BMC Complementary Medicine and Therapies最新文献

{"title":"The effectiveness of mandala coloring on the psychological and physiological symptoms in adult hospitalized patients: a meta-analysis.","authors":"Seda Pehli̇van, Öznur Erbay Dalli","doi":"10.1186/s12906-026-05404-4","DOIUrl":"https://doi.org/10.1186/s12906-026-05404-4","url":null,"abstract":"<p><strong>Background: </strong>Hospitalization often imposes significant psychological and physiological demands on patients. Mandala coloring may help reduce these challenges. This meta-analysis aimed to evaluate the effectiveness of mandala coloring interventions across psychological and physiological symptoms in adult hospitalized patients.</p><p><strong>Methods: </strong>A comprehensive search was conducted using nine databases. Randomized controlled and controlled studies comparing mandala coloring with control groups were included. Data extraction was performed independently by two authors, and risk of bias was assessed using the Cochrane RoB tool. GRADE Pro software was used to assess the quality of the evidence. Standardized mean differences (SMD) with 95% confidence intervals (CIs) were pooled using RevMan (version 5.4). Subgroup analyses were performed by session frequency and duration.</p><p><strong>Results: </strong>Seventeen studies with a total of 987 participants were included. Mandala coloring significantly reduced anxiety (SMD = - 2.16, 95% CI [-3.38, - 0.95]) and stress (SMD = - 2.45, 95% CI [-3.06, - 1.85]). Improvements were also observed in well-being (SMD = 4.51, 95% CI [0.81, 8.21]) and hope (SMD = 0.42, 95% CI [0.09, 0.75]). No significant effects were found for resilience, pain, fatigue, nausea, comfort, or vital parameters. Subgroup analyses indicated that brief (≤ 30 min) and multiple-session interventions were especially effective in alleviating anxiety. The level of evidence, as assessed using GRADE, was, however, low.</p><p><strong>Conclusion: </strong>Mandala coloring provides nurses and healthcare professionals with an inexpensive, low-resource, and patient-friendly method to enhance psychological well-being during hospitalization. Incorporating short, repeated sessions into routine care may strengthen resilience and patient comfort. Further large-scale and high-quality trials are required to establish standardized protocols and clarify effects on physiological symptoms.</p><p><strong>Trial registration: </strong>PROSPERO meta-analysis registration: CRD420251130565.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the subsequent benign prostate hyperplasia-related surgery risk and patients treated with Chinese herbal medicine: a population-based Taiwanese cohort study.","authors":"Ming-Yen Tsai, Chun-Ting Liu, Yu-Sin Shen, Hao-Lun Luo, Tai-Lin Chen, Ying-Hsiu Shih, Yu-Tung Hung, Tzu-Ju Hsu, Fuu-Jen Tsai, Yung-Hsiang Chen","doi":"10.1186/s12906-026-05400-8","DOIUrl":"https://doi.org/10.1186/s12906-026-05400-8","url":null,"abstract":"<p><strong>Background: </strong>The association of Chinese herbal medicines (CHM) with the decreased risk of benign prostatic hyperplasia (BPH)-related surgery in patients with BPH is limited by the small sample size and short follow-up. We try to address this association in a large national sample using 21 years of data.</p><p><strong>Methods: </strong>A random sample composed of two million beneficiaries with newly diagnosed BPH between 2001 and 2016, followed until 2021 in Taiwan's National Health Insurance Research Database was analyzed with a multivariate Cox proportional-hazards model. After 1:1 propensity score matching by baseline comorbidities, age, and the index year, a total of 11,172 patients were assigned to the CHM group (CHM + Western medicine) and 11,172 patients were assigned to the non-CHM group (Western medicine only). The occurrence of BPH-related surgery during the follow-up period was the primary outcome. The Kaplan-Meier method was used to calculate the cumulative incidence of BPH-related surgery in patients with BPH, both those who received CHM treatment and those who did not.</p><p><strong>Results: </strong>During the study period, 875 CHM users and 870 CHM non-users underwent BPH-related surgery, resulting in surgery incidence rates of 6.89 and 7.26 per 1,000 person-years, respectively. Significantly fewer CHM users than CHM non-users received BPH-related surgery (adjusted HR = 0.89; 95% CI = 0.81, 0.98). A significantly lower risk was observed in those treated with CHM for more than 12 months. Dan Shen and Ji-Sheng-Shen-Qi-Wan were the most commonly prescribed single herb and CHM formula, respectively.</p><p><strong>Conclusions: </strong>Our study demonstrated that CHM may reduce the long-term risk of BPH-related surgery. Co-treatment with CHM reduced the risk of BPH-related surgery, especially in patients using CHM for over a year.