Brain Research最新文献

{"title":"Advancing Alzheimer’s disease therapy through engineered exosomal Macromolecules","authors":"Smita Jain,&nbsp;Ankita Murmu,&nbsp;Aparna Chauhan","doi":"10.1016/j.brainres.2025.149590","DOIUrl":"10.1016/j.brainres.2025.149590","url":null,"abstract":"<div><div>Exosomes are a subject of continuous investigation due to their function as extracellular vesicles (EVs) that significantly contribute to the pathophysiology of certain neurodegenerative disorders (NDD), including Alzheimer’s disease (AD). Exosomes have shown the potential to carry both therapeutic and pathogenic materials; hence, researchers have used exosomes for medication delivery applications. Exosomes have reduced immunogenicity when used as natural drug delivery vehicles. This guarantees the efficient delivery of the medication without causing significant side reactions. Exosomes have lately enabled the potential for drug delivery in AD, along with promising future therapeutic uses for the detection of neurodegenerative disorders. Furthermore, exosomes have been examined for their prospective use in illness diagnosis and prediction before the manifestation of symptoms. This review will document prior studies and will concentrate on the rationale behind the substantial potential of exosomes in the treatment of AD and their prospective use as a diagnostic and predictive tool for this condition.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1855 ","pages":"Article 149590"},"PeriodicalIF":2.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cerebellar activity and cognitive deficits in Type 2 diabetes: Insights from resting-state fMRI","authors":"Shuang He ,&nbsp;Juan-Juan Lu ,&nbsp;Jia-Jia Wu ,&nbsp;Mou-Xiong Zheng ,&nbsp;Jie Ma ,&nbsp;Xu-Yun Hua ,&nbsp;Jian-Guang Xu","doi":"10.1016/j.brainres.2025.149586","DOIUrl":"10.1016/j.brainres.2025.149586","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate alterations in brain activity in patients with Type 2 Diabetes and explore the relationship between altered regions and neuropsychological performances.</div></div><div><h3>Methods</h3><div>A total of 36 patients with Type 2 Diabetes and 40 age- and education-matched healthy controls were recruited for this case-control study. All participants underwent resting-state functional magnetic resonance imaging (Resting-state fMRI) and neuropsychological tests. The neuropsychological scales included the Auditory Verbal Learning Test (AVLT), Shape Trajectory Test B (STT-B), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Boston Naming Test (BNT), Symbol Digit Modality Test (SDMT), Regional homogeneity (ReHo) and the amplitude of low-frequency fluctuations (ALFF) were used to assess differences in spontaneous regional brain activity. For functional connectivity (FC) analyses, the differences identified among the groups were selected as seed regions. Then, the correlations between neuropsychological scale scores (AVLT, HAMA, HAMD, STT-B, BNT, and SDMT) and ALFF/ReHo values were specifically analyzed in the focal regions that exhibited significant alterations between the T2DM and control groups, as detailed in Tables 2 and 3.</div></div><div><h3>Results</h3><div>Patients with Type 2 Diabetes exhibited significantly higher ALFF values in the superior lobe of the cerebellum, specifically in the left cerebellar crus I (Cerebellum_Crus I_L), left cerebellar lobule VI (Cerebellum_6_L), and left cerebellar lobule IV-V (Cerebellum_4_5_L). Additionally, they exhibited elevated ReHo values in the Cerebellum_Crus I_L and Cerebellum_6_L. The findings were statistically significant with a family-wise error-corrected, cluster-level p-value of less than 0.05. However, the FC analysis was not significant. AVLT scores were significantly lower in the diabetes group. The correlation analysis demonstrated a negative association between ALFF values of the Cerebellum_6_L and AVLT scores (R² = 0.1375, P &lt; 0.001). The ReHo values within the Cerebellum_6_L also exhibited a negative association with AVLT scores (R² = 0.0937, P = 0.007).</div></div><div><h3>Conclusion</h3><div>Patients with Type 2 Diabetes showed abnormal neural activities in diverse cerebellar regions mainly related to cognitive functions. This provides supplementary information to deepen our insight into the neural mechanisms by which Type 2 Diabetes affects the functional activity of the brain’s posterior circulation, as well as the potential association of these changes with cognitive impairment.