priorities in the perception of parents/caregivers. The profiles of functional priorities were similar between the different levels of support and age groups. Approximately 64% of the priorities were classified in the activity domain of the ICF. In general, the MIG program resulted in significant improvements in performance and satisfaction for the majority of functional priorities (p < 0.05).</p><p><strong>Conclusion: </strong>Activities of daily living appear to be the main priority of parents of children and adolescents with ASD, regardless of the level of support or age group. The MIG program has been associated with improvements in performance and satisfaction across several of the functional priorities identified by parents.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"75"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of public health interventions regarding both infant sleep position and pertussis immunization with sudden infant death syndrome rates: an ecological study.","authors":"Jacqueline Müller-Nordhorn, Amir Hakimhashemi, Stefan N Willich, Sylvia Binting, Thomas Keil","doi":"10.1186/s12887-025-05429-7","DOIUrl":"10.1186/s12887-025-05429-7","url":null,"abstract":"<p><strong>Background: </strong>Infections may play a role in the etiology of sudden infant death syndrome (SIDS), with Bordetella pertussis being a potential agent. The objective was to analyze the association of SIDS and infant pertussis hospitalization rates over time, comparing a previously unvaccinated population (West Germany) versus a predominantly vaccinated population (East Germany).</p><p><strong>Methods: </strong>We calculated SIDS rates per 1000 live births per state. Live births and SIDS were available from 1980 onwards for the West German states and from 1991 onwards for the East German states. We applied interrupted time series (ITS) analyses to investigate the role of two public health interventions in 1991 (West Germany) and in 2000 (West and East Germany), respectively. Infant pertussis hospitalizations were available for five West German and three East German states between 1994 and 2019. We used multilayer and multivariate correlation analyses to determine the correlation between SIDS and pertussis hospitalization rates, including Pearson correlation test and vector autoregressive (VAR) analysis.</p><p><strong>Results: </strong>In West Germany, the average annual SIDS rate (per 1000 live births) increased from 1.08 in 1980 to 1.68 in 1991, before declining to 1.18 in 1992 and subsequently to 0.10 in 2020. In East Germany, the average annual SIDS rate (per 1000 live births) decreased from 0.79 in 1991 to 0.12 in 2020. The results of the ITS model indicated a significant change in both level and slope at the 1991 interventions (West Germany) and in slope at the 2000 interventions (West and East Germany). The correlation coefficients between SIDS and infant pertussis hospitalization rates were 0.69 (95% CI [confidence interval] 0.41, 0.85; p < 0.001) in West Germany, and 0.41 (95% CI 0.03, 0.69; p = 0.037) in East Germany. The correlation decreased during later periods (2000-2019, 2010-2019), particularly in East Germany. The results of the VAR analysis corroborated the findings of the main analyses.</p><p><strong>Conclusions: </strong>SIDS and infant pertussis hospitalization rates were correlated in both West and East Germany. Further studies - including improved diagnostic assessment of pertussis - seem warranted.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"79"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is maternal diabetes during pregnancy associated with neurodevelopmental, cognitive and behavioural outcomes in children? Insights from individual participant data meta-analysis in ten birth cohorts.","authors":"Rachelle A Pretorius, Demetris Avraam, Mònica Guxens, Jordi Julvez, Jennifer R Harris, Johanna Thorbjornsrud Nader, Tim Cadman, Ahmed Elhakeem, Katrine Strandberg-Larsen, Hanan El Marroun, Serena Defina, Tiffany C Yang, Rosie McEachan, John Wright, Jesús Ibarluzea, Loreto Santa-Marina, Juana Mari Delgado, Marisa Rebagliato, Marie-Aline Charles, Chloe Vainqueur, Silvia Maritano, Daniela Zugna, Wen Lun Yuan, Barbara Heude, Rae-Chi Huang","doi":"10.1186/s12887-024-05365-y","DOIUrl":"10.1186/s12887-024-05365-y","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence shows that dysregulated metabolic intrauterine environments can affect offspring's neurodevelopment and behaviour. However, the results of individual cohort studies have been inconsistent. We aimed to investigate the association between maternal diabetes before pregnancy and gestational diabetes mellitus (GDM) with neurodevelopmental, cognitive and behavioural outcomes in children.</p><p><strong>Methods: </strong>Harmonised data from > 200 000 mother-child pairs across ten birth cohorts in Europe and Australia were available. Mother-child pairs were included for analysis to determine whether GDM was recorded (yes or no) and whether at least one neurodevelopmental, cognitive and behavioural outcome was available in children aged 3 to 13 years. Confounder-adjusted regression models were used to estimate associations between maternal diabetes and child outcomes using two-stage individual participant data (IPD) meta-analysis. Model 1 included a crude estimate. The full adjustment model (model 2) included adjustment for child sex, maternal age, pre-pregnancy BMI, pregnancy weight gain, maternal smoking during pregnancy, plurality, parity and maternal education.