Archives in cancer research最新文献

{"title":"The Role of Biological Clock in Gynecologic Cancer","authors":"E. Karoutsou, P. Karoutsos, D. Karoutsos","doi":"10.21767/2254-6081.1000133","DOIUrl":"https://doi.org/10.21767/2254-6081.1000133","url":null,"abstract":"Disruption in coordinated co-expression of clock genes, like Period genes mutations, is linked with the increased risk of lung, gastrointestinal, hematologic and gynecologic cancers. Several clock genes have been found to functionally interplay with regulators of the cell cycle. It is suggested that abnormal cell cycle function in cancer could also be a consequence of a disrupted biological clock. Chrono-disruption, being studied in different cancer entities, including the gynecologic cancer, could provide time set intervention in cancer therapeutics– chronotherapy in a 24 h–period.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68111075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of D2-40 in Benign and Malignant Breast Lesions and Study the Correlation between Lymphovascular Density and other Prognostic Factors of Breast Cancer","authors":"M. Abdel-Dayem, A. Ibraheim","doi":"10.21767/2254-6081.1000132","DOIUrl":"https://doi.org/10.21767/2254-6081.1000132","url":null,"abstract":"Background: D2-40 is a mouse monoclonal antibody specific for human podoplanin and has been used in identifying lymphovascular invasion (LVI) of tumors; also its expression has been used as a marker for myoepithelial cells (MEC) of breast. Lymphangiogenesis, assessed as lymphovascular density (LVD), is the initial step of generalized tumor lymphovascular invasion (LVI). It also involves VEGF-C as the most important protein family. Lymphangiogenesis among breast cancer cases correlations with several clinicopathological factors are important to determine prognosis and treatment strategies, but results have been controversial and require clarification. Aim: The aims of this work (1) To explore the expression of D2-40 as a marker for myoepithelial cells (MECs) of the breast lesions, (2) To investigate the clinicopathological significance of VEGF-C, D2-40 expression and lympovascular density (LVD) in breast cancer patients. Methods: Sections from 88 paraffin-embedded archival specimens of breast lesions were selected to include benign breast lesions as fibrocystic changes of the breast and ductal hyperplasia (15 cases); and invasive breast cancer (73 cases). Immunohistochemistry (IHC) for D2-40, calponin and VEFG-C were performed and IHC staining results and the associations of intratumoral and peritumoral LVD were correlated with clinic-pathological features and prognosis were assessed. Results: D2-40 highlighted the MECs of benign breast lesions beside it identified lymphatic vessels and LVI in breast carcinomas. VEGF-C expression was significantly higher in invasive breast cancer than benign breast lesions (p < 0.01). VEGF-C (p < 0.001) expression was significantly associated with peritumoral LVD, but not intratumoral LVD. VEGF-C expression, peritumoral LVD and LVI were significantly associated with lymph node metastasis (p = 0.025, p = 0.006 and p = 0.017, respectively). Moreover, peritumoral LVD was an independent risk factor for axillary lymph node metastasis, disease-free survival in multivariate analysis. Conclusion: our results show that D2-40 is a reliable marker highlights MECs in benign breast lesions beside it is a useful tool for identification of LVI in breast carcinomas which reflecting a potential for lymphatic metastatic spread and possible poor prognosis. Our study also demonstrated that high expression of VEGF-C in invasive breast carcinoma may induce lymphangiogenesis in the peritumoral area. Peritumoral LVD appeared to be a potential","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68111239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelargonium graveolens (Rose Geranium) - A Novel Therapeutic Agent for Antibacterial, Antioxidant, Antifungal and Diabetics","authors":"R. Hamidpour, S. Hamidpour, M. Hamidpour, Victoria Marshall, Roxanna Hamidpour","doi":"10.21767/2254-6081.1000134","DOIUrl":"https://doi.org/10.21767/2254-6081.1000134","url":null,"abstract":"Objectives: Draw upon published research articles for evidence and comprise the collected evidence in an evaluation of the preserving and therapeutic abilities of Pelargonium graveolens. Design: The articles used as research for this research review were