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149586"},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal ganglia connectivity and network asymmetry in Parkinson’s disease: A resting-state fMRI study","authors":"Yan Liu ,&nbsp;Yu Cheng ,&nbsp;Tianran Chen ,&nbsp;Jun Wang ,&nbsp;Jiajin He ,&nbsp;Fuwu Yan ,&nbsp;Lirong Yan","doi":"10.1016/j.brainres.2025.149576","DOIUrl":"10.1016/j.brainres.2025.149576","url":null,"abstract":"<div><div>This study investigates the impact of basal ganglia network asymmetry on motor function in Parkinson’s Disease (PD). Using resting-state functional magnetic resonance imaging (rs-fMRI), functional connectivity and network asymmetry were analyzed in 15 non-demented PD patients and 15 healthy controls. Sixteen basal ganglia substructures, including the caudate, putamen, and globus pallidus, were selected for a unified analysis of variance framework to evaluate inter-hemispheric connectivity differences.</div><div>After spatial preprocessing, regions of interest were defined, and time-series data were extracted for functional connectivity and network asymmetry analysis. The results revealed significant alterations in the functional connectivity of the caudate, putamen, and nucleus accumbens (NAc) in PD patients. Notably, the absence of intra-network asymmetry in the left NAc and bilateral amygdala correlated with motor dysfunction, likely due to overactivity of the inhibitory indirect pathway. Furthermore, pronounced asymmetry in the left putamen and right frontal gyrus suggested a compensatory neural mechanism supporting motor performance.</div><div>These findings highlight the critical role of basal ganglia network asymmetry in the pathophysiology of PD. The identified asymmetry characteristics may serve as potential biomarkers for early diagnosis and disease progression monitoring, offering new directions for targeted therapeutic interventions.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149576"},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and reliability of fNIRS to detect cochlear implant-induced auditory cortical activation in prelingually deaf children with inner ear malformation or cochlear nerve deficiency","authors":"Hiroshi Yamazaki ,&nbsp;Saburo Moroto ,&nbsp;Tomoko Yamazaki ,&nbsp;Rinko Tamaya ,&nbsp;Naoko Fujii ,&nbsp;Keizo Fujiwara ,&nbsp;Yasushi Naito","doi":"10.1016/j.brainres.2025.149578","DOIUrl":"10.1016/j.brainres.2025.149578","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149578"},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRACE-ing fixations in the Visual World Paradigm: Extending linking hypotheses and addressing individual differences by simulating trial-level behavior","authors":"James S. Magnuson","doi":"10.1016/j.brainres.2025.149563","DOIUrl":"10.1016/j.brainres.2025.149563","url":null,"abstract":"<div><div>I review several alternative linking hypotheses for relating eye tracking data from the VWP to cognitive theories and models. While some models are able to simulate VWP data surprisingly well (such as the TRACE model), there is still ample ambiguity to resolve in the meaning of fixation proportions over time, despite decades of work with the VWP. I also present a simple fixation model based on probabilistic sampling from underlying lexical activation that allows simulation of individual trials. Unsurprisingly, a properly-parameterized sampling procedure approximates the underlying activation patterns when sufficient trials are averaged together. However, the utility of simulating trial-level behavior is not in reconstructing central tendencies (which can be derived directly without simulating fixations), but in addressing, for example, individual differences. I also discuss critiques and misunderstandings of linking models to the VWP, and analogies to a simpler paradigm – lexical decision – to illuminate the logic of linking hypotheses in the VWP.