BMC Complementary Medicine and Therapies最新文献

{"title":"Antiproliferative potential of sweetpotato in breast (BT549) and lung (A549) cancer cell lines.","authors":"Sochinwechi Nwosisi, Dilip Nandwani, Elbert Lewis Myles","doi":"10.1186/s12906-025-04770-9","DOIUrl":"10.1186/s12906-025-04770-9","url":null,"abstract":"<p><strong>Background: </strong>Researchers have searched for plant-derived medicines over the last few decades. Although much of the focus has been on medicinal herbs, many vegetables, such as sweetpotato, have also been discovered to have medicinal properties due to their high levels of nutrients and phytochemicals. This study aimed to determine the effects of methanolic extracts from sweetpotato leaves and leaves/stems on human lung (A549) and breast (BT549) cancer cell lines. The authors obtained the leafy greens from Tennessee State University's Organic research farm, extracted with methanol and studied for their cytotoxicity.</p><p><strong>Methods: </strong>Alamar blue Assay was used to determine whether the methanolic extracts from fresh sweetpotato leaves (cv. All Purple) and leaves/stems (cv. Carolina Ruby) had the potential to affect cell proliferation in the human lung (A549) and breast (BT549) cell lines in-vitro. Tamoxifen was used as the positive control, while DMSO was used as the negative control.</p><p><strong>Results: </strong>Sweetpotato leaves of the All-Purple cultivar and the stem/leaves of the Carolina Ruby cultivar inhibited lung and breast cancer cell growth in a dose-dependent manner. The All purple sweetpotato produced EC₅₀ values of 0.013 µg/µl (R2 = 0.67, P < 0.05) and 0.002 µg/µl (R2 = 0.89, P < 0.05) in the A549 and BT549 cell lines respectively, using the Alamar blue assay. The BT549 cell line treated with all purple leaf extract was less significant than that of the A549 cell line. However, the sweetpotato stem and leaf extract of Carolina ruby had a more significant cytotoxic effect on the A549 cell line with an EC₅₀ value of 0.0014 µg/µl (R2 = 0.99, P < 0.05).</p><p><strong>Conclusions: </strong>Anticancer activities of these extracts showed their ability to inhibit the growth of cancer cell lines, such as BT549 (breast cancer) and A549 (lung cancer), in a concentration-dependent manner. Further studies would help determine the bioactive compounds present in these compounds that produce this effect, but more studies would also help determine whether the extracts could induce apoptosis in BT549 and A549 cancer cells, the mechanism of action, and cell cycle progression.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"79"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant, urobactericidal and antibiotic modulating activity of the methanolic extract of the stem and resin of Acacia catechu (L.f.) Willd.","authors":"Lipsa Panigrahy, Swarna Rani Panda, Shaikh Ameeruddin, N Susmita Pradhan, Sarita Das","doi":"10.1186/s12906-024-04719-4","DOIUrl":"10.1186/s12906-024-04719-4","url":null,"abstract":"<p><strong>Background: </strong>Emergence of multidrug resistant pathogens has opened new vistas for novel drug discovery or combinatorial drug surveillance, often in form of some natural products, which is considered to be cheap and safe. In this study, the urobactericidal activity of the methanolic extract of the stem and resin of Acacia catechu (L.f.) Willd (Fabaceae) was explored against five uropathogenic bacterial strains i.e. Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris and Staphylococcus aureus.</p><p><strong>Methods: </strong>Varieties of antibacterial (disc diffusion, agar well diffusion, modified agar well diffusion) and antioxidant assays (DPPH and OH free radical scavenging assay) were tried to prove the efficacy of stem and resin extracts of A. catechu and to compare their urobactericidal and free radical scavenging properties.