Archives in cancer research最新文献_第10页

The Burden of Unplanned Excision of Soft Tissue Tumours in Developing Countries: A 10-Yearsâ Experience at a Regional Cancer Centre 发展中国家非计划切除软组织肿瘤的负担:一个区域癌症中心10年的经验

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.1000105

S. Altaf, K. Dev, J. Gurawalia, V. Kurpad, P. Arun, Ey

{"title":"The Burden of Unplanned Excision of Soft Tissue Tumours in Developing Countries: A 10-Yearsâ Experience at a Regional Cancer Centre","authors":"S. Altaf, K. Dev, J. Gurawalia, V. Kurpad, P. Arun, Ey","doi":"10.21767/2254-6081.1000105","DOIUrl":"https://doi.org/10.21767/2254-6081.1000105","url":null,"abstract":"Background: Local recurrence in soft tissue sarcomas is the major onus of the disease which could result in nonfunctioning extremities. The local recurrence of soft tissue tumours is the major morbidity and cause for this is the unplanned surgery at inexperienced peripheral centers. We noticed that a major proportion approximate one fourth patient with soft tissue tumours presented in outdoor, were with residual or recurrent lesion. Aim: The aim was to examine the clinical and pathological profile of soft tissue tumours that had undergone unplanned excision in aspect to the natural event of recurrence in respect to surgery which has been performed. Materials and methods: In total, 126 patients who had undergone prior surgery of the tumour without oncological planning presented to our institute with residual or recurrent soft tissue tumours between January 2005 to December 2014 were analyzed in a retrospective study. Results: There were a total of 126 patients analyzed. The mean age was 44.3 ± 16.9 years. Average duration from previous unplanned excision to presentation was 5.3 months (1-57 months). 29 patients were presented immediately after the first surgery with clinical residual lesion with a diagnosis of soft tissue sarcoma, while 97 patients presented after apparent local recurrence. Most of the tumours were almost evenly distributed among low and high grade (40.5% vs. 59.5%), superficial and deep seated (48.4% vs. 51.6%), and <5 cm in size (62.9%). 99 (78.6%) patients presented within 24 months after unplanned excision. 22 (17.4%) patients were presented with distant metastasis also with local recurrence. Conclusion: The appropriate planning regarding as diagnosis as treatment purpose for the soft tissue sarcoma without assuming the soft tissue mass as benign lesion. It helps to reduce the morbidity due to recurrence after inadequate surgical excision.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Colorectal Adenocarcinoma: A Case Report of Cutaneous Metastatic Disease 结直肠癌:皮肤转移性疾病1例报告

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.1000112

Clara Curiel-Lew, rowski, I. Krase, J. Chao

引用次数: 0

Comparative Evaluation of Different Docking Tools for Kinases Against Cancerous (Malignant) Cells 不同抗癌(恶性)细胞激酶对接工具的比较评价

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.1000117

Sadia Bano, Aisha Umar

{"title":"Comparative Evaluation of Different Docking Tools for Kinases Against Cancerous (Malignant) Cells","authors":"Sadia Bano, Aisha Umar","doi":"10.21767/2254-6081.1000117","DOIUrl":"https://doi.org/10.21767/2254-6081.1000117","url":null,"abstract":"Protein-ligand docking attempts to study and predict the protein-ligand complex which is formed by interaction of receptor with its ligand. Different methods have been used for designing molecular docking algorithms which are initially command based complex procedures and are now user friendly GUI systems. Comparative study of various docking algorithms gives us useful information to select the proper algorithm for our research and design drugs of our choice by using computational techniques. The selection of particular algorithm is important for selected protein dataset. In present study, an important class of Protein, Kinases are considered, which are regulatory in nature, to find appropriate docking tool for their study. Tyrosine Kinases are particularly targeted for making inhibitors which can be used as anticancer drugs. Consequently, specifically suitable docking algorithm for Tyrosine Kinases can be helpful in drug designing against Tyrosine Kinases. This analysis explored four different docking algorithms for docking named as Auto dock, Auto dock Vina, Hex Server and Patch dock. In this study, Auto dock Vina produced suitable ligand conformations.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68109951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gross Total Resection, Radiotherapy and Temozolomide as an Aggregate Management, in Patients Suffering Glioblastoma Multiforme (GBM). Can it be Beneficial? 多形性胶质母细胞瘤(GBM)患者的总体全切除、放疗和替莫唑胺综合治疗。它会有益吗?