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin enhances the effects of TRAIL in TRAIL-resistant non-small cell lung cancer cell lines.","authors":"Nurul Izzah Mohd Pauzi, Noor Atiqah Fakharuzi, Nor Rizan Kamaluddin, Moon Nian Lim, Yuslina Mat Yusoff, Adiratna Mat Ripen, Kamal Shaik Fakiruddin","doi":"10.1186/s12906-026-05398-z","DOIUrl":"https://doi.org/10.1186/s12906-026-05398-z","url":null,"abstract":"<p><strong>Background: </strong>TRAIL acts as a selective anticancer agent in non-small cell lung cancer (NSCLC). However, some NSCLC are resistance to TRAIL due to the presence of several anti-apoptotic mechanisms. With the help of natural compound such as curcumin, TRAIL-resistance can be overcome and the effect of TRAIL-induce apoptosis in NSCLC can be improved. In this study, we investigated the effect of curcumin in NSCLC as sensitiser to TRAIL as well as their molecular underlying mechanism.</p><p><strong>Method: </strong>Proliferation assay was conducted to determine whether curcumin could enhance the cytotoxic effect of TRAIL in NSCLC cell lines. Flow cytometry was performed for the assessment of TRAIL receptors expression (DR4 and DR5) and apoptosis assay (Annexin-V / PI staining). Gene expression analysis using RT² profiler PCR array and KEGG tools were performed to analyse the transcriptional levels of 84 significant apoptotic genes in NSCLC.</p><p><strong>Results: </strong>Treatment of NSCLC cell lines with TRAIL revealed that NSCLC cell lines can be classified as TRAIL-sensitive (H2170 and H1437) and TRAIL-resistant (A549 and H1299) based on their IC₅₀ values. H1299 has slightly lower expression of DR5, as compared to the other NSCLC cell lines which have more than 90% expression of DR4 and DR5. The combined treatment of curcumin and TRAIL were able to reduce cell viability and enhanced apoptosis in both TRAIL resistant and sensitive NSCLC cells than TRAIL alone. In addition, the combined treatment seems to induce the intrinsic apoptotic pathway in P53-deficient H1299, by activating the pro-apoptotic genes which are independent of P53.</p><p><strong>Conclusion: </strong>Hence, this study provides evidence on the potential of curcumin as a sensitiser to enhance the efficacy of TRAIL in NSCLC and in TRAIL-resistance NSCLC.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fenugreek seed extract-doxorubicin synergy against hepatocellular carcinoma in HepG2 cells: in vitro and in silico mechanistic studies.","authors":"Wesam Ragab, Kamel Mahmoud, Rasha M Allam, Wesam S Qayed, Osama M Gomaa, Seham S El-Hawary, Abeer S Moawad, Rabab Mohammed","doi":"10.1186/s12906-026-05386-3","DOIUrl":"10.1186/s12906-026-05386-3","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. The therapeutic efficacy of conventional chemotherapeutic agents such as doxorubicin (DOX) is limited by dose-dependent toxicity and the development of drug resistance. Combination strategies incorporating bioactive natural products may enhance anticancer efficacy while enabling dose reduction. The present study aimed to evaluate the potential synergistic cytotoxicity of combining Fenugreek aqueous extract (FAE) with (DOX) against the HepG2 cell line.</p><p><strong>Methods: </strong>Phytochemical characterization was performed using UHPLC-QTOF-MS/MS Profiling and HPLC. Cell viability and selectivity were assessed using the SRB assay. Apoptosis, necrosis, autophagy, and cell cycle distribution were analysed by flow cytometry and Western blotting. Drug-drug interaction was evaluated using the Chou-Talalay method. Molecular docking was performed to explore potential interactions between selected FAE constituents and apoptosis- and autophagy-related protein targets.</p><p><strong>Results: </strong>FAE enhanced DOX's cytotoxicity on HepG2 cells, with the interaction ranging from synergistic to additive depending on the concentration ratio. The DOX/FAE combination enhanced cell death through sub-G1 arrest and augmented apoptotic, necrotic, and autophagic responses compared with monotherapies. Western blot analysis demonstrated modulation of the Bax/Bcl-2 ratio and increased LC3-II expression. Docking simulations suggested favourable binding of selected steroidal saponins to Bcl-2 and LC3 proteins.</p><p><strong>Conclusion: </strong>These findings indicate that FAE potentiates DOX-induced cytotoxicity in vitro through modulation of multiple regulated cell death pathways. While the results support the possibility of this combination as a dose-modulating strategy, further validation in additional HCC models and in vivo systems is required.