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149563"},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear factor erythroid 2-related factor improves depression and cognitive dysfunction in rats with ischemic stroke by mediating wolfram syndrome 1","authors":"Guangxu Hu,&nbsp;Hongjun Cao","doi":"10.1016/j.brainres.2025.149572","DOIUrl":"10.1016/j.brainres.2025.149572","url":null,"abstract":"<div><h3>Objective</h3><div>This research aims to investigate the molecular mechanism of nuclear factor erythroid 2-related factor (Nrf2) in improving post-stroke depression and cognitive impairment (PSDCI) by mediating wolfram syndrome 1 (Wfs1).</div></div><div><h3>Methods</h3><div>PSDCI rat model was established through middle cerebral artery occlusion (MCAO) and chronic unpredictable mild stress (CUMS). Dimethyl fumarate (DMF) was utilized as an Nrf2 activator, while Wfs1 knockdown lentiviral plasmid was injected into rats for functional investigations. Cognitive function- and depression-relevant parameters were assessed using Morris water maze, forced swimming, sucrose preference, modified neurological severity score (mNSS) tests. The infarct size, pathological changes, and neuronal damage were also evaluated. Additionally, oxidative stress- and inflammatory response-associated proteins were detected by enzyme-linked immunosorbent assay. The binding relation between Nrf2 and the Wfs1 promoter region was analyzed and verified by dual-luciferase and chromatin immunoprecipitation assays.</div></div><div><h3>Results</h3><div>PSDCI rats had reduced Nrf2 and Wfs1 expression in the hippocampal tissue and inhibited nuclear translocation of Nrf2, showing aggravated oxidative stress and inflammatory responses as well as cognitive dysfunction- and depressive-like symptoms. However, these symptoms in PSDCI rats can be alleviated in response to Nrf2 activation. Furthermore, Nrf2 activation increased the enrichment level of Nrf2 in the Wfs1 promoter region, promoting the transcriptional expression of Wfs1. Wfs1 knockdown partly reversed the effect of Nrf2 activation on the neuronal damage, cognitive dysfunction- and depressive-like symptoms of PSDCI rats.</div></div><div><h3>Conclusion</h3><div>Nrf2 activation can promote Wfs1 expression to reduce neuroinflammation and oxidative stress responses, ultimately alleviating PSDCI in rats.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149572"},"PeriodicalIF":2.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipopolysaccharide-binding protein levels, obstructive sleep apnea, and depression: A cross-sectional study of adults","authors":"Oliwia Gawlik-Kotelnicka ,&nbsp;Agata Gabryelska ,&nbsp;Marcin Sochal ,&nbsp;Karolina Czarnecka-Chrebelska ,&nbsp;Ewa Pikus ,&nbsp;Ewa Brzeziańska-Lasota ,&nbsp;Piotr Białasiewicz ,&nbsp;Dominik Strzelecki","doi":"10.1016/j.brainres.2025.149575","DOIUrl":"10.1016/j.brainres.2025.149575","url":null,"abstract":"<div><div>Obstructive sleep apnea (OSA) and depression are highly comorbid. Increased intestinal permeability has been hypothesized to play a role in the pathogenesis of both. The current study aimed to assess the severity of OSA symptoms, comorbid depressive symptoms, and lipopolysaccharide-binding protein (LBP) levels in adult patients being diagnosed for OSA syndrome. The study population consisted of 176 subjects. An apnea-hypopnea index (AHI) ≥ 5/hour was used for the diagnosis of OSA syndrome. Depressive symptoms were assessed with the Beck Depression Inventory-2. LBP levels were measured in the blood serum by enzyme-linked immunosorbent assay (ELISA). Associations between clinical symptom profiles or severity and LBP as an intestinal permeability biomarker marker were tested. LBP levels were not different between patients with different OSA severity, as assessed with AHI or daily sleepiness. Nor were LBP levels different in subjects with different depressiveness severity. Daily sleepiness was weakly positively correlated with depression score, and LBP levels correlated positively with a neutrophils-to-lymphocytes ratio. Finally, LBP levels were not explained by multiple linear regression models, including sleep-related parameter values and depression score. Intestinal permeability, as measured with LBP level, may not explain the comorbidity of depression and daily sleepiness in the course of OSA syndrome.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149575"},"PeriodicalIF":2.