BMC Complementary Medicine and Therapies最新文献

{"title":"Retraction Note: Antitumor effect and molecular mechanism of fucoidan in NSCLC.","authors":"Xiaohan Chen, Li Sun, Xiaojuan Wei, Haijun Lu, Ye Tan, Zhanyi Sun, Jinju Jiang","doi":"10.1186/s12906-026-05648-0","DOIUrl":"https://doi.org/10.1186/s12906-026-05648-0","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Phytochemistry, antioxidant, anticancer, and acute toxicity of traditional medicinal food Biarum bovei (Kardeh).","authors":"Bassam Ali Abed Wahab, Zaenah Zuhair Alamri, Ahmed A J Jabbar, Ibrahim Abdel Aziz Ibrahim, Riyad A Almaimani, Hussain A Almasmoum, Mazen M Ghaith, Wesam F Farrash, Yahya A Almutawif, Khalid Aidarous Ageeli, Soliman Mohammed Alfaifi, Rahaf Frehan Alharthi","doi":"10.1186/s12906-026-05643-5","DOIUrl":"10.1186/s12906-026-05643-5","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of metronidazole, metformin, and onion extract on GAPDH activity and nitric oxide production in Blastocystis sp. cultures: a biochemical and therapeutic approach.","authors":"Gehad A Basuony, Alshaimaa M R Hamed, Amal M Mahfoz, Abdel Wahab M Mahmoud, Hala Ramadan, Magda S A Abdeltawab","doi":"10.1186/s12906-026-05605-x","DOIUrl":"10.1186/s12906-026-05605-x","url":null,"abstract":"<p><strong>Background: </strong>Blastocystis sp. is a highly prevalent anaerobic intestinal protozoan increasingly associated with gastrointestinal disorders. Its survival within the gut microenvironment depends on metabolic pathways such as glycolysis, where glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a central role, alongside interactions with nitric oxide (NO) derived from host defenses and surrounding microbiota. The emergence of metronidazole resistance necessitates exploration of alternative therapeutic strategies.</p><p><strong>Objective: </strong>To evaluate the in vitro effects of metronidazole, metformin, and Allium cepa (onion) extract on Blastocystis sp. growth, and GAPDH activity and NO levels within the xenic culture medium.</p><p><strong>Methods: </strong>Twenty-one Blastocystis-positive stool samples were cultured in Jones' medium under xenic conditions. Cultures were treated with graded concentrations of metronidazole, metformin, and onion extract. Parasite counts were assessed microscopically, while GAPDH activity and NO levels were quantified using gas chromatography-mass spectrometry (GC-MS)-based analysis.</p><p><strong>Results: </strong>All tested agents significantly reduced Blastocystis counts compared with untreated controls (p < 0.05), with metronidazole demonstrating the greatest antiparasitic effect. Significant reductions in NO levels and GAPDH activity were observed across all treatment groups (p < 0.001). Metformin (1000 µg/mL) showed the strongest inhibition of GAPDH activity, whereas metronidazole (500 µg/mL) resulted in the lowest NO levels. Correlation analysis revealed a significant negative association between NO and GAPDH in metronidazole-treated cultures, while a positive correlation was observed with metformin.</p><p><strong>Conclusion: </strong>Metronidazole, metformin, and onion extract exhibit significant anti-Blastocystis activity, accompanied by modulation of key metabolic and nitrosative pathways within the microbial milieu supporting the growth of Blastocystis sp. Targeting GAPDH and NO-related mechanisms represents a promising therapeutic approach, particularly in the context of emerging drug resistance and co-colonization with other gut microbiota.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of resveratrol on the hippocampus in the pentylenetetrazol (PTZ) - dependent kindling model of epilepsy.","authors":"Omer Unal, Nilufer Akgun-Unal, Emre Soner Tiryaki, Elif Gulbahce-Mutlu, Seda Simsek, Dervis Dasdelen","doi":"10.1186/s12906-026-05638-2","DOIUrl":"10.1186/s12906-026-05638-2","url":null,"abstract":"<p><strong>Aims: </strong>Epilepsy is a long-term neurological condition marked by neuronal excitotoxicity, oxidative stress, and inflammation of the nervous system. This study seeks to explore the neuroprotective and anti-seizure properties of Resveratrol (RSV) and the molecular processes involved in a pentylenetetrazol (PTZ)-induced kindling epilepsy model, with a focus on ion channels, apoptosis, and SIRT1 pathway.