Brain Research最新文献_第4页

Deep brain stimulation of the olfactory bulb alleviates depressive-like behaviors and alters prefrontal cortex hippocampal coherence 对嗅球的深部脑刺激可减轻抑郁样行为并改变前额皮质海马的一致性

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-26 DOI: 10.1016/j.brainres.2025.149902

Mahta Bastani , Mohammad Reza Raoufy , Behrooz Khakpour-Taleghani , Mohammad Rostampour , Adele Jafari , Kambiz Rohampour

{"title":"Deep brain stimulation of the olfactory bulb alleviates depressive-like behaviors and alters prefrontal cortex hippocampal coherence","authors":"Mahta Bastani , Mohammad Reza Raoufy , Behrooz Khakpour-Taleghani , Mohammad Rostampour , Adele Jafari , Kambiz Rohampour","doi":"10.1016/j.brainres.2025.149902","DOIUrl":"10.1016/j.brainres.2025.149902","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD), marked by persistent depressive symptoms unresponsive to standard treatments, presents a significant challenge in psychiatry. Deep brain stimulation (DBS) has emerged as a novel intervention for TRD. This study examined the impact of DBS in the olfactory bulb (OB) on depressive symptoms, local field potentials (LFPs), and the medial prefrontal cortex (mPFC)-ventral hippocampus (vHPC) connectivity.</div><div>Thirty-six male Wistar rats were assigned to four groups: control, chronic mild stress (CMS), CMS + DBS, and DBS. Stereotactic surgery was performed to implant electrodes in the OB, mPFC, and vHPC. The CMS protocol was administered for 3 weeks to induce depression. Behavioral assessments included the sucrose preference test (SPT), forced swim test (FST), and open field test (OFT). During the final 4 days of CMS induction, the DBS groups received OB stimulation for one hour daily. On day 22, LFPs were recorded from the mPFC and vHPC and analyzed using MATLAB. Data were evaluated using ANOVA, with <em>P</em>-values ≤ 0.05 considered significant.</div><div>Results indicated that three weeks of CMS reduced low-frequency gamma power in the mPFC and overall gamma power in the vHPC, along with decreased delta and theta band coherence between these regions. CMS also increased delta, theta, and alpha band power during exploration. OB-DBS improved depressive-like behaviors, enhanced low-frequency gamma power in both mPFC and vHPC, and increased delta and theta coherence.</div><div>These findings suggest that depression’s pathogenesis involves alterations in the mPFC-vHPC neural network, and that OB-DBS may counteract these changes, offering a potential therapeutic target for TRD.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149902"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality and social attention: Trait-driven differences in neural engagement 人格和社会注意：神经参与的特质驱动差异

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-26 DOI: 10.1016/j.brainres.2025.149905

Yuzhan Hang , Wei Wu , Satoshi Shioiri , Xiaosong He

引用次数: 0

Selectin E upregulation upon forkhead box P1 loss augments neutrophil infiltration and brain damage in hypertensive intracerebral hemorrhage 叉头盒P1缺失时选择素E的上调增加了高血压脑出血中性粒细胞浸润和脑损伤

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-26 DOI: 10.1016/j.brainres.2025.149901

Naizhu Wang , Jingkun Wu , Zhaofei Song , Hongbin Wang , Yan Zhao

{"title":"Selectin E upregulation upon forkhead box P1 loss augments neutrophil infiltration and brain damage in hypertensive intracerebral hemorrhage","authors":"Naizhu Wang , Jingkun Wu , Zhaofei Song , Hongbin Wang , Yan Zhao","doi":"10.1016/j.brainres.2025.149901","DOIUrl":"10.1016/j.brainres.2025.149901","url":null,"abstract":"<div><div>Hypertension in the brain may lead to hypertensive intracerebral hemorrhage (HICH), a devastating disease. This study, grounded on bioinformatics insights, aims to investigate the functions of Selectin E (SELE) and forkhead box P1 (FOXP1) in the progression of HICH. Increased SELE expression was detected in the striatum of a mouse model of HICH generated via angiotensin II and L-NAME treatments. Knockdown of SELE alleviated hemorrhage, neutrophil infiltration, and blood–brain barrier (BBB) rupture in the mouse brain. FOXP1, poorly expressed in the HICH mice, was found to repress SELE transcription by binding to its promoter region. Overexpression of FOXP1 resulted in analogous alleviating effects in the HICH mice; however, the effects were abrogated by the additional SELE overexpression. <em>In vitro</em>, human brain microvascular endothelial cells (HBMECs) were treated with thrombin to generate a cellular model of ICH, followed by co-culture with HL-60 cell-derived neutrophils. The FOXP1 overexpression reduced the adhesion of neutrophils, and it alleviated HBMEC apoptosis and permeability while enhancing angiogenesis. Still, these effects were counteracted by the SELE upregulation. In conclusion, this study demonstrates that SELE upregulation upon FOXP1 loss is associated with neutrophil infiltration and BBB rupture in HICH.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149901"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utilization of non-human primates in the investigation of autism spectrum disorder 非人类灵长类动物在自闭症谱系障碍研究中的应用