</p><p><strong>Results: </strong>Phytochemical analysis envisaged that the stem and resin contained phytoconstituents like alkaloids, phenols, tannins, proteins, glycosides, flavonoids, steroids and terpenoids, which were reported to have excellent antioxidant and antibacterial activities. The total phenolic contents of the methanolic extract of A. catechu stem (ACs) and A. catechu resin (ACr) were calculated as 37.74 ± 0.023 and 51.98 ± 0.011 mg/g Gallic Acid equivalents. The total flavonoid contents of methanolic extract of ACs and ACr were calculated to be 71.33 ± 0.004 and119.6 ± 0.010 mg/g Rutin equivalent. ACs had IC₅₀ value of 93.68 ± 0.71; 90.92 ± 0.54 µg/mL and ACr had 79.21 ± 0.54; 85.74 ± 0.61 µg/mL in comparison to an IC₅₀ value of 72.33 ± 1.20; 66.96 ± 0.61 µg/mL for standard Ascorbic acid in the DPPH and hydroxyl free radical scavenging assay. Phytocompounds present in both ACs and ACr were proved to have improved the urobactericidal efficacies of conventional antibiotics especially against the E. faecalis and E. coli, the prime etiological agents of uropathogenesis.</p><p><strong>Conclusion: </strong>Our results indicated the excellent urobactericidal effects of the stem and resin extracts of a least explored natural remedy against uropathogens, which will be beneficial for treating urinary tract infections and augmenting the quest for novel therapies in future for uropathogenesis.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"78"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring men's cancer journeys in Norway: a comprehensive survey on diet, supplements, and use of complementary and alternative therapies.","authors":"Agnete E Kristoffersen, Kiwumulo Nakandi, Arne Johan Norheim, Mona Bjelland, Jorunn V Nilsen, Eran Ben-Arye","doi":"10.1186/s12906-025-04748-7","DOIUrl":"10.1186/s12906-025-04748-7","url":null,"abstract":"<p><strong>Background: </strong>Each year, over 20,000 men are diagnosed with cancer in Norway, and approximately 150,000 men who have previously been diagnosed with cancer are currently alive. Many of these cancer survivors encounter a range of challenges, including fatigue, sexual dysfunction, urinary issues, and pain, all of which can significantly impact their quality of life. Consequently, a substantial number of men seek support beyond conventional healthcare. This study aims to investigate the motivations behind the use of Complementary and Alternative Medicine (CAM) and dietary changes/supplements in men with cancer in Norway, and further explore their communication with healthcare providers, self-reported effects and adverse effects, and the sources of information they rely on regarding these practices.</p><p><strong>Method: </strong>In collaboration with the Norwegian Cancer Society (NCS), we conducted an online cross-sectional study involving participants of their user panel who have current or past experiences with cancer (n = 706), of whom 218 identified as men. The study was conducted during the autumn of 2021, employing a modified cancer-specific version of the International Questionnaire to Measure Use of Complementary and Alternative Medicine (I-CAM-Q). A total of 153 men agreed to participate, yielding a response rate of 70%.</p><p><strong>Results: </strong>A large proportion of the respondents used CAM (62%), dietary supplements (65%), and/or adjusted their diet (81%) to boost their immune systems and increase their quality of life. The dietary adjustments involved eating more fruits, vegetables, fish, and whole grains. Many participants also used relaxation techniques and visited CAM providers to enhance quality of life. Most participants reported better health outcomes as a result of these interventions. The Internet and healthcare professionals were the main source of information, although many did not disclose their dietary changes and CAM therapy use with healthcare professionals.</p><p><strong>Conclusion: </strong>By leveraging these insights, healthcare providers, policymakers, and researchers can collectively work towards a more holistic and patient-centred approach to cancer care, ultimately improving the overall well-being and quality of life for male cancer survivors.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"74"},"PeriodicalIF":3.