</p><p><strong>Results: </strong>Children (aged 7-10 years) born to mothers with GDM had higher attention-deficient hyperactive disorder (ADHD) symptoms compared to non-exposed controls (model 2, regression coefficient (β) 3.67 (95% CI 1.13, 6.20), P = 0.001). Moreover, children (aged 4-6 years) born to mothers with GDM exhibited more externalising problems than those born to mothers without GDM (model 2, β 2.77 (95% CI 0.52, 5.02), P = 0.01). A pre-existing maternal history of type 1 and type 2 diabetes mellitus was associated with ADHD symptoms at 4-6 years (model 1, β 8.82 (95% CI 2.21, 15.45, P = 0.009) and β 7.90 (95% CI 0.82, 14.98, P = 0.02), respectively). The association was no longer apparent in further adjustments.</p><p><strong>Conclusions: </strong>This study found that children between 4 - 6 and 7-10 years of age born to mothers with GDM have a greater likelihood of developing externalising problems and ADHD symptoms, respectively. Externalising problems often co-exist with ADHD symptoms and precede formal ADHD diagnosis. Overall, this large-scale multi-cohort study suggested that a dysregulated metabolic environment during pregnancy may contribute to ADHD symptoms and externalising problems in young children.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"76"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A community-based father education intervention on breastfeeding practice in Ethiopia: a quasi-experimental study.","authors":"Wolde Melese Ayele, Tesfaye Birhane Tegegne, Asnakew Molla Mekonen","doi":"10.1186/s12887-024-05372-z","DOIUrl":"10.1186/s12887-024-05372-z","url":null,"abstract":"<p><strong>Background: </strong>Breastfeeding is the cornerstone of a newborn's nutrition, containing crucial nutritional components. While a substantial body of research focuses on mothers, there is limited understanding regarding effective strategies to engage fathers in promoting breastfeeding practices. Therefore, this quasi-experimental study investigated a community-based intervention to improve breastfeeding exclusivity and initiation rates by targeting fathers in breastfeeding education.</p><p><strong>Methods: </strong>This research was conducted in Dessie City in the Amhara region of Northeast Ethiopia from 5th October 2020 to 30th August 2021. Fathers and their wives were assigned individually to the intervention and control groups. Baseline data were gathered from selected Kebeles (Kebele: the lowest administrative level in Ethiopia) to identify couples seeking care through routine maternal and child health services. Fathers in the intervention area received breastfeeding education services at health facilities or home visits during antenatal, delivery, and postpartum periods. Trained midwives participated in giving breastfeeding education. In the control arm, they received routine counseling activities. Factors associated with early initiation and exclusive breastfeeding were analyzed using multivariable analysis among the two groups.</p><p><strong>Results: </strong>The intervention involved 327 participants, 155 in the intervention arm and 172 in the control group. The multivariable analysis indicated that the community-based father health education intervention significantly influenced the early initiation of breastfeeding. Mothers in the intervention group were found to be nearly five times more likely to initiate breastfeeding within the first hour of their infants' lives (AOR: 4.85, 95% CI: 1.36-17.32). A significant positive impact was also found for exclusive breastfeeding (EBF) of infants at the 1st, 4th, and 6th months (AOR: 3.95, 95% CI: 1.09-14.27), (AOR: 5.47, 95%CI: 2.18-13.70), and (AOR: 1.70, 95% CI: 1.02-2.85) respectively.</p><p><strong>Conclusion: </strong>This study confirmed the positive effects of a community-based father education intervention on the rates of exclusive breastfeeding during the first, fourth, and sixth months, as well as the early initiation of breastfeeding. The government and healthcare workers should implement policies supporting father-inclusive breastfeeding initiatives such as creating awareness and the critical role fathers' play.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"78"},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study.","authors":"Orian Raviv, Yael Lebenthal, Michal Yackobovitch-Gavan, Eyal Cohen-Sela, Shlomo Almashanu, Ronella Marom, Jacky Herzlich, Liran Hiersch, Avivit Brener","doi":"10.1186/s12887-025-05452-8","DOIUrl":"10.1186/s12887-025-05452-8","url":null,"abstract":"<p><strong>Background: </strong>The diagnosis of depression or anxiety treated by SSRIs has become relatively common in women of childbearing age. However, the impact of gestational SSRI treatment on newborn thyroid function is lacking. We explored the impact of gestational SSRI treatment on newborn thyroid function as measured by the National Newborn Screening (NBS) Program and identified contributory factors.