</p><p><strong>Methods: </strong>A total of thirty-two Wistar albino rats were assigned into four groups: Sham, RSV, PTZ, and PTZ + RSV. Following kindling induction via PTZ (35 mg/kg, 3 days/week) or equivalent saline administration for control groups, subsequent RSV treatment (5 mg/kg/day, i.p.) or saline was administered for 28 days. Brain tissues were harvested 24 h after the final injection. Epileptic activity was captured through the use of electrocorticography (ECoG), while tissue damage to the hippocampus was evaluated via hematoxylin-eosin (H&E) staining. Molecular levels of SIRT1, Caspase-3, and S100B protein were assessed via immunofluorescence, whereas SERCA2a, CACNA1G, HCN2, Caspase-3, Caspase-9, and SIRT1 gene expression levels were measured through qPCR analysis.</p><p><strong>Results: </strong>RSV treatment greatly extended the initial myoclonic jerk delay (p = 0.0001) and lowered both the seizure phase and total spike count compared to the PTZ group. Microscopic examination revealed that RSV maintained tissue health by reducing neuronal deterioration and inflammation in the hippocampal CA1 area. Immunofluorescence analysis revealed that RSV treatment restored SIRT1 levels, which were previously diminished by PTZ, and significantly reduced the elevated markers of apoptosis and glial activation. Furthermore, qPCR analysis demonstrated that RSV treatment significantly reversed PTZ-induced gene expression alterations by upregulating the expressions of SERCA2α, CACNA1G, HCN2, and SIRT1 (p < 0.0001), while downregulating the expressions of Caspase-3 and Caspase-9.</p><p><strong>Conclusion: </strong>RSV exerts significant neuroprotective effects in the PTZ kindling model by modulating the SIRT1-mediated stress response and preventing neuronal apoptosis. Notably, this study provides the first in vivo evidence that RSV modulates SERCA2a, CACNA1G, and HCN2 ion channel gene expressions to control intracellular calcium balance and neuronal excitability during epileptogenesis.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green extraction routes for conversion of Nerium oleander L. biomass into bioactive agents: phytochemical insights and antimicrobial promise.","authors":"Mohamed T Selim, Nashaat N Mahmoud","doi":"10.1186/s12906-026-05594-x","DOIUrl":"10.1186/s12906-026-05594-x","url":null,"abstract":"<p><strong>Background: </strong>Nerium oleander L. (N. oleander) is a species of shrub or small tree in the Apocynaceae family that has high levels of digitalin linear activity and cardiac glycosides, especially nerine and oleander. The study was researched to assess the in vitro proximate compositions, phytochemical analysis, and antimicrobial activity of the dried stems, leaves, and flowers of N. oleander extracted using various solvents.</p><p><strong>Methods: </strong>Petroleum ether, ethyl acetate, acetone, methanol, and water extracts of the various solvents were tested for total phenol, flavonoid, and tannin contents using various phytochemical assays, while the antimicrobial activity was evaluated using the agar well diffusion method against six bacterial and fungal strains.</p><p><strong>Results: </strong>The flowers had a higher moisture content (9.40%), whereas the stems had a higher ash content (18.58%) than the leaves and flowers. The flowers also had higher lipid, carbohydrate, and crude protein contents (4.33, 66.16, and 15.29%, respectively). The leaves of the N. oleander produced a maximum yield followed by flowers and stems, respectively. The highest percentage extractive yield was demonstrated by water extracts, which were followed by methanol, acetone, ethyl acetate petroleum ether extracts. The findings of the study showed that alkaloids, flavonoids, tannins, glycosides, steroids, coumarins, quinones, phenols, cardiac glycosides, and terpenoids were found by phytochemical analysis of N. oleander in different parts, while