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices regarding food-medicine dual-purpose substances among adults in China: a cross-sectional online survey.","authors":"Haixian Jia, Chunyu Li, Zheng Li, Yao Zhao, Zhonghui Chen, Jiali Duan, Xiaochen Ma","doi":"10.1186/s12906-025-04822-0","DOIUrl":"10.1186/s12906-025-04822-0","url":null,"abstract":"<p><strong>Background: </strong>Food medicine homology originated in ancient China and has been officially named food-medicine dual-purpose substances (FMS). However, the relationship between residents' knowledge, attitudes, practices (KAP) and FMS among adults in China remains unclear. This study evaluated the current situation of FMS-related knowledge, awareness and actual consumption behaviors and practices of Chinese residents to provide a basis for both perfect related regulations and scientific advice on FMS consumption.</p><p><strong>Methods: </strong>A cross-sectional online survey on FMS perception and consumption was conducted through a convenience sampling strategy from August to December 2020. A total of 2,815 residents (96.3% were aged between 18 and 50 years old, 47.8% were male and 52.2% were female) from 31 provinces were recruited for this study. Descriptive analysis and multivariate logistic regression analysis was performed in the statistical analysis.</p><p><strong>Results: </strong>The results showed that residents' identification of FMS had an accurate response rate of 22.7% (640/2,815). Educational level was the factor associated with residents' knowledge of FMS. A total of 62.0% (1,744/2,815) of the residents would take the initiative to learn more about FMS. 93.8% (2,639/2,815) of them thought that manufacturers should make clear food labels when they add FMS. Almost half of the residents bought FMS products frequently (more than 12 times per year), and 96.1% (1,880/2,747) of the residents bought FMS mainly used for healthcare. Among the FMS they had ever consumed, the two most frequently consumed FMS by residents were yam (35.3%) and wolfberry (15.9%). 40.6%(1,143/2,815) of residents hoped that the government could increase publicity and conduct more popular science activities.</p><p><strong>Conclusion: </strong>The findings indicate that adult residents in China who have substantial knowledge of FMS are not optimistic; however, they express positive attitudes toward knowing and consuming FMS, and there is a high need for labeling and a high demand for consumption. It is imperative to enhance research and policy development regarding FMS, to actively promote FMS knowledge, and to guide residents towards a more scientific and rational consumption of FMS in the future.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"76"},"PeriodicalIF":3.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice.","authors":"Ikponmwosa Owen Evbuomwan, Oluyomi Stephen Adeyemi, Olarewaju Michael Oluba","doi":"10.1186/s12906-025-04745-w","DOIUrl":"10.1186/s12906-025-04745-w","url":null,"abstract":"<p><strong>Background: </strong>Malaria is an infectious disease, which has continued to cause inconceivable loss of lives every year, almost unabatedly. Currently, it has become more difficult to treat the disease due to the emergence and spread of resistance to recommended antimalarial drugs. This situation necessitates an urgent search for antimalarial compounds with unique modes of action. Here, we investigate the antimalarial activity, antioxidant and anti-inflammatory capacity of Enantia chlorantha aqueous stem bark extract (EcASBE) in vivo.</p><p><strong>Methods: </strong>The extract was screened for selected phytoconstituents including alkaloids and flavonoids. We evaluated the antimalarial activity of EcASBE against Plasmodium berghei NK65 infection in mice, using curative, prophylactic, and suppressive antimalarial test models, respectively. In addition, the antioxidant and anti-inflammatory activities of the extract were assessed.</p><p><strong>Results: </strong>The EcASBE significantly (p < 0.05) inhibited parasitaemia dose-dependently, with the highest inhibition (80.4%) and prolonged survival (MST = 20) observed in the curative test. Our findings reveal significant (p < 0.05) improvement of serum ALT, AST, ALP, GGT, and levels of TNF-α, creatinine and urea following extract administration. Furthermore, the extract led to a significant (p < 0.05) rise in the levels of CAT, SOD, GPx, and GSH, with a concomitant reduction in NO and MDA levels.