Brain Research最新文献_第4页

Corticotropin-releasing hormone neurons in the central Amygdala: An integrative hub for pain, emotion, and addiction neurobiology 杏仁核中央的促肾上腺皮质激素释放激素神经元：疼痛、情绪和成瘾神经生物学的综合中枢。

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-02 DOI: 10.1016/j.brainres.2025.149753

Jia Li , Zi-Ang Li , Hui-Min Tian , Sha-Sha Tao , Qian Zhang , Fei Li , Yun-Qing Li

引用次数: 0

Association between epigenetic mark 5-hydroxymethylcytosine and brain pathophysiology 表观遗传标记5-羟甲基胞嘧啶与脑病理生理的关系

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-02 DOI: 10.1016/j.brainres.2025.149755

Amandeep Kaur Kang , Uma Dhawan , Birendra Nath Mallick

{"title":"Association between epigenetic mark 5-hydroxymethylcytosine and brain pathophysiology","authors":"Amandeep Kaur Kang , Uma Dhawan , Birendra Nath Mallick","doi":"10.1016/j.brainres.2025.149755","DOIUrl":"10.1016/j.brainres.2025.149755","url":null,"abstract":"<div><div>Over the last decade, the identification of the sixth base, 5-hydroxymethylcytosine (5-hmC), and its emerging association with brain disorders have provided new insights into the pathophysiological implications of neuroepigenetic changes. This epigenetic modification occurs due to Ten-eleven translocase 1/2/3 (Tet1/2/3) mediated oxidation of 5-methylcytosine (5-mC) molecules, reversing the methyl-dependent silencing of genes and changing the genomic landscape within the cells, thereby altering downstream signaling cascades. 5-hmC is enriched in the brain tissues and is involved in neurogenesis and brain development. However, the exact functional significance of 5-hmC has not been fully explored. The level of 5-hmC is altered with age, environmental toxicity, hormonal imbalances, exposure to challenges like sleep loss, changes in the level of neurotransmitters, and mutations in the Tet enzymes, resulting in the onset, sensitization or predisposition to brain pathology. In this review, we have discussed the recent studies investigating the role of DNA hydroxymethylation in various neurological disorders. These findings suggest that 5-hmC may play a regulatory role in the aetiology of neurodevelopmental, neurodegenerative and neuropsychiatric disorders. We also propose a potential role of 5-hmC in neuronal disorders associated with REM sleep deprivation.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149755"},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spearmint extract Neumentix downregulates amyloid-β accumulation by promoting phagocytosis in APP23 mice 留兰薄荷提取物新清通过促进吞噬作用下调APP23小鼠淀粉样蛋白-β的积累。

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-02 DOI: 10.1016/j.brainres.2025.149752

Xinran Hu , Ryuta Morihara , Yusuke Fukui , Yuting Bian , Hongming Sun , Ricardo Satoshi Ota-Elliott , Hiroyuki Ishiura , Koji Abe , Toru Yamashita

{"title":"Spearmint extract Neumentix downregulates amyloid-β accumulation by promoting phagocytosis in APP23 mice","authors":"Xinran Hu , Ryuta Morihara , Yusuke Fukui , Yuting Bian , Hongming Sun , Ricardo Satoshi Ota-Elliott , Hiroyuki Ishiura , Koji Abe , Toru Yamashita","doi":"10.1016/j.brainres.2025.149752","DOIUrl":"10.1016/j.brainres.2025.149752","url":null,"abstract":"<div><div>In recent years, many researchers have focused on natural compounds that can effectively delay symptoms of Alzheimer’s disease (AD). The spearmint extract Neumentix, which is rich in phenolic compounds, has been shown to reduce inflammatory responses and oxidative stress in mice. However, the effect of Neumentix on AD has not been thoroughly studied. In this study, APP23 transgenic female and male mice were administered Neumentix orally from 4 to 18 months of age at a dosage of 2.65 g/kg/day (containing 0.41 g/kg/day of rosmarinic acid). The impact was evaluated by behavioral tests and histological analyses and compared with APP23 mice to which Neumentix was not administered. The results showed that Neumentix administration increased the survival rate of APP23 mice and effectively reduced Aβ accumulation by enhancing its phagocytosis by microglial cells. These findings suggest that Neumentix is a potential natural nutritional treatment for improving the progression of AD.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149752"},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute high glucose exposure impairs synaptosomal vesicle release activity 急性高糖暴露损害突触体囊泡释放活性。

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-01 DOI: 10.1016/j.brainres.2025.149751

