Growth in the first two years in children born to mothers infected with COVID-19 during pregnancy: a cohort study.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-06-03 DOI:10.1186/s12887-025-05663-z

Habibe Nejad Biglari, Atefeh Ahmadi, Katayoun Alidousti, Malihe Pouredalati, Forouzandeh Kalantari, Effat Kargar, Farzaneh Salajegheh Tezerji, Sahebeh Dadshahi, Parya Jangipour Afshar, Hamid Sharifi, Masumeh Ghazanfarpour, Fatemeh Janipour, Fariba Heidari

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引用次数: 0

Abstract

Introduction: Because the impact of COVID-19 on the growth of infants whose mothers were infected with this virus during pregnancy is unclear, this study investigated the effect of mothers' infection with this virus during pregnancy on their infant's growth during the first two years of life.

Method: In this prospective cohort study, the available information from 697 mothers referring to Iran's health care centers for pregnancy and breastfeeding care was used to compare the growth of 367 children born to mothers infected with COVID-19 during pregnancy with that of 330 children born to mothers who were not infected and not exposed to COVID-19 during pregnancy. Their growth was evaluated for two years.

Results: Concerning the weight, height, and head circumference 6 months, 12 months, and 24 months after birth, although the values obtained in the exposed group were slightly higher than the non-exposed group, no statistically significant difference was observed (P > 0.05). Comparing the exposed group's growth indices (weight, height, and head circumference) based on whether the mother was infected with COVID-19 during the first, second, or third trimester showed no significant difference (P > 0.05). The birth height of the babies whose mothers infected with COVID-19 in the first and second trimesters of pregnancy was slightly lower than those whose mothers were infected in the third trimester (P = 0.019). Children in the exposed group weighed 76.61 g more than those in the non-exposed group (P = 0.018).

Conclusion: More long-term studies in different populations about growth of children are needed to generalized the findings.

Clinical trial number: Not applicable (A cohort study).

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怀孕期间感染COVID-19的母亲所生儿童头两年的生长情况：一项队列研究

由于COVID-19对母亲在怀孕期间感染该病毒的婴儿生长的影响尚不清楚，因此本研究调查了母亲在怀孕期间感染该病毒对婴儿出生后头两年生长的影响。方法：在这项前瞻性队列研究中，利用697名在伊朗怀孕和母乳喂养保健中心就诊的母亲的现有信息，比较367名感染COVID-19的母亲所生的孩子在怀孕期间与330名未感染COVID-19的母亲所生的孩子在怀孕期间的生长情况。对他们的成长进行了两年的评估。结果：新生儿出生后6个月、12个月、24个月的体重、身高、头围，暴露组虽略高于未暴露组，但差异无统计学意义（P < 0.05）。根据母亲是否感染COVID-19比较暴露组在妊娠前、中、晚期的生长指标（体重、身高、头围），差异无统计学意义（P < 0.05）。母亲在妊娠前、中期感染COVID-19的婴儿出生身高略低于母亲在妊娠晚期感染的婴儿（P = 0.019）。暴露组比未暴露组重76.61 g （P = 0.018）。结论：需要对不同人群的儿童生长进行更长期的研究，以推广这一发现。临床试验编号：不适用（队列研究）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.