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-25 DOI: 10.1016/j.brainres.2025.149900

Long Zhang, Jian-Hong Wang

{"title":"The utilization of non-human primates in the investigation of autism spectrum disorder","authors":"Long Zhang, Jian-Hong Wang","doi":"10.1016/j.brainres.2025.149900","DOIUrl":"10.1016/j.brainres.2025.149900","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD), a prevalent neurodevelopmental condition characterized by social communication deficits and repetitive behaviors, presents significant therapeutic challenges due to its multifactorial etiology, clinical heterogeneity, and frequent comorbidities. To address these complexities, animal models have become indispensable tools for unraveling ASD pathogenesis and evaluating potential interventions. This review synthesizes recent advances across three pivotal research domains—neuroimaging biomarkers, metabolic dysregulation, and etiological mechanisms—while providing a critical evaluation of animal models, including rodent and non-human primate (NHP) paradigms developed through pharmacological induction, spontaneous mutations, and CRISPR-based gene editing. Although rodent models have substantially advanced our understanding of ASD-linked genetic pathways and neural circuitry, their limited capacity to model higher-order social cognition underscores the need for evolutionarily proximate systems. Non-human primates (NHPs), with their neuroanatomical homology to humans and complex socio-cognitive behaviors, offer unparalleled advantages for recapitulating core ASD phenotypes. Current evidence demonstrates that NHP models faithfully replicate hallmark behavioral manifestations while elucidating aberrant neural network dynamics and synaptic plasticity underlying these traits. Key challenges in the field include standardizing model validation protocols, addressing sex-specific phenotypic variability, and integrating multi-omics approaches for biomarker discovery and circuit-level analysis, and evaluating the translational utility of NHP models.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149900"},"PeriodicalIF":2.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural visually guided behavior 自然的视觉引导行为

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-25 DOI: 10.1016/j.brainres.2025.149899

Mary Hayhoe , Constantin Rothkopf , Alexander Goettker , Nathaniel Powell

引用次数: 0

The influence of speaker accent on the neurocognitive processing of politeness 说话者重音对礼貌神经认知加工的影响

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-21 DOI: 10.1016/j.brainres.2025.149897

Peter C.H. Lam, Haining Cui, Marc D. Pell

{"title":"The influence of speaker accent on the neurocognitive processing of politeness","authors":"Peter C.H. Lam, Haining Cui, Marc D. Pell","doi":"10.1016/j.brainres.2025.149897","DOIUrl":"10.1016/j.brainres.2025.149897","url":null,"abstract":"<div><div>Does speaking with a foreign accent alter how listeners respond to verbal requests? Cooperative outcomes depend on multiple social factors, such as the politeness of the speaker who makes a request (e.g., their tone of voice). However, little is known about how indexical features derived from the speaker’s voice influence neurocognitive operations during politeness communication. In an event-related potential (ERP) study, 31 participants listened to requests (“Please lend me a nickel”) that varied in prosodic politeness (polite/rude), imposition level (low/high cost to perform an action), and accent (native/foreign English speaker). In separate rating tasks, participants made a social inference (speaker friendliness) or pragmatic inference (likelihood of request compliance) about each request based on available speech cues. ERPs time-locked to request onset revealed an interaction of speaker accent and prosodic (im)politeness on the P200 component (180–260 ms) and the subsequent late positivity (450–700 ms). Findings pointed to rapid perceptual differentiation of the speaker’s linguistic status and stance (P200), after which listeners attended more deeply to attitudinal cues expressed by native <em>ingroup</em> speakers. ERPs evoked by the sentence-final imposition word showed that speaker characteristics influenced how the “cost” of requests was later evaluated, hampering N400 semantic operations (300–500 ms) when speakers acted rudely <em>or</em> had a foreign accent—conditions less frequently associated with cooperative interactions. Selective uptake of particular social cues relevant for drawing social versus pragmatic inferences about requests was also noted. Our data identify a time course and brain mechanisms that integrate speaker and message during politeness communication.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149897"},"PeriodicalIF":2.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry-based proteomics in glioblastoma – current understanding and future impact 质谱为基础的蛋白质组学在胶质母细胞瘤-目前的认识和未来的影响

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-20 DOI: 10.1016/j.brainres.2025.149890

Sweety Asija , Sakshi Bhat , Abhishek Chatterjee , Godhanjali Chekuri , Rahul Purwar , Jayant S. Goda

