新型光敏剂、原卟啉或多胺衍生物光动力治疗前列腺癌的体内外效应分析

Archives in cancer research Pub Date : 2016-01-01 DOI:10.21767/2254-6081.100092

Chloë Fidanzi-Dugas, Bertr, Liagre, G. Chemin, A. Perraud, C. Carrion, R. Granet, V. Sol, D. Léger

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引用次数: 0

摘要

确定PpIX-PA(原卟啉ix -多胺);PpIX与两种亚精胺(PpIX- dsd)或精胺(PpIX- dsm)偶联可抑制前列腺癌细胞的活力，我们研究了其对线粒体膜电位的影响，因为线粒体结构和功能的改变已被证明在细胞凋亡的早期阶段起着至关重要的作用

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Analysis of the In Vitro and In Vivo Effects of the Photodynamic Therapy on Prostate Cancer by Using News Photosensitizers, Protoporphyrin IXPolyamines Derivatives

To determine potential mechanisms by which PpIX-PA (protoporphyrin IX-polyamines; PpIX is coupled with two molecules of spermidine (PpIX-dSd) or spermine (PpIX-dSm)) inhibited prostate cancer cell viability, we studied its effects on mitochondrial membrane potential because alterations in mitochondrial structure and function have been shown to play a crucial role at early stages of apoptosis

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Archives in cancer research

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