</p><p><strong>Methods: </strong>An observational large-scale study of mother-infant dyads of liveborn infants delivered between 2011 and 2022. The Israeli NBS Program thyroid dataset [total thyroxine (TT4) obtained between 36-72 h after delivery] was linked with the electronic medical records of mothers and their infants born at Lis Maternity and Women's Hospital, to generate a unified database. The MDClone big data platform was utilized to extract maternal, perinatal, and neonatal characteristics from the medical records of mother-infant dyads. Only term liveborn infants born to mothers without documented thyroid disease and/or chronic medication administration, except for SSRIs, were included in order to minimize potential confounding effects on the infant's thyroid function. Group stratification relied on the documentation of gestational SSRIs treatment. The variables of interest were maternal, pregnancy, delivery, and perinatal characteristics of the mother-infant dyads. Multivariable forward linear regression model was applied to evaluate explanatory variables for newborn total thyroxine (TT4) levels.</p><p><strong>Results: </strong>Out of 105,928 infant-mother dyads, 2321(2.2%) mothers had been treated with SSRIs during pregnancy. The SSRI-treated mothers were older (34.8 ± 4.7 vs 32.6 ± 4.8 years, p < 0.001) and had a higher pre-pregnancy body mass index (23.4 ± 4.5 vs 22.7 ± 4.1, p < 0.001), but similar mean weight gain (13 kg) during pregnancy. Cesarean delivery was more common among SSRI-treated mothers than in the general population (p < 0.001). Infants of SSRI-treated mothers had lower WHO-classified birthweight z-scores (-0.25 ± 0.93 vs -0.04 ± 0.92, p < 0.001) and a higher rate of small-for-gestational-age infants (13.4% vs 8.2%, p < 0.001). A multivariable forward linear regression model revealed that SSRI treatment during pregnancy was not a significant contributor to TT4 levels (p = 0.497).</p><p><strong>Conclusions: </strong>SSRI treatment during pregnancy had no direct effect upon the newborn's adaptation of the hypothalamic-pituitary-thyroidal axis, but several other maternal and delivery characteristics were revealed to possibly impact newborn thyroid function.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"74"},"PeriodicalIF":2.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the experience of the mothers' ability to take care of their preterm infants related to in-hospital and post-discharge: a qualitative content analysis.","authors":"Saleheh Tajalli, Soroor Parvizy, Abbas Ebadi, Fateme Zamaniashtiani, Carole Kenner","doi":"10.1186/s12887-024-05338-1","DOIUrl":"10.1186/s12887-024-05338-1","url":null,"abstract":"<p><strong>Background: </strong>Preterm infants may experience many health and developmental issues, which continue even after discharge from the neonatal intensive care unit. Once home, the mother, as a non-professional and the primary caregiver will be responsible for the essential care of her preterm infant.</p><p><strong>Purpose: </strong>Understanding the take care ability in mothers with preterm infants.</p><p><strong>Methods: </strong>The content analysis method was used. The data were collected using in-depth and semi-structured interviews from April 2021 to February 2022. Eleven mothers, two fathers, two grandmothers, one neonatal nurse, and two neonatologists with a mean age of 36.05 ± 10.88 years were selected using purposeful and snowballing sampling in Tehran, Iran. Allocating adequate time for data collection, gathering data through different methods, peer checking by two qualitative researchers, long interaction with the settings, maximum variation sampling, appropriate quotations, and showing the range of facts fairly and honestly were considered to ensure the trustworthiness of this study. The data were analyzed through Lindgren et al.'s approach using MAXQDA software.</p><p><strong>Results: </strong>Based on the findings and participants' experiences in 18 deep interviews, the mothers with desirable care ability have adequate ability as described by 17 subcategories and are categorized into five dimensions. The care ability of the mothers of preterm infants upon neonatal intensive care unit discharge consisted of five categories including maternal identity, infant's needs, cognitive ability, technical ability, and psychological ability.</p><p><strong>Implications for practice and research: </strong>In the mothers of preterm infants, maternal identity and the infant's needs are antecedents of the care ability concept. The care ability of the mothers with preterm infants is distinct from those of other caregivers. This is a multi-dimensional concept and trait related to maternal cognitive ability, technical ability, and maternal psychological ability. Professional neonatal nurses should assess their care ability from multiple perspectives: cognitive, technical, and psychological abilities. They should be considered in designing empowerment and engagement programs for the improvement of the care ability of the mothers of preterm infants. Both mothers and professional neonatal nurses should take responsibility for improving the mothers' ability to take care of their preterm infants.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"72"},"PeriodicalIF":2.