Nadine Alshakhshir , Lucy He , Liqin Zhao

{"title":"Acute high glucose exposure impairs synaptosomal vesicle release activity","authors":"Nadine Alshakhshir , Lucy He , Liqin Zhao","doi":"10.1016/j.brainres.2025.149751","DOIUrl":"10.1016/j.brainres.2025.149751","url":null,"abstract":"<div><h3>Background</h3><div>Increasing evidence indicates an association between Alzheimer’s disease (AD) and diabetes. AD and diabetic brains share a hyperglycemic phenotype, making it a plausible mechanistic link between the two diseases. The vacuolar-type ATPase (V-ATPase) is essential for neurotransmitter concentration in synaptic vesicles and subsequent neuronal transmission. However, its role in AD pathogenesis is unclear.</div></div><div><h3>Objectives</h3><div>We sought to examine whether acute hyperglycemic exposure would alter synaptic vesicular exocytosis and V-ATPase function in synaptosomes freshly extracted from wildtype mouse brains.</div></div><div><h3>Methods</h3><div>Synaptic exocytosis was studied by analyzing the synaptosomal release of the fluorescent dye acridine orange (AO) and the neurotransmitter glutamate. Synaptic V-ATPase activity was assessed by measuring V-ATPase assembly using co-immunoprecipitation and V-ATPase-released phosphates.</div></div><div><h3>Results</h3><div>Acute hyperglycemia reduced synaptic vesicular exocytosis as indicated by attenuated AO and glutamate release. Moreover, acute hyperglycemia reduced synaptic V-ATPase assembly but not V-ATPase-released phosphates.</div></div><div><h3>Conclusions</h3><div>The present work demonstrates that hyperglycemia can impair synaptic vesicular exocytosis, partially by reducing V-ATPase assembly. We hypothesize that these molecular changes can be a shared mechanistic contributor to synaptic dysfunction in AD and diabetes. Further studies are needed to investigate the impact of chronic hyperglycemia and glycolytic metabolism on synaptic vesicular activity and V-ATPase function in animal models of AD and diabetes.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149751"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACE2/Angiotensin-(1-7)/Mas and the brain ACE2/血管紧张素-(1-7)/Mas与脑的关系

IF 2.7 4区医学

Brain Research Pub Date : 2025-05-31 DOI: 10.1016/j.brainres.2025.149739

Maria José Campagnole-Santos , Marco Antônio Peliky Fontes , Thiago Verano-Braga , Andrea Siqueira Haibara , Michael Bader , Robson A.S. Santos

引用次数: 0

Unraveling Laser-Induced peripheral Pain: Proteomic profiling and electrophysiological Dynamics in mice 解开激光诱导的外周疼痛：小鼠的蛋白质组学分析和电生理动力学。

IF 2.7 4区医学

Brain Research Pub Date : 2025-05-31 DOI: 10.1016/j.brainres.2025.149743

Ying Guo , XiaoMei Ren , HuiMing Li , RuoFei Tian , ShengLong Xu , Zhi Cao , XinMei Gu , MengJuan Shang , Haonan Wang , JunLing Xing

{"title":"Unraveling Laser-Induced peripheral Pain: Proteomic profiling and electrophysiological Dynamics in mice","authors":"Ying Guo , XiaoMei Ren , HuiMing Li , RuoFei Tian , ShengLong Xu , Zhi Cao , XinMei Gu , MengJuan Shang , Haonan Wang , JunLing Xing","doi":"10.1016/j.brainres.2025.149743","DOIUrl":"10.1016/j.brainres.2025.149743","url":null,"abstract":"<div><div>With the rapid development of their technology, lasers are now widely used in science and industry over a range of fields. Unfortunately, accidents involving lasers also occur, in which there is a risk of skin damage and pain. At present, there are few studies on laser-induced pain, and the mechanism of peripheral pain following irradiation remains unclear. In this study, we aim to explore the pain-causing effects of laser irradiation on the skin. The plantar skin of mice was irradiated with an 808 nm diode laser. Different laser power levels and durations were used to determine optimal parameters for a laser-induced pain model. The mechanical withdrawal threshold detected by von Frey, skin cell damage via hematoxylin and eosin (H&E) staining, electrophysiological properties of dorsal root ganglia (DRG) and applied proteomics were employed to explore mechanisms underlying laser-induced skin pain. Our findings indicate that after being irradiated with 808 nm light from a diode laser at 2.5 W for 25 s, mice produce relatively stable pain responses, with peak pain sensitivity reached on the 14th day. The results of H&E staining of the plantar skin tissue after irradiation showed inflammation. Compared with the control group, the excitability of small DRG neurons in the laser-treated group was significantly elevated. Proteomic profiling revealed differential expression of S100A8/A9, TRPV1, and IL-17A, implicating these proteins as potential mediators of laser-induced nociception at the cellular level. This laser-induced pain model provides a robust platform for developing protective interventions.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149743"},"PeriodicalIF":2.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of NOTCH3 in CADASIL pathogenesis: insights into novel therapies NOTCH3在CADASIL发病机制中的作用：新疗法的见解

IF 2.7 4区医学

Brain Research Pub Date : 2025-05-31 DOI: 10.1016/j.brainres.2025.149754

Favour Felix-Ilemhenbhio , Klaudia Kocsy , Mimoun Azzouz , Arshad Majid

引用次数: 0

Anticipatory eye movements revisited: From affordances and actions to consequences and states 重新审视预期眼动：从启示和行动到结果和状态。