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications.","authors":"Abdullah, Tahir Hussain, Shah Faisal, Muhammad Rizwan, Mervt M Almostafa, Nancy S Younis, Galal Yahya","doi":"10.1186/s12906-026-05394-3","DOIUrl":"https://doi.org/10.1186/s12906-026-05394-3","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of traditional medicine services into public health centers in Indonesia: a qualitative study.","authors":"Sri Mumpuni Yuniarsih, Retna Siwi Padmawati, Ema Madyaningrum, Siwi Sri Widhowati, Yodi Mahendradhata","doi":"10.1186/s12906-025-04885-z","DOIUrl":"https://doi.org/10.1186/s12906-025-04885-z","url":null,"abstract":"<p><strong>Background: </strong>Many people are still using traditional medicine in various countries. This is a challenge for governments because they must effectively manage services, maintain quality, and protect patients. Integrating traditional medicine into public health centers provides safe and quality services. This study aimed to explore the perceptions and experiences of traditional medicine users and program implementers in Indonesian public health centers.</p><p><strong>Methods: </strong>This study used an exploratory qualitative research design. Data were collected from program implementers and traditional medicine users. Data were collected through focus group discussions and in-depth interviews from March to June 2023. The study had 16 participants which included 10 implementers in focus group discussions and six users in in-depth interviews. Analysis using an inductive approach was employed.</p><p><strong>Results: </strong>Three key themes emerged: user preferences, success factors for integration, and challenges for improvement. Users preferred traditional medicine at public health centers over traditional medicine practitioners due to trust, accessibility, and therapeutic effects. Implementers highlighted the importance of human resource readiness and community support for successful integration, despite obstacles like limited training and resources.</p><p><strong>Conclusion: </strong>The integration of traditional medicine services into public health centers is essential to provide easy access and preserve traditional health services that are in line with local wisdom, effective, and safe.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of extraction method on the chemical composition and antibacterial potential of Salvia fruticosa essential oil.","authors":"Nashwa Hashad, Hanan G Sary, Mohamed T Khazaal, Fatma A Moharram","doi":"10.1186/s12906-026-05376-5","DOIUrl":"10.1186/s12906-026-05376-5","url":null,"abstract":"<p><strong>Background: </strong>Salvia fruticosa (Lamiaceae) is traditionally used to treat gastrointestinal (GIT) issues, stomach and abdominal pain, and ulcers. In this work, we aimed to extract essential oils (EOs) from the aerial parts of S. fruticosa, a plant commonly found in Egypt, and to evaluate their antibacterial activity against GIT pathogens.</p><p><strong>Methods: </strong>Fresh samples' essential oils (EOs) were extracted using hydrodistillation (HD) and headspace (HS) techniques, while dried samples' EOs were obtained via supercritical fluid (SF) extraction. GC/MS analysis was used to analyze the EOs. Their antibacterial activity was tested against Clostridium perfringens ATCC 13124, Listeria monocytogenes ATCC 7644, Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 8739, and Salmonella enterica ATCC 14028 through agar diffusion, microwell dilution, time-kill, and biofilm formation methods.</p><p><strong>Results: </strong>The SF method yielded the highest EO (0.6 mL/100 g). In HD and SF-EOs, oxygenated compounds were predominant, accounting for 68.74% and 41.71%, respectively, while non-oxygenated compounds were most common in HS-EOs at 53.64%. Eucalyptol was the main component in both HD (43.87%) and HS-EOs (35.67%), whereas iso-caryophyllene (17.07%) and 13-epi-manoyl oxide (12.52%) were key in SF-EOs. Both HD and SF EOs showed kinetics similar to the bacterial control, indicating their potential as effective antimicrobials. Significantly, these EOs exhibited strong bactericidal activity against GIT pathogens, including C. perfringens (MBC: 500 µg/mL), L. monocytogenes (MBC: 125 µg/mL), S. aureus (MBC: 31.25 µg/mL), E. faecalis (MBC: 125 µg/mL), E. coli (MBC: 500 µg/mL), and S. enterica (MBC: 250 µg/mL). The reductions in colony-forming units (CFU/mL) were 3.8, 3.94, 7.76, 6.2, 3.7, and 5.47 log10 CFU/mL for each pathogen, with effects lasting 24 h at concentrations of 2× MIC. The MICs ranged from 31.25 to 250 µg/mL for HD and from 3.91 to 250 µg/mL for SF-EOs, demonstrating their superior antibacterial activity against GIT pathogens compared to previous research.</p><p><strong>Conclusion: </strong>S. fruticose EO includes both oxygenated and non-oxygenated volatile compounds and exhibits potent antibacterial effects. They are recommended as bioactive agents for the treatment of gastrointestinal infections, although further research is required to verify their safety for clinical use.