</p><p><strong>Conclusion: </strong>The antimalarial, antioxidative, antiperoxidative, and inflammatory-inhibiting properties of the plant in infected mice demonstrate its great value for therapeutic intervention, and substantiate its use in traditional medicine for malaria treatment. Hence, further investigation to identify the repertoire of the active antimalarial components is warranted.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"73"},"PeriodicalIF":3.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UHPLC-Q Exactive-Orbitrap-MS and network pharmacology analyses to investigate the mechanism by which Danggui-Shaoyao-San affects 27-OHC-induced cell damage in SH-SY5Y/C6 coculture.","authors":"Yi Huang, Yingying Zhai, Di Zhao, Mingan Wu, Qi Shen, Wei Zhao, Qi Wang, Limei Yao, Weirong Li","doi":"10.1186/s12906-025-04751-y","DOIUrl":"10.1186/s12906-025-04751-y","url":null,"abstract":"<p><strong>Background: </strong>Danggui-Shaoyao-San (DSS) is a classic Chinese medicine formula that has been extensively studied for its efficacy in treating Alzheimer's disease (AD). However, its mechanism of action is still unclear.</p><p><strong>Methods: </strong>In this study, UHPLC-Q Exactive-Orbitrap-MS was used to analyze and identify the compounds in DSS. Network pharmacology was used to analyze the common targets of drug-containing serum chemistries and AD, as well as the AD pathways in which drug-containing serum chemistries may be involved. The 27-OHC-induced SH-SY5Y/C6 coculture cell injury model was used to explore the mechanism of action of DSS in the treatment of AD.</p><p><strong>Results: </strong>UHPLC-Q Exactive-Orbitrap-MS analysis identified 73 chemical constituents in DSS aqueous extract and 39 compounds in drug-containing serum. According to network pharmacology analysis, DSS and AD share 181 common targets, with interleukin-6 (IL-6) and tumor necrosis factor (TNF) being the main effective targets. Furthermore, DSS may treat AD through the modulation of lipid metabolism-related pathways and the interleukin-17 (IL-17) signaling pathway. 27-hydroxycholesterol acid (27-OHC) significantly reduced the viability of SH-SY5Y cells and C6 cells in vitro, while DSS administration upregulated the expression of cytochrome P450 46A1 (CYP46A1) and cytochrome P450 7B1 (CYP7B1) enzymes and reduced cholesterol levels in SH-SY5Y cells. Additionally, DSS decreased reactive oxygen species (ROS) levels and increased glutathione (GSH) levels in coculture systems. DSS downregulated the expression of IL-17 in 27-OHC-injured SH-SY5Y cells and downregulated the expression of TNF-α, IL-6 and transforming growth factor-β1 (TGF-β1) in 27-OHC-injured C6 cells.</p><p><strong>Conclusion: </strong>This study revealed the effective components, targets and mechanisms of DSS in the treatment of AD, highlighting the significant potential of DSS in treating this disease.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"75"},"PeriodicalIF":3.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators for patients' acceptance and adherence to auriculotherapy: A qualitative systematic review using the theoretical domains framework.","authors":"Ying Zhang, Kun Li, Siyuan Wu, Keping Zhu, Fuchao Xie, Binbin Zhu, Lijun Wang, Wei Wang","doi":"10.1186/s12906-025-04814-0","DOIUrl":"10.1186/s12906-025-04814-0","url":null,"abstract":"<p><strong>Background: </strong>Auriculotherapy has become a promising complementary therapy and is widely used to manage various symptoms and diseases. However, little is known about patients' knowledge and attitudes. This study aimed to identify and synthesize the factors that influence acceptance and adherence related to auriculotherapy from patients' perspectives.</p><p><strong>Methods: </strong>The thematic synthesis developed by Thomas and Harden was applied to guide this review. Six common English databases (PubMed, Web of Science, Embase, Cochrane Library, CINAHL, and PsycINFO) and four common Chinese databases (CNKI, VIP, WangFang, and Sinomed) were searched in December 2023. The quality of the included studies was assessed using the Critical Appraisal Skills Programme. Data synthesis was conducted using the theoretical domains framework.