IF 2.7 4区医学

Brain Research Pub Date : 2025-05-31 DOI: 10.1016/j.brainres.2025.149742

Kyra L. Krass , Joslyn S. Hoang , Gitte H. Joergensen , Gerry T.M. Altmann

引用次数: 0

Auricular neuromodulation may act through interoception modulation 耳穴神经调节可能通过内感受调节起作用。

IF 2.7 4区医学

Brain Research Pub Date : 2025-05-30 DOI: 10.1016/j.brainres.2025.149736

Frédéric Canini , Damien Claverie , Florence Weill , Christine Pailler , Béatrice Paquier , Mireille Michel-Cherqui , Sonia Pellissier , Marion Trousselard , Emmanuel Sagui

{"title":"Auricular neuromodulation may act through interoception modulation","authors":"Frédéric Canini , Damien Claverie , Florence Weill , Christine Pailler , Béatrice Paquier , Mireille Michel-Cherqui , Sonia Pellissier , Marion Trousselard , Emmanuel Sagui","doi":"10.1016/j.brainres.2025.149736","DOIUrl":"10.1016/j.brainres.2025.149736","url":null,"abstract":"<div><div>Auricular neuromodulation (ANM) is a non-invasive method of stimulating the trigeminal, spinal, and vagal nerves that innervate the auricle, the outer part of the ear. ANM, and the vagal nerve stimulation in particular, has been shown to be effective in treating a number of symptoms, including pain and anxiety. However, the mechanisms by which ANM exerts its beneficial effects are still under investigation. We hypothesized that ANM produces its effects by modulating interoception, a physiological function involved in homeostatic regulation and awareness of internal physical and emotional sensations. Interoception, activated by visceral and sensory afferences, in turn modulates body function by regulating the autonomic nervous system (ANS). Therefore, we reviewed the anatomical, physiological, and pathophysiological evidence linking ANM to interoception, ultimately defining an auricle-brain axis. We propose two functional pathways that are activated directly or indirectly by the auricular nerves. The first pathway processes the sensory information coming from the parabrachial and solitary tract nuclei. The second pathway activates the monoaminergic and cholinergic pathways, thereby regulating the interoceptive response. ANM modulates the two outputs of interoception — that is, the ANS and the stress response — and changes the body response. We hypothesized that ANM provides new sensory information for interoception and thereby improves body-brain interactions previously compromised by ongoing pathological processes. Therefore, we assessed the effects of ANM on interoception-related pathologies. Finally, we evaluated whether empirical features of ANM can be explained by interoceptive mechanisms.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149736"},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of chronic stress and angiotensin II type 1 receptor blockade on rats’ performance in the five-choice serial reaction time task (5-CSRTT) 慢性应激和血管紧张素II型1受体阻断对大鼠5-选择系列反应时间任务表现的影响

IF 2.7 4区医学

Brain Research Pub Date : 2025-05-30 DOI: 10.1016/j.brainres.2025.149741

Dominik Wincewicz

{"title":"Effects of chronic stress and angiotensin II type 1 receptor blockade on rats’ performance in the five-choice serial reaction time task (5-CSRTT)","authors":"Dominik Wincewicz","doi":"10.1016/j.brainres.2025.149741","DOIUrl":"10.1016/j.brainres.2025.149741","url":null,"abstract":"<div><div>Pinpointing the bidirectional relationship between psychiatric and cardiovascular disorders holds the potential to tailor therapy and apply concepts of personalized treatment. Recent findings from both basic and clinical studies indicate effectives of central Renin-Angiotensin System (RAS) blockade in treatment of neuropsychiatric disorders, including the negative effects of stress. Here, to further investigate the long-term utility and translational value of angiotensin II type 1 receptor blockade on stress-induced impairment of learning and memory, we used an advanced behavioral paradigm – the five-choice serial reaction time task (5-CSRTT). Male Wistar rats, receiving vehicle (0.5 % metylcellulose) or telmisartan (TLM) (1 mg/kg), were subjected to a repeated restraint stress (21 days, 2.5 h/d) followed by training to the 5-CSRTT. Initial test parameters were altered on subsequent sessions according to individual animal’s performance until reaching target parameters. Trained rats were subjected to a second 21-day trial of chronic stress and drug administration followed by the 5-CSRTT re-executed on target parameters. In the course of the study rats acquired accurate responses to the task at different rate. Unexpectedly, chronic stress preceding the 5-CSRTT training improved the procedural learning. Moreover, repeated restraint in previously trained subjects failed to alter the 5-CSRTT performance in statistically significant manner. Therefore, the translational value of animal model of chronic stress may be limited, as this commonly used research method failed to show long-lasting learning deficits. Our previous findings indicating ‘anti-stress’ capacity of TLM were not supported in the course of this study.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149741"},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0