discovered by searching public databases with keywords such as “Pelargonium graveolens”, “P. graveolens”, “pelargoniums”, “rose-scented geranium”, and “geraniums.” Then the articles were reviewed, summarized, and organized based on findings. Results: Many articles were reviewed and many different benefits to the Pelargonium genus were discovered. The major focus in the reviewed articles, however, was on the species Pelargonium graveolens (P. graveolens). P. graveolens displayed many positive benefits. The major benefits that were reviewed were the plant’s antibacterial, antioxidant and anti-fungal activities. Other noteworthy benefits that were reviewed include hypoglycemic and anti-reprotoxic activities as well as fairly low toxicity levels. Conclusion: Pelargonium graveolens antibacterial activity shows promise and could move to human trials. However, more research needs to be performed on Gram-negative bacteria because the essential from the plant does not have as strong of an effect as it does on Gram-positive bacteria. As an antioxidant, results are very positive and human trials could ensue. Regarding anti-fungal activity, the essential oil outperformed the drugs currently in place to treat fungal activity and in doing so led to the conclusion that P. graveolens could be used as a viable anti-fungal. Pelargonium graveolens’s antioxidant ability is linked to its hypoglycemic effects against diabetes as diabetes has been linked to oxidative stress. Human trials in this area could also ensue. Against toxins that affected the male reproductive system, P. graveolens showed to reverse the negative effects and more research should be done to look into the potential for human trials. In most cases thus far observed, P. graveolens’s toxicity level was relatively low and within limits to be harmless to humans. However, it was not low enough to be considered without any hesitation and more research should be performed to look for ways to lower this level.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68111305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of Anti-Robo1 Immunotoxin Cytotoxicity to Head and Neck Squamous Cell Carcinoma via Photochemical Internalization","authors":"N. Komatsu, Kenichi Mitsui, Osamu Kusano-Arai, H. Iwanari, K. Hoshi, T. Takato, Takahiro Abe, T. Hamakubo","doi":"10.21767/2254-6081.100157","DOIUrl":"https://doi.org/10.21767/2254-6081.100157","url":null,"abstract":"Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. The long-term complications arising from standard therapy with surgery, chemotherapy and radiotherapy lower the quality of life (QOL) due to eating disorders, speech problems and cosmetic issues. Recently the importance of antibody therapy has increasingly come to be recognized for its capacity to enhance QOL. Robo1, an axon guidance receptor, has been received considerable attention as a monoclonal antibody target in various cancers. Methods and findings: We checked the expression of Robo1 and the cytotoxic effect of saporin-conjugated anti- Robo1 immunotoxin (IT) against several HNSCC cell lines. The Robo1 cell surface expression level estimated by flow cytometry using the antibody B5209B was approximately 220,000 copies in Robo1 over-expressed CHO (Robo1/ CHO) cells, and in HNSCCs, 22,000 copies in HSQ-89 cells, 3,000 copies in Sa3 cells, and few copies inSAS cells. Conventional IT treatment exhibited an inadequate cytotoxic effect even in HSQ-89 cells. When we added a photosensitizer and LED light illumination (650 nm), the cytotoxic effect was remarkably improved in HSQ89. With longer exposure, significant cytotoxicity was observed, even in Sa3 cells. Conclusion: These results suggest that the photochemical internalization (PCI) is a promising method for augmenting the cytotoxicity of IT against tumors. The drug delivery system shown in this study should be applicable to other targets with low level expression on cancer cells, thus widening the therapeutic window in rare cancers.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68123016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinoblastoma Case: Shall we Get A Paramagnetic Trend in Chemotherapy?","authors":"Alrx, er A. Bukhvostov, A. Dvornikov, K. Ermakov, D. Kuznetsov","doi":"10.21767/2254-6081.100158","DOIUrl":"https://doi.org/10.21767/2254-6081.100158","url":null,"abstract":"We have performed our study on a NEN-treated RB cell culture derived from a real clinical autopsy material. 