</p><p><strong>Results: </strong>Ten studies with eleven publications were included. Twenty-four barriers and fourteen facilitators on patients' acceptance and adherence to auriculotherapy were identified under nine of the theoretical domains framework domains. Among these domains, \"knowledge (n = 2)\", \"memory, attention and decision processes (n = 2)\", and \"environmental context and resources (n = 5)\" reported only barriers. Besides, the most frequently mentioned domains in the included studies were \"beliefs about consequences (n = 10)\" and \"emotions (n = 6)\".</p><p><strong>Conclusions: </strong>Our findings provide a comprehensive overview of the factors affecting the patients' behavior in receiving and complying with auriculotherapy, which may help healthcare professionals deeply understand the factors that influence patients' intentions to use auriculotherapy and better interact with them. Further research that addresses these modifiable factors and develops relevant interventions may aid in meeting the growing use of auriculotherapy by patients.</p><p><strong>Trial registration: </strong>This study was registered with PROSPERO in Dec 2023 (Registration number: CRD42023488856).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"69"},"PeriodicalIF":3.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of music therapy on physiological response and anxiety in perioperative ophthalmic patients: a systematic review.","authors":"Jingyu Yan, Jun Liu, Jingpin Wang, Wei Chen, Jinping Hu","doi":"10.1186/s12906-025-04815-z","DOIUrl":"10.1186/s12906-025-04815-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to evaluate the effectiveness of music therapy on physiological response and anxiety in perioperative ophthalmic patients. Furthermore, to explore the differentiation of intervention effects based on different intervention timing and music types.</p><p><strong>Methods: </strong>Five databases including PubMed, Embase, Web of Science, the Cochrane library and CINAHL were adopted for comprehensive search, from the inception of the database to October 2024. Reported according to the PRISMA 2020 statement. Methodological quality was assessed using Version 2 of the Cochrane tool for assessing risk of bias in randomized trial (Rob2). Revman manager 5.4 software was used for meta-analysis.</p><p><strong>Results: </strong>Nine studies (1331 patients) were included. The meta-analysis results showed that the intervention effect of the music intervention group was better than that of the control group, which had positive effects on lower systolic blood pressure (SBP) [mean difference (MD)=-5.86, 95% confidence interval (CI)=-7.97~-3.74, Z = 5.44, p < 0.001], lower diastolic blood pressure (DBP) (MD=-3.57, 95%CI=-6.80~-0.35, Z = 2.17, p = 0.03) and reducing anxiety [standard mean difference (SMD)=-0.80, 95%CI=-0.94~-0.66, Z = 11.2, p < 0.001)], but not statistically significant for heart rate/pulse rate (HR/PR) change (MD=-1.08, 95%CI=-2.29 ~ 0.12, Z = 1.77, p = 0.08). The subgroup analysis results showed that music intervention before surgery, as well as before and during surgery, could reduce the function of SBP and DBP (p-values all less than 0.05); All types of music have significance in reducing SBP (p-values all less than 0.001); Better intervention effect in binaural beats music (BBM) group than control group in decreasing HR/PR (p = 0.01) can be found; Regardless of the timing of intervention (preopertive, p < 0.001; intraoperative, p = 0.008; preoperative and intraoperative, p < 0.001) or the type of music (BBM, p < 0.001; other types of music, p < 0.001), music therapy has a significant effect on reducing patient perioperative anxiety compared to the control group.</p><p><strong>Conclusion: </strong>Overall, music therapy contributes to reducing both SBP and DBP, and anxiety level for perioperative ophthalmic patients. The intervention timing of preoperative, or both in preoperative and intraoperative, as well as music type of binaural beats, may have better effects on clinical indicators.</p><p><strong>Prospero registration: </strong>This systematic review was registered a priori with PROSPERO in September 22, 2023. PROSPERO registration number: CRD42023465797.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"72"},"PeriodicalIF":3.