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations for estimating indirect costs in children and adolescents with chronic conditions: a scoping review.","authors":"Anne Kitschen, Lulseged M Asegu, Dirk Sauerland","doi":"10.1186/s12887-024-05384-9","DOIUrl":"10.1186/s12887-024-05384-9","url":null,"abstract":"<p><strong>Background: </strong>In children and adolescents, the prevalence of chronic diseases, e.g., obesity, asthma, and attention-deficit/hyperactivity disorder (ADHD), has increased in the last decades. These diseases have negative effects on patients and their families and pose a significant economic burden. Indirect costs related to caregivers' lost workdays or children's and adolescents' missed education are likely to be high. However, there are no guidelines for measuring and valuing indirect costs in this population. Thus, this scoping review aims to examine methods in published articles, compare these approaches, and analyze benefits and shortcomings.</p><p><strong>Methods: </strong>The systematic literature search was conducted in Medline, PsycINFO, Embase, NHS EED, and the HTA Database considering all articles from inception until 16 October 2024. Two researchers independently screened title, abstract, and full text. Cost-of-illness studies (COIs) reporting indirect costs for obesity, asthma, or attention-deficit/hyperactivity disorders (ADHD) in children and adolescents up to 24 years were included. Only studies published in English or German were considered. Methodological characteristics, measurement of indirect costs, cost components, data source, and costing methods were extracted.</p><p><strong>Results: </strong>The literature search revealed 45 studies. Thirty-two articles on asthma, eight on ADHD, and five on obesity were included. While all studies included absenteeism, only a few assessed and valued unpaid work (31.1%) or presenteeism (13.3%). Overall, 88.9% of the studies considered indirect costs for caregivers. Additionally, 51.1% considered productivity losses for children and adolescents, with 47.8% of these studies assigning a monetary value to these losses. The largest share of studies (53.3%) considered indirect costs by measuring and valuing caregivers' lost work time.</p><p><strong>Discussion: </strong>In conclusion, various methodologies were used to consider indirect costs for chronic diseases in children and adolescents, underlining the need for standardization. This scoping review presents methodologies for incorporating indirect costs in COIs and other types of economic evaluations, which focus on children and adolescents and adopt a societal perspective. These indirect costs include both paid and unpaid activities, as well as absenteeism and presenteeism, not only for caregivers but also for children and adolescents themselves.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"73"},"PeriodicalIF":2.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the epidemiological characteristics of mycoplasma pneumoniae infections among children during two epidemics in Wuhan from 2018 to 2024.","authors":"Jieyu Mao, Zhili Niu, Mengling Liu, Liangyu Li, Haiyue Zhang, Ruiyun Li, Pingan Zhang, Xiaojun Wu","doi":"10.1186/s12887-025-05435-9","DOIUrl":"10.1186/s12887-025-05435-9","url":null,"abstract":"<p><strong>Background: </strong>Mycoplasma pneumoniae (M pneumoniae, MP) is a common pathogen causing respiratory tract infections, particularly in children. In 2023, a resurgence of MP epidemics was observed in Wuhan, Hubei Province, China. This study aims to examine the epidemiological trends and clinical characteristics of MP infections among children in Wuhan from 2018 to 2024, providing valuable scientific evidence to guide local prevention strategies.</p><p><strong>Methods: </strong>From January 1, 2018, to June 30, 2024, samples were collected from children under 14 years with Acute Respiratory Tract Infections (ARTI) at Renmin Hospital of Wuhan University. MP infections were diagnosed through MP-IgM antibody detection and MP-DNA detection. Results were analyzed and compared across distinct epidemic periods.</p><p><strong>Results: </strong>Of the 183 626 ARTI children, 57 393 (31.26%) tested positive for MP, with an average age of 4.87 ± 2.99 years and a male-to-female ratio of 1.12:1. The annual positive rates from 2018 to 2024 were 45.92%, 32.23%, 22.84%, 16.22%, 16.26%, and 42.93%, respectively. Across the study period, the highest positive rate was recored in autumn (35.13%, P < 0.05). Two distinct MP outbreaks were identified, in 2018-2019 and 2023. Significant differences were observed between the two outbreaks. The 2018-2019 epidemic peaked in summer, while the 2023 epidemic peaked in November and persisted into February 2024. By age, the 2018-2019 outbreaks predominantly affected pre-school children, whereas the 2023 outbreaks mainly involved school-aged children. In boths outbreaks, girls had higher positive rates. Antibody and DNA testing results followed similar trends.</p><p><strong>Conclusion: </strong>This study highlights the epidemiological trends and clinical characteristics of MP infections in Wuhan from 2018 to 2024, including two distinct outbreaks with differing seasonal patterns. The MP strain in 2023 appeared to predominantly affect older children.The trends observed suggest that MP infections may persist into the winter of 2024. Enhanced surveillance of respiratory pathogens and early diagnosis and prevention of MP infections in children remain critical in this region.</p>","PeriodicalId":9144,"journal":{"name":"BMC Pediatrics","volume":"25 1","pages":"71"},"PeriodicalIF":2.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}