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing levetiracetam and zonisamide effects on rivastigmine anti-Alzheimer’s activity in aluminum chloride-induced Alzheimer’s-like disease in rats: Impact on α7 nicotinic acetylcholine receptors and amyloid β","authors":"Raafat A. Abdel-Aal ,&nbsp;Fatma Y. Meligy ,&nbsp;Nashwa Maghraby ,&nbsp;Nehal Sayed ,&nbsp;Israa El-Sayed Mohamed Ashry","doi":"10.1016/j.brainres.2025.149573","DOIUrl":"10.1016/j.brainres.2025.149573","url":null,"abstract":"<div><h3>Background and aim</h3><div>Alzheimer’s disease (AD) is the most progressive form of neurodegenerative disease, which severely impairs cognitive function. The leading class of drugs used to treat AD is acetylcholinesterase inhibitors (AChE-Is) as Rivastigmine (RIVA), partially ameliorate its cognitive symptoms. Since epilepsy is a common comorbidity with AD, we explored the potential that new the antiepileptic drugs; Levetiracetam (LEV) and Zonisamide (ZNS) may possess an additional therapeutic benefit to RIVA in AlCl₃-induced AD rat model.</div></div><div><h3>Materials and methods</h3><div>AlCl₃ was used to provoke AD in rats which were then supplemented with treatment drugs for 2 weeks. Treated groups were: Control, AlCl₃, RIVA, LEV, RIVA + LEV, ZNS and RIVA + ZNS. Then, the behavioral tests; passive avoidance (PA), Morris water maze (MWM) and novel object recognition (NOR) were conducted to assess cognitive behavior and memory. The Hippocampal Aβ assembly was thoroughly examined by histopathology and ELISA. α7 Nicotinic ACh receptors’ (α7nAChRs) expression was assessed immunohistochemically and by real-time quantitative polymerase chain reaction (qPCR). Caspase 3 expression was also assessed by real-time qPCR in hippocampal tissues.</div></div><div><h3>Results</h3><div>AlCl₃ administration impaired memory and cognitive functions in rats, augmented hippocampal Aβ deposition, with subsequent neurodegeneration and α7nAChRs down-regulation. LEV, but not ZNS, administration significantly mitigated AlCl₃-induced cognitive impairment probably through suppression of amyloid β (Aβ) deposition, enhancement of neurogenesis and α7nAChRs expression. When combined to RIVA, ZNS treatment negatively affected cognition possibly through its impact on hippocampal Aβ and subsequent neuronal damage.</div></div><div><h3>Conclusion</h3><div>Although our results indicated that neither LEV nor ZNS provided any extra benefit to cognitive enhancements in AD rats receiving rivastigmine, LEV demonstrated positive effects individually while ZNS had negative effects when combined with RIVA. As a result, this study suggests the use of LEV rather than ZNS for managing epilepsy in patients with AD given that Alzheimer’s and epilepsy can coexist.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1855 ","pages":"Article 149573"},"PeriodicalIF":2.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico screening to search for selective sodium channel blockers: When size matters","authors":"Maximiliano José Fallico ,&nbsp;Lucas Nicolás Alberca ,&nbsp;Nicolás Enrique ,&nbsp;Federico Orsi ,&nbsp;Denis Nihuel Prada Gori ,&nbsp;Pedro Martín ,&nbsp;Luciana Gavernet ,&nbsp;Alan Talevi","doi":"10.1016/j.brainres.2025.149571","DOIUrl":"10.1016/j.brainres.2025.149571","url":null,"abstract":"<div><div>Dravet Syndrome is a severe childhood drug-resistant epilepsy. The predominant etiology of this condition is related to <em>de novo</em> mutations within the SCN1A gene, which codes for the alpha subunit of the NaV1.1 sodium channels. This dysfunction leads to hypoexcitability of GABAergic interneurons. In turn, the loss of electrical excitability in GABAergic interneurons leads to an imbalance of excitation over inhibition in many neural circuits.</div><div>Notably, exacerbation of symptoms is observed when non-selective sodium channel blockers are administered to patients with Dravet. Recent studies in animal models of Dravet have highlighted the potential of highly specific sodium channel blockers capable of blocking other sodium channel subtypes without inhibiting NaV1.1 current and selective activators of NaV1.1 as viable therapeutic strategies for alleviating Dravet Syndrome symptoms.