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does supplementation with pine bark extract improve cardiometabolic risk factors? A systematic review and meta-analysis.","authors":"Shooka Mohammadi, Tamas Fulop, Abdelouahed Khalil, Sara Ebrahimi, Motahareh Hasani, Somayeh Ziaei, Farnaz Farsi, Elham Mirtaheri, Mostafa Afsharianfar, Javad Heshmati","doi":"10.1186/s12906-025-04819-9","DOIUrl":"10.1186/s12906-025-04819-9","url":null,"abstract":"<p><strong>Background: </strong>Supplementation with pine bark extract (PBE) may improve risk factors associated with cardiometabolic syndrome (CMS). The effects of PBE supplementation on cardiometabolic risk factors were evaluated in this systematic review and meta-analysis of randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>A comprehensive search of various databases was performed to identify relevant RCTs published up to September 2024. A random-effects model was employed for the meta-analysis, which included 27 RCTs with 1,685 participants.</p><p><strong>Results: </strong>The findings indicated that PBE supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -2.26 mmHg, 95% confidence interval (CI): -3.73, -0.79; P = 0.003), diastolic blood pressure (DBP) (WMD: -2.62 mmHg, 95% CI: -3.71, -1.53; P < 0.001), fasting blood sugar (FBS) (WMD: -6.25 mg/dL, 95% CI: -9.97, -2.53; P = 0.001), hemoglobin A1c (HbA1c) (WMD: -0.32%, 95% CI: -0.54, -0.11; P = 0.003), body weight (WMD: -1.37 kg, 95% CI: -1.86, -0.88; P < 0.001), and low-density lipoprotein (LDL) cholesterol (WMD: -5.07 mg/dL, 95% CI: -9.21, -0.94; P = 0.016) in the PBE-treated group compared to their untreated counterparts. However, no significant impact of PBE was observed on waist-to-hip ratio (WHR), body mass index (BMI), waist circumference (WC), or serum levels of insulin, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), and total cholesterol (TC).</p><p><strong>Conclusions: </strong>Supplementation with PBE may ameliorate specific cardiometabolic risk factors, as indicated by reductions in body weight, DBP, SBP, FBS, LDL, and HbA1c levels. This approach can be regarded as an adjunct therapeutic strategy for CMS management. Further high-quality trials with larger sample sizes and longer durations are required to validate these findings.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"71"},"PeriodicalIF":3.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of sesamol against cigarette smoke toxicity on the blood-brain barrier.","authors":"Ildem Koru, Belkıs Atasever-Arslan","doi":"10.1186/s12906-025-04796-z","DOIUrl":"10.1186/s12906-025-04796-z","url":null,"abstract":"<p><p>Cigarette smoke comprises nicotine, reactive oxygen species (ROS), and carcinogens, which can induce oxidative stress and inflammation, leading to disruption of the blood-brain barrier. This study utilized cigarette smoke extract (CSE) in an in vitro model of the blood-brain barrier (BBB).Sesamol is a phenolic compound derived from Sesamum indicum L. Its potential to reduce inflammation and provide protection was also examined. As a result of the study, it was found that CSE significantly increases permeability by degrading the BBB, whereas a protective effect was observed in the sesamol-incubated group within the BBB model. While the Sesamol + CSE group does not entirely prevent the damage induced by CSE in the barrier, it does exhibit a mitigating effect on the damage.In HUVEC cells, a significant decrease in IL-8 levels was observed in sesamol and sesamol + CSE groups. In T98G cells, IL-8 levels were elevated in the CSE group, while a reduction was observed in the sesamol and sesamol + CSE groups. TNF-α levels went up in the CSE group but down in the sesamol and sesamol + CSE groups in T98G cells. Furthermore, the IL-6 levels were significantly increased in both the sesamol and sesamol + CSE groups in HUVEC cells, while a decrease was noted in T98G cells in sesamol treatment. The increase in IL-8 and TNF-α levels in T98G cells due to CSE indicates an inflammatory response. It can contribute to the enhanced BBB permeability. As a result, sesamol reduced inflammation caused by CSE by controlling IL-8, IL-6, and TNF-α. This molecule may serve a therapeutic role by diminishing inflammation and protecting the blood-brain barrier from damage.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"68"},"PeriodicalIF":3.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}