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.100053

Tsianaka Eleni, Fotakopoulos George, Vagkopoulos Konstantinos, Siasios Ioannis, Kotlia Polikceni, Kapsalaki Effie, Fountas Kostas

{"title":"Gross Total Resection, Radiotherapy and Temozolomide as an Aggregate Management, in Patients Suffering Glioblastoma Multiforme (GBM). Can it be Beneficial?","authors":"Tsianaka Eleni, Fotakopoulos George, Vagkopoulos Konstantinos, Siasios Ioannis, Kotlia Polikceni, Kapsalaki Effie, Fountas Kostas","doi":"10.21767/2254-6081.100053","DOIUrl":"https://doi.org/10.21767/2254-6081.100053","url":null,"abstract":"Background: Glioblastoma multiforme (GBM) is the most aggressive glioma subtype. Objective of this study is to find out if there is any benefit from the combination of Gross Total Resection (GTR) of the tumor and postoperative management with Radiotherapy and Temozolomide (RT&TMZ), for the overall survival of these patients. Material and methods: In this 5 year study, were included 82 patients who underwent surgery for GBM. After the surgical removal of the tumor, there were two different options for the patients: treatment with combination of RT and TMZ, or doing nothing more. Collected information included sex, age, Ki-67 levels, preoperative Karnofsky performance score (KPS), therapeutic approach and survival time. Results: 82 patients were meeting the inclusion criteria for this study. Studying the statistical correlation of individual factors, it is clear that KPS, GTR and RT&TMZ represent statistical significance over survival of the patients. Patients with combined GTR, RT and TMZ have longer survival time, compared with all others. Conclusion: The modification of the conventional treatment for GBM, adding GTR and RT&TMZ could lead to a more efficient management and effective treatment for GBM, elongating the survival of these patients.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68118611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should the Scope of Historical Citations on Cancer be Broadened 癌症历史引文的范围是否应该扩大

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.100091

W. Onuigbo

引用次数: 0

Analysis of the In Vitro and In Vivo Effects of the Photodynamic Therapy on Prostate Cancer by Using News Photosensitizers, Protoporphyrin IXPolyamines Derivatives 新型光敏剂、原卟啉或多胺衍生物光动力治疗前列腺癌的体内外效应分析

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.100092

Chloë Fidanzi-Dugas, Bertr, Liagre, G. Chemin, A. Perraud, C. Carrion, R. Granet, V. Sol, D. Léger

引用次数: 0

Study of the Role of Anti-Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues 不同大小抗癌分子对相应体积肿瘤多器官或组织减少作用的研究

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.100083

A. Heidari

引用次数: 104

Liposarcoma of the Uterine Cervix in Nigeria: Case Report 尼日利亚子宫颈脂肪肉瘤1例

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.1000110

W. Onuigbo, O. Okezie

引用次数: 0

A 2 Year Old Female Child with Huge Vaginal Rhabdomyosarcoma 2岁女童伴巨大阴道横纹肌肉瘤

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.100043

P. Vaibhav, Ey, An, K. Das, I. Choudhary, O. Singh

引用次数: 0

Post Irradiation Pelvic Sarcoma 8 Years after Treatment for Adenocarcinoma for Prostate: About a Case 前列腺腺癌放疗后8年盆腔肉瘤1例

Archives in cancer research Pub Date : 2016-01-01 DOI: 10.21767/2254-6081.100050

F. Lai-Tiong, M. Michalet, A. Ruyer, J. Ripoche, S. Van-Hulst, N. Houédé

引用次数: 0