</div><div>Here, we describe the development and validation of ligand-based machine learning models to identify ligands with inhibitory effects on sodium channel isoforms NaV1.1 and NaV1.2. These models were built based on <em>in-house</em> open-source routines and Mordred molecular descriptors. First, linear classifiers were inferred using a combination of feature-bagging and Forward Stepwise selection. Secondly, ensemble learning was applied to build <em>meta</em>-classifiers with improved predictive ability, whose performance was tested in retrospective screening experiments. After <em>in silico</em> validation, the models were applied to screen for drug repurposing opportunities in the DrugBank and Drug Repurposing Hub databases, to identify selective blocking agents of NaV1.2 devoid of NaV1.1 blocking activity, as potential compounds for the treatment of Dravet Syndrome.</div><div>Forty <em>in silico</em> hits were later identified in a prospective screening experiment. Four of them were acquired and submitted to experimental confirmation via patch clamp: three of these candidates, Eltrombopag, Sufugolix, and Glesatinib, showed blocking effects on NaV1.2 currents, although no subtype selectivity was observed. The different predictive abilities of the NaV1.1 and NaV1.2 models may be attributed to the different sizes of the datasets used to train and validate the respective models.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149571"},"PeriodicalIF":2.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corpus callosum morphology does not depend on hand preference or hemispheric dominance for language","authors":"René Westerhausen ,&nbsp;Emma M. Karlsson ,&nbsp;Leah Johnstone ,&nbsp;David P. Carey","doi":"10.1016/j.brainres.2025.149574","DOIUrl":"10.1016/j.brainres.2025.149574","url":null,"abstract":"<div><div>It is traditionally assumed that the corpus callosum has a pivotal role in supporting hemispheric lateralisation, which originated from a series of studies suggesting differences in callosal morphology in relation to handedness. However, recent systematic reviews document that the callosal differences are only inconsistently reported, and it has been speculated that these inconsistencies might arise from focussing on handedness alone, without considering other lateralized functional modules. To address this short-coming, the present pre-registered study was designed to re-examine possible effects on callosal morphology while considering hand preference in interaction with hemispheric dominance for language. It was predicted that only those individuals who write with the hand ipsilateral to their language dominant hemisphere, have an increased need for interhemispheric integration that is reflected in detectable alteration to callosal morphology. That is, individual writing with the left hand (LW) while being left hemispheric dominant for language (LLD) are predicted to have a larger or thicker corpus callosum than individuals in which hand motor and language production are controlled by the same hemisphere. We tested this prediction by comparing the corpus callosum between the three common groups that result when combing the preferred writing hand (LW vs. right writers, RW) and the hemisphere dominant for language processing. For this purpose, language dominance (LLD vs. right dominance, RLD) was determined using a verbal-fluency task in functional magnetic resonance (fMRI) that has been previously validated. The study included N = 220 participants of both sexes, of which 97 were classified as LW/LLD, 73 as RW/LLD, and 50 as LW/RLD. The morphology of the corpus callosum was assessed on T1-weighted structural MR images as midsagittal surface area (subdivided into the three subregions genu, truncus, posterior third) as well as regional thickness (at 100 measuring points). The statistical analyses did not reveal any evidence to support our predictions and our sample size provides sufficient test power to rule out comparatively small effects with reasonable confidence. Thus, the midsagittal corpus callosum appears not substantially affected by the supposed increased requirement for interhemispheric integration in LW/LLD as compared with RW/LLD and LW/RLD individuals.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1856 ","pages":"Article 149574"},"PeriodicalIF":2.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}