{"title":"Mass spectrometry-based proteomics in glioblastoma – current understanding and future impact","authors":"Sweety Asija , Sakshi Bhat , Abhishek Chatterjee , Godhanjali Chekuri , Rahul Purwar , Jayant S. Goda","doi":"10.1016/j.brainres.2025.149890","DOIUrl":"10.1016/j.brainres.2025.149890","url":null,"abstract":"<div><div>Neoplasia represents an interplay between multiple complex biological systems with numerous tumor tissue-linked biomarkers contributing as modulators of tumorigenesis. Several bio-signaling pathways and processes undergo remodeling consequent to multiple mutations and alterations. In particular, cellular or molecular biomarkers, including DNA, messenger RNAs(mRNAs), microRNAs(miRNAs), and proteins, coupled with alterations in genetic, epigenetic, and metabolic profiles, are good potential candidates for acting as biomarkers throughout the natural history of cancer response to therapy. In the era of personalized cancer therapy, one of the critical challenges in the evolution of novel therapeutics is identifying unique and specific biomarkers. Proteomics has the potential to identify and categorize unforeseen or unidentified mutational biomarkers that can be useful in advancing effective therapeutic strategies. Besides various analysis techniques, mass spectrometry is one of the most efficient technologies utilized in this field. In this review, we discuss fundamental and nuanced aspects of mass spectrometry in the identification and characterization of the proteomic landscape of Glioblastoma Multiforme (GBM) and suggest the use of this data as a surrogate biomarker to not only understand gliomagenesis but also to reprogram anti-glioma therapeutic strategies to improve outcomes. Furthermore, the review also elaborates on applying mass-spectrometric-based proteomics in translational studies with the aim of full integration into interventional clinical trials.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149890"},"PeriodicalIF":2.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel derivative of rhein overcomes temozolomide resistance in glioblastoma by regulating SOX9 through m6A methylation 一种新的大黄酸衍生物通过m6A甲基化调节SOX9，克服了胶质母细胞瘤对替莫唑胺的耐药性

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-20 DOI: 10.1016/j.brainres.2025.149889

Li Cheng , Ting Wang , Rongbiao Pi , Peiliang Zhao , Jingkao Chen

{"title":"A novel derivative of rhein overcomes temozolomide resistance in glioblastoma by regulating SOX9 through m6A methylation","authors":"Li Cheng , Ting Wang , Rongbiao Pi , Peiliang Zhao , Jingkao Chen","doi":"10.1016/j.brainres.2025.149889","DOIUrl":"10.1016/j.brainres.2025.149889","url":null,"abstract":"<div><div>Temozolomide (TMZ) resistance remains a critical barrier to effective treatment of glioblastoma (GBM), the most aggressive form of glioma. Fat mass and obesity-associated protein (FTO), an m<sup>6</sup>A demethylase, has been implicated in tumor progression and chemoresistance. SYSUP007, a novel derivative of the FTO inhibitor rhein, exhibits anti-glioma activity; however, its role in modulating TMZ resistance remains unexplored. The present study aimed to investigate the mechanism by which SYSUP007 regulates TMZ resistance via FTO signaling. TMZ-resistant glioma cells were subjected to combinatorial treatment with SYSUP007 and TMZ. Cell proliferation was assessed using the MTT assay, while m<sup>6</sup>A dot blotting was employed to evaluate global m<sup>6</sup>A methylation levels. Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) were performed to analyze FTO and downstream target expression. The results revealed that SYSUP007 inhibited glioma cell proliferation in a dose-dependent manner and synergistically enhanced TMZ sensitivity <em>in vitro.</em> SYSUP007 significantly suppressed FTO expression and elevated m<sup>6</sup>A methylation levels, concomitant with downregulation of the oncogenic FTO target SOX9. Notably, SOX9 expression was markedly upregulated in TMZ-resistant cells compared with parental cells, and SYSUP007 effectively reversed this phenotype. These findings suggest that SYSUP007 potentiates TMZ efficacy by targeting the FTO/m<sup>6</sup>A/SOX9 axis. As a single-molecule multi-target agent, SYSUP007 represents a promising therapeutic candidate to overcome TMZ resistance in glioma.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149889"},"PeriodicalIF":2.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction notice to “Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model” [Brain Res. 1608 (2015) 215–224] “姜黄素包埋在纳米级PLGA中，下调核因子κB （p65）和蛛网膜下腔出血致早期大鼠脑损伤模型”的研究进展[j] .脑科学进展，2016(08):215-224。

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-20 DOI: 10.1016/j.brainres.2025.149886

Chih-Zen Chang , Shu-Chuan Wu , Chih-Lung Lin , Aij-Lie Kwan

引用次数: 0

Editorial: Origins of variability in acquiring and using linguistic knowledge 编辑：获取和使用语言知识的可变性的起源

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-19 DOI: 10.1016/j.brainres.2025.149894

Florian Hintz , Johanna Funk

引用次数: 0