3.5- year-old male donor has died of a massive complex abdominal trauma being previously RB-diagnosed with NMR and ultrasound tests, tumor located behind the eye globe equator line. This is a first report ever on magnetic isotope effects of metal ions to cause the clear anti-cancer consequences in retinoblastoma cells by depriving them of the DNA repair capabilities. Both molecular mechanism of phenomenon and its possible meaning for retinoblastoma chemotherapy are presented here.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68124386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Cervical Cancer Screening andAssociated Factors among Female HealthWorkers in Governmental Health Institutionof Arba Minch Town and Zuria District, GamoGofa Zone, Arba Minch, Ethiopia, 2016","authors":"T. Seyoum, Aman Yesuf, G. Kejela, Feleke Gebremeskel","doi":"10.21767/2254-6081.100165","DOIUrl":"https://doi.org/10.21767/2254-6081.100165","url":null,"abstract":"Background: Cervical cancer screening is a key to detect the pre-cervical cancer earlier, but it is almost not utilized in all developing countries and most cases were diagnosed at late stage of cervical cancer. The current screening level has no much effect to control cervical cancer unless addressing female health workers since they are a role model to the public. Objective: The study was conducted to assess the utilizations of cervical cancer screening and associated factors among female Health workers in Arba Minch town and Zuria woreda public health facilities in 2016/17. Methods: A facility based cross-sectional study design was conducted in Arba Minch town and Zuria district, among selected female health professions using computer generated technique of simple random sampling. The data was collected by means of self-administered questionnaires and ethical issue had been given more emphasized during data collection time. Data was entered using EPI info version 7.2.0.1 and analyzed by SPSS version 20. The associations of explanatory and outcome variables were assessed by binary logistic regression and those variables with p value of less than 0.25 were included in multivariate analysis and Statistical significant was considered with odd ratio, 95% of confidence interval and p value of <0.05. Result: About 281 of the respondents were correctly completed the questionnaire of the total respondents, only 27 (9.6%) have had cervical screening within the past three years. There was an association between service year utilization of cervical cancer screening (AOR=4.99, 95% CI: 1.36-18.10), knowledge of cervical cancer screening and utilization of cervical cancer screening (AOR 1.78, 95% CI: 1.05-3.02). Conclusion: The level of utilization of screening was low in female health workers, service year and knowledge were associated with the utilization of cervical screening. Sustaining awareness creation and sensitization of screening should be given emphasis broadly for female’s health workers to increase the number of utilization in health workers.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68124557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specimen Orientation in Breast Conserving Surgery: An Argument for using Specimen Kits","authors":"F. Iqbal, H. Tafazal, F. Salem, R. Vidya","doi":"10.21767/2254-6081.1000151","DOIUrl":"https://doi.org/10.21767/2254-6081.1000151","url":null,"abstract":"Breast cancer becoming a major threat now a day. About 45,000 women are diagnosed with breast cancer in the UK each year and about 60% have breast conserving surgery. The rate of re-excision rates following breast conserving surgery varies between 12% to 30%across the UK. The use of margin status and re-excision rate as a measure of quality is controversial. Specimen orientation kits are important as they can influence the re-excision rates. Here in this study, there is used a new specimen orientation kit called 'Klin tray' and assessed its impact on margins and re-excision rate.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68113533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undifferentiated Lymphoepithelial Carcinoma of Cervix: A Rare Case Report","authors":"Y. Echchikhi, Asmae Touil, S. Elabbassi, Tayeb Elkebdani, N. Benjaafar","doi":"10.21767/2254-6081.1000150","DOIUrl":"https://doi.org/10.21767/2254-6081.1000150","url":null,"abstract":"Lymphoepithelial Carcinoma (LEC) is a rare malignancy. It has been diagnosed in head and neck region, but it was extremely rare in the cervix. There are only few case reports describing the cytology and the management of these tumors. In this report, we describe a very rare case of undifferentiated lymphoepithelial carcinoma of cervix in 50-year-old woman.