saponins and anthraquinones were completely absent in all parts. On the other hand, anthocyanins are present only in flowers and completely absent in stems and leaves. The greatest levels of phenol content, flavonoids and tannins were found in acetone extract of the flowers (157.12 ± 17.62 mg GAE/g, 187.43 ± 15.91 mg QE/g, and 89.93 ± 18.77 mg TAE/g, respectively), while the petroleum ether extract of stems had the lowest amount (5.45 ± 2.65 mg GAE/g, 6.43 ± 0.29 mg QE/g and 3.45 ± 2.05 mg TAE/g, respectively). Antimicrobial tests revealed the extract's ability to inhibit several Gram-positive bacteria (Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633), Gram-negative bacteria (Pseudomonas aeruginosa ATCC 9027, Salmonella Typhimurium ATCC 14028 and Escherichia coli ATCC 11229), and eukaryotic strains such as unicellular fungi (Candida albicans ATCC 10231).</p><p><strong>Conclusion: </strong>These results highlight the potential of N. oleander extracts as natural antimicrobials.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats.","authors":"Zhiguang Qiao, Jiaxin Tang, Wen Wu, Jian Tang, Ming Liu","doi":"10.1186/s12906-026-05627-5","DOIUrl":"https://doi.org/10.1186/s12906-026-05627-5","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment choices: insights into disease-specific use and self-perceived benefits of traditional, complementary and integrative medicine in Germany.","authors":"Tido von Schoen-Angerer, Manfred Wischnewsky, Michael Jeitler, Benno Brinkhaus, Miriam Ortiz, Rasmus Hoffmann, Christian S Kessler","doi":"10.1186/s12906-026-05496-y","DOIUrl":"https://doi.org/10.1186/s12906-026-05496-y","url":null,"abstract":"<p><strong>Background: </strong>Previous cross-sectional studies suggest that Traditional, Complementary and Integrative Medicine (TCIM) is used frequently in Germany. We assessed TCIM usage patterns across different disease categories in the German population.</p><p><strong>Method: </strong>In this cross-sectional survey of an online-representative sample of the German population aged 18-75 years, participants were asked about their use and acceptance of TCIM. Participants were also queried about 15 illness categories. Health-related quality of life was assessed using the EQ-5D-5L questionnaire. Data were analyzed descriptively and inferentially.</p><p><strong>Results: </strong>A total of 4,065 individuals (52% female) responded. 70% had used TCIM at some point in their lives, 32% in the last 12 months, and 18% were current users. Over half (52%) reported a mostly or very positive attitude towards TCIM. The highest rates of TCIM use were reported for acute respiratory illness (55.9%), chronic gastrointestinal illness (51.4%) and acute gastrointestinal illness (49.2%). The illness-specific, self-reported benefit from TCIM ranged from 61.4 to 86.2% (mean 70.8%) and remained high even among individuals of poorer health-related quality of life. No relation between TCIM use across different disease categories and the global research activity in those categories was apparent in the scatter plot.</p><p><strong>Conclusions: </strong>TCIM is widely used and perceived as beneficial for acute and chronic conditions in Germany. Individuals with poorer health status also reported substantial benefit. Stakeholders in the German healthcare system should critically examine the high level of TCIM use, promote rigorous scientific evaluation, integrate evidence-informed TCIM with conventional medicine, and ensure appropriate reimbursement for TCIM through statutory health insurance.