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute neurotoxicity in a child following multi-component medicinal fungi supplementation: a case report.","authors":"Hacer Efnan Melek Arsoy, Öner Özdemi̇r","doi":"10.1186/s12906-026-05367-6","DOIUrl":"https://doi.org/10.1186/s12906-026-05367-6","url":null,"abstract":"<p><strong>Background: </strong>Medicinal fungi supplements have gained widespread recognition, increasing off-label use in pediatric populations. However, their safety profile remains inadequately characterized, and the potential for toxic effects, including neurotoxicity, is underrecognized in clinical practice. Here we report a pediatric case of suspected multi-component medicinal fungi supplement-related neurotoxicity, in which the parents were aware that the ingredient was a mushroom for their son's alternative treatment.</p><p><strong>Case presentation: </strong>We report acute neurotoxicity in a 9-year-old boy with prematurity, cerebral palsy, and well-controlled epilepsy presenting with generalized myoclonic seizures, hallucinations, and altered mental status following ingestion of multiple medicinal fungi supplements, including Ganoderma lucidum and Cordyceps sinensis. Comprehensive investigations, including laboratory studies and neuroimaging, excluded infectious, structural, and metabolic etiologies. The temporal relationship between dose escalation of the supplement and symptom onset, combined with resolution upon discontinuation, suggested a supplement-related mechanism.</p><p><strong>Conclusions: </strong>This case highlights the potential neurotoxic effects of mushroom supplements containing both Ganoderma lucidum (reishi mushroom) and Cordyceps sinensis in children with underlying neurological disorders. The temporal association between dose escalation and symptom onset, with complete symptom resolution upon discontinuation, suggests a supplement-related mechanism. Given the increasing use of medicinal fungi in complementary medicine, greater clinical vigilance and public awareness of their potential risks are essential.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of music during endoscopy on pain, anxiety and vital signs: a randomized controlled study.","authors":"Serife Naz Bozkurt, Sema Kocasli","doi":"10.1186/s12906-026-05381-8","DOIUrl":"https://doi.org/10.1186/s12906-026-05381-8","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation and evaluation of anti-inflammatory and wound healing activities of Plantago major subsp. intermedia (Gilib.) Lange.","authors":"Hilal Bacanak, Zeynep Dogan, Esra Küpeli, Akito Nagatsu, Iclal Saracoglu","doi":"10.1186/s12906-026-05393-4","DOIUrl":"https://doi.org/10.1186/s12906-026-05393-4","url":null,"abstract":"<p><strong>Background: </strong>Plantago major subsp. intermedia has been traditionally used in Türkiye for the treatment of wounds, abscesses, constipation, pain, ulcers, hemorrhoids and gynecological diseases. In the present study, the phytochemical composition of P. major subsp. intermedia (Gilib.) Lange was investigated and its anti-inflammatory and wound healing effects were examined in light of existing experimental evidence from related Plantago species.</p><p><strong>Methods: </strong>MeOH, 80% EtOH and water extracts of the plant were prepared. In vivo anti-inflammatory effects of these extracts were investigated using an acetic acid-induced capillary permeability model and their wound healing effects were studied using linear incision and circular excision wound models. Isolation studies were performed on the 80% EtOH extract. Furthermore, in vitro studies were conducted on the 80% EtOH extract, the main fractions obtained from this extract and the some of the isolated pure compounds. In these in vitro studies, anti-inflammatory effects were investigated by measuring nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels and wound healing effects were investigated using the scratch test.</p><p><strong>Results: </strong>A total of six compounds were isolated from P. major subsp. intermedia: Isotachioside (1), aucubin (2), 10-hydroxymajoroside (3), 10-acetoxymajoroside (4), martynoside (5) and acteoside (6). All tested compounds significantly inhibited NO production at concentrations of 25, 50 and 100 µM (12.68%-61.89%). Although in vivo results were not statistically significant, the 80% EtOH extract showed the highest efficacy in linear incision and circular excision wound models.</p><p><strong>Conclusions: </strong>The results of this study indicate the in vitro anti-inflammatory and wound healing activities of P. major subsp. intermedia and are consistent with previously reported biological activities of P. major.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}