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68113627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Based Cytology Cervical Cancer Screening Program - Georgian Experience","authors":"S. Bojgua, E. Kldiashvili","doi":"10.21767/2254-6081.100089","DOIUrl":"https://doi.org/10.21767/2254-6081.100089","url":null,"abstract":"Objective: The study aimed to evaluate liquid based cytology as a tool for cervical cancer screening in Georgia. \u0000Materials and methods: 1293 cervical cytology samples have been analyzed in Georgia. The samples had been collected and processed by the usage of materials and equipment provided by Hologic. Prepared smears were post-fixed in 96% ethanol and stained accordingly with Papanicolau protocol. The Bethesda 2001 system terminology was employed for reporting and diagnoses of cervical smears. \u0000Results: The negative for intraepithelial lesion or malignancy (NILM) category was equal to 1156 cases (89.40%). Other categories in decreasing order were atypical squamous cells of undetermined significance (ASCUS) with 104 cases (8.04%), low grade squamous intraepithelial lesion (L-SIL) with 8 cases (0.62%), high grade squamous intraepithelial lesion (H-SIL) with 1 cases (0.08%), atypical squamous cells, cannot exclude high grade intraepithelial lesion (ASC-H) with 21 case (1.63%) and atypical glandular cells of undetermined significance (AGUS) with 3 case (0.23%). Cellularity was lower in liquid based cytology (LBC) as compared with conventional smears (CS). Also, nuclar overlap was significantly less observed compared to CS. The smear background was notably cleaner and cell morphology was better evaluated in LBC. In terms of Trichomonas and Candida detection, LBC was superior compared to CS. Doderlein lactobacilli were seen in significantly lesser amounts and were mainly situated in close vicinity to the squamous epithelial cells. Due to lack of pretreatment, the degree of inflammation was better assessed in CS. \u0000Conclusion: Our experience shows that LBC is superior to CS in the evaluation of cell morphology and detection of certain microorganisms such as Trichomonas and Candida. The degree of inflammation is better assessed with CS.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68122107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Central Nervous System Lymphoma: A Critical Review of the Role of Surgery for Resection.","authors":"Jonathan Yun,&nbsp;Fabio M Iwamoto,&nbsp;Adam M Sonabend","doi":"10.21767/2254-6081.100071","DOIUrl":"https://doi.org/10.21767/2254-6081.100071","url":null,"abstract":"<p><strong>Background: </strong>Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that carry a poor prognosis, with most patients suffering recurrence. Progress has been made in the treatment of this pathology, notably with the widespread use of systemic high dose methotrexate. However, unlike most other malignant CNS neoplasms, surgery for cytoreduction is not routinely performed for this disease, mainly as a result of negative experiences decades ago. Since these studies were published, the availability of intraoperative monitoring, MR imaging and neuro-navigation as well as surgical adjuncts such as fluorescence- guided resection have greatly improved the safety of intracranial procedures. More recent data is suggestive of a potential survival benefit for resection of single PCNSL lesions when patients are subsequently treated with modern regimen high-dose methotrexate, yet this evidence is limited, and should be interpreted conservatively.</p><p><strong>Methods and findings: </strong>A systematic review of the literature was performed to identify trials evaluating surgical options for the treatment of PCNSL.</p><p><strong>Conclusion: </strong>In this review, we provide a critical overview of the evidence favoring and discouraging resection for PCNSL. This literature suffers from several biases and limitations that must be considered in the context of the extrapolation of this literature into clinical decision-making.</p>","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34765967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}