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacological insights into type 2 diabetes management by traditional Moroccan herbal teas: HPLC-MS characterization of phenolic compounds and their related antioxidant and enzyme inhibitory activities.","authors":"Ahmed Zayed, Meryem El Jemli, Mourad Kharbach, My El Abbes Faouzi, Rasha Ali Radwan, Shahira M Ezzat","doi":"10.1186/s12906-026-05588-9","DOIUrl":"10.1186/s12906-026-05588-9","url":null,"abstract":"<p><strong>Background: </strong>Traditional Moroccan herbal teas are widely consumed and have been traditionally used for managing chronic metabolic disorders, particularly type 2 diabetes mellitus (T2DM). Although these preparations have a long history of ethnomedicinal use, their phenolic composition and biological activities remain insufficiently characterized. Scientific validation is needed to support their traditional application and provide evidence for their potential relevance to T2DM management. This study aimed to characterize the phenolic profile, antioxidant potential, and carbohydrate-digestive enzyme inhibitory activity of 21 traditional Moroccan herbal teas used for glycaemic control.</p><p><strong>Methods: </strong>Phenolic constituents were identified and quantified using HPLC-MS. Antioxidant capacity was evaluated through DPPH, ABTS, and FRAP assays. Inhibitory effects on α-amylase and α-glucosidase were assessed in vitro. Correlation analyses were conducted to explore associations between phenolic constituents and biological activities.</p><p><strong>Findings: </strong>Marked variability in total phenolic content (TPC) was observed, with Mentha × piperita and Thymus broussonetii exhibiting the highest levels at 883.2 ± 13.0 and 746.8 ± 22.4 mg GAE/g dry weight, respectively. Antioxidant activity varied substantially among the investigated teas, with T. broussonetii (FRAP reducing power: 423.6 ± 9.8 µg/mL) and Mentha rotundifolia (162.6 ± 0.6 µg/mL) showing significant reducing capacities. TPC exhibited strong positive correlations with antioxidant indices (r = 0.93-0.96). Pelargonium graveolens presented potent α-amylase inhibition (IC₅₀ = 2.98 ± 1.7 µg/mL), whereas Mentha viridis and Calamintha officinalis were among the most active α-glucosidase inhibitors (IC₅₀ = 1.9 ± 0.4 and 1.2 ± 0.1 µg/mL, respectively). Negative correlations were found between rutin (r = - 0.49) and gallic acid (r = - 0.44) contents and α-amylase IC₅₀ values.</p><p><strong>Conclusion: </strong>The investigated Moroccan herbal teas exhibited variable antioxidant and digestive-enzyme inhibitory activities that were associated with their phenolic composition. Variability among samples may reflect differences in plant species and environmental or agronomic factors. These findings provide comparative in vitro evidence supporting the traditional use of Moroccan herbal teas and highlight several species as promising sources of bioactive phenolics. However, the present findings do not establish therapeutic efficacy, and further in vivo, mechanistic, pharmacokinetic, and clinical studies are required to confirm their efficacy, safety, and clinical relevance.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harvest-Time-Dependent variations in phytochemistry and in vitro bioactivities of Vitis vinifera Leaves.","authors":"Amal M El-Feky, Noha E Ibrahim, Wael Mahmoud Aboulthana","doi":"10.1186/s12906-026-05578-x","DOIUrl":"10.1186/s12906-026-05578-x","url":null,"abstract":"<p><strong>Background: </strong>Vitis vinifera L. leaves are rich in bioactive phytochemicals, but their composition and biological activities may vary considerably with harvest time. This study investigated harvest-dependent changes in the phytochemical profile and in vitro biological activities of grape leaves.</p><p><strong>Methods: </strong>Methanolic extracts of V. vinifera leaves collected in March, May, and September were evaluated for photosynthetic pigments, total polyphenols, flavonoids, and tannins. HPLC analysis was used to characterize individual phenolic and flavonoid constituents, while major compounds were isolated and structurally identified. The extracts were further assessed for antioxidant and radical-scavenging, antidiabetic, anti-Alzheimer's, anti-inflammatory, anti-arthritic, and cytotoxic activities.