The effect of Citrus aurantium inhalation aromatherapy on chemotherapy-induced nausea and vomiting in breast cancer patients: a randomized controlled trial.

IF 3.4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Parsa Tabei, Zahra Molazem, Mozhgan Rivaz, Parvin Ghaem Maghami, Niloofar Ahmadloo
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Abstract

Background: Breast cancer (BC) is the second most common cancer globally and the most prevalent among women. Chemotherapy, a primary treatment, frequently induces distressing side effects like nausea and vomiting. This study evaluated the efficacy of Citrus aurantium inhalation aromatherapy in reducing chemotherapy-induced nausea and vomiting (CINV) in women with BC.

Methods: In this CONSORT-compliant parallel-group randomized controlled trial (registered at IRCT: 20240305061177N1), 92 BC patients at Motahari Clinic were randomly allocated (between April to August 2024) to an aromatherapy group (n = 46) or a control group (n = 46). Alongside standard antiemetic medications, the aromatherapy group inhaled two drops of C. aurantium essential oil applied to the philtrum, while the control group received sunflower oil. The Rhodes Index assessed nausea, vomiting, and retching over five days.

Results: Significant reductions in mean total scores for nausea, vomiting, and retching were observed in the aromatherapy group compared to the control group from days 3 to 5 (P < 0.05), with no significant differences on days 1 and 2. Total symptom scores significantly decreased from Day 1 to Day 5 in the aromatherapy group while the control group showed no change.

Conclusion: C. aurantium aromatherapy significantly alleviated CINV during the delayed phase (days 3-5). Given its safety, affordability, and accessibility, this intervention offers a promising complementary approach for managing CINV in BC patients.

Trial registration: This trial was registered with the Iranian Registry of Clinical Trials (IRCT20240305061177N1, march 17, 2024).

Abstract Image

金柑橘吸入芳香疗法对乳腺癌化疗引起的恶心和呕吐的影响:一项随机对照试验。
背景:乳腺癌(BC)是全球第二大常见癌症,在女性中发病率最高。化疗是一种主要的治疗方法,经常会引起恶心和呕吐等令人痛苦的副作用。本研究评估了金柑橘吸入芳香疗法在减少BC女性化疗引起的恶心和呕吐(CINV)方面的疗效。方法:在这项符合concont标准的平行组随机对照试验中(注册于IRCT: 20240305061177N1),将Motahari诊所的92例BC患者随机分配(2024年4月至8月)到芳香疗法组(n = 46)或对照组(n = 46)。除了标准的止吐药物外,香薰组还吸入两滴金薰衣草精油,涂在中耳上,而对照组则服用葵花籽油。罗德指数评估5天内的恶心、呕吐和干呕。结果:与对照组相比,香薰治疗组在第3-5天恶心、呕吐和干呕的平均总分显著降低(P结论:金桂香薰治疗在延迟期(第3-5天)显著缓解了CINV。鉴于其安全性、可负担性和可及性,这种干预措施为治疗BC患者的CINV提供了一种有希望的补充方法。试验注册:该试验已在伊朗临床试验注册中心注册(IRCT20240305061177N1, 2024年3月17日)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
6.10
自引率
2.60%
发文量
300
审稿时长
19 weeks
期刊介绍:
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