</p><p><strong>Results: </strong>Harvest time markedly affected the phytochemical composition and biological activities of the leaves. The May-harvested leaves showed the highest levels of total chlorophyll, polyphenols, flavonoids, and tannins, whereas carotenoids were comparatively higher in the September and March samples. HPLC analysis revealed greater accumulation of phenolic and flavonoid constituents in the May extract, with chlorogenic acid, rosmarinic acid, gallic acid, and naringenin among the predominant compounds. Consistently, the May extract exhibited the strongest antioxidant and radical-scavenging activities and showed superior inhibitory effects in the antidiabetic, anti-Alzheimer's, anti-inflammatory, anti-arthritic, and cytotoxic assays compared with the other harvest periods.</p><p><strong>Conclusion: </strong>Harvest time substantially influences the accumulation of bioactive constituents and the in vitro biological potential of V. vinifera leaves. Among the investigated periods, May appeared to be the most favorable harvest time for obtaining grape leaves enriched in bioactive phytochemicals with promising biological activities, supporting their potential valorization as a value-added viticultural by-product.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dance movement therapy on traumatized refugee women - a clinical controlled trial.","authors":"Sabine C Koch, Zahra Nazemi, Christina Arnaud, Kayleigh Cook, Sonja J Steltmann, Crystal Tomaszewski","doi":"10.1186/s12906-026-05299-1","DOIUrl":"10.1186/s12906-026-05299-1","url":null,"abstract":"<p><strong>Background: </strong>Women worldwide are fleeing war, persecution and violence. Typically, they experienced multiple traumata in the home country, on the way, and in the host country. In Germany, less than 10% of the refugees in need receive mental health treatment. Dance movement therapy (DMT) was tested as a treatment option for traumatized refugee women regarding its potential to reduce symptoms of trauma, stress, depression and anxiety.</p><p><strong>Methods: </strong>In a controlled within-group design, N = 24 traumatized refugee women from six countries, dwelling in communities of Southern Germany, were tested at baseline (t1), pretest (t2), and posttest (t3), with an exploratory follow-up (N = 10) on symptoms of trauma, stress, depression and anxiety. We employed the RHS-15 as the primary outcome measure, and the DASS21 and PCL-S as secondary measures. Scales were administered in an interview format in the participants' native or a well-spoken language. After an initial 8-week waiting period, the intervention-integrating participants' emotionally meaningful music and their own dance improvisations-was conducted in 8 weekly group sessions of 1.5 h. In the study period, no woman had any other psychotherapy. Results were analyzed with Greebhouse-Geisser corrected F-tests and with t-tests for related samples.</p><p><strong>Results: </strong>Results suggest that (a) the trauma symptoms of all women were clinically relevant at baseline, that (b) all symptoms remained unchanged after the waiting period, and that (c) symptoms of trauma, stress, depression, and anxiety dropped significantly after the DMT intervention; in the case of trauma (PCL-S) so markedly that they fell under the clinical cutoff value. The exploratory follow-up suggests that effects carry on after eight weeks, but not after one year. Limitations of the study are the use of a within-group design, and a relatively small, yet fully powered, sample.</p><p><strong>Conclusions: </strong>The refugee women in this study experienced a pronounced symptom reduction regarding trauma, stress, depression, and anxiety after an 8-week DMT intervention. Based on this preliminary evidence, DMT seems to be a promising low-threshold and cost-effective therapy approach that can improve the mental health and wellbeing of refugee women of diverse cultural backgrounds suffering from PTSD symptoms. The lack of high-quality studies with proper control conditions and follow-ups points to the need for future research with more rigorous methodologies.</p><p><strong>Trial registration: </strong>OSF clinical trial registration (retrospectively registered at Center for Open Science on 27/03/2023).  https://doi.org/10